CN114522205A - 一种用于治疗靶向药治疗后的手足综合征的中药组合物及其制备方法 - Google Patents
一种用于治疗靶向药治疗后的手足综合征的中药组合物及其制备方法 Download PDFInfo
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- CN114522205A CN114522205A CN202210315505.1A CN202210315505A CN114522205A CN 114522205 A CN114522205 A CN 114522205A CN 202210315505 A CN202210315505 A CN 202210315505A CN 114522205 A CN114522205 A CN 114522205A
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Abstract
一种用于治疗靶向药治疗后的手足综合征的中药组合物,主要由以下重量份的组分制备而成:苦参20~50份、蒲公英20~50份、野菊花20~50份、紫花地丁20~50份、土茯苓20~50份、黄芪30~60份、地肤子10~35份、红花10~45份、白鲜皮15~45份、麻黄5~15份、当归5~25份、川芎5~25份、生地10~30份、桂枝5~15份、白芍10~30份、白芥子5~15份、生南星5~20份、生半夏5~20份、生甘草10~40份。本发明的中药组合物用于靶向药治疗后的手足皮肤反应处,具有益气养血、清热解毒、燥湿化痰的功效,对靶向药治疗后的手足综合征具有良好治疗作用,且简单方便,成本低廉,易于实现。
Description
技术领域
本发明属于中药技术领域,尤其涉及一种用于治疗靶向药治疗后的手足综合征的中药组合物及其制备方法。
背景技术
恶性肿瘤作为一种生存率低、预后不良的多系统难治性疾病,其中将来源于上皮组织的恶性肿瘤称为癌症;2020年,我国新发癌症病例数为457万,其中大部分人接受靶向药物治疗,而靶向药物治疗如:索拉非尼,舒尼替尼等,带来的明显影响患者生活质量的副作用就是手足综合征(HFS)。手足综合征是手掌足底(掌跖)感觉丧失性红斑、肢端红斑、化疗诱发的肢端红斑、手掌足底(掌跖)感觉丧失、手掌足底红斑、手掌足底红皮病、毒性红斑等,具体特征表现为:手足肢体末端麻木、感觉迟钝、感觉异常、麻刺感、无痛感或疼痛感,皮肤肿胀或红斑,脱屑、皲裂、硬结样水泡或严重的疼痛等。现有的西医诊疗规范中尚未对此进行系统性论治,西医推荐口服维生素加外用凡士林软膏或护肤产品来进行对症治疗,治疗效果因人而异,且效果欠佳,易于反复,患者往往不能耐受手足综合征而终止靶向药治疗。
中医药防治手足综合征有一定的优势,因中医不仅可以内服中药汤剂来调和内部阴阳寒热失调,更可以通过外用中药改善手足综合征局部症状来配合靶向药治疗。常见的中药外治方法包括外涂药膏、汤液熏洗,其中,外涂药膏有炎敌油(主要由紫草、黄芷、当归等组成)、湿润烧伤膏(黄连、黄柏、黄苓、紫草、川菖、白芷、珍珠、硼砂、冰片)等;汤液包括:芷归通络汤(黄芷、桂枝、紫草、木瓜、姜黄、当归、细辛、红花、附片)、四妙活血散(黄柏、苍术、生慧茂仁、川牛膝、桃仁、红花、苏木、伸筋草)、黄芷桂枝五物汤(黄芷、桂枝、当归、海风藤、红花、赤芍、白芍)、桃红四物汤加减(桃仁、红花、熟地黄、当归、川萼、桂枝、川牛膝、甘草、大枣)等。但治疗效果有待进一步提升,因此开发一种用于治疗靶向药治疗后的手足综合征的中药组合物,对于手足综合征的中医特色治疗具有重大意义。
