CN1189204C - Medicine compositions for treating biliary calculus, and its prepn. method - Google Patents
Medicine compositions for treating biliary calculus, and its prepn. method Download PDFInfo
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- CN1189204C CN1189204C CNB021534578A CN02153457A CN1189204C CN 1189204 C CN1189204 C CN 1189204C CN B021534578 A CNB021534578 A CN B021534578A CN 02153457 A CN02153457 A CN 02153457A CN 1189204 C CN1189204 C CN 1189204C
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- radix
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- rhizoma
- fine powder
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- Expired - Lifetime
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- 239000003814 drug Substances 0.000 title claims abstract description 9
- 229940079593 drug Drugs 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 201000001883 cholelithiasis Diseases 0.000 claims abstract description 17
- 241000903946 Clematidis Species 0.000 claims abstract description 10
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 235000014375 Curcuma Nutrition 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- 239000000706 filtrate Substances 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 238000004821 distillation Methods 0.000 claims description 10
- 239000000341 volatile oil Substances 0.000 claims description 10
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- 239000007864 aqueous solution Substances 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 244000164439 Curcuma angustifolia Species 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
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- 239000000890 drug combination Substances 0.000 claims 2
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- 244000163122 Curcuma domestica Species 0.000 abstract 2
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 241000758993 Equisetidae Species 0.000 abstract 1
- 241000287828 Gallus gallus Species 0.000 abstract 1
- 241000219991 Lythraceae Species 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 240000004534 Scutellaria baicalensis Species 0.000 abstract 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract 1
- 240000007284 Stenochlaena palustris Species 0.000 abstract 1
- 235000003373 curcuma longa Nutrition 0.000 abstract 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract 1
- 210000004317 gizzard Anatomy 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 210000000941 bile Anatomy 0.000 description 9
- 210000004185 liver Anatomy 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 210000000232 gallbladder Anatomy 0.000 description 6
- 206010008617 Cholecystitis chronic Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 201000001352 cholecystitis Diseases 0.000 description 4
- 230000000994 depressogenic effect Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 239000003809 bile pigment Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 230000001989 choleretic effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 206010004637 Bile duct stone Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 240000001307 Myosotis scorpioides Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 239000010839 body fluid Substances 0.000 description 1
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- 239000000679 carrageenan Substances 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 208000003167 cholangitis Diseases 0.000 description 1
- 210000001953 common bile duct Anatomy 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
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- 238000004090 dissolution Methods 0.000 description 1
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- 210000001198 duodenum Anatomy 0.000 description 1
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- 208000001130 gallstones Diseases 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 208000013210 hematogenous Diseases 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000002631 hypothermal effect Effects 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000000387 litholytic effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229960002275 pentobarbital sodium Drugs 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a medicine composition for treating cholelithiasis. The medicine composition is characterized in that the medicine composition is prepared from the following raw medicinal materials by part by weight: 83 to 248 parts of prepared radix bupleuri, 83 to 248 parts of green tangerine peel, 83 to 248 parts of baikal skullcap root, 83 to 248 parts of radix paeoniae alba, 33 to 99 parts of rhubarb horsetails, 83 to 248 parts of curcuma, 83 to 248 parts of loosestrife, 83 to 248 parts of climbing fern, 83 to 248 parts of chicken's gizzard membrane, 83 to 248 parts of herba artemisiae, 83 to 248 parts of curcuma longa, 55 to 165 parts of prepared common prism tuber and 83 to 248 parts of radix clematidis. The present invention also discloses a preparation method.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of cholelithiasis and preparation method thereof.
The delay of chronic cholecystitis, the cholelithiasis state of an illness, outbreak repeatedly, feelings will is smooth, thick greasy, the overwork of surfeit delicious food etc. be its main diseases because of.The conditions of patients delay, outbreak feels depressed repeatedly, and feelings will is not smooth, the liver failing to maintain the normal flow of QI, the mechanism of qi retardance, stagnation of QI and blood may bring about pain is then seen upper right abdomen dull pain repeatedly, leads and take on the back of the body; And chronic cholecystitis, the cholelithiasis course of disease are with the passing of time, damp and hotly stop over unclearly, are bored with, overwork etc. that then taste are impaired if the surfeit delicious food is thick, and middle soil is killd, taste lose in fortuneization, and endogenous dampness accumulates and heat-transformation, damp and hot interior knot, accumulate in liver and gall, the liver failing to maintain the normal flow of QI then, gallbladder loses logical falling, the moment of desperation outbreak of often causing a disease; Retention of damp-heat in the interior is fumigated in last, then dry mouth with bitter taste; Liver and gall are lost and are dredged, and building is sick together, dysfunction of the spleen in transportation, and stomach loses and is received, and then Na Gu owes fragrant; Retention of damp-heat in the interior, body fluid is impaired, large intestine conduction mistake department, then constipation with dry stool; Stagnation of QI due to depression of the liver, pathogen usually intruding into collateral in protracted disease, hematogenous blockage, blood-stasis internal-depression, or twinge, or sore spot fixes, or the hypnalgia work etc.; Body of the tongue is red partially, yellow, greasy and thin fur, and thready and stringy pulse or puckery is QI stagnation of the liver and galibladder, damp and hot the resembling of folder of holding concurrently.In sum, primary disease the disease being located in the liver gallbladder, closely related with taste, pathology character is based on reality, and the pathogenesis key is QI stagnation of the liver and galibladder, and the folder of holding concurrently is damp and hot, controls and works as depressed liver-energy dispersing and QI regulating, clearing liver-gallbladder.
The object of the invention is to provide a kind of pharmaceutical composition and preparation method thereof of the treatment calculus that has no side effect of evident in efficacy, taking convenience.
Technical solution of the present invention is achieved in that
Bulk drugs as described below:
83～248 parts of 83～248 parts of Radix Scutellariaes of system 83～248 parts of Pericarpium Citri Reticulatae Virides of Radix Bupleuri
83～248 parts of 33～99 portions of Radix Curcumaes of 83～248 parts of Radix Et Rhizoma Rhei of the Radix Paeoniae Alba
83～248 parts of 83～248 parts of Endothelium Corneum Gigeriae Galli of 83～248 parts of Spora Lygodii of Herba Lysimachiae
55～165 parts of 83～248 parts of systems of 83～248 portions of Rhizoma Curcumae Longaes of Herba Artemisiae Scopariae rhizoma sparganic
83～248 parts of Radix Clematidis
It is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues decoct with water 2～3 times with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, each 1～3 hour, filter, filtrate after filtrate and the distillation merges, and is condensed into clear paste, adds ethanol and makes and contain the alcohol amount and reach 40～80%, stir evenly, cold preservation 12～48 hours filters, decompression filtrate recycling ethanol continues to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, with volatile oil, Radix Et Rhizoma Rhei fine powder mixing, add starch or dextrin, encapsulated, promptly.
Through laboratory observation, found that pharmaceutical composition of the present invention has significant difference to Cavia porcellus bile pigment calculus gallstone formation rate than matched group decline; And can be reversed into the rising of free bile pigments in stone animal bile, the serum, be lowered into the weight of stone animal cyst wall; 3 kinds of calculus of human body all there is in various degree external litholytic effect; Can reduce the wealthy swelling of mouse ear due to the dimethylbenzene; And can suppress rat paw edema due to the carrageenin; The agar granulation hyperplasia there is the significance inhibitory action; Blue induced mice capillary permeability rising has significant inhibitory effect to ivens; Writhing response to 0.6% glacial acetic acid induced mice has remarkable inhibitory action; Rat fever has the significant hypothermal effect due to the on Carrageenan; Clinical isolating golden Portugal bacterium, escherichia coli, streptococcus bacteriocidal concentration are respectively 4,4 and 2 times of Mlc; Salmonella typhi, (first, second) type Hemolytic streptococcus, streptococcus pneumoniae, golden Portugal bacterium there is bacteriostasis in various degree; Can significantly improve the rat bile secretory volume; Experiment shows to also have certain spasmolysis to isolated guinea pig ileum.Experimental result shows that pharmaceutical composition of the present invention has the effect of treatment chronic cholecystitis, cholelithiasis, the remaining calculus of liver inside and outside bile duct stone and operation back.
The pharmaceutical composition that the present invention treats cholelithiasis has depressed liver-energy dispersing and function of gallbladder promoting, promoting the circulation of QI to relieve pain, and effects such as heat-clearing and toxic substances removing calculus can be used for syndrome behind chronic cholecystitis, cholelithiasis, cholangitis, the operation on gallbladder, and treatment of conditions such as biliary tract functional disease.
Experimental example 1: pharmaceutical composition of the present invention is to the dissolution healthy rabbits fasting of rabbit cholelithiasis after 16 hours, intravenous injection pentobarbital sodium 1ml/kg anesthesia.The surgical exposure gallbladder is implanted people's cholelithiasis.Get after 1 week and recover normal postoperative animal, oral administration gavage gives pharmaceutical composition of the present invention or the normal saline contrast of 6g crude drug/kg, continuous 30 days respectively.With sacrifice of animal, take out gallbladder after the off-test, the variation of record bile and cholelithiasis weight.Administration treated animal bile is rare clearly as a result, cholelithiasis weight with implant before compare all and alleviate, and normal saline matched group part animal bile retrogradation, and have new cholelithiasis to occur, the cholelithiasis weight average increases than before implanting, two groups of significant differences.
Experimental example 2: the choleretic effect rat of pharmaceutical composition of the present invention is pharmaceutical composition of the present invention or the normal saline contrast of oral administration gavage 3g crude drug/kg respectively, continuous 1 week.Opened the abdominal cavity with urethane anesthesia back operation in second day after the last administration, find out common bile duct and carry out the plastic catheter intubate, bile drainage writes down the bile milliliter number of drain in per ten minutes.Duodenum gives pharmaceutical composition 6g crude drug/kg of the present invention then, the bile amount of record drain.Pharmaceutical composition of the present invention as a result and the comparison of normal saline matched group and with the last administration before more all can obviously improve the rat bile secretory volume, show that pharmaceutical composition of the present invention has obvious choleretic effect.
Embodiment 1:
System Radix Bupleuri 165g Pericarpium Citri Reticulatae Viride 165g Radix Scutellariae 165g
Radix Paeoniae Alba 165g Radix Et Rhizoma Rhei 66g Radix Curcumae 165g
Herba Lysimachiae 165g Spora Lygodii 165g Endothelium Corneum Gigeriae Galli 165g
Herba Artemisiae Scopariae 165g Rhizoma Curcumae Longae 165g system rhizoma sparganic 110g
Radix Clematidis 165g
It is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues decoct with water secondary with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, and each 1.5 hours, filter, the filtrate after filtrate and the distillation merges, be condensed into clear paste, add ethanol and make and contain the alcohol amount and reach 50%, stir evenly, cold preservation 24 hours filters decompression filtrate recycling ethanol, continue to be condensed into thick paste, vacuum drying gets dry extract, be ground into fine powder,, add starch to 400g with volatile oil, Radix Et Rhizoma Rhei fine powder mixing, encapsulated, make 1000, promptly.
Embodiment 2:
System Radix Bupleuri 165g Pericarpium Citri Reticulatae Viride 165g Radix Scutellariae 165g
Radix Paeoniae Alba 165g Radix Et Rhizoma Rhei 66g Radix Curcumae 165g
Herba Lysimachiae 165g Spora Lygodii 165g Endothelium Corneum Gigeriae Galli 165g
Herba Artemisiae Scopariae 165g Rhizoma Curcumae Longae 165g system rhizoma sparganic 110g
Radix Clematidis 165g
It is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues decoct with water secondary with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, and each 1.5 hours, filter, the filtrate after filtrate and the distillation merges, be condensed into clear paste, add ethanol and make and contain the alcohol amount and reach 50%, stir evenly, cold preservation 24 hours filters decompression filtrate recycling ethanol, continue to be condensed into thick paste, vacuum drying gets dry extract, be ground into fine powder,, add starch to 400g with volatile oil, Radix Et Rhizoma Rhei fine powder mixing, encapsulated, make 1000, promptly.
Claims (3)
1, a kind of pharmaceutical composition for the treatment of cholelithiasis is characterized in that this pharmaceutical composition made by following bulk drugs:
165 parts of 165 parts of Radix Scutellariaes of system 165 parts of Pericarpium Citri Reticulatae Virides of Radix Bupleuri
165 parts of 66 portions of Radix Curcumaes of 165 parts of Radix Et Rhizoma Rhei of the Radix Paeoniae Alba
165 parts of 165 parts of Endothelium Corneum Gigeriae Galli of 165 parts of Spora Lygodii of Herba Lysimachiae
110 parts of 165 parts of systems of 165 portions of Rhizoma Curcumae Longaes of Herba Artemisiae Scopariae rhizoma sparganic
165 parts of Radix Clematidis.
2, a kind of preparation of drug combination method for the treatment of cholelithiasis as claimed in claim 1, it is characterized in that this method is: it is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues decoct with water 2～3 times with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, each 1～3 hour, filter, filtrate after filtrate and the distillation merges, and is condensed into clear paste, adds ethanol and makes and contain the alcohol amount and reach 40～80%, stir evenly, cold preservation 12～48 hours filters, decompression filtrate recycling ethanol continues to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, with volatile oil, Radix Et Rhizoma Rhei fine powder mixing, add adjuvant, encapsulated, promptly.
3, according to the described a kind of preparation of drug combination method for the treatment of cholelithiasis of claim 2, it is characterized in that this method is: it is standby that Radix Et Rhizoma Rhei powder is broken into fine powder; In addition Herba Artemisiae Scopariae, Radix Curcumae, Pericarpium Citri Reticulatae Viride, Rhizoma Curcumae Longae, rhizoma sparganic are extracted volatile oil, standby; Aqueous solution after the distillation filters, and filtrate device is in addition collected; Medicinal residues decoct with water secondary with system Radix Bupleuri, Radix Scutellariae, the Radix Paeoniae Alba, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Radix Clematidis again, each 1.5 hours, filter, filtrate after filtrate and the distillation merges, and is condensed into clear paste, adds ethanol and makes and contain the alcohol amount and reach 50%, stir evenly, cold preservation 24 hours filters, decompression filtrate recycling ethanol continues to be condensed into thick paste, vacuum drying, get dry extract, be ground into fine powder, with volatile oil, Radix Et Rhizoma Rhei fine powder mixing, add starch or dextrin, encapsulated, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021534578A CN1189204C (en) | 2002-11-29 | 2002-11-29 | Medicine compositions for treating biliary calculus, and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021534578A CN1189204C (en) | 2002-11-29 | 2002-11-29 | Medicine compositions for treating biliary calculus, and its prepn. method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1418682A CN1418682A (en) | 2003-05-21 |
| CN1189204C true CN1189204C (en) | 2005-02-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021534578A Expired - Lifetime CN1189204C (en) | 2002-11-29 | 2002-11-29 | Medicine compositions for treating biliary calculus, and its prepn. method |
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| Country | Link |
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| CN (1) | CN1189204C (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1309367C (en) * | 2004-03-17 | 2007-04-11 | 咸阳步长医药科技发展有限公司 | Preparation of Chinese traditional medicine for curing gallstone and preparation method |
| CN100340285C (en) * | 2005-09-21 | 2007-10-03 | 马云翔 | Cholelithiasis treating medicine and its prepn |
| CN102274452A (en) * | 2011-06-03 | 2011-12-14 | 文登市大水泊镇乐园村卫生室 | Traditional Chinese medicine for treating gall-stone |
| CN102961680B (en) * | 2012-11-06 | 2014-01-22 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating gallstone and cholecystitis and preparation method thereof |
| CN102973884A (en) * | 2012-11-06 | 2013-03-20 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treatment of gallstones and cholecystitis and preparation method thereof |
| CN102973883A (en) * | 2012-11-06 | 2013-03-20 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treatment of gallstones and cholecystitis and preparation method thereof |
| CN102961677B (en) * | 2012-11-06 | 2014-02-26 | 陕西步长高新制药有限公司 | Traditional Chinese medicine preparation for treating gallstone and cholecystitis and preparation method thereof |
| CN104645225A (en) * | 2015-01-27 | 2015-05-27 | 孙彦明 | Traditional Chinese medicine preparation for treating chronic hepatobiliary diseases |
-
2002
- 2002-11-29 CN CNB021534578A patent/CN1189204C/en not_active Expired - Lifetime
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| Publication number | Publication date |
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| CN1418682A (en) | 2003-05-21 |
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