CN1144113A

CN1144113A - Medicine for curing throat disease and its preparation method

Info

Publication number: CN1144113A
Application number: CN 95111230
Authority: CN
Inventors: 王时新
Original assignee: Individual
Current assignee: Individual
Priority date: 1995-01-19
Filing date: 1995-01-19
Publication date: 1997-03-05

Abstract

The present invention relates to a medicine for curing throat disease and its preparation method. Said invention can be made into a solution preparation and a solid preparation by using refined mirabilite as main medicine, using isatis root, borax, bear's gall powder, apricot kernel extract, fritillaria bulb, chebule and borneol, etc. as auxiliary medicines. It is used for curing acute and chronic pharyngitis, sore-throat and aphthosis, etc.. The total effective rate of said spray is 98%.

Description

A kind of medicine for curing throat disease and preparation method thereof

The present invention relates to a kind of medicine for curing throat disease and preparation method thereof, belong to the medical and health neck

The territory.

Laryngopharyngeal diseases is a class commonly encountered diseases, frequently-occurring disease.Ancient Chinese medicine doctor is praised highly and is used the special side's BINGPENG SAN of larynx section to blow deposited affected part.BINGPENG SAN is aided with Borneolum Syntheticum, Borax composition mainly by Cinnabaris.Through long-term clinical use, find that the BINGPENG SAN administration is extremely inconvenient, dosage is restive; Blow apply easily cause foreign body sensation behind the throat and cause nauseating, vomiting, the child is difficult for accepting; And Cinnabaris is mercurous, and human body is had certain injury; Its reducing swelling and alleviating pain power is strong, and a little less than the heat-clearing and toxic substances removing expelling phlegm for arresting cough power.

The objective of the invention is to avoid above-mentioned weak point of the prior art and a kind of convenient drug administration is provided, patient is easy to have no side effect by being subjected to, medicine for curing throat disease of reducing swelling and alleviating pain, expelling phlegm for arresting cough and preparation method thereof.

Purpose of the present invention can reach by following measure: (1) prescription:

A. lead (monarch) medicine Matrii Sulfas Exsiccatus 20～50g

B. auxilliary (minister) medicine Radix Isatidis 40～100g, Fel Ursi powder 2～8g, Borax 10～35g,

C. adjuvant drug aqua armeniacae 10～80ml, Bulbus Fritillariae Uninbracteatae 20～80g, Fructus Chebulae 20～90g,

Radix Platycodonis 10～70g;

D. messenger drug Mentholum 0.5～5g, Borneolum Syntheticum 0.5～5g;

E. appropriate amount of auxiliary materials (2) is made solution or solid formulation with the A.B.C.D raw material; (3) be 0.001～40g by crude drug weight per kilogram of body weight every day dosage.

Purpose of the present invention also can reach by following measure: (1) prescription:

Matrii Sulfas Exsiccatus 25～35g Borax 15～25g Radix Isatidis 55～65g

Fel Ursi powder 3.5～6.5g aqua armeniacae 35～45ml Fructus Chebulae 55～65g

Bulbus Fritillariae Uninbracteatae 35～45g Radix Platycodonis 25～35g Mentholum 1.5～2.5g

Borneolum Syntheticum 1.5～2.5g (2) adjuvant:

Sorbic acid 1～3g cyclamate 5～12g

Above-mentioned crude drug is made solution, with the medicinal liquid atomisation, enter the human body bottleneck throat through shower nozzle, by crude drug weight, every day, the dosage of per kilogram of body weight was 0.04～0.07g.

Of the present invention day can also reach by following measure:

Take by weighing each crude drug by recipe quantity, make the solvent extraction Radix Isatidis with the ethanol of 20-99.95%, the active ingredient of Fructus Chebulae, Bulbus Fritillariae Uninbracteatae, Radix Platycodonis, concentrated extracting solution, Matrii Sulfas Exsiccatus, Borax, Fel Ursi powder, Borneolum Syntheticum, Mentholum, aqua armeniacae are added in the concentrated solution, add adjuvant, add suitable quantity of water, pack in the aerosol container container, make spray.

Excipient is added in the medicinal liquid of making, and drying is distributed into powder, or inserts capsule, makes capsule, or is pressed into tablet.

Its drying can adopt spray drying.

The present invention is further described below in conjunction with embodiment.Embodiment one:

(1) prescription:

Matrii Sulfas Exsiccatus 30g Borax 20g Radix Isatidis 60g Fel Ursi powder 5g

Aqua armeniacae 40ml Fructus Chebulae 60g Bulbus Fritillariae Cirrhosae 40g Radix Platycodonis 30g

Mentholum 2g Borneolum Syntheticum 2g

(2) adjuvant:

Sorbic acid 2g cyclamate 8g tween 80 10ml

(3) Fructus Chebulae, Radix Isatidis, Bulbus Fritillariae Cirrhosae, Radix Platycodonis are pulverized, the percolator of packing into is made solvent with 70% ethanol, speed with per minute 0.2～10ml is slowly collected percolate 1500ml, transfer PH7～9 with ammonia, stir and left standstill 24 hours, get supernatant and filter, filtrate recycling ethanol is to there not being the alcohol flavor, add the about 900ml of water, add Borax, Matrii Sulfas Exsiccatus, Fel Ursi powder, boil and make dissolving, add Borneolum Syntheticum, Mentholum and sorbic acid 2g, tween 80 10ml, stir evenly, filter, filtrate adds cyclamate 8g, add aqua armeniacae 40ml, add water to 1000ml, stir evenly, packing.

Pharmacodynamic study shows that the present invention has significantly antibiotic, antiinflammatory, antiviral, eases pain, eliminates the phlegm, cough-relieving, the effect of human body immunity improving power.Mouse cough due to the ammonia had significantly alleviate effect, promote the mice phenol red excretion of trachea section and be the stronger nitrogen effect of dispelling.Alleviate the pain of hot plate or acetic acid induced mice, suppress rat Ovum Gallus domesticus album foot swelling and dimethylbenzene induced mice auricle edema.Strengthen the mice carbon granule and clean up effect, the human body immunity improving ability has obvious bacteriostasis to the multiple common bacteria of respiratory tract, to adenovirus AdV ₃Type has deactivation.

To mouse peritoneal injection or 337 times of per os spray medicines, all do not cause death with 600 times of 400 times of giving mice coloclysis or adult's amount of Coming-of-Age Day consumption.With 100,50,5 times of amounts of Coming-of-Age Day consumption continuously to around the rat administration, its growth promoter, liver function, renal function all there is not the obvious damage effect, and do not find that vital organs such as the heart, lung, spleen, liver, kidney have the pathomorphology damage, show said preparation safety.

Clinical test results shows that this product has the obvious treatment effect to laryngopharynx swelling and pain, oral ulcer etc., and produce effects rapidly, taking convenience, good, the nonirritant of mouthfeel.Be applicable to the treatment acute/chronic pharyngitis, laryngopharynx swelling and pain, dryness and heat, aphtha of the mouth and tongue, the thirsty disease of waiting of generating heat.The clinical trial total effective rate is 98%, does not see untoward reaction.

The present invention has following advantage compared to existing technology:

1, prescription rationally, safely, effectively;

2, direct spray delivery, the medicine focus of going directly, mucosa absorption is complete rapidly, affected part blood drug level height, produce effects is rapid.

3, mouthfeel is good, does not have obvious rate and swashs property, is easy to particularly child patient's acceptance by the patient;

4, convenient drug administration, dosage are easy to control.Alcohol is made solvent, slowly collects percolate 1500ml with the speed of per minute 0.2～10ml, transfers PH7～9 with ammonia, stirring was left standstill 24 hours, got supernatant and filtered, and filtrate recycling ethanol is to there not being the alcohol flavor, add the about 900ml of water, add Borax, Matrii Sulfas Exsiccatus, Fel Ursi powder, boil and make dissolving, add Borneolum Syntheticum, Mentholum and sorbic acid 2g, tween 80 10ml stirs evenly, and filters, filtrate adds cyclamate 8g, adds aqua armeniacae 40ml, adds water to 1000ml, stir evenly packing.

To mouse peritoneal injection or 337 times of per os spray medicines, all do not cause death with 600 times of 400 times of giving mice coloclysis or adult's amount of Coming-of-Age Day consumption.Continuously to around the rat administration, its growth promoter, liver function, renal function are not all had the obvious damage effect with 100,50,5 times of amounts of Coming-of-Age Day consumption, and do not find that life officials such as the heart, lung, spleen, liver, kidney have the pathomorphology damage, show said preparation safety.

The present invention has following advantage compared to existing technology:

1, prescription rationally, safely, effectively;

3, mouthfeel is good, no obvious irritation, be easy to by the particularly young patient of patient connect by;

4, convenient drug administration, dosage are easy to control.

Claims

1, a kind of curing throat disease comprises: (1) prescription: A. master (monarch) medicine Matrii Sulfas Exsiccatus 20～50g; B. auxilliary (minister) medicine Radix Isatidis 40～100g. Fel Ursi powder 2～8g, Borax 10～35g; C. adjuvant drug aqua armeniacae 10～80ml, Bulbus Fritillariae Uninbracteatae 20～80ml, Fructus Chebulae 20～90g, Radix Platycodonis 10～70gD. messenger drug Mentholum 0.5～5g, Borneolum Syntheticum 0.5～5g; E. appropriate amount of auxiliary materials; (2) the A.B.C.D.E raw material is made solution or solid formulation; (3) be 0.001～40g by crude drug weight per kilogram of body weight every day dosage.

2, according to the medicine for curing throat disease of claim 1, its prescription is: Matrii Sulfas Exsiccatus 25～35g, Borax 15～25g, Radix Isatidis 55～65g, Fel Ursi powder 3.5～6.5g, aqua armeniacae 35～4ml, Fructus Chebulae 55～65g, Bulbus Fritillariae Uninbracteatae 35～45g, Radix Platycodonis 25～35g, Mentholum 1.5～2.5g, Borneolum Syntheticum 1.5～2.5g.

3, according to the medicine for curing throat disease of claim 1 or 2, its adjuvant is the sweet close plain 5～12g of sorbic acid 1～3g.

4, according to the medicine for curing throat disease of claim 1 or 2, be that crude drug is made solution, use shower nozzle, the medicinal liquid atomisation is entered the human body bottleneck throat.

5, according to the medicine for curing throat disease of claim 1, its dosage is counted per kilogram of body weight 0.04～0.07g every day by crude drug weight.

6, according to the medicine for curing throat disease of claim 1 or 2, its preparation method comprises: (1) connects recipe quantity and takes by weighing each crude drug; (2) active ingredient of usefulness solvent extraction Radix Isatidis, Fructus Chebulae, Bulbus Fritillariae Uninbracteatae, Radix Platycodonis; (3) concentrated extracting solution; (4) Matrii Sulfas Exsiccatus, Borax, Fel Ursi powder, Borneolum Syntheticum, Mentholum, aqua armeniacae are added in the concentrated solution (3); (5) add adjuvant, add suitable quantity of water; (6) pack in the aerosol container container, make spray.

7, according to the method for claim 6, the medicinal liquid of making adds excipient, and drying: A. is distributed into powder; B. insert capsule, make capsule; C. make tablet.

8, according to the medicine for curing throat disease of claim 6, extracting solution is the ethanol of 20%～99% concentration in its preparation.