CN1149492A - Technology for producing strengthening waist and invigorating kidney oral liquor - Google Patents
Technology for producing strengthening waist and invigorating kidney oral liquor Download PDFInfo
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- CN1149492A CN1149492A CN 96119075 CN96119075A CN1149492A CN 1149492 A CN1149492 A CN 1149492A CN 96119075 CN96119075 CN 96119075 CN 96119075 A CN96119075 A CN 96119075A CN 1149492 A CN1149492 A CN 1149492A
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- kadsurae coccineae
- caulis kadsurae
- oral liquid
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Abstract
A Chinese patent drug oral liquor for invigorating waist and kidney and its production technique. It extracts volatile oil distilled liquid from Kadsura coccinea for ready use, the medicinal dregs along with other 8 medicine materials are extracted with water and concentrated, after impurities adsorbed by active carbon, it is filtered, cold-stored and super-quick-centrifuged, hen it is merged with Kadsura coccinea distilled liquid, a corrective and water are added to obtain the product. This invented production technique has low cost and simple operation, the product has good clarity and stability, convenience for taking, raised curingeffect and no obvious bad effect.
Description
The present invention relates to a kind of production technology of Chinese medicine liquor, particularly a kind ofly have strengthening the loins and invigorating the kidney, nourish blood, the oral liquid of wind-damp dispelling function, by the production technology of the oral liquid of loins-strengthening and kidney-invigorating bolus remodeling.
At present, the extract oral liquid formulation adopts water extract-alcohol precipitation more, concentrates the filtration technology and purifies clarifying treatment, production cost height, operation sequence complexity, manufactured goods clarity and poor stability; It is ancient that loins-strengthening and kidney-invigorating bolus has dosage form, technology is outmoded, dose is big, take inconvenient shortcoming, the Sanitation Ministry medicine standard WS3-B-0538-91 records, be big honeyed pills, except that big honeyed pills, also have water-honeyed pill and tablet in using at present, be half extractum solid preparation, dosage calculates with number and weight, dose is big, take the back the molten diffusing time long, the absorption, onset is slow, interpolation Mel and drug powder amount are big during making, content of dispersion only is half a heavy amount of ball, increases patient's dose, and storage requires high, make the unhygienic infested and mould phenomenon that loses that has, limited its clinical practice.
Purpose of the present invention just is to overcome the production cost height of present Chinese medicine liquor decoction and alcohol sedimentation technique, the shortcoming that manufactured goods clarity is not enough, provide a kind of production cost low, simplified control, manufactured goods clarity and good stability, eye is used convenient, the production technology of the oral liquid for strengthening waist and kidney that curative effect improves.
The present invention is achieved in that Caulis Kadsurae Coccineae in the prescription was soaked two hours that the way of distillation is collected distillate, and is standby.Get Rhizoma Cibotii, Herba Taxilli, R.laevigata, Fructus Ligustri Lucidi, Millettia Speciosa, Radix Flemingiae Philippinensis, Caulis Spatholobi, the Semen Cuscutae of full dose by prescription in addition, the Caulis Kadsurae Coccineae medicinal residues merging with after the distillation decocts with water secondary, merges decoction liquor, filter, filtrate concentrates, and adds active carbon while hot, boils, filter, be cooled to room temperature, cold preservation 24 hours is taken out, ultracentrifugation is handled, and adds the Caulis Kadsurae Coccineae distillate, and Mel sucrose is an amount of, mixing adds water to about 1.5 times of volumes/medical material weight, filters, embedding, sterilization, promptly.
The production technology of oral liquid for strengthening waist and kidney of the present invention is good with following condition:
(1) Caulis Kadsurae Coccineae adds 8 times of water gagings immersions, adds thermal distillation 1.5 hours, and the collection distillate is 2.2 times of medical material amount;
(2) Caulis Kadsurae Coccineae and eight flavor medical material water extraction add 8 times of water gagings for the first time and extracted 2 hours, add 6 times of water gagings for the second time and extract 2 hours;
(3) filtrate to be concentrated into relative density be about 1.05;
(4) concentrated solution adds 0.8% active carbon while hot, boils 30 minutes.
The production technology of oral liquid for strengthening waist and kidney of the present invention is compared with the decoction and alcohol sedimentation technique of routine, and experiment shows that its production cost reduces, and the clarity of product improves greatly, does not have precipitation in the shelf-life, does not have muddy phenomenon.
The invention will be further described below in conjunction with embodiment.
Prescription: Rhizoma Cibotii 187.6g, Herba Taxilli 56.3g, Fructus Rosae Laevigatae 60g, Caulis Kadsurae Coccineae 112.5g, Fructus Ligustri Lucidi 9.4g, Millettia Speciosa 75g, Radix Flemingiae Philippinensis 45g, Caulis Spatholobi 112.5g, Semen Cuscutae 9.4g.
Embodiment 1, and production procedure is the same, and working condition is as follows:
(1) Caulis Kadsurae Coccineae adds 8 times of water logging bubbles, adds thermal distillation 1.5 hours, and the collection distillate is 2.2 times of medical material amount;
(2) Caulis Kadsurae Coccineae and eight flavor medical material water extraction add 8 times of water gagings for the first time and extracted 2 hours, add 6 times of water gagings for the second time and extract 2 hours;
(3) filtrate to be concentrated into relative density be about 1.05;
(4) concentrated solution adds 0.8% active carbon while hot, boils 30 minutes.
Embodiment 2, and production procedure is the same, and working condition is as follows:
(1) Caulis Kadsurae Coccineae adds 8 times of water logging bubbles, adds thermal distillation 1.5 hours, and the collection distillate is 2.2 times of medical material amount;
(2) Caulis Kadsurae Coccineae and eight flavor medical material water extraction add 8 times of water gagings for the first time and extracted 4 hours, add 6 times of water gagings for the second time and extract 3 hours;
(3) filtrate to be concentrated into relative density be about 1.05;
(4) concentrated solution adds 1.0% active carbon while hot, boils 30 minutes.
Embodiment 3, and production procedure is the same, and working condition is as follows:
(1) Caulis Kadsurae Coccineae adds 8 times of water logging bubbles, adds thermal distillation 1.5 hours, and the collection distillate is 2.2 times of medical material amount;
(2) Caulis Kadsurae Coccineae and eight flavor medical material water extraction add 7 times of water gagings for the first time and extracted 2 hours, add 5 times of water gagings for the second time and extract 1 hour;
(3) filtrate to be concentrated into relative density be about 1.05;
(4) concentrated solution adds 0.9% active carbon while hot, boils 30 minutes.
Embodiment 4, and production procedure is the same, and working condition is as follows:
(1) Caulis Kadsurae Coccineae adds 8 times of water logging bubbles, adds thermal distillation 1.5 hours, and the collection distillate is 2.2 times of medical material amount;
(2) Caulis Kadsurae Coccineae and eight flavor medical material water extraction add 6 times of water gagings for the first time and extracted 3 hours, add 6 times of water gagings for the second time and extract 2 hours;
(3) filtrate to be concentrated into relative density be about 1.05;
(4) concentrated solution adds 0.5% active carbon while hot, boils 30 minutes.
The oral liquid for strengthening waist and kidney of production technology preparation of the present invention, in the assessment period of a year and a half, each quality detecting index result is stable for examination character, discriminating, clarity, relative density, pH value, saponin component assay, health examination (comprise assorted bacterium, mycete, other).The oral liquid for strengthening waist and kidney that studies show that of pharmacodynamics has obvious enhance immunity to be subjected to press down the body weight of mice, the weight of immune organ spleen and thymus, its restitution of promotion is arranged, can propose immunity and be subjected to press down the T lymphocyte of mice and the phagocytic activity of macrophage, improve immunity and be subjected to press down the hemolysin IgM that mice produces antigen (SRBC).Oral liquid for strengthening waist and kidney can obviously improve the content of the blood plasma testosterone of moulding mice.Oral liquid for strengthening waist and kidney can increase the ability of mice normal pressure anoxia enduring.Clinical research is the result show, the clinical efficacy of treatment lumbago due to renal deficiency (curing and obvious effective rate 58.8%) is better than loins-strengthening and kidney-invigorating bolus (curing and obvious effective rate 33.1%), no serious adverse reaction.
Claims (4)
1. the production technology of a Chinese medicine liquor oral liquid for strengthening waist and kidney has following steps: soaked two hours by the prescription Caulis Kadsurae Coccineae, the way of distillation is collected distillate, and is standby; Get Rhizoma Cibotii, Herba Taxilli, Fructus Rosae Laevigatae, Fructus Ligustri Lucidi, Millettia Speciosa, Radix Flemingiae Philippinensis, Caulis Spatholobi, the Semen Cuscutae of full dose by prescription in addition, the Caulis Kadsurae Coccineae medicinal residues merging with after the distillation decocts with water secondary, merge decoction liquor, filter, filtrate concentrates, add active carbon while hot, boil, filter, be cooled to room temperature, centrifugal treating is taken out in cold preservation 24 hours, add the Caulis Kadsurae Coccineae distillate, Mel sucrose is an amount of.
2. the production technology of oral liquid for strengthening waist and kidney according to claim 1 is characterized in that:
A. Caulis Kadsurae Coccineae adds 8 times of water logging bubbles, adds thermal distillation 1.5 hours, and the collection distillate is 2.2 times of medical material amount;
B. Caulis Kadsurae Coccineae medicinal residues and eight flavor medical material water extraction add 8 times of water gagings for the first time and extracted 2 hours, add 6 times of water gagings for the second time and extract 2 hours;
C. filtrate to be concentrated into relative density be about 1.05;
D. concentrated solution adds 0.5%～1.0% active carbon while hot, boils 30 minutes.
3. the production technology of oral liquid for strengthening waist and kidney according to claim 1 and 2 is characterized in that: activated carbon dosage with 0.8% for good.
4. the production technology of oral liquid for strengthening waist and kidney according to claim 1 and 2 is characterized in that: after Caulis Kadsurae Coccineae medicinal residues and the eight flavor medical material water extract cold preservations, take out, adopt ultracentrifugation to handle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96119075 CN1149492A (en) | 1996-05-16 | 1996-05-16 | Technology for producing strengthening waist and invigorating kidney oral liquor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96119075 CN1149492A (en) | 1996-05-16 | 1996-05-16 | Technology for producing strengthening waist and invigorating kidney oral liquor |
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| Publication Number | Publication Date |
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| CN1149492A true CN1149492A (en) | 1997-05-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 96119075 Pending CN1149492A (en) | 1996-05-16 | 1996-05-16 | Technology for producing strengthening waist and invigorating kidney oral liquor |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266379A (en) * | 2011-07-22 | 2011-12-07 | 中国热带农业科学院热带作物品种资源研究所 | Liquid preparation for strengthening tendons and bones, relaxing tendons, activating collaterals and relieving arthralgia due to wind-dampness and aching pain of waist and knees and preparation method thereof |
| CN101342002B (en) * | 2008-08-28 | 2012-12-19 | 中国热带农业科学院热带生物技术研究所 | Millettia speciosa champ health care beverage and preparation method thereof |
| CN108210624A (en) * | 2018-01-12 | 2018-06-29 | 广东力罗定制药有限公司 | A kind of oral liquid for strengthening waist and kidney and preparation method thereof |
| CN114917286A (en) * | 2022-06-10 | 2022-08-19 | 山西旺龙药业集团有限公司 | Preparation method of traditional Chinese medicine compound honeyed pill for treating neurasthenia |
-
1996
- 1996-05-16 CN CN 96119075 patent/CN1149492A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342002B (en) * | 2008-08-28 | 2012-12-19 | 中国热带农业科学院热带生物技术研究所 | Millettia speciosa champ health care beverage and preparation method thereof |
| CN102266379A (en) * | 2011-07-22 | 2011-12-07 | 中国热带农业科学院热带作物品种资源研究所 | Liquid preparation for strengthening tendons and bones, relaxing tendons, activating collaterals and relieving arthralgia due to wind-dampness and aching pain of waist and knees and preparation method thereof |
| CN102266379B (en) * | 2011-07-22 | 2012-09-05 | 中国热带农业科学院热带作物品种资源研究所 | Liquid preparation for strengthening tendons and bones, relaxing tendons, activating collaterals and relieving arthralgia due to wind-dampness and aching pain of waist and knees and preparation method thereof |
| CN108210624A (en) * | 2018-01-12 | 2018-06-29 | 广东力罗定制药有限公司 | A kind of oral liquid for strengthening waist and kidney and preparation method thereof |
| CN108210624B (en) * | 2018-01-12 | 2020-12-22 | 一力制药(罗定)有限公司 | Waist strengthening and kidney invigorating oral liquid and preparation method thereof |
| CN114917286A (en) * | 2022-06-10 | 2022-08-19 | 山西旺龙药业集团有限公司 | Preparation method of traditional Chinese medicine compound honeyed pill for treating neurasthenia |
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| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |