CN100340285C - Cholelithiasis treating medicine and its prepn - Google Patents
Cholelithiasis treating medicine and its prepn Download PDFInfo
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- CN100340285C CN100340285C CNB2005100864527A CN200510086452A CN100340285C CN 100340285 C CN100340285 C CN 100340285C CN B2005100864527 A CNB2005100864527 A CN B2005100864527A CN 200510086452 A CN200510086452 A CN 200510086452A CN 100340285 C CN100340285 C CN 100340285C
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Abstract
The present invention provides a medicine for treating cholelithiasis and a preparation method thereof. The raw medicinal materials of the medicine are composed of medicinal broth raw medicinal materials and powder raw medicinal materials, wherein the medicinal broth raw medicinal materials comprise curcuma, curcuma root, radix paeoniae alba, fructus aurantii immaturus, curcuma zedoaria, chinaberry fruit, astragalus root, herba artemisiae, radix bupleuri and hawthorn fruit, and the powder raw medicinal materials comprise the curcuma, the curcuma root, the radix paeoniae alba, the fructus aurantii immaturus, potassium nitrate, melanterite, artificial bezoar, chicken's gizzard membrane powder and Qingdai powder. The preparation method comprises the following steps that 1) the required medicinal broth raw medicinal materials are prepared into a boiled solution; 2) the required powder raw medicinal materials are prepared into powder; 3) the powder of the powder raw medicinal materials and the boiled solution are packed; 4) the boiled solution and the powder of the powder raw medicinal materials are processed to be filled into capsules or pressed into tablets. Chinese medical physician Mayun Xiang who accumulates clinical experience more than 70 years invents the medicine on the basis of carrying out large amounts of gallstone clinic treatment medicinal practice. The pure Chinese herbs as the raw material have safe use, good effect and little side effect. The medicine is suitable for various kinds of gallstones existing at any positions. Furthermore, the medicine has the efficacy of dissolving, crushing and expelling stones, and the medicine has the rapid stone expelling effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of cholelithiasis, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Background technology
Cholelithiasis sickness rate height has certain mortality rate when merging obstruction of biliary tract and infecting.Cholelithiasis can be divided into bile pigments type (about 38%), cholesterol type (19%) and mixed type (about 43%) according to its composition.Therapeutic Method is opened abdomen (or peritoneoscope) with surgery and is got Shi Weizhu at present, though the most patients of this treatment may obtain the alleviation of a period of time, but in the short run, misery is big, expense is high, operation has the complication risk, especially to oldaged physically weak, immunocompromised, patient's risk of existence and emergency operation is bigger in spite of illness, and also may have to consider lobectomy of liver because of exploration of common bile duct reaches to elevated calculus of intrahepatic duct, more increased risk; In the long run, calculus has at that time only been taken out in operation, does not block it and continues to generate, it is reported, and the recurrence of hepatolithiasis rate 60% behind the surgical calculus removing, operation risk is bigger once more, and how non-the haveing no alternative but of surgeon actively advise.Surgical method is real to be unavoidable symptomatic treatment.
Non-operative treatment is the main direction of treatment cholelithiasis, but it is limited to be used for the treatment of the curative effect of medicine of cholelithiasis at present, and the medicine scope of application that has is little, and the medicine that has has side effect, and the drug use that has is dangerous, is far from replacing the main flow that operation becomes treatment.Therefore seeking a kind of calculus, Sal Nitri medicinal preparation for oral administration safe, efficient, applied widely, that side effect is little is the demand of extensive patients, also is the target of medical matters circle.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of cholelithiasis and preparation method thereof.The present invention treats the medicine of cholelithiasis, is raw material with pure Chinese crude drug, and is safe in utilization, effective, side effect is little; Be applicable to various each position cholelithiasis; Have dissolving, rubble, urinary calculus removing effect, calculus speed is fast; Thereby overcome the shortcoming of the medicine existence that is used for the treatment of cholelithiasis at present.
