CN114533753A - 含硒组合物及其治疗和预防与线粒体功能障碍有关的疾病或病症的应用 - Google Patents

含硒组合物及其治疗和预防与线粒体功能障碍有关的疾病或病症的应用 Download PDF

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Publication number
CN114533753A
CN114533753A CN202210024252.2A CN202210024252A CN114533753A CN 114533753 A CN114533753 A CN 114533753A CN 202210024252 A CN202210024252 A CN 202210024252A CN 114533753 A CN114533753 A CN 114533753A
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selenium
present application
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enriched yeast
composition
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Chinese (zh)
Inventor
R.鲍威尔
C.伊根
A.伊安尼库里斯
兰子鉴
肖日进
L.C.杰克逊
S.奎亚特科夫斯基
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Alltech Corp
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Alltech Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202210024252.2A 2013-03-15 2014-03-14 含硒组合物及其治疗和预防与线粒体功能障碍有关的疾病或病症的应用 Pending CN114533753A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361788133P 2013-03-15 2013-03-15
US61/788133 2013-03-15
CN201480028372.3A CN105377271A (zh) 2013-03-15 2014-03-14 含硒组合物及其治疗和预防与线粒体功能障碍有关的疾病或病症的应用
PCT/US2014/029328 WO2014144776A1 (en) 2013-03-15 2014-03-14 Compositions comprising selenium and use of same for the treatment and prevention of disease or conditions associated with mitochondrial dysfunction

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CN201480028372.3A Division CN105377271A (zh) 2013-03-15 2014-03-14 含硒组合物及其治疗和预防与线粒体功能障碍有关的疾病或病症的应用

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CN114533753A true CN114533753A (zh) 2022-05-27

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CN202210024252.2A Pending CN114533753A (zh) 2013-03-15 2014-03-14 含硒组合物及其治疗和预防与线粒体功能障碍有关的疾病或病症的应用
CN202210387608.9A Pending CN114984038A (zh) 2013-03-15 2014-03-14 含硒组合物及其治疗和预防与线粒体功能障碍有关的疾病或病症的应用
CN201480028372.3A Pending CN105377271A (zh) 2013-03-15 2014-03-14 含硒组合物及其治疗和预防与线粒体功能障碍有关的疾病或病症的应用

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CN201480028372.3A Pending CN105377271A (zh) 2013-03-15 2014-03-14 含硒组合物及其治疗和预防与线粒体功能障碍有关的疾病或病症的应用

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Country Link
US (1) US9833486B2 (https=)
EP (1) EP2968404A4 (https=)
JP (1) JP6313418B2 (https=)
KR (1) KR102245702B1 (https=)
CN (3) CN114533753A (https=)
AU (1) AU2014228785B2 (https=)
BR (1) BR112015022514A2 (https=)
CA (1) CA2903845C (https=)
CL (1) CL2015002677A1 (https=)
HK (1) HK1216506A1 (https=)
MX (1) MX359626B (https=)
RU (1) RU2663127C2 (https=)
SG (2) SG10202101918RA (https=)
WO (1) WO2014144776A1 (https=)
ZA (1) ZA201506759B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114931569A (zh) * 2022-06-22 2022-08-23 中国农业科学院油料作物研究所 甲基硒代半胱氨酸在制备提高雄性生殖能力的产品中的应用
CN116333302A (zh) * 2023-03-31 2023-06-27 中南大学 一种稳定持久抗氧化纳米点及其在二型糖尿病中的应用
CN116421618A (zh) * 2023-06-15 2023-07-14 暨南大学 Se@NADH的制备方法及其在脊髓损伤治疗中的应用

