CN114432375A - 一种用于治疗高原肺动脉高压的中药组合物 - Google Patents
一种用于治疗高原肺动脉高压的中药组合物 Download PDFInfo
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Abstract
本发明涉及一种治疗高原肺动脉高压的中药组合物,它是由以下重量配比的原料药材制备而成:红景天25‑35份,三七粉5‑7份,桂枝5‑15份,赤芍10‑20份,丹参20‑40份,桃仁14‑16份,土鳖虫10‑20份,枳壳15‑25份,鸡内金10‑20份,川芎10‑20份。本发明的药物组份经辩证配伍,在作用上相辅相成,具有协同作用,共奏益智养心、温经通脉、活血化瘀、止咳平喘之功效,对高原肺动脉高压达到标本兼治的目的。经临床试验验证治疗高原肺动脉高压安全有效。
Description
技术领域
本发明涉及一种治疗高原肺动脉高压的药物组合物,属于中药领域。
背景技术
高原肺动脉高压(High altitude pulmonary hypertension,HAPH)是由于高原低氧(缺氧)环境下,代偿性地使肺通气增加、血管收缩引起的,常见于高原习服不适应,或是不良适应而发生的一种高原疾病。HAPH是由于低氧引起血管内皮细胞损伤,血管内皮合成和分泌的各种血管舒张因子和收缩因子平衡失调,导致早期的肺血管收缩以及后期的肺血管重建。
肺血管重建是最终出现的病理特征,在长期慢性高原缺氧的条件下,肺血管重构会逐渐发生发展,其主要的分子机制主要包括以下环节:①低压缺氧及继发的红细胞增多症所致内皮屏障功能的破坏;②血管平滑肌细胞的表型转换与增殖;③外膜成纤维细胞增生及胞外基质的沉积。目前西医主要治疗方案为扩张血管、抗血管重构及抗凝,效果不理想,而且长期应用副作用大,而中医中药在抗缺氧、抗氧化和活血化瘀等方面有较大优势,在高原肺动脉高压的治疗上有很好的应用前景。
发明内容
本发明人在援青支医期间,根据高原肺动脉高压特点,依据中医理论和临床试验反复验证,终于找到了有效治疗高原肺动脉高压的中药组合物,从而完成了本发明。
本发明的目的是提供一种有效治疗高原肺动脉高压的中药组合物。
本发明的技术方案为:一种治疗高原肺动脉高压的中药组合物,它是由以下重量配比的原料药材制备而成:红景天25-35份,三七粉5-7份,桂枝5-15份,赤芍10-20份,丹参20-40份,桃仁14-16份,土鳖虫10-20份,枳壳15-25份,鸡内金10-20份,川芎10-20份。
本发明的优选技术方案为:一种治疗高原肺动脉高压的中药组合物,其中药原料和重量配比为:红景天30份,三七粉6份,桂枝10份,赤芍15份,丹参30份,桃仁15份,土鳖虫15份,枳壳20份,鸡内金15份,川芎15份。
本发明中药组合物是在传统中医理论和临床试验指导下,精选药物组方。本发明中药组合物中红景天具有补气清肺,益智养心,对抗缺氧、止咳平喘之功效;三七粉具有散瘀止血、消肿定痛、补虚强壮之功效;桂枝具有发汗解肌、温经通脉之功效;赤芍具有清热凉血、散瘀止痛之功效;丹参具有活血祛瘀,通经止痛,清心除烦,凉血消痈之功效;桃仁具有活血祛瘀、润肠通便、止咳平喘之功效;土鳖虫具有疏通经络、活血散瘀、健脾养胃之功效;枳壳具有行气宽中,行痰消痞之功效;鸡内金具有健脾消食,涩精止遗、通淋化石之功效。川芎具有行气开郁、活血化瘀、止痛之功效。本发明组合物中的药物组份经辩证配伍,在作用上相辅相成,具有协同作用,共奏益智养心、温经通脉、活血化瘀、止咳平喘之功效,对高原肺动脉高压达到标本兼治的目的。
下面结合临床试验数据说明本发明的有益效果。
1、一般资料
发明人2020年5月-2020年10月间共收集高原肺动脉高压患者50例,均来自肺病门诊,年龄45-65岁,男性28例,女性22例。病程1年-10年。
2、诊断标准:①从低海拔到更高海拔(2500m以上)或长期居住在高海拔地区(海拔2500m以上);②有低氧的临床表现,如口唇紫绀、血氧饱和度下降;③有不同程度的低氧性肺动脉高压,临床检查见肺动脉瓣听诊区第二心音亢进,心脏超声示肺动脉高压;④排除其他导致肺动脉高压的疾病。
3、试验方法
所有患者口服本发明按照实施例1制得煎剂,每日3次,疗程2周。
4、疗效标准
治疗前后mPAP降低的差值用△mPAP表示,治疗后mPAP<25mmHg 为显效;治疗后25mmHg≤mPAP≤35mmHg,且△mPAP≥ 10mmHg,或者mPAP>35mmHg且△mPAP≥ 15mmHg为有效;治疗后25mmHg≤mPAP≤35mmHg 且△mPAP<10mmHg,或者mPAP>35mmHg且 △mPAP<15mmHg为无效。(参考文献:包政权,刘永梅,胡进明,等.灯盏花素治疗高原低氧性肺动脉高压的临床分析[J].高原医学杂志,2010,20(2):43-45.)。
5、治疗结果
50例患者显效30例,有效26例,无效4例,总有效率92%。治疗期间未见明显不良反应。可见本发明用于治疗高原肺动脉高压安全有效,有很好的推广应用价值。
具体实施方式
为了更好的理解和实施本发明,下面结合具体实施例进一步说明本发明。
实施例1
称取:红景天30g,桂枝10g,赤芍15g,丹参30g,桃仁15g,土鳖虫15g,枳壳20g,鸡内金15g,川芎15g;加8倍量水,浸泡1小时,武火煮沸,沸后文火煎煮1小时,过滤;滤渣加6倍量水,水沸后煎煮30分钟,过滤;合并滤液,浓缩至150g,加入三七粉6g混匀,即得符合正常成人一天用量的煎剂。
用于治疗高原肺动脉高压。口服,每日早中晚三次分服。
实施例2
称取:红景天30g,桂枝10g,赤芍15g,丹参30g,桃仁15g,土鳖虫15g,枳壳20g,鸡内金15g,川芎15g;加10倍量水,浸泡1小时,武火煮沸,沸后文火煎煮1.5小时,过滤;滤渣加8倍量水,水沸后煎煮1小时,过滤;合并滤液,加入三七粉6g混匀,浓缩,干燥,包装,即得符合正常成人一天用量的散剂。
用于治疗高原肺动脉高压。口服,每日早晚两次分服。
实施例3
称取:红景天30g,桂枝10g,赤芍15g,丹参30g,桃仁15g,土鳖虫15g,枳壳20g,鸡内金15g,川芎15g;加6倍量水,浸泡1小时,煎煮3次,每次煎煮30分钟,合并煎煮液,加入三七粉6g混匀,浓缩、干燥,装入胶囊壳,即得符合正常成人一天用量的胶囊剂。
用于治疗高原肺动脉高压。口服,每日早晚两次分服。
Claims (5)
1.一种治疗高原肺动脉高压的中药组合物,其特征在于:它是由以下重量配比的原料药材制备而成:红景天25-35份,三七粉5-7份,桂枝5-15份,赤芍10-20份,丹参20-40份,桃仁14-16份,土鳖虫10-20份,枳壳15-25份,鸡内金10-20份,川芎10-20份。
2.根据权利要求1所述的一种治疗高原肺动脉高压的中药组合物,优选地,它是由以下重量配比的原料药材制备而成:红景天30份,三七粉6份,桂枝10份,赤芍15份,丹参30份,桃仁15份,土鳖虫15份,枳壳20份,鸡内金15份,川芎15份。
3.根据权利要求2所述的一种治疗高原肺动脉高压的中药组合物,其特征在于,其制备方法为:称取红景天30份,桂枝10份,赤芍15份,丹参30份,桃仁15份,土鳖虫15份,枳壳20份,鸡内金15份,川芎15份;加8倍量水,浸泡1小时,武火煮沸,沸后文火煎煮1小时,过滤;滤渣加6倍量水,水沸后煎煮30分钟,过滤;合并滤液,浓缩至150g,加入三七粉6份混匀,即得煎剂;上述份均是指重量份。
4.根据权利要求2所述的一种治疗高原肺动脉高压的中药组合物,其特征在于,其制备方法为:称取红景天30份,桂枝10份,赤芍15份,丹参30份,桃仁15份,土鳖虫15份,枳壳20份,鸡内金15份,川芎15份;加10倍量水,浸泡1小时,武火煮沸,沸后文火煎煮1.5小时,过滤;滤渣加8倍量水,水沸后煎煮1小时,过滤;合并滤液,加入三七粉6份混匀,浓缩,干燥,包装,即得散剂;上述份均是指重量份。
5.根据权利要求2所述的一种治疗高原肺动脉高压的中药组合物,其特征在于,其制备方法为:称取红景天30份,桂枝10份,赤芍15份,丹参30份,桃仁15份,土鳖虫15份,枳壳20份,鸡内金15份,川芎15份;加6倍量水,浸泡1小时,煎煮3次,每次煎煮30分钟,合并煎煮液,加入三七粉6份混匀,浓缩、干燥,装入胶囊壳,即得胶囊剂;上述份均是指重量份。
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