China's Chinese medicine is a huge treasure-house, and therefrom developing and seek suitable medicine is the shortcut of treatment cholelithiasis pertinacious disease.Calculus is stopped up bile duct, and obstructive jaundice can take place, and the date is of a specified duration, and jaundice becomes dark yellow, becomes Zhang Zhongjing alleged " jaundice due to sexual intemperance ", and also the black subcutaneous ulcer of name together.For this reason the present invention cube at the beginning of promptly be decided to be principal agent (monarch drug) with Sal Nitri, Alumen (Melanteritum) two flavors, minister is helped with Herba Artemisiae Scopariae with Radix Curcumae, Rhizoma Curcumae Longae, Fructus Aurantii, Rhizoma Curcumae again more in addition, makes with Radix Bupleuri, Indigo Naturalis etc.Be used for clinically, in most of cases, obtained the curative effect of calculus dissolving and excreting, benefit and also allow patient's gown after seven to ten days, the eggs claw and of can taking food arbitrarily relatively surely no longer because of promoting gallbladder to shrink discharging bile cholelithiasis disease.The present invention treats year clinical experience surplus the Chinese physician of Yunxiang of invention forces long-pending 70 of medicine of cholelithiasis, carry out the medical practice of a large amount of cholelithiasis clinical treatments, accumulated a large amount of experiences and data, obtained significant curative effect, on this basis the present invention the treatment cholelithiasis medicine.
Crude drug and weight proportion thereof that the present invention treats the medicine of cholelithiasis are:
Rhizoma Curcumae Longae 5-30, Radix Curcumae 5-20, Radix Paeoniae Alba 6-20, Fructus Aurantii 0-25, Rhizoma Curcumae 2-20, Fructus Toosendan 0-20, Radix Astragali 0-20, Herba Artemisiae Scopariae 0-10, Radix Bupleuri 0-15, Fructus Crataegi 0-20, Sal Nitri 1-8, Melanteritum 1-10, artificial Calculus Bovis 2-10, Endothelium Corneum Gigeriae Galli powder 0-15, Indigo Naturalis 0-20;
Rhizoma Curcumae in the above-mentioned raw materials medicine, Fructus Toosendan, the Radix Astragali, Herba Artemisiae Scopariae, Radix Bupleuri and Fructus Crataegi only are used for decoction; Sal Nitri in the above-mentioned raw materials medicine, Melanteritum, artificial Calculus Bovis, Endothelium Corneum Gigeriae Galli powder and Indigo Naturalis only are used for powder;
Rhizoma Curcumae Longae in the above-mentioned raw materials medicine, Radix Curcumae, the Radix Paeoniae Alba and Fructus Aurantii partly are used for decoction, and part is used for powder, and the percentage by weight that every Chinese medicine is used for decoction, powder is respectively:
Rhizoma Curcumae Longae: decoction 50-60%, powder 40-50%;
Radix Curcumae: decoction 50-60%, powder 40-50%;
The Radix Paeoniae Alba: decoction 70-80%, powder 20-30%;
Fructus Aurantii: decoction 60-70%, powder 30-40%.
Crude drug and preferred weight proportioning thereof that the present invention treats the medicine of cholelithiasis are:
Rhizoma Curcumae Longae 5-20, Radix Curcumae 5-12, Radix Paeoniae Alba 6-17, Fructus Aurantii 0-11, Rhizoma Curcumae 2-15, Fructus Toosendan 5-15, Radix Astragali 8-20, Herba Artemisiae Scopariae 5-10, Radix Bupleuri 5-15, Fructus Crataegi 4-15, Sal Nitri 1-5, Melanteritum 1-5, artificial Calculus Bovis 2-8, Endothelium Corneum Gigeriae Galli powder 0-8, Indigo Naturalis 2-20.
