CN1562178A - Preparation of Chinese traditional medicine for curing gallstone and preparation method - Google Patents
Preparation of Chinese traditional medicine for curing gallstone and preparation method Download PDFInfo
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- CN1562178A CN1562178A CNA2004100220667A CN200410022066A CN1562178A CN 1562178 A CN1562178 A CN 1562178A CN A2004100220667 A CNA2004100220667 A CN A2004100220667A CN 200410022066 A CN200410022066 A CN 200410022066A CN 1562178 A CN1562178 A CN 1562178A
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- 238000002360 preparation method Methods 0.000 title claims description 42
- 208000001130 gallstones Diseases 0.000 title 1
- 201000001883 cholelithiasis Diseases 0.000 claims abstract description 18
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- 238000002347 injection Methods 0.000 claims abstract description 5
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- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A Chinese medicine in the form of tablet, particle, oral liquid and injection for treating cholelithiasis is prepared from 6 Chinese-medicinal materials including bupleurum root, ash bark, scutellaria root, white peony root, etc.
Description
Technical field: the present invention relates to a kind of Chinese medicine preparation for the treatment of cholelithiasis and preparation method thereof, belong to the field of traditional Chinese medicine technology.
Technical background: the delay of chronic cholecystitis, the cholelithiasis state of an illness, outbreak repeatedly, feelings will is smooth, thick greasy, the overwork of surfeit delicious food etc. be its main diseases because of.Prevent and treat purpose in order to reach, a large amount of research has been done by many inventors and medicine enterprise, and the product of some treatments also is provided; The applicant had once submitted to name to be called with employee comrade's Zhang Huifang of unit name to Patent Office of the People's Republic of China: " a kind of pharmaceutical composition for the treatment of cholelithiasis and preparation method thereof ", application number are 02153457 patent application.In this part patent application document, because the dosage form of mentioning only is capsule, content uniformity easily transfinites, and causes taking dose inaccurate; The stimulating gastrointestinal road; Moisture-sensitive, deliquescing, caking, even go mouldy, light, air, moisture etc. are bigger to its influence; Be difficult for swallowing, the child be difficult for to accept, and patient that can not oral drugs also can't use, and application surface is little; And contained volatile oil is effective ingredient in its preparation in the Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic, but owing to have incomplete place in its technology, makes loss of volatile oil in Radix Bupleuri and the Ramulus Cinnamomi, thereby drug effect is reduced; Although so the medicine that this part application provides can be treated the disease of being narrated, the effect of finding them in actual use is not special ideal.
Summary of the invention: the object of the invention is to provide a kind of Chinese medicine preparation and preparation method thereof of the treatment cholelithiasis that has no side effect of evident in efficacy, taking convenience.
Technical solution of the present invention is achieved in that the Chinese medicine preparation of treatment cholelithiasis, calculate according to components by weight percent: it is by 83～248 parts of system Radix Bupleuri, 83～248 parts on Pericarpium Citri Reticulatae Viride, 83～248 parts of Radix Scutellariaes, 83～248 parts of the Radix Paeoniae Albas, 33～99 parts of Radix Et Rhizoma Rhei, 83～248 parts of Radix Curcumaes, 83～248 parts of Herba Lysimachiaes, 83～248 parts of Spora Lygodii, 83～248 parts of Endothelium Corneum Gigeriae Galli, 83～248 parts of Herba Artemisiae Scopariaes, 83～248 parts in Rhizoma Curcumae Longae, 55～165 parts of system rhizoma sparganic, 83～248 parts of Radix Clematidis are prepared from, prepared preparation is all preparations that medically allow: can be tablet, granule, soft capsule, oral liquid, drop pill, pill, extractum, ejection preparation, comprise: common injection, injectable powder, lyophilized injectable powder, infusion solution, other special preparations; Comprise sustained-release preparation, membranous patch, gel etc.Reasonable dosage form is tablet, granule, soft capsule, oral liquid and pill.Preparation method: it is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues are again with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis decocts with water or add the water reflux, extract, 1～3 time, each 1～3 hour, filter, filtrate after filtrate and the distillation merges, be condensed into clear paste, add ethanol and make and contain the alcohol amount and reach 40～80%, stir evenly, cold preservation 12～48 hours, filter, decompression filtrate recycling ethanol continues to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, with Radix Et Rhizoma Rhei fine powder mixing, volatile oil adds 4 times of amount beta-cyclodextrin inclusion compounds, and the reuse diverse ways is made different preparations.
The preparation method of tablet is among the present invention: it is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues decoct with water 1～2 time with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, each 1～2 hour, filter, the filtrate after filtrate and the distillation merges, be condensed into clear paste, add ethanol and make and contain the alcohol amount and reach 40～60%, stir evenly cold preservation 12～24 hours, filter, decompression filtrate recycling ethanol continues to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder,, add water-wet with Radix Et Rhizoma Rhei fine powder mixing, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 4 times, tabletting, promptly.
The preparation method of granule is among the present invention: it is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues decoct with water 2～3 times with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, each 2～3 hours, filter, the filtrate after filtrate and the distillation merges, and is condensed into clear paste, adding ethanol makes and contains the alcohol amount and reach 60～80%, stir evenly, cold preservation 12～24 hours filters, decompression filtrate recycling ethanol, continue to be condensed into thick paste, vacuum drying gets dry extract, be ground into fine powder, with Radix Et Rhizoma Rhei fine powder mixing, add water-wet, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 4 times, promptly.
The preparation method of soft capsule is that preparation method is among the present invention: it is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues add the water reflux, extract, 1～3 time with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, each 1～3 hour, filter, the filtrate after filtrate and the distillation merges, be condensed into clear paste, add ethanol and make and contain the alcohol amount and reach 40～80%, stir evenly cold preservation 12～48 hours, filter, decompression filtrate recycling ethanol continues to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, with Radix Et Rhizoma Rhei fine powder mixing, volatile oil adds 4 times of amount beta-cyclodextrin inclusion compounds, mixing, add 20% vegetable oil, pill promptly gets soft capsule.
According to the theory of motherland's medical science, Radix Bupleuri is monarch in the side, and the Radix Bupleuri toil is slightly cold, and returns the liver and gall warp, and merit is apt to the depressed liver-energy dispersing and QI regulating function of gallbladder promoting.Pericarpium Citri Reticulatae Viride toil temperature is gone into Liver Channel, " pearl sac " cloud: " the Pericarpium Citri Reticulatae Viride master stagnation of QI, removing mass knot ", the power of soothing the liver circulation of qi promoting more so with its Fructus Aurantii, with the Radix Bupleuri compatibility, increases the merit of depressed liver-energy dispersing and QI regulating in generation, the Radix Scutellariae bitter cold is gone into the liver and gall warp, function clearing heat secreting bile, the heat of the few positive gallbladder meridian of You Shanqing, Radix Paeoniae Alba picric acid is slightly cold, and returns the liver spleen channel, function nourishing blood to suppress the hyperactive liver, relieving spasm to stop pain, the power of Radix et Rhizoma Rhei (processed) bitter cold purging FU-organs is slow, and the benefit intestinal stasis relieving that can blood stasis dispelling stimulates the menstrual flow is ministerial drug altogether, get the dachaihu decoction meaning, reach depressed liver-energy dispersing and function of gallbladder promoting, the effect of purging FU-organs pain relieving.The cold of Radix Curcumae toil, function depressed liver-energy dispersing and function of gallbladder promoting jaundice eliminating, the promoting flow of QI and blood pain relieving, Herba Lysimachiae, Spora Lygodii sweetness and bitterness are trembled with fear, clearing away heat-damp and promoting diuresis, the power of calculus function of gallbladder promoting is outstanding especially, and Endothelium Corneum Gigeriae Galli is sweet flat, and merit is apt to the eliminate indigestion Sal Nitri, and four medicines share into four gold medal soup, and the merit of cholagogic and lithagogue Sal Nitri is arranged; Rhizoma Wenyujin Concisum toil temperature, the rhizoma sparganic toil is flat, the stagnation of QI in the removing blood stasis, merit benefaction gas promoting blood circulation and stopping pain, the hot temperature of Radix Clematidis is gone into Liver Channel, and walk and do not keep, the logical twelve channels and collaterals of a surname, removing obstruction in the collateral to relieve pain is adjuvant drug altogether.The cold of Herba Artemisiae Scopariae toil is apt to into the liver and gall warp, is the special medicine of liver heat removing dampness removing jaundice eliminating.The heat of Herba Artemisiae Scopariae liver heat removing gallbladder is held concurrently and is managed the strongly fragrant of liver and gall, makes damp and hot elimination, and stasis must be opened; Match with Radix Bupleuri, Radix Scutellariae, can help the power of depressed liver-energy dispersing and function of gallbladder promoting, with all blood circulation promoting medicines mutually 5, then blood stagnation can be to be messenger drug with the capable cloth of failing of gas in liver and gall person.The present invention selects tablet, granule, soft capsule, oral liquid, drop pill, pill, medicated wine, tincture, extractum for use, and ejection preparation comprises: common injection, injectable powder, lyophilized injectable powder, infusion solution, other special preparations; Comprise sustained-release preparation, membranous patch, gel etc.Tablet dose is accurate, and the content content difference is little, steady quality, and some easy oxidation deterioration and deliquescent medicine can be protected by coating, and light, air, moisture etc. are less to its influence; Granule, GI irritation is little; Drug loading is big, and mouthfeel is good, is beneficial to acceptance; Oral liquid absorbs fast, the bioavailability height, and the use crowd is wide; Injection bioavailability height, onset speed is fast, no first pass effect, be applicable to can not be oral the patient; Sustained-release preparation is easy to use, provides balance persistent effective blood drug concentration, needing to be particularly useful for the patient of long-term prescription.The present invention is directed to prior art simultaneously, the volatile oil that Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic distillation extraction are gone out carries out enclose with cyclodextrin, can prevent the volatilization of volatile oil; Improve stability of drug; Also can cover the bad smell of volatile oil simultaneously.
Effectively controlled in order to confirm method provided by the invention, the preparation good effect, the applicant carries out a series of experiments:
Experimental example 1: to the dissolution of rabbit cholelithiasis
After the healthy rabbits fasting 16 hours, intravenous injection pentobarbital sodium 1ml/kg anesthesia.The surgical exposure gallbladder is implanted people's cholelithiasis.Get after 1 week and recover normal postoperative animal, oral administration gavage gives tablet experimental group of the present invention and the capsule matched group of 6g crude drug/kg, continuous 30 days respectively.With sacrifice of animal, take out gallbladder after the off-test, the variation of record bile and cholelithiasis weight.Administration treated animal bile is rare clearly as a result, cholelithiasis weight with implant before compare all and alleviate, similar to the capsule group, show that preparation of the present invention is good to the dissolution of rabbit cholelithiasis.
Experimental example 2: choleretic effect
Rat is granule experimental group of the present invention and the capsule matched group of oral administration gavage 3g crude drug/kg respectively, continuous 1 week.Opened the abdominal cavity with urethane anesthesia back operation in second day after the last administration, find out common bile duct and carry out the plastic catheter intubate, bile drainage writes down the bile milliliter number of drain in per ten minutes.Duodenum gives pharmaceutical composition 6g crude drug/kg of the present invention then, the bile amount of record drain.More all can obviously improve the rat bile secretory volume before granule experimental group of the present invention as a result and capsule matched group and the last administration, show that preparation of the present invention has obvious choleretic effect.
Experimental example 3: adjuvant screening, the selection of adjuvant be for particular importance of the present invention, selects badly, do not reach due effect, even just can not make desired dosage form product at all;
The volatile oil of Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic is its effective ingredient, and is diffusing for preventing waving of volatile oil, improves stability of drug, covers the bad smell of volatile oil, better brings into play drug effect, and the cyclodextrin parcel is its key technology.
Inclusion rate=[amount of volatile oil/volatile oil addition in the clathrate] * 100%
Recovery rate=[clathrate actual amount/(cyclodextrin amount+volatile oil addition)] * 100%
Cyclodextrin: oil 8: 16: 14: 1
Inclusion rate % recovery rate % inclusion rate % recovery rate % inclusion rate % recovery rate %
Beta-schardinger dextrin-73.5 91.6 74.3 91.5 75.7 95.6
Alpha-cyclodextrin 72.3 90.1 71.5 91.1 70.3 92.3
Gamma-cyclodextrin 73.0 91.3 72.1 91.5 73.3 90.1
White dextrin 65.7 83.2 66.3 87.2 63.5 82.3
Yellow starch gum 60.5 81.2 62.0 82.1 65.3 81.5
Check disintegration:
The soft capsule disperse medium
Vegetable oil Polyethylene Glycol-400
Consumption (%) 10 15 20 10 15 20
Disintegration 310243
(not by the screen cloth number)
By the adjuvant screening experiment, the made preparation of adjuvant that adopts the present invention to select, steady quality, product is controlled, good moldability
Embodiments of the invention 1:
System Radix Bupleuri 83g Pericarpium Citri Reticulatae Viride 83g Radix Scutellariae 83g
Radix Paeoniae Alba 83g Radix Et Rhizoma Rhei 33g Radix Curcumae 83g
Herba Lysimachiae 83g Spora Lygodii 83g Endothelium Corneum Gigeriae Galli 83g
Herba Artemisiae Scopariae 83g Rhizoma Curcumae Longae 83g system rhizoma sparganic 55g
Radix Clematidis 83g
It is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues added water 1 hour with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, filtered, and the filtrate after filtrate and the distillation merges, be condensed into clear paste, add ethanol and make and contain the alcohol amount and reach 40%, stir evenly cold preservation 14 hours, filter, decompression filtrate recycling ethanol continues to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder,, add water-wet with Radix Et Rhizoma Rhei fine powder mixing, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 4 times, and tabletting promptly gets tablet, oral, every day 3 times, each 3.
Embodiments of the invention 2:
System Radix Bupleuri 248g Pericarpium Citri Reticulatae Viride 248g Radix Scutellariae 248g
Radix Paeoniae Alba 248g Radix Et Rhizoma Rhei 99g Radix Curcumae 248g
Herba Lysimachiae 248g Spora Lygodii 248g Endothelium Corneum Gigeriae Galli 248g
Herba Artemisiae Scopariae 248g Rhizoma Curcumae Longae 248g system rhizoma sparganic 165g
Radix Clematidis 248g
It is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues decoct with water 3 times with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, each 3 hours, filter, filtrate after filtrate and the distillation merges, be condensed into clear paste, add ethanol and make and contain the alcohol amount and reach 80%, stir evenly, cold preservation 48 hours, filter, decompression filtrate recycling ethanol continues to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, with Radix Et Rhizoma Rhei fine powder mixing, add water-wet, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 4 times, promptly gets granule, oral, every day 3 times, each 3 bags.
Embodiments of the invention 3:
System Radix Bupleuri 165g Pericarpium Citri Reticulatae Viride 165g Radix Scutellariae 165g
Radix Paeoniae Alba 165g Radix Et Rhizoma Rhei 66g Radix Curcumae 165g
Herba Lysimachiae 165g Spora Lygodii 165g Endothelium Corneum Gigeriae Galli 165g
Herba Artemisiae Scopariae 165g Rhizoma Curcumae Longae 165g system rhizoma sparganic 110g
Radix Clematidis 165g
It is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues added the water reflux, extract, 1 hour with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, filtered, and the filtrate after filtrate and the distillation merges, be condensed into clear paste, add ethanol and make and contain the alcohol amount and reach 40%, stir evenly cold preservation 12 hours, filter, decompression filtrate recycling ethanol continues to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, with Radix Et Rhizoma Rhei fine powder mixing, volatile oil adds 4 times of amount beta-cyclodextrin inclusion compounds, mixing, add 20% vegetable oil, pill promptly gets soft capsule, oral, every day 3 times, each 3.
Embodiments of the invention 4:
System Radix Bupleuri 165g Pericarpium Citri Reticulatae Viride 165g Radix Scutellariae 165g
Radix Paeoniae Alba 165g Radix Et Rhizoma Rhei 66g Radix Curcumae 165g
Herba Lysimachiae 165g Spora Lygodii 165g Endothelium Corneum Gigeriae Galli 165g
Herba Artemisiae Scopariae 165g Rhizoma Curcumae Longae 165g system rhizoma sparganic 110g
Radix Clematidis 165g
It is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues add the water reflux, extract, 3 times with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, each 3 hours, filter, filtrate after filtrate and the distillation merges, and is condensed into clear paste, adds ethanol and makes and contain the ferment amount and reach 80%, stir evenly, cold preservation 48 hours filters decompression filtrate recycling ethanol, continue to be condensed into thick paste, vacuum drying gets dry extract, and is ground into fine powder, with Radix Et Rhizoma Rhei fine powder mixing, volatile oil adds 4 times of amount beta-cyclodextrin inclusion compounds, and mixing adds refined honey, pill, promptly get pill, oral, every day 3 times, each 3.
Claims (6)
1, a kind of Chinese medicine preparation for the treatment of cholelithiasis, it is characterized in that: calculate according to components by weight percent: it is by 83～248 parts of system Radix Bupleuri, 83～248 parts on Pericarpium Citri Reticulatae Viride, 83～248 parts of Radix Scutellariaes, 83～248 parts of the Radix Paeoniae Albas, 33～99 parts of Radix Et Rhizoma Rhei, 83～248 parts of Radix Curcumaes, 83～248 parts of Herba Lysimachiaes, 83～248 parts of Spora Lygodii, 83～248 parts of Endothelium Corneum Gigeriae Galli, 83～248 parts of Herba Artemisiae Scopariaes, 83～248 parts in Rhizoma Curcumae Longae, 55～165 parts of system rhizoma sparganic, Radix Clematidis is prepared into tablet for 83～248 parts, granule, soft capsule, oral liquid, drop pill, pill, extractum, ejection preparation, comprise: common injection, injectable powder, lyophilized injectable powder, infusion solution, other special preparations; Comprise sustained-release preparation, membranous patch, gel etc.
2, according to the Chinese medicine preparation of the described treatment cholelithiasis of claim 1, it is characterized in that: its dosage form is tablet, granule, soft capsule, oral liquid and pill.
3, the preparation method of the Chinese medicine preparation of treatment cholelithiasis as claimed in claim 1 or 2 is characterized in that: it is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues are again with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis decocts with water or add the water reflux, extract, 1～3 time, each 1～3 hour, filter, filtrate after filtrate and the distillation merges, be condensed into clear paste, add ethanol and make and contain the alcohol amount and reach 40～80%, stir evenly, cold preservation 12～48 hours, filter, decompression filtrate recycling ethanol continues to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, with Radix Et Rhizoma Rhei fine powder mixing, volatile oil adds 4 times of amount beta-cyclodextrin inclusion compounds, and the reuse diverse ways is made different preparations.
4, treat the preparation method of the Chinese medicine preparation of cholelithiasis according to the described kind of claim 3, it is characterized in that: its method for preparing tablet thereof is: it is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues decoct with water 1～2 time with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, each 1～2 hour, filter, the filtrate after filtrate and the distillation merges, be condensed into clear paste, add ethanol and make and contain the alcohol amount and reach 40～60%, stir evenly cold preservation 12～24 hours, filter, decompression filtrate recycling ethanol continues to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder,, add water-wet with Radix Et Rhizoma Rhei fine powder mixing, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 4 times, tabletting, promptly.
5, treat the preparation method of the Chinese medicine preparation of cholelithiasis according to the described kind of claim 3, it is characterized in that: its process for producing granula is: it is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues decoct with water 2～3 times with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, each 2～3 hours, filter, the filtrate after filtrate and the distillation merges, and is condensed into clear paste, adding ethanol makes and contains the alcohol amount and reach 60～80%, stir evenly, cold preservation 12～24 hours filters, decompression filtrate recycling ethanol, continue to be condensed into thick paste, vacuum drying gets dry extract, be ground into fine powder, with Radix Et Rhizoma Rhei fine powder mixing, add water-wet, granulate, volatile oil is sneaked into after measuring beta-cyclodextrin inclusion compounds with 4 times, promptly.
6, treat the preparation method of the Chinese medicine preparation of cholelithiasis according to the described kind of claim 3, it is characterized in that: its its soft capsule preparation method is that preparation method is: it is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues add the water reflux, extract, 1～3 time with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, each 1～3 hour, filter, the filtrate after filtrate and the distillation merges, be condensed into clear paste, add ethanol and make and contain the alcohol amount and reach 40～80%, stir evenly cold preservation 12～48 hours, filter, decompression filtrate recycling ethanol continues to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, with Radix Et Rhizoma Rhei fine powder mixing, volatile oil adds 4 times of amount beta-cyclodextrin inclusion compounds, mixing, add 20% vegetable oil, pill promptly gets soft capsule.
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| CNB2004100220667A CN1309367C (en) | 2004-03-17 | 2004-03-17 | Preparation of Chinese traditional medicine for curing gallstone and preparation method |
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| CNB2004100220667A CN1309367C (en) | 2004-03-17 | 2004-03-17 | Preparation of Chinese traditional medicine for curing gallstone and preparation method |
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| CN1562178A true CN1562178A (en) | 2005-01-12 |
| CN1309367C CN1309367C (en) | 2007-04-11 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100878A (en) * | 2011-03-08 | 2011-06-22 | 马卫东 | Chinese medicinal preparation for treating gall-stone |
| CN102961680A (en) * | 2012-11-06 | 2013-03-13 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating gallstone and cholecystitis and preparation method thereof |
| CN102961677A (en) * | 2012-11-06 | 2013-03-13 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating gallstone and cholecystitis and preparation method thereof |
| CN102973883A (en) * | 2012-11-06 | 2013-03-20 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treatment of gallstones and cholecystitis and preparation method thereof |
| CN102973884A (en) * | 2012-11-06 | 2013-03-20 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treatment of gallstones and cholecystitis and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1189204C (en) * | 2002-11-29 | 2005-02-16 | 咸阳步长制药有限公司 | Medicine compositions for treating biliary calculus, and its prepn. method |
-
2004
- 2004-03-17 CN CNB2004100220667A patent/CN1309367C/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100878A (en) * | 2011-03-08 | 2011-06-22 | 马卫东 | Chinese medicinal preparation for treating gall-stone |
| CN102961680A (en) * | 2012-11-06 | 2013-03-13 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating gallstone and cholecystitis and preparation method thereof |
| CN102961677A (en) * | 2012-11-06 | 2013-03-13 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating gallstone and cholecystitis and preparation method thereof |
| CN102973883A (en) * | 2012-11-06 | 2013-03-20 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treatment of gallstones and cholecystitis and preparation method thereof |
| CN102973884A (en) * | 2012-11-06 | 2013-03-20 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treatment of gallstones and cholecystitis and preparation method thereof |
| CN102961680B (en) * | 2012-11-06 | 2014-01-22 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating gallstone and cholecystitis and preparation method thereof |
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|---|---|
| CN1309367C (en) | 2007-04-11 |
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