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX384232B (es) 2013-03-14 2025-03-14 Jerome J Schentag Vesiculas colestosomicas para incorporacion de moleculas en quilomicrones.
RU2665135C2 (ru) * 2014-03-14 2018-08-28 Олтек, Инк. Композиции селеноорганических соединений и способы их применения
WO2016160594A1 (en) 2015-03-27 2016-10-06 The Research Foundation For The State University Of New York Methods and materials for reducing amyloid beta levels within a mammal
WO2017048252A1 (en) * 2015-09-15 2017-03-23 Alltech, Inc. Compositions of selenoorganic compounds and methods of use thereof
WO2017160678A1 (en) * 2016-03-14 2017-09-21 Mitogenetics, Llc Materials and methods for treating hypoxic conditions
AU2018269403B2 (en) 2017-05-19 2025-03-27 Alltech, Inc. Pharmaceutical agents, compositions, and methods relating thereto
JP7250810B2 (ja) * 2018-04-25 2023-04-03 オンコクロス カンパニー，リミテッド 筋肉疾患の予防及び治療用組成物
CN108283711A (zh) * 2018-05-06 2018-07-17 冷立娟 一种治疗酒精性心肌病的中药冲剂及其制备方法
CN109820933A (zh) * 2019-02-27 2019-05-31 北京曲佳科技有限公司 减肥片及其制备方法
CN111493325A (zh) * 2020-05-07 2020-08-07 恩施德源健康科技发展有限公司 植物硒肽在制备改善肥胖及代谢综合征组合物中的应用
US20230129707A1 (en) * 2020-06-29 2023-04-27 Bristol-Myers Squibb Company Automated system and method for analyzing samples from a bioreactor
CN112129864B (zh) * 2020-09-24 2022-04-01 江南大学 一种富硒植物干粉中硒形态测定的方法
KR102328808B1 (ko) * 2020-12-02 2021-11-22 동의대학교 산학협력단 맥주효모를 이용한 근감소증 예방 및 개선용 조성물
CN114053298A (zh) * 2021-11-19 2022-02-18 华中农业大学 一种用于抑制心肌肥大的药物及模型的构建方法
CN114235989A (zh) * 2021-11-27 2022-03-25 山东省烟台市农业科学研究院 一种测定福美甲胂含量的高效液相色谱法
CN114031650B (zh) * 2021-11-29 2023-05-02 上海交通大学 壳寡糖硒配位化合物及其制备方法和应用
CN114924001B (zh) * 2022-05-12 2024-11-19 中国计量科学研究院 一种基于独立校准的含磷或含硒化合物标准溶液定值方法
CN120531844A (zh) * 2025-07-02 2025-08-26 内蒙古肽元生物科技有限公司 生物活性肽在增强哺乳动物卵母细胞成熟及胚胎发育潜能中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070026090A1 (en) * 2003-09-05 2007-02-01 Oren Tirosh Treatment and prevention of inflammatory disease and mitochondrial dysfunction with high dose selenium
EP1774972A1 (en) * 2005-10-14 2007-04-18 Alltech, Inc. Use of selenium compounds, especially selenium yeasts in the treatment of Alzheimer, neurodegenerative diseases and diabetes
US20080008692A1 (en) * 2005-10-14 2008-01-10 Alltech, Inc. Methods and compositions for altering cell function

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5896024A (ja) * 1981-10-16 1983-06-07 リチヤ−ド・エフ・ストツケル 白金毒解毒剤
US5221545A (en) 1992-03-09 1993-06-22 Abbott Laboratories Method of providing selenium in a nutritional product
US6197295B1 (en) 1996-09-25 2001-03-06 Viva America Marketing Corporation Dietary supplementation with, and methods for administration of yeast-derived selenium product
US6911550B2 (en) 2003-02-21 2005-06-28 Zinpro Corporation Derivatives of seleno-amino acids with improved bioavailability and method for their preparation
OA13177A (en) * 2003-06-04 2006-12-13 Willem Jacob Serfontein Nutritional compositions and use thereof.
PL214402B1 (pl) * 2003-08-11 2013-07-31 Tomasz Byrski Zastosowanie selenu albo jego zwiazku do otrzymywania srodka do obnizania odziedziczonego ryzyka zachorowania na raka piersi lub jajnika
US20050069594A1 (en) 2003-08-11 2005-03-31 Jan Lubinski Pharmaceutical compositions and methods for the prevention of breast and ovarian cancer
US20100247679A1 (en) * 2006-04-24 2010-09-30 Alltech, Inc. Methods and compositions for altering cell function
US8846111B2 (en) * 2007-05-18 2014-09-30 Alltech, Inc. Compositions and methods for establishing and/or maintaining pregnancy
WO2009018492A2 (en) * 2007-07-31 2009-02-05 The Board Of Regents Of The University Of Texas System Micro-rnas that control myosin expression and myofiber identity
WO2009032057A2 (en) * 2007-08-29 2009-03-12 Adam Lubin Method for the selective therapy of disease
ES2378595T3 (es) * 2007-10-16 2012-04-16 Actigenomics S.A. Composición destinada a la regulación del metabolismo de los lípidos
CN101579355B (zh) * 2009-05-27 2010-12-08 徐建兴 一种维护线粒体功能的营养组合物及其应用
EP3095458B1 (en) * 2009-10-22 2018-07-25 Propanc Pty Ltd Pharmaceutical composition for treating cancer comprising trypsinogen and chymotrypsinogen
US8575320B2 (en) 2010-03-18 2013-11-05 Alltech, Inc. Compositions and methods for separating, characterizing and administering soluble selenoglycoproteins
WO2011132799A1 (en) * 2010-04-22 2011-10-27 Kyoto University Method for inducing differentiation of pluripotent stem cells into skeletal muscle or skeletal muscle progenitor cells
KR20120048205A (ko) * 2010-11-05 2012-05-15 한국식품연구원 메틸셀레노시스테인을 유효성분으로 함유하는 비만 및 지질 관련 대사성 질환의 예방 및 치료용 조성물
EP2705844B1 (en) 2011-04-13 2019-05-22 Ajinomoto Co., Inc. Nutritional composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070026090A1 (en) * 2003-09-05 2007-02-01 Oren Tirosh Treatment and prevention of inflammatory disease and mitochondrial dysfunction with high dose selenium
EP1774972A1 (en) * 2005-10-14 2007-04-18 Alltech, Inc. Use of selenium compounds, especially selenium yeasts in the treatment of Alzheimer, neurodegenerative diseases and diabetes
CN101073584A (zh) * 2005-10-14 2007-11-21 全面技术公司 改变细胞功能的方法和组合物
US20080008692A1 (en) * 2005-10-14 2008-01-10 Alltech, Inc. Methods and compositions for altering cell function

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114931569A (zh) * 2022-06-22 2022-08-23 中国农业科学院油料作物研究所 甲基硒代半胱氨酸在制备提高雄性生殖能力的产品中的应用
CN116333302A (zh) * 2023-03-31 2023-06-27 中南大学 一种稳定持久抗氧化纳米点及其在二型糖尿病中的应用
CN116421618A (zh) * 2023-06-15 2023-07-14 暨南大学 Se@NADH的制备方法及其在脊髓损伤治疗中的应用
CN116421618B (zh) * 2023-06-15 2023-09-29 暨南大学 Se@NADH的制备方法及其在脊髓损伤治疗中的应用

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KR102245702B1 (ko) 2021-04-28
MX359626B (es) 2018-10-01
SG11201507061XA (en) 2015-10-29
US9833486B2 (en) 2017-12-05
US20160113977A1 (en) 2016-04-28
EP2968404A4 (en) 2017-01-04
JP6313418B2 (ja) 2018-04-18
JP2016516058A (ja) 2016-06-02
AU2014228785B2 (en) 2018-01-25
CA2903845A1 (en) 2014-09-18
KR20150132374A (ko) 2015-11-25
AU2014228785A1 (en) 2015-09-24
RU2663127C2 (ru) 2018-08-01
EP2968404A1 (en) 2016-01-20
RU2015139742A (ru) 2017-04-21
BR112015022514A2 (pt) 2017-07-18
CL2015002677A1 (es) 2016-12-09
MX2015013275A (es) 2015-12-11
CN114984038A (zh) 2022-09-02
CA2903845C (en) 2022-08-23
SG10202101918RA (en) 2021-03-30
NZ711842A (en) 2021-04-30
HK1216506A1 (zh) 2016-11-18
ZA201506759B (en) 2017-03-29
CN105377271A (zh) 2016-03-02
WO2014144776A1 (en) 2014-09-18

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Application publication date: 20220527