The present invention treats the preparation method of the medicine of cholelithiasis, and its step is as follows:
1. required decoction crude drug Rhizoma Curcumae Longae, Radix Curcumae, the Radix Paeoniae Alba, Fructus Aurantii, Rhizoma Curcumae, Fructus Toosendan, the Radix Astragali, Herba Artemisiae Scopariae, Radix Bupleuri and Fructus Crataegi are added water to and do not have, decoct, waited to boil back 1-2 hour, incline and decoction liquor, residue adds water and continues and boil 1-1.5 hour, and inclining two decocting liquids, is merged into decoct with preceding decocting liquid, the volume of decoct is joined 10ml by every 2.4g powder crude drug and is calculated, and makes the oral liquid of every bottle of 10ml; Or decoct filtered, is concentrated into the weight of 4-6 the weight portion that is equivalent to crude drug, obtain the concentrated juice of frying in shallow oil;
2. required powder crude drug Rhizoma Curcumae Longae, Radix Curcumae, the Radix Paeoniae Alba, Fructus Aurantii, Sal Nitri, Melanteritum, artificial Calculus Bovis, Endothelium Corneum Gigeriae Galli powder and Indigo Naturalis are pulverized and fine ground powder, crossed 50 orders, obtain the powder of powder crude drug with top sieve;
3. with the powder packing of above-mentioned powder crude drug, every bag 2.4 gram is mixed for every bag and is stated 1 bottle of oral liquid, the medicine of the cholelithiasis that obtains medical treatment;
4. be 50-130 ℃ drying in oven with above-mentionedly concentrating the powder mixes fry in shallow oil juice and powder crude drug, stir, putting into temperature, to water content less than 3%, fine ground again mistake 50 orders are with top sieve, the drug powder of the cholelithiasis that obtains medical treatment; Incapsulate 0.4 gram/capsule then; Or compacting in flakes, 0.4 gram/sheet.Preferred temperature in the baking oven is 80-110 ℃.
The medicine that the present invention treats cholelithiasis cooperates with powder medicine with decoction medicine and makes, and can give full play to the drug effect of crude drug, thereby reduce the cost of medicine.
The present invention treats the instructions of taking of the medicine of cholelithiasis: every day three times, and each 1 bag and use 1 bottle of oral liquid of being joined to take after mixing it with water, or each 4-6 sheet (capsule), swallow; Be 1 hour before the meal and take, period in a medicine is not avoided greasy.
Take continuously, be interrupted (every 2-4 week) biliary tract ultrasonic monitoring, discharge unless confirmed calculus, taking medicine should be more than 4 week.
Raw material of wanting required for the present invention and equipment all can be bought on market.
The specific embodiment
The medicine that the present invention treats cholelithiasis is a raw material with pure Chinese crude drug, is applicable to various each position cholelithiasis, has dissolving, rubble, urinary calculus removing effect, and calculus speed is fast.Patient about 90% is relief of symptoms effectively, the ultrasonic confirmation calculus of the patient of 30-50% is discharged or is melted, can eluriate out calculus in patient's feces of 70-90%,, gallbladder contraction function less for the calculus volume be the cholelithiasis patient preferably, and lithagogue rate can reach 90%.And this medicament is pure extract oral agent, and is safe and effective, makes tablet or capsule, takes easier.
Embodiment 1
1. with Rhizoma Curcumae Longae 1770 gram, Radix Curcumae 260 grams, the Radix Paeoniae Alba 800 grams, Rhizoma Curcumae 1000 grams, add water to and do not have altogether, the flame enrichment decoction was waited to boil back 1 hour, inclining decoction liquor, and residue adds water and continues and boil 1 hour, and inclining two decocting liquids, merge, filter with preceding decocting liquid, about 500 grams of the amount of being concentrated into obtain concentrating and fry in shallow oil juice;
2. Rhizoma Curcumae Longae 1230 grams, Radix Curcumae 240 grams, the Radix Paeoniae Alba 200 grams, Sal Nitri 100 grams, Melanteritum 1000 grams, artificial Calculus Bovis 800 grams are pulverized and fine ground powder altogether, crossed 80 mesh sieves, obtain the powder of powder crude drug;
3. the above-mentioned powder mixes fry in shallow oil juice and powder crude drug that concentrates is stirred, puts into temperature and be 50 ℃ drying in oven, to water content less than 3%; Fine ground again mistake 80 mesh sieves; The medicine of the cholelithiasis that obtains medical treatment;
4. the medicine with above-mentioned treatment cholelithiasis incapsulates, 0.4 gram/capsule.
Embodiment 2
With Rhizoma Curcumae Longae 600 gram, Radix Curcumae 600 grams, the Radix Paeoniae Alba 1200 grams, Fructus Aurantii 540 grams, Rhizoma Curcumae 1200 grams, Fructus Toosendan 1000 grams, the Radix Astragali 1100 grams, Herba Artemisiae Scopariae 1000 grams, Radix Bupleuri 700 grams, Fructus Crataegi 900 grams add water to did not altogether have, flame enrichment decocts, waited to boil back 2 hours, incline and decoction liquor, residue adds water and continues and boil 1.5 hours, and inclining two decocting liquids, merges, filters with preceding decocting liquid, about 600 grams of the amount of being concentrated into obtain concentrating and fry in shallow oil juice;
2. Rhizoma Curcumae Longae 500 grams, Radix Curcumae 400 grams, the Radix Paeoniae Alba 500 grams, Fructus Aurantii 360 grams, Sal Nitri 200 grams, Melanteritum 100 grams, artificial Calculus Bovis 700, Endothelium Corneum Gigeriae Galli powder 500 grams, Indigo Naturalis 200 grams are pulverized and fine ground powder altogether, crossed 60 mesh sieves, obtain the powder of powder crude drug;
3. the above-mentioned powder mixes fry in shallow oil juice and powder crude drug that concentrates is stirred, puts into temperature and be 130 ℃ drying in oven, to water content less than 3%; Fine ground again mistake 60 mesh sieves; The medicine of the cholelithiasis that obtains medical treatment;
The medicine compacting of above-mentioned treatment cholelithiasis is in blocks 4., 0.4 gram/sheet.
Embodiment 3
With Rhizoma Curcumae Longae 400 gram, Radix Curcumae 969 grams, the Radix Paeoniae Alba 1000 grams, Rhizoma Curcumae 2000 grams, Fructus Toosendan 1500 grams, the Radix Astragali 2000 grams, Herba Artemisiae Scopariae 500 grams, Radix Bupleuri 1500 grams, Fructus Crataegi 400 grams add water to did not altogether have, flame enrichment decocts, waited to boil back 2 hours, incline and decoction liquor, residue adds water and continues and boil 1 hour, inclining two decocting liquids, merges with preceding decocting liquid, filters, about 400 grams of the amount of being concentrated into, and obtains concentrating and fries in shallow oil juice;
2. Rhizoma Curcumae Longae 300 grams, Radix Curcumae 731 grams, the Radix Paeoniae Alba 300 grams, Sal Nitri 500 grams, Melanteritum 200 grams, artificial Calculus Bovis 200 grams, Endothelium Corneum Gigeriae Galli powder 800 grams are pulverized and fine ground powder altogether, crossed 100 mesh sieves, obtain the powder of powder crude drug;
3. the above-mentioned powder mixes fry in shallow oil juice and powder crude drug that concentrates is stirred, puts into the drying in oven of 110 ℃ of temperature, to water content less than 3%; Fine ground again mistake 100 mesh sieves; The medicine of the cholelithiasis that obtains medical treatment;
4. the medicine with above-mentioned treatment cholelithiasis incapsulates, 0.4 gram/capsule.
Embodiment 4
With Rhizoma Curcumae Longae 1200 grams, Radix Curcumae 1100 grams, the Radix Paeoniae Alba 1500 grams, Fructus Aurantii 1750 grams, Rhizoma Curcumae 1500 grams, Fructus Toosendan 2000, the Radix Astragali 800 grams, Fructus Crataegi 1500 grams add water to did not altogether have, flame enrichment decocts, waited to boil back 2 hours, incline and decoction liquor, residue adds water and continues and boil 1.5 hours, and inclining two decocting liquids, merges, filters with preceding decocting liquid, about 600 grams of the amount of being concentrated into obtain concentrating and fry in shallow oil juice;
2. with Rhizoma Curcumae Longae 800 gram, Radix Curcumae 900 grams, the Radix Paeoniae Alba 500 grams, Fructus Aurantii 750 grams, Sal Nitri 800 grams, Melanteritum 300 grams, artificial Calculus Bovis 600 grams, Endothelium Corneum Gigeriae Galli powder 400 grams, Indigo Naturalis 2000 grams, pulverize and fine ground powder altogether, cross 80 mesh sieves, obtain the powder of powder crude drug;
3. the above-mentioned powder mixes fry in shallow oil juice and powder crude drug that concentrates is stirred, puts into the drying in oven of 80 ℃ of temperature, to water content less than 3%; Fine ground again mistake 80 mesh sieves; The medicine of the cholelithiasis that obtains medical treatment;
The medicine compacting of above-mentioned treatment cholelithiasis is in blocks 4., 0.4 gram/sheet.
Embodiment 5
With Rhizoma Curcumae Longae 250 gram, Radix Curcumae 600 grams, the Radix Paeoniae Alba 420 grams, Fructus Aurantii 704 grams, Rhizoma Curcumae 200 grams, Fructus Toosendan 500 grams, the Radix Astragali 200 grams, Herba Artemisiae Scopariae 200 grams, Radix Bupleuri 500 grams, Fructus Crataegi 2000 grams add water to did not altogether have, flame enrichment decocts, waited to boil back 1-2 hour, inclining decoction liquor, and residue adds water and continues and boil 1-1.5 hour, and inclining two decocting liquids, be merged into decoct with preceding decocting liquid, the volume of decoct is joined 10ml by per 2.4 gram powder crude drug and is calculated, i.e. 19690ml is made into the oral liquid of every bottle of 10ml again;
2. Rhizoma Curcumae Longae 250 grams, Radix Curcumae 600 grams, the Radix Paeoniae Alba 180 grams, Fructus Aurantii 396 grams, Sal Nitri 300g, Melanteritum 500 grams, artificial Calculus Bovis 1000 grams, Endothelium Corneum Gigeriae Galli powder 1500 grams are pulverized and fine ground powder altogether, crossed 100 mesh sieves, obtain the powder of powder crude drug;
3. with the powder packing of above-mentioned powder crude drug, every bag 2.4 gram is mixed for every bag and is stated 1 bottle of oral liquid, the medicine of the cholelithiasis that obtains medical treatment.
Clinical observation is summed up
One. the cholelithiasis diagnostic criteria: all are observed cases and are B ultrasonic and confirm the cholelithiasis diagnosis, symptoms such as the acute onset clinical symptoms comprises abdominal pain, feels sick, vomiting, heating, jaundice, the back untoward reaction of oils and fats eggs food.
Two. Therapeutic Method: take the medicine three times that the present invention treats cholelithiasis every day, each 1 bag and use 1 bottle of oral liquid of being joined to take after mixing it with water; Or each 4-6 sheet (capsule), swallow; Be 1 hour before the meal and take, period in a medicine is not avoided greasy; Take continuously, be interrupted (every 2-4 week) biliary tract ultrasonic monitoring, discharge unless confirmed calculus, taking medicine should be more than 4 week.
Three. efficacy assessment standard:
1. cure: clinical symptom disappearance has no adverse reaction after the oils and fats eggs food; The ultrasound diagnosis calculus disappears.
2. produce effects: clinical symptom disappearance has no adverse reaction after the oils and fats eggs food; The ultrasound diagnosis calculus reduces or major diameter dwindles.
3. clinical effective: clinical symptoms is complete obiteration not, but seizure frequency obviously reduces; Still respond after the oils food, but degree obviously alleviates; The ultrasound diagnosis calculus changes little.
4. invalid: adhere to taking medicine 4 weeks or more than, clinical symptoms and outbreak frequency still do not have significant change before and after take medicine.
Four. therapeutic effect: clinical observation is totally 92 examples, wherein male 33 examples, women 59 examples, in age 13-86 year, the course of disease (the conscious symptom that occurs) is more than the 14-2; The diagnosis of ultrasound diagnosis cholelithiasis.Through taking the medicine that the present invention treats cholelithiasis, cure 16 examples (17.4%), produce effects 32 examples (34.8%), effective 34 examples (26.9%), total effective rate 89.1%, invalid 10 examples (10.9%).
