CN114533737B - 治疗眼部病状的方法 - Google Patents

治疗眼部病状的方法 Download PDF

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Publication number
CN114533737B
CN114533737B CN202210034408.5A CN202210034408A CN114533737B CN 114533737 B CN114533737 B CN 114533737B CN 202210034408 A CN202210034408 A CN 202210034408A CN 114533737 B CN114533737 B CN 114533737B
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formula
compound
iiib
iiia
nasal cavity
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Chinese (zh)
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CN114533737A (zh
Inventor
小道格拉斯·M·阿克曼
J·劳丁
K·J·曼德尔
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Oyster Point Pharma Inc
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Oyster Point Pharma Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202210034408.5A 2016-04-07 2017-04-06 治疗眼部病状的方法 Active CN114533737B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210034408.5A CN114533737B (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662319648P 2016-04-07 2016-04-07
US62/319,648 2016-04-07
CN202210034408.5A CN114533737B (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法
PCT/US2017/026385 WO2017177024A1 (en) 2016-04-07 2017-04-06 Methods of treating ocular conditions
CN201780034734.3A CN109310692B (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法

Related Parent Applications (1)

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CN201780034734.3A Division CN109310692B (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法

Publications (2)

Publication Number Publication Date
CN114533737A CN114533737A (zh) 2022-05-27
CN114533737B true CN114533737B (zh) 2024-05-31

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CN202210034408.5A Active CN114533737B (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法
CN201780034734.3A Active CN109310692B (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法
CN202210040168.XA Pending CN114432313A (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法

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CN201780034734.3A Active CN109310692B (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法
CN202210040168.XA Pending CN114432313A (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法

Country Status (19)

Country Link
US (3) US10709707B2 (https=)
EP (2) EP3439661B1 (https=)
JP (3) JP7090551B2 (https=)
KR (2) KR102485299B1 (https=)
CN (3) CN114533737B (https=)
AU (1) AU2017248276B2 (https=)
DK (1) DK3439661T3 (https=)
EA (1) EA201892265A1 (https=)
ES (1) ES2893126T3 (https=)
IL (3) IL299204A (https=)
MX (2) MX385698B (https=)
MY (1) MY199237A (https=)
NZ (1) NZ746468A (https=)
PH (1) PH12018502154A1 (https=)
PT (1) PT3439661T (https=)
SG (1) SG11201808650QA (https=)
TW (2) TWI876258B (https=)
WO (1) WO2017177024A1 (https=)
ZA (1) ZA201807438B (https=)

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US9145396B2 (en) 2008-12-01 2015-09-29 Targacept, Inc. Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
EP3848028B9 (en) 2014-10-20 2024-10-16 Oyster Point Pharma, Inc. Methods of treating ocular conditions
MX385698B (es) 2016-04-07 2025-03-18 Oyster Point Pharma Inc Uso de un compuesto que comprende un grupo pirrolidinilo y pirimidinilo para tratar enfermedades oculares
EP3820443A1 (en) 2018-07-10 2021-05-19 Oyster Point Pharma, Inc. Combinations of positive allosteric modulators and nicotinic acetylcholine receptor agonists for treating ocular conditions
WO2020014217A1 (en) 2018-07-10 2020-01-16 Oyster Point Pharma, Inc. Methods of treating ocular conditions
ES3039903T3 (en) * 2020-04-28 2025-10-27 Oyster Point Pharma Inc Local administration of nicotinic acetylcholine receptor agonists for the inhibition of coronavirus infections
KR20240021783A (ko) * 2021-05-07 2024-02-19 오이스터 포인트 파마 인코포레이티드 벡터 및 니코틴 작용제 병용 요법
WO2026080563A1 (en) 2024-10-09 2026-04-16 Oyster Point Pharma, Inc. Simpinicline oral formations and use thereof

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WO2004039366A1 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy
WO2010065443A1 (en) * 2008-12-01 2010-06-10 Targacept, Inc. Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine
CN102216289A (zh) * 2008-10-14 2011-10-12 塞扣吉尼克斯公司 烟碱乙酰胆碱受体配体及其用途
CN109310692B (zh) * 2016-04-07 2022-01-25 奥伊斯特普安生物制药公司 治疗眼部病状的方法

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US7098331B2 (en) 2003-03-05 2006-08-29 Targacept, Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
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WO2004039366A1 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy
CN102216289A (zh) * 2008-10-14 2011-10-12 塞扣吉尼克斯公司 烟碱乙酰胆碱受体配体及其用途
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Also Published As

Publication number Publication date
TW201737917A (zh) 2017-11-01
EP3970724A1 (en) 2022-03-23
NZ746468A (en) 2023-06-30
NZ785093A (en) 2024-07-05
CN114533737A (zh) 2022-05-27
WO2017177024A8 (en) 2018-11-08
KR20230010813A (ko) 2023-01-19
US20250000861A1 (en) 2025-01-02
IL290069B2 (en) 2023-05-01
MX2018012230A (es) 2019-03-28
CA3020170A1 (en) 2017-10-12
IL262102A (en) 2018-11-29
EP3439661B1 (en) 2021-08-04
CN109310692A (zh) 2019-02-05
EP3439661A1 (en) 2019-02-13
TWI790997B (zh) 2023-02-01
ES2893126T3 (es) 2022-02-08
IL262102B (en) 2022-03-01
WO2017177024A1 (en) 2017-10-12
IL290069B1 (en) 2023-01-01
TWI876258B (zh) 2025-03-11
TW202320785A (zh) 2023-06-01
CN114432313A (zh) 2022-05-06
JP2019513759A (ja) 2019-05-30
KR102512777B1 (ko) 2023-03-23
DK3439661T3 (da) 2021-10-18
ZA201807438B (en) 2024-09-25
US20200345734A1 (en) 2020-11-05
ES2893126T8 (es) 2022-05-23
US20190201397A1 (en) 2019-07-04
JP7090551B2 (ja) 2022-06-24
MX385698B (es) 2025-03-18
BR112018070497A2 (pt) 2019-01-29
IL290069A (en) 2022-03-01
AU2017248276A1 (en) 2018-11-22
SG11201808650QA (en) 2018-10-30
JP2022120125A (ja) 2022-08-17
PH12018502154A1 (en) 2019-07-08
US10709707B2 (en) 2020-07-14
PT3439661T (pt) 2021-09-30
KR20190005859A (ko) 2019-01-16
IL299204A (en) 2023-02-01
EA201892265A1 (ru) 2019-04-30
CN109310692B (zh) 2022-01-25
MX2021010399A (es) 2022-01-18
MY199237A (en) 2023-10-22
AU2017248276B2 (en) 2023-07-13
JP2024103594A (ja) 2024-08-01
KR102485299B1 (ko) 2023-01-06

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