发明内容
本发明要解决的技术问题是克服现有技术的不足,提供一种用于治疗靶向药治疗后的手足综合征的中药组合物及其制备方法。
本发明提出的技术方案之一:
一种用于治疗靶向药治疗后的手足综合征的中药组合物,所述中药组合物主要由以下重量份的组分制备而成:
苦参20~50份、蒲公英20~50份、野菊花20~50份、紫花地丁20~50份、土茯苓20~50份、黄芪30~60份、地肤子10~35份、红花10~45份、白鲜皮15~45份、麻黄5~15份、当归5~25份、川芎5~25份、生地10~30份、桂枝5~15份、白芍10~30份、白芥子5~15份、生南星5~20份、生半夏5~20份、生甘草10~40份。
优选的,所述苦参和所述土茯苓的质量比为1:1。
优选的,所述野菊花、蒲公英和紫花地丁的质量比为1:1:1。
优选的,所述当归与所述川芎的质量比为1:1。
优选的,所述生南星、生半夏和生甘草的质量比为1:1:2。
本发明的技术方案之二:
一种上述的用于治疗靶向药治疗后的手足综合征的中药组合物的制备方法,包括以下步骤:
(1)按配方称取药材;
(2)将生南星、生半夏碾碎成粉末状混合物A;将其余药材搅拌混合均匀后,碾碎成粉末状混合物B;
(3)将所述粉末状混合物A加水煎煮一段时间后,加入粉末状混合物B继续煎煮一段时间,然后冷却过滤,得到冷却液和药渣;
(4)将所述药渣加水进行二次煎煮,冷却后过滤,得到滤液;
(5)将步骤(3)中的冷却液和步骤(4)中的滤液合并,灭菌处理,封装,得到用于治疗靶向药治疗后的手足综合征的中药组合物。
优选的,步骤(3)中,将所述粉末状混合物A加水加热至沸腾后,持续煎煮40-50min。
优选的,步骤(3)中,加入粉末状混合物B后,继续煎煮30-40min。
优选的,步骤(4)中,二次煎煮过程中加热至沸腾状后,继续煎煮30-40min。
本发明的用于治疗靶向药治疗后的手足综合征的中药组合物以苦参、黄芪为君,清热燥湿,益气固卫;臣以白鲜皮、地肤子祛风除湿;野菊花、蒲公英、紫花地丁清热解毒;土茯苓解毒除湿;当归、红花、川芎、生地养血活血;佐以麻黄、桂枝开腠理;白芍养血敛痛;白芥子、生南星、生半夏燥湿化痰;使以生甘草调和诸药,并制生南星、生半夏之毒性;全方共奏益气养血、清热解毒、燥湿化痰之功,对肿瘤靶向药物所致手足综合征具有显著药效。中医认为,手足综合征发展机制为靶向药物治疗恶性肿瘤后,机体气血亏虚,热毒积于体内无法排除,又内兼痰湿;中药外治法可经体表给药就近透邪,起益气养血、清热解毒、燥湿化痰之功,从而缓解靶向药物治疗后的手足综合征。
与现有技术相比,本发明的优点在于:
本发明的中药组合物可用于靶向药治疗后的手足皮肤反应处,具有益气养血、清热解毒、燥湿化痰的功效,对于靶向药治疗后的手足综合征具有良好治疗作用,且简单方便,成本低廉,易于实现。
附图说明
图1是本发明的制备用于治疗靶向药治疗后的手足综合征的中药组合物的工艺流程图。
具体实施方式
为了便于理解本发明,下文将结合说明书附图和较佳的实施例对本发明作更全面、细致地描述,但本发明的保护范围并不限于以下具体的实施例。
本发明的具体实施方式中,用于治疗靶向药治疗后的手足综合征的中药组合物,主要由以下重量份的组分制备而成:苦参20~50份、蒲公英20~50份、野菊花20~50份、紫花地丁20~50份、土茯苓20~50份、黄芪30~60份、地肤子10~35份、红花10~45份、白鲜皮15~45份、麻黄5~15份、当归5~25份、川芎5~25份、生地10~30份、桂枝5~15份、白芍10~30份、白芥子5~15份、生南星5~20份、生半夏5~20份、生甘草10~40份,苦参和土茯苓的质量比为1:1,野菊花、蒲公英和紫花地丁的质量比为1:1:1,当归与所述川芎的质量比为1:1,生南星、生半夏和生甘草的质量比为1:1:2。
本发明的具体实施方式中,用于治疗靶向药治疗后的手足综合征的中药组合物的制备方法,其工艺流程图如图1所示,包括以下步骤:
(1)按配方称取药材;
(2)将生南星、生半夏碾碎成粉末状混合物A;将其余药材搅拌混合均匀后,碾碎成粉末状混合物B;
(3)往粉末状混合物A加水,加热到100℃,持续煎煮40-50min然后加入粉末状混合物B继续煎煮30-40min,然后冷却过滤,得到冷却液和药渣;
(4)将所述药渣加水,加热到100℃,持续煎煮30-40min,冷却后过滤,得到滤液;
(5)将步骤(3)中的冷却液和步骤(4)中的滤液合并,灭菌处理,封装,得到用于治疗靶向药治疗后的手足综合征的中药组合物。
为证明本发明的中药组合物药物的效果,采用随机双盲试验研究设计,在江西中医药大学附属医院开展治疗HFS的临床研究。试验组入组42例,对照组入组42例。试验组采用本发明实施例1中的中药组合物药液200mL,泡洗患部,每日2次;对照组采用普通艾叶提取物药液200mL,泡洗患部,每日2次;两组观察时间均为2周。
以下为实验的主要内容:
1.资料与方法
1.1临床设计
采用随机、双盲、对照设计,由江西中医药大学附属医院完成,病例主要来源于该院住院及门诊的肿瘤患者,选择其中有效患者数据60例,根据本发明的中药组合物药物前期用于治疗手足综合征的愈显率83%,既往文献报道对照组治疗手足综合征的愈显率为46%。
1.2病例选择
1.2.1诊断标准
1.2.1.1西医诊断标准
肿瘤诊断标准参照中华人民共和国卫生部医政司《中国常见恶性肿瘤诊治规范》,分期标准参照《NCCN临床实践指南(中国版)2012年第一版》:HFS分级标准参照NCI制定的抗肿瘤药急性及亚急性毒性反应分度标准。
手足综合征NCI分级标准:
一级:轻微的皮肤改变或皮炎(如红斑、脱屑)伴感觉异常(如麻木感,针刺感,烧灼感),但不影响日常活动;
二级:如前皮肤改变伴有疼痛,轻度影响日常活动,皮肤表面完整;
三级:溃疡性皮炎或皮肤改变,伴有剧烈疼痛,严重影响日常生活,明显组织破坏(如脱屑、水泡、出血、水肿)。
1.2.1.2中医诊断标准
气虚证:患部肤色暗淡,气短声低,神疲乏力;少气或懒言;自汗;舌质淡胖或有齿印;脉虚无力(弱、软、濡),或有头晕目眩,动则诸症加重。
血虚证:患部肤色苍白,皮炎改变不甚明显,面色苍白或萎黄,眼睑、口唇、舌质、爪甲的颜色淡白,头晕,或见眼花、两目干涩,心悸,多梦,健忘,神疲,手足发麻,或妇女月经量少、色淡、延期甚或经闭,脉细无力。
湿热证:患部易汗出,常有潮湿感,两胁胀满,情志不舒,口干口苦,脘腹胀满,大便稀溏,不爽不畅,小便不利,尿赤短涩,舌苔黄腻,脉弦滑。
痰湿证:患部多有肿胀,按之凹陷;咳嗽痰多,胸脘痞闷,纳呆;面色晦暗,自觉头身沉重,或见下肢水肿;大便粘滞,脉滑涩(弦、濡),苔腻滑。
毒瘀证:患部肤色暗淡,甚如紫黑色,有疼痛、肿块、出血、瘀血色脉征等方面的证候。其疼痛特点为刺痛、痛处拒按、固定不移;面色晦暗,或唇甲青紫,或皮下紫斑,或肌肤甲错,或腹露青筋,或皮肤出现丝状红缕,或舌有紫色斑点、舌下络脉曲张,脉多细涩或结、代、无脉等。
1.3试验用药及药品分配
1.3.1试验用药
试验组:本发明的实施例1的中药组合物药液200mL,泡洗患部,每日2次。
对照组:对照组采用普通艾叶提取物药液200mL,泡洗患部,每日2次。
两组各干预14天。
1.3.2药品分配
患者将按1:1比例随机分入试验组和对照组,观察医生按照药品编号顺序发药,不得选择药品,不得破坏编号,该药品编号在整个试验过程中保持不变。
1.3.3药品清点
每次随访时,观察医生详细记录患者接受、服用和归还的药品数量,用以判定受试者服药的依从性,并在病例报告表上及时记录,并决定该患者是否继续参加试验。如果患者每次评价均按方案规律服药,且达到应服药量的80%,则认为该患者依从性好。
1.3.4合并用药的规定
①试验期间,不得使用其它治疗手足综合征的药物。
②合并其他疾病必须服用的其他药物和治疗方法,入组后仍维持原有治疗方法但必须在合并用药表中详细记录。
1.4不良反应及安全性评价
1级:无任何不良反应;安全性指标未见异常;
2级:出现轻微不良反应尚但可忍受,不需额外处理,安全性指标未见异常;
3级:受试者出现中度不良反应,需要适当处理,安全性指标出现轻度或中度异常;
4级:受试者出现重度不良反应,危及生命或致残,需要紧急处理,安全性指标出现严重异常,应立即中断研究治疗。
1.5统计学处理
统计方法采用SPSS26软件进行统计分析。计量资料用均数±标准差进行描述,符合正态分布、方差齐性者,采用t检验,不满足方差齐性者使用方差分析,不满足正态分布者以及等级资料使用秩和检验。分析结果均进行双侧检验,P>0.05表示两者差异无统计学意义,P<0.05表示两者差异具有统计学意义。
2.用药两周后的疗效评价
从表1中的手足综合征的症状改善情况来看,使用本发明的中药组合物的患者的手足综合征的症状改善明显。
表1手足综合征的症状改善情况
下述实施例中的病例全部来自2010年1月至2021年11月符合恶性肿瘤靶向药物治疗后出现手足综合征的患者,肿瘤诊断标准参照中华人民共和国卫生部医政司《中国常见恶性肿瘤诊治规范》;手足综合征HFS分级标准如下(具体参照NCI制定的抗肿瘤药急性及亚急性毒性反应分度标准):
一级:轻微的皮肤改变或皮炎(如红斑、脱屑)伴感觉异常(如麻木感,针刺感,烧灼感),但不影响日常活动;
二级:如前皮肤改变伴有疼痛,轻度影响日常活动,皮肤表面完整;
三级:溃疡性皮炎或皮肤改变,伴有剧烈疼痛,严重影响日常生活,明显组织破坏(如脱屑、水泡、出血、水肿)。
实施例1:
一种用于治疗靶向药治疗后的手足综合征的中药组合物,主要由以下质量份数的组分制备而成:苦参30份、蒲公英50份、野菊花50份、紫花地丁50份、土茯苓30份、黄芪30份、地肤子15份、红花20份、白鲜皮20份、麻黄5份、当归10份、川芎10份、生地15份、桂枝5份、白芍10份、白芥子5份、生南星5份、生半夏5份、生甘草10份。
本实施例的用于治疗靶向药治疗后的手足综合征的中药组合物的制备方法,包括以下步骤:
(1)按配方称取药材;
(2将生南星、生半夏碾碎成粉末状混合物A;将其余药材搅拌混合均匀后,碾碎成粉末状混合物B;
(3)往粉末状混合物A中加入蒸馏水,加热到100℃至沸腾,持续煎煮40min,然后加入粉末状混合物B,继续煎煮40min,然后冷却过滤,得到冷却液和药渣;
(4)往药渣中加入蒸馏水,加热到100℃至沸腾,继续煎煮40min,冷却后过滤,得到滤液;
(5)将步骤(3)中的冷却液和步骤(4)中的滤液合并,然后进行灭菌处理,封装,即得到中药组合物药液。
选取80例病例,其中男44例,女36例,发病年龄最小者35岁,最大者82岁,平均年龄为53岁。按年龄和病情随机分成8组,每组10例。疗效判定基于HFS分级,以皮肤改变或皮炎、感觉异常、组织破坏为主。
治疗采用本实施例的药物,服用剂量:35-55岁,每天1次,每次熏洗患处200ml;56-82岁,每日2次,每次熏洗患处200ml;熏洗一周后,72%的患者HFS分级下降一级(三级降为二级,二级降为一级);熏洗两周后,85%的患者皮肤改变或皮炎基本恢复正常,感觉异常基本消失,治疗过程中未有患者出现明显不良反应,未观察到试验药物不良反应存在。
实施例2:
一种用于治疗靶向药治疗后的手足综合征的中药组合物,主要由以下质量份数的组分制备而成:苦参50份、蒲公英25份、野菊花25份、紫花地丁25份、土茯苓50份、黄芪35份、地肤子35份、红花20份、白鲜皮45份、麻黄5份、当归15份、川芎15份、生地10份、桂枝5份、白芍15份、白芥子5份、生南星10份、生半夏10份、生甘草20份。
本实施例的用于治疗靶向药治疗后的手足综合征的中药组合物的制备方法,包括以下步骤:
(1)按配方称取药材;
(2将生南星、生半夏碾碎成粉末状混合物A;将其余药材搅拌混合均匀后,碾碎成粉末状混合物B;
(3)往粉末状混合物A中加入蒸馏水,加热到100℃至沸腾,持续煎煮45min,然后加入粉末状混合物B,继续煎煮40min,然后冷却过滤,得到冷却液和药渣;
(4)往药渣中加入蒸馏水,加热到100℃至沸腾,继续煎煮35min,冷却后过滤,得到滤液;
(5)将步骤(3)中的冷却液和步骤(4)中的滤液合并,然后进行灭菌处理,封装,即得到中药组合物药液。
选取病例70例,其中男38例,女32例,发病年龄最小者32岁,最大者65岁,平均年龄为45岁。按年龄和病情随机分成7组,每组10例。疗效判定基于HFS分级,以皮肤改变或皮炎、感觉异常、组织破坏为主。
治疗采用本实施例的药物,服用剂量:32-48岁,每天1次,每次熏洗患处200ml;49-65岁,每天2次,每次熏洗患处200ml;熏洗一周后,75%的患者HFS分级下降一级(三级降为二级,二级降为一级);熏洗两周后,82%的患者皮肤改变或皮炎基本恢复正常,感觉异常基本消失,治疗过程中未有患者出现明显不良反应,未观察到试验药物不良反应存在。
实施例3:
一种用于治疗靶向药治疗后的手足综合征的中药组合物,主要由以下质量份数的组分制备而成:苦参25份、蒲公英35份、野菊花35份、紫花地丁35份、土茯苓25份、黄芪40份、地肤子15份、红花35份、白鲜皮20份、麻黄15份、当归25份、川芎25份、生地15份、桂枝15份、白芍20份、白芥子10份、生南星10份、生半夏10份、生甘草20份。
本实施例的用于治疗靶向药治疗后的手足综合征的中药组合物的制备方法,包括以下步骤:
(1)按配方称取药材;
(2将生南星、生半夏碾碎成粉末状混合物A;将其余药材搅拌混合均匀后,碾碎成粉末状混合物B;
(3)往粉末状混合物A中加入蒸馏水,加热到100℃至沸腾,持续煎煮50min,然后加入粉末状混合物B,继续煎煮35min,然后冷却过滤,得到冷却液和药渣;
(4)往药渣中加入蒸馏水,加热到100℃至沸腾,继续煎煮30min,冷却后过滤,得到滤液;
(5)将步骤(3)中的冷却液和步骤(4)中的滤液合并,然后进行灭菌处理,封装,即得到中药组合物药液。
选取病例90例,其中男48例,女42例,发病年龄最小者28岁,最大者69岁,平均年龄为46岁。按年龄和病情随机分成9组,每组10例。疗效判定基于HFS分级,以皮肤改变或皮炎、感觉异常、组织破坏为主。
治疗药物采用本实施例的药物,服用剂量:28-48岁,每天1次,每次熏洗患处200ml;49-69岁,每日2次,每次熏洗患处200ml;熏洗一周后,81%的患者HFS分级下降一级(三级降为二级,二级降为一级);熏洗两周后,90%的患者皮肤改变或皮炎基本恢复正常,感觉异常基本消失,治疗过程中未有患者出现明显不良反应,未观察到试验药物不良反应存在。
实施例4:
一种用于治疗靶向药治疗后的手足综合征的中药组合物,主要由以下质量份数的组分制备而成:苦参30份、蒲公英20份、野菊花20份、紫花地丁20份、土茯苓30份、黄芪60份、地肤子10份、红花45份、白鲜皮15份、麻黄5份、当归25份、川芎25份、生地30份、桂枝10份、白芍25份、白芥子5份、生南星15份、生半夏15份、生甘草30份。
本实施例的用于治疗靶向药治疗后的手足综合征的中药组合物的制备方法,包括以下步骤:
(1)按配方称取药材;
(2将生南星、生半夏碾碎成粉末状混合物A;将其余药材搅拌混合均匀后,碾碎成粉末状混合物B;
(3)往粉末状混合物A中加入蒸馏水,加热到100℃至沸腾,持续煎煮50min,然后加入粉末状混合物B,继续煎煮40min,然后冷却过滤,得到冷却液和药渣;
(4)往药渣中加入蒸馏水,加热到100℃至沸腾,继续煎煮35min,冷却后过滤,得到滤液;
(5)将步骤(3)中的冷却液和步骤(4)中的滤液合并,然后进行灭菌处理,封装,即得到中药组合物药液。
选取150例病例,其中男80例,女70例,发病年龄最小者24岁,最大者87岁,平均年龄为54岁。按年龄和病情随机分成15组,每组10例。疗效判定基于HFS分级,以皮肤改变或皮炎、感觉异常、组织破坏为主。
治疗药物采用本实施例的药物,服用剂量:24-55岁,每天1次,每次熏洗患处200ml;56-87岁,每日2次,每次熏洗患处200ml;熏洗一周后,82%的患者HFS分级下降一级(三级降为二级,二级降为一级);熏洗两周后,93%的患者皮肤改变或皮炎基本恢复正常,感觉异常基本消失,治疗过程中未有患者出现明显不良反应,未观察到试验药物不良反应存在。
实施例5:
一种用于治疗靶向药治疗后的手足综合征的中药组合物,主要由以下质量份数的组分制备而成:苦参20份、蒲公英25份、野菊花25份、紫花地丁25份、土茯苓20份、黄芪45份、地肤子20份、红花35份、白鲜皮25份、麻黄10份、当归15份、川芎15份、生地20份、桂枝10份、白芍30份、白芥子15份、生南星20份、生半夏20份、生甘草40份。
本实施例的用于治疗靶向药治疗后的手足综合征的中药组合物的制备方法,包括以下步骤:
(1)按配方称取药材;
(2将生南星、生半夏碾碎成粉末状混合物A;将其余药材搅拌混合均匀后,碾碎成粉末状混合物B;
(3)往粉末状混合物A中加入蒸馏水,加热到100℃至沸腾,持续煎煮40min,然后加入粉末状混合物B,继续煎煮40min,然后冷却过滤,得到冷却液和药渣;
(4)往药渣中加入蒸馏水,加热到100℃至沸腾,继续煎煮40min,冷却后过滤,得到滤液;
(5)将步骤(3)中的冷却液和步骤(4)中的滤液合并,然后进行灭菌处理,封装,即得到中药组合物药液。
选取80例病例,其中男46例,女44例,发病年龄最小者33岁,最大者66岁,平均年龄为43岁。按年龄和病情随机分成8组,每组10例。疗效判定基于HFS分级,以皮肤改变或皮炎、感觉异常、组织破坏为主。
治疗药物采用本实施例的药物,服用剂量:33-47岁,每天1次,每次熏洗患处200ml;48-66岁,每日2次,每次熏洗患处200ml;熏洗一周后,76%的患者HFS分级下降一级(三级降为二级,二级降为一级);熏洗两周后,88%的患者皮肤改变或皮炎基本恢复正常,感觉异常基本消失,治疗过程中未有患者出现明显不良反应,未观察到试验药物不良反应存在。
综上所述,本发明的中药组合物用于靶向药治疗后的手足皮肤反应处,具有益气养血、清热解毒、燥湿化痰的功效,对于靶向药治疗后的手足综合征具有良好治疗作用,且简单方便,成本低廉,易于实现。
Claims (9)
1.一种用于治疗靶向药治疗后的手足综合征的中药组合物,其特征在于,所述中药组合物主要由以下重量份的组分制备而成:
苦参20~50份、蒲公英20~50份、野菊花20~50份、紫花地丁20~50份、土茯苓20~50份、黄芪30~60份、地肤子10~35份、红花10~45份、白鲜皮15~45份、麻黄5~15份、当归5~25份、川芎5~25份、生地10~30份、桂枝5~15份、白芍10~30份、白芥子5~15份、生南星5~20份、生半夏5~20份、生甘草10~40份。
2.如权利要求1所述的用于治疗靶向药治疗后的手足综合征的中药组合物,其特征在于,所述苦参和所述土茯苓的质量比为1:1。
3.如权利要求1所述的用于治疗靶向药治疗后的手足综合征的中药组合物,其特征在于,所述野菊花、蒲公英和紫花地丁的质量比为1:1:1。
4.如权利要求1所述的用于治疗靶向药治疗后的手足综合征的中药组合物,其特征在于,所述当归与所述川芎的质量比为1:1。
5.如权利要求1所述的用于治疗靶向药治疗后的手足综合征的中药组合物,其特征在于,所述生南星、生半夏和生甘草的质量比为1:1:2。
6.一种如权利要求1~5中任一项所述的用于治疗靶向药治疗后的手足综合征的中药组合物的制备方法,其特征在于,包括以下步骤:
(1)按配方称取药材;
(2)将生南星、生半夏碾碎成粉末状混合物A;将其余药材搅拌混合均匀后,碾碎成粉末状混合物B;
(3)将所述粉末状混合物A加水煎煮一段时间后,加入粉末状混合物B继续煎煮一段时间,然后冷却过滤,得到冷却液和药渣;
(4)将所述药渣加水进行二次煎煮,冷却后过滤,得到滤液;
(5)将步骤(3)中的冷却液和步骤(4)中的滤液合并,灭菌处理,封装,得到用于治疗靶向药治疗后的手足综合征的中药组合物。
7.如权利要求6所述的制备方法,其特征在于,步骤(3)中,将所述粉末状混合物A加水加热至沸腾后,持续煎煮40-50min。
8.如权利要求6所述的制备方法,其特征在于,步骤(3)中,加入粉末状混合物B后,继续煎煮30-40min。
9.如权利要求6所述的制备方法,其特征在于,步骤(4)中,二次煎煮过程中加热至沸腾状后,继续煎煮30-40min。
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