Model case
1. turn round and look at mound, woman, 56 years old; Before the treatment repeatedly B ultrasonic confirm pilosity and huge calculus in the gallbladder.On April 12nd, 1994, the B ultrasonic report: be full of grain of rice size strong echo light group and tiny hot spot accompanying sound shadow in the gallbladder, gallbladder 64 * 24mm loses the bile liquid level in the gallbladder, ductus choledochus 8mm; B ultrasonic report on August 31st, 1994, gallbladder has lost normality, in be full of and strengthen light group shadow, one piece of diameter 16mm wherein, gallbladder 46 * 16mm, ductus choledochus expansion, Diagnosis of Fatty, cholecystitis, cholelithiasis (calculus is full of the gallbladder chamber).This patient began to take medicine of the present invention on the 16th from JIUYUE in 1994, take the medicine three times that the present invention treats cholelithiasis every day, taking medicine before meal is used, each 6, December in 1994 (after taking medicine continuously 70 days) B ultrasonic report review on the 1st: gallbladder 58 * 17mm, wall portion is smooth, sees 26mm increasing diameter high light group accompanying sound shadow in the gallbladder, and photo shows that half has been liquid level approximately in the gallbladder; March 8 nineteen ninety-five (after continuing to take medicine 110 days), the B ultrasonic report review: slight fatty liver, cholecystitis, common bile duct 8mm, gallbladder 65 * 16mm does not see the calculus shadow; Go another hospital's B ultrasonic report review March 12 nineteen ninety-five: cholecystitis, splenomegaly, surplus no abnormal.
2. Guo Zhi woods, man, 68 years old; B ultrasonic report on January 24th, 1994: common bile duct and nearly right common hepatic duct initial part calculus, carry out gallbladder removal in February, 1994 at this institute's surgery.Symptoms such as stomachache, heating, jaundice appear again in postoperative soon, and ultrasonic check on March 25th, 1994 finds to have in the common hepatic duct of the leftlobe of liver sagittal portion outside 15 * 8mm high light in heaps group shadow, one piece of diameter 6mm wherein, and the patient that had a medical check-up at that time still has slight jaundice; On May 8th, 1994 began to take medicine of the present invention, took the medicine three times that the present invention treats cholelithiasis every day, taking medicine before meal usefulness, and each 6 capsules, (after taking medicine continuously 14 days) further consultation on May 22nd, 1994, jaundice disappears, and suffering of illness is alleviated, advises and continues to take medicine; After this, repeatedly further consultation, clinical obvious improvement still continues to take medicine; On JIUYUE 8th, 1994, ultrasonic report review: the more preceding apparent in view minimizing of the nearly sagittal portion calculus of intrahepatic duct of leftlobe of liver quantity, but still have calculus number piece, and the maximum diameter still is 6mm, calculus top hepatic duct is still expanded; After this patient is still asymptomatic, but continues this medicine of clothes, May 4 nineteen ninety-five ultrasonic once more report review: liver, spleen, bile duct no abnormality seen.Took medicine altogether 320 days before and after this patient, clinical symptoms is promptly alleviated in early days and is disappeared, but when its calculus discharge, and then is limited to JIUYUE in 1994 and does not do ultrasonic examination on 8th during May 4 nineteen ninety-five, therefore is difficult to estimation.
The hole book female, male, 57 years old; 1987 because of the excision of colon cancer operation row left hemicolon; Diagnose the upper left leaf thing that swells in March, 1994, the tracheascope biopsy pathology confirms the lung adenosquamous carcinoma, and ordinary circumstance is poor, expectant treatment.On June 22nd, 1994, a large amount of calculus of ultrasonic confirmation gallbladder, cholecystitis emergency treatment were admitted to hospital because of burst right hypochondrial region one day.Ordinary circumstance is poor, cholelithiasis and biliary tract infection is gone bail for keep treatment, the vein antibiotic; On June 23rd, 1994 rose and takes medicine of the present invention, took the medicine three times that the present invention treats cholelithiasis every day, taking medicine before meal usefulness, and each 4, remission after a day was left hospital in two days.After this took this medicine continuously individual month, the check B ultrasonic, Biliary Calculi all disappears.
4. Xu wealth army, man, 40 years old show effect that the right hypochondrial region companion feels sick, vomiting nineteen ninety-five repeatedly, through ultrