CN112206279B - 一种治疗室性心律失常的中药组合物及其制备方法和应用 - Google Patents
一种治疗室性心律失常的中药组合物及其制备方法和应用 Download PDFInfo
- Publication number
- CN112206279B CN112206279B CN202011210079.2A CN202011210079A CN112206279B CN 112206279 B CN112206279 B CN 112206279B CN 202011210079 A CN202011210079 A CN 202011210079A CN 112206279 B CN112206279 B CN 112206279B
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- decoction
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 206010047281 Ventricular arrhythmia Diseases 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
- 239000000706 filtrate Substances 0.000 claims description 27
- 239000010975 amethyst Substances 0.000 claims description 18
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 11
- 244000037364 Cinnamomum aromaticum Species 0.000 claims description 10
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims description 10
- 241000234435 Lilium Species 0.000 claims description 9
- 244000132619 red sage Species 0.000 claims description 8
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 7
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 7
- 235000017443 Hedysarum boreale Nutrition 0.000 claims description 7
- 235000007858 Hedysarum occidentale Nutrition 0.000 claims description 7
- 241001643730 Hydrangea sect. Dichroa Species 0.000 claims description 7
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 230000000410 anti-febrile effect Effects 0.000 claims description 6
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 claims description 5
- 240000007185 Albizia julibrissin Species 0.000 claims description 5
- 240000002948 Ophiopogon intermedius Species 0.000 claims description 5
- 235000002226 Ranunculus ficaria Nutrition 0.000 claims description 5
- 241000405414 Rehmannia Species 0.000 claims description 5
- 241000219784 Sophora Species 0.000 claims description 5
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 244000081426 Ranunculus ficaria Species 0.000 claims 1
- 239000012467 final product Substances 0.000 claims 1
- 206010033557 Palpitations Diseases 0.000 abstract description 15
- 238000011282 treatment Methods 0.000 abstract description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 10
- 201000010099 disease Diseases 0.000 abstract description 9
- 208000024891 symptom Diseases 0.000 abstract description 5
- 206010008479 Chest Pain Diseases 0.000 abstract description 4
- 231100000957 no side effect Toxicity 0.000 abstract description 3
- 241000756943 Codonopsis Species 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 25
- 229940079593 drug Drugs 0.000 description 14
- 239000008280 blood Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 208000009729 Ventricular Premature Complexes Diseases 0.000 description 9
- 230000001737 promoting effect Effects 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 210000005036 nerve Anatomy 0.000 description 8
- 206010047289 Ventricular extrasystoles Diseases 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 4
- 241001530126 Scrophularia Species 0.000 description 4
- 230000001914 calming effect Effects 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 208000019622 heart disease Diseases 0.000 description 4
- 206010047302 ventricular tachycardia Diseases 0.000 description 4
- 208000001431 Psychomotor Agitation Diseases 0.000 description 3
- 206010038743 Restlessness Diseases 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 206010003119 arrhythmia Diseases 0.000 description 3
- 230000006793 arrhythmia Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 230000002936 tranquilizing effect Effects 0.000 description 3
- 241000007126 Codonopsis pilosula Species 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 206010061818 Disease progression Diseases 0.000 description 2
- 241000606266 Nardostachys Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 230000005750 disease progression Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000002861 ventricular Effects 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- IYIKLHRQXLHMJQ-UHFFFAOYSA-N amiodarone Chemical compound CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCCN(CC)CC)C(I)=C1 IYIKLHRQXLHMJQ-UHFFFAOYSA-N 0.000 description 1
- 229960005260 amiodarone Drugs 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 229940127292 dihydropyridine calcium channel blocker Drugs 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 235000005412 red sage Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 208000003663 ventricular fibrillation Diseases 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明属于中药组合物领域,特别是涉及一种治疗室性心律失常的中药组合物及其制备方法和应用。本发明提供了一种治疗室性心律失常的中药组合物,包括以下原料:炙甘草、桂枝、麦冬、生地、党参、丹参、玄参、苦参、百合、合欢皮、磁石、紫石英、常山和甘松。本发明提供的中药组合物针对室性心律失常能有效减少患者24h内室性心律失常发作的次数,能够缓解心悸,胸闷的症状,还可以延缓疾病进展,改善患者的生存质量,没有副作用;本发明所述中药组合物后续的实施能够提供一种针对室性心律失常的规范且标准的治疗方案。由实施例可知,患者服用上述中药组合物治疗室性心律失常5~18d后,24h室性心律失常的数量明显减少,有效率为100%。
Description
技术领域
本发明属于中药组合物领域,特别是涉及一种治疗室性心律失常的中药组合物及其制备方法和应用。
背景技术
室性心律失常指起源于心室的心律紊乱,是常见的心律失常,包括室性期前收缩、阵发性室性心动过速等。阵发性室性心动过速,尤其是合并器质性心脏病的阵发性室性心动过速通常是可导致心室颤动、猝死等严重后果的心律失常,要及时明确诊断,判断阵发性室性心动过速的原因、诱因及对预后的影响并及时处理。老年人群中室性心律失常的发生情况,就象器质性心脏病一样随年龄而增加。一项临床研究显示,通过24h动态心电图检查发现,室性期前收缩患病率高达40%~75%,在大于75岁的人群中发病率高达69%。对于非结构性心脏病的室性期前收缩患者,可考虑使用β受体阻滞剂或非二氢吡啶类钙拮抗剂治疗,但仅有10%~15%的患者室性期前收缩发作次数减少大于90%,与安慰剂相比没有统计学意义。而且上述药物或治疗方法常会引发一些临床症状,有自身的局限性。对于伴有严重结构性心脏病室性期前收缩的患者,推荐使用胺碘酮,但因其副作用和禁忌症等原因,不宜久服,在临床的使用上受到了极大的限制。
室性心律失常属于中医学心悸病的范畴,中药组合物治疗室性心律失常具有副作用少,禁忌症少,临床疗效好,停药后不易复发等优点,受到许多室性心律失常患者的青睐。中医学治疗室性心律失常采用按中医证型辨证论治的治疗方法,比如心悸的心脾两虚证用归脾汤治疗,水饮凌心证用苓桂术甘汤治疗等,但上述技术的治疗效果参差不齐,缺乏规范化和标准化的临床治疗方案。
发明内容
为了解决上述问题,本发明提供了一种治疗室性心律失常的中药组合物及其制备方法和应用。本发明提供的中药组合物针对室性心律失常能有效减少患者24h内室性心律失常发作的次数,能够缓解心悸,胸闷的症状,还可以延缓疾病进展,改善患者的生存质量,没有副作用,是一种针对室性心律失常疾病,规范且标准的药物。
为了实现上述目的,本发明提供了如下技术方案:
本发明提供了一种治疗室性心律失常的中药组合物,包括以下质量份的原料:炙甘草20份、桂枝20份、麦冬30份、生地30份、党参20份、丹参25份、玄参20份、苦参20份、百合20份、合欢皮20份、磁石30份、紫石英20份、常山10份和甘松20份。
本发明还提供了上述中药组合物的制备方法,包括以下步骤:将上述原料用水煎煮,取滤液,得到中药组合物。
优选的,所述煎煮包括:
将磁石和紫石英与水混合后进行预煎煮,然后加入其余原料和水进行第一煎煮,得到第一滤渣和第一滤液;
将第一滤渣与水混合后进行第二煎煮,得到第二滤渣和第二滤液;
将第二滤渣与水混合后进行第三煎煮,得到第三滤渣和第三滤液;
合并第一滤液、第二滤液和第三滤液,得到中药组合物。
优选的,所述预煎煮中,磁石和紫石英的总质量与水的质量比为1:(8~10)。
优选的,所述第一煎煮中,去除磁石和紫石英外其余原料的总质量与再次添加的水的质量比为1:(8~10);所述预煎煮的时间为0.25h,所述第一煎煮的时间为1.25~1.45h。
优选的,所述第二煎煮中,所述第一滤渣与水的质量比为1:(6~8),所述第二煎煮的时间为0.5~0.7h。
优选的,所述第三煎煮中,所述第二滤渣与水的质量比分别为1:(6~8),所述第三煎煮的时间为0.5~0.7h。
本发明还提供了上述中药组合物或上述制备方法制备得到中药组合物在制备治疗室性心律失常的药物中的应用。
优选的,所述药物的服用方法包括:患者每日服用两次,每次服用150mL。
本发明提供了一种治疗室性心律失常的中药组合物,包括以下原料:炙甘草、桂枝、麦冬、生地、党参、丹参、玄参、苦参、百合、合欢皮、磁石、紫石英、常山和甘松。本发明提供的中药组合物中,党参为君药,有补中益气,养血生津之效;麦冬和生地同为臣药,其中麦冬益胃生津,清心除烦,生地清热凉血,养阴生津,二者共同发挥养阴生津的功效;桂枝、丹参、玄参、苦参、百合、合欢皮、磁石、紫石英、常山和甘松共为佐药,其中桂枝辛行温通,温心阳,通血脉,使中药组合物中的滋腻之品滋而不腻,丹参活血化瘀,清心除烦,玄参清热凉血,滋阴降火,苦参有清热安神止悸的功效,百合养阴润肺,清心安神,合欢皮和血宁心,磁石镇惊安神,紫石英镇心安神,常山和甘松合用安神止悸;炙甘草为使药,有滋阴养血,益气通阳,复脉定悸,调和诸药之用。上述14味药物共奏益气养阴,安神止悸的功效,能够有效起到专病专治的技术效果。由实施例可知,患者服用上述中药组合物治疗室性心律失常5~18d后,24h室性心律失常的数量明显减少,有效率为100%。
具体实施方式
本发明提供了一种治疗室性心律失常的中药组合物,包括以下质量份的原料:炙甘草20份、桂枝20份、麦冬30份、生地30份、党参20份、丹参25份、玄参20份、苦参20份、百合20份、合欢皮20份、磁石30份、紫石英20份、常山10份和甘松20份。
在本发明中,所述党参为君药,有补中益气,养血生津之效。
所述麦冬和生地同为臣药,其中麦冬益胃生津,清心除烦,生地清热凉血,养阴生津,二者共同发挥养阴生津的功效。
所述桂枝、丹参、玄参、苦参、百合、合欢皮、磁石、紫石英、常山和甘松共为佐药,其中桂枝辛行温通,温心阳,通血脉,使中药组合物中的滋腻之品滋而不腻;丹参活血化瘀,清心除烦;玄参清热凉血,滋阴降火;苦参有清热安神止悸的功效;百合养阴润肺,清心安神;合欢皮和血宁心;磁石镇惊安神;紫石英镇心安神;常山和甘松合用安神止悸。所述炙甘草为使药,有滋阴养血,益气通阳,复脉定悸,调和诸药之用。本发明提供的中药组合物中的14味药物共奏益气养阴,安神止悸的功效,能够有效起到专病专治,治疗室性心律失常的技术效果。
本发明对上述原料的来源没有特殊限定,采用本领域技术人员熟知的常规市售产品即可。
本发明还提供了上述中药组合物的制备方法,包括以下步骤:将上述原料用水煎煮,取滤液,得到中药组合物。本发明提供的制备方法简单高效,还能提高制备得到的中药组合物的药效。
在本发明中,所述煎煮优选包括:
将磁石和紫石英与水混合后进行预煎煮,然后加入其余原料和水进行第一煎煮,得到第一滤渣和第一滤液;所述磁石和紫石英的总质量与水的质量比优选为1:(8~10),进一步优选为1:8;所述第一煎煮中,去除磁石和紫石英外其他原料的总质量与再次添加的水的质量比优选为1:(8~10),进一步优选为1:10;所述预煎煮的时间优选为0.25h,所述第一煎煮的时间优选为1.25~1.45h,进一步优选为1.45h;
将第一滤渣与水混合后进行第二煎煮,得到第二滤渣和第二滤液;所述第一滤渣与水的质量比优选为1:(6~8),进一步优选为1:8,所述第二煎煮的时间优选为0.5~0.7h,进一步优选为0.7h;
将第二滤渣与水混合后进行第三煎煮,得到第三滤渣和第三滤液;所述第二滤渣与水的质量比分别优选为1:(6~8),进一步优选为1:8,所述第三煎煮的时间优选为0.5~0.7h,进一步优选为0.7h;
合并第一滤液、第二滤液和第三滤液,得到中药组合物。本发明提供的制备方法煎煮时间充足,能够有效释放中药组合物中的有效成分进入滤液,提高治疗效果。
本发明还提供了上述中药组合物或上述制备方法制备得到中药组合物在制备治疗室性心律失常的药物中的应用;所述药物的服用方法优选包括:患者每日服用两次,每次服用150mL。本发明提供的中药组合物在患者服用5~18d后,24h室性心律失常的数量明显减少,有效率为100%。
为了进一步说明本发明,下面结合实施例对本发明提供的一种治疗室性心律失常的中药组合物及其制备方法和应用进行详细地描述,但不能将它们理解为对本发明保护范围的限定。
实施例1
按照以下质量份准备原料:炙甘草20份、桂枝20份、麦冬30份、生地30份、党参20份、丹参25份、玄参20份、苦参20份、百合20份、合欢皮20份、磁石30份、紫石英20份、常山10份和甘松20份。
取炙甘草20g、桂枝20g、麦冬30g、生地30g、党参20g、丹参25g、玄参20g、苦参20g、百合20g、合欢皮20g、磁石30g、紫石英20g、常山10g和甘松20g。
将磁石和紫石英与400g水煎煮0.25h后加入其余原料和2550g水煎煮1.45h后分离第一滤渣和第一滤液;
将第一滤渣与2440g水混合后煎煮0.7h,分离第二滤渣和第二滤液;
将第二滤渣与2440g水混合后煎煮0.7h,分离第三滤渣和第三滤液;
合并第一滤液、第二滤液和第三滤液,得到中药组合物。
应用例1
1、病例选择的标准:
随机选择临床诊断为室性心律失常病患者,其中年龄最小的40岁,最大的84岁,平均年龄64.95岁。病程最短的1个月,最长的3年。其中5人有治疗史。
2、疾病的诊断标准:
主要表现心悸,气短,胸闷,乏力,头晕等症状。
3、用药方法:
服用实施例1提供的中药组合物,每次150ml,每日2次,10d为1个疗程。
4、疗效的判断标准:
①显效:24h室性期前收缩次数较治疗前减少≥70%以上;
②有效:24h室性期前收缩次数较治疗前减少≥30%并且<70%;
③无效:24h室性期前收缩次数较治疗前减少<30%或无明显变化。
④加重:24h室性期前收缩次数较治疗前增加。
对多病例进行治疗后,对19名患者病情变化进行统计,统计结果如表1所示。
表1本发明所述中药组合物对室性期前收缩的治疗效果
病情诊断采信正规医院出具的检验报告。由表1可知,对19例年龄在40~84岁的室性心律失常病患进行治疗5~18d后,显效10人,占52.63%;有效率为100%。临床研究显示本发明所述中药组合物对心脏内不同起源部位的室性期前收缩均有治疗效果。
经临床证明,服用本发明提供的中药组合物能明显减少24h室性心律失常发作的次数,缓解心悸,胸闷的症状,可延缓疾病进展,改善患者的生存质量,且没有副作用。
由上述实施例和应用实例可知,本发明提供的中药组合物疗效好、治愈率高、不含有毒物质,可以减少室性心律失常数量,具有益气养阴,安神止悸的功效,能够抑制疾病进展,改善患者的生活质量。
以上所述仅是本发明的优选实施方式,应当指出,对于本发明的发明人来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。
Claims (9)
1.一种治疗室性心律失常的中药组合物,由以下质量份的原料制成:炙甘草20份、桂枝20份、麦冬30份、生地30份、党参20份、丹参25份、玄参20份、苦参20份、百合20份、合欢皮20份、磁石30份、紫石英20份、常山10份和甘松20份。
2.根据权利要求1所述中药组合物的制备方法,包括以下步骤:将权利要求 1所述原料用水煎煮,取滤液,得到中药组合物。
3.根据权利要求2所述的制备方法,其特征在于,所述煎煮包括:
将磁石和紫石英与水混合后进行预煎煮,然后加入其余原料和水进行第一煎煮,得到第一滤渣和第一滤液;
将第一滤渣与水混合后进行第二煎煮,得到第二滤渣和第二滤液;
将第二滤渣与水混合后进行第三煎煮,得到第三滤渣和第三滤液;
合并第一滤液、第二滤液和第三滤液,得到中药组合物。
4.根据权利要求3所述的制备方法,其特征在于,所述预煎煮中,磁石和紫石英的总质量与水的质量比为1:(8~10)。
5.根据权利要求3所述的制备方法,其特征在于,所述第一煎煮中,除磁石和紫石英外的其余原料的总质量与再次添加的水的质量比为1:(8~10);所述预煎煮的时间为0.25h,所述第一煎煮的时间为1.25~1.45h。
6.根据权利要求3所述的制备方法,其特征在于,所述第二煎煮中,所述第一滤渣与水的质量比为1:(6~8),所述第二煎煮的时间为0.5~0.7h。
7.根据权利要求3所述的制备方法,其特征在于,所述第三煎煮中,所述第二滤渣与水的质量比分别为1:(6~8),所述第三煎煮的时间为0.5~0.7h。
8.权利要求1所述中药组合物或权利要求2~6任一项所述制备方法制备得到的中药组合物在制备治疗室性心律失常的药物中的应用。
9.根据权利要求8所述的应用,其特征在于,所述药物的服用方法为:每日服用两次,每次服用150mL。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011210079.2A CN112206279B (zh) | 2020-11-03 | 2020-11-03 | 一种治疗室性心律失常的中药组合物及其制备方法和应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011210079.2A CN112206279B (zh) | 2020-11-03 | 2020-11-03 | 一种治疗室性心律失常的中药组合物及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN112206279A CN112206279A (zh) | 2021-01-12 |
CN112206279B true CN112206279B (zh) | 2022-05-27 |
Family
ID=74058035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011210079.2A Active CN112206279B (zh) | 2020-11-03 | 2020-11-03 | 一种治疗室性心律失常的中药组合物及其制备方法和应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112206279B (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103877512A (zh) * | 2014-04-01 | 2014-06-25 | 青岛市中心医院 | 一种用于治疗心律失常的中药及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100386112C (zh) * | 2005-09-16 | 2008-05-07 | 高松寿 | 一种治疗心律失常的中药制剂及其制备方法 |
CN105535852A (zh) * | 2016-01-21 | 2016-05-04 | 李宪秋 | 一种治疗心律失常的中药制剂 |
-
2020
- 2020-11-03 CN CN202011210079.2A patent/CN112206279B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103877512A (zh) * | 2014-04-01 | 2014-06-25 | 青岛市中心医院 | 一种用于治疗心律失常的中药及其制备方法 |
Non-Patent Citations (6)
Title |
---|
中药治疗心律失常性室性早搏疗效分析;左玉芹等;《中华中医药学刊》;20070410(第04期);第857-859页正文第一段以及2. 1 中药治疗 * |
定心汤治疗快速心律失常50例;罗新民;《中国中医急症》;20051115(第11期);第1095页正文第一段以及2. 1 中药治疗 * |
平心定悸汤加减治疗气阴两虚型快速性心律失常30例疗效观察;魏希进等;《山东医药》;20091117(第43期);全文 * |
熄风止悸汤治疗阵发性心房纤颤30例;韩婧等;《环球中医药》;20150506(第05期);全文 * |
黄永生治疗阵发性房颤验案;贾云洛等;《中国中医药现代远程教育》;20181125(第22期);全文 * |
齐律汤治疗虚证室性早搏84例临床观察;汪晓芳等;《中医杂志》;19000101(第10期);全文 * |
Also Published As
Publication number | Publication date |
---|---|
CN112206279A (zh) | 2021-01-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1061854C (zh) | 治疗、预防妇科疾患的药物制剂 | |
CN104547496B (zh) | 一种润肺止咳的中药组合物及其制备方法 | |
CN101822789B (zh) | 一种治疗原发性高血压的降压药 | |
CN103386022A (zh) | 一种治疗结核性胸膜炎的中药组合物 | |
CN103623280A (zh) | 一种治疗心脑血管疾病的中药制剂 | |
CN115282229B (zh) | 一种治疗气虚血淤型冠心病的中药组合物及其制备方法 | |
CN114748603B (zh) | 一种防治新冠病毒肺炎变异或复阳的药物组合物和应用 | |
CN112206279B (zh) | 一种治疗室性心律失常的中药组合物及其制备方法和应用 | |
CN115837065A (zh) | 一种中药组合物及其用途 | |
CN104257883A (zh) | 一种治疗化疗后白细胞减少症的中药组合物 | |
CN102552724B (zh) | 一种治疗高血压的中药组合物 | |
CN105456887A (zh) | 一种用于治疗再生障碍性贫血的药物 | |
CN111529659A (zh) | 治疗缓慢性心律失常的中药组合物及其制备方法和应用 | |
CN1245197C (zh) | 治疗冠心病、病毒性心肌炎的中药制剂 | |
CN112294901B (zh) | 治疗室上性心律失常的中药组合物及其制备方法和应用 | |
CN104224962A (zh) | 一种治疗间质性膀胱炎的中药组合物 | |
CN104056207B (zh) | 一种治疗胃癌的中药组合物及其制备方法 | |
CN102772723A (zh) | 一种治疗肺结核的中药配方 | |
CN111514237B (zh) | 一种治疗病毒性心肌炎的中药组合物及其制备方法 | |
CN103028088B (zh) | 一种治疗冠心病、心绞痛的中药组合物 | |
CN110151922B (zh) | 用于治疗心绞痛合并高血压病的中药组合物及其制备方法 | |
CN105288171A (zh) | 一种治疗男性更年期综合征的药物组合物 | |
CN105079580A (zh) | 一种治疗风温肺热病的中药组合物 | |
CN105456447A (zh) | 一种含有艾叶的具有活血化淤功能的中药组合物及其制备方法 | |
CN105326972A (zh) | 一种治疗外伤、疮疡的外用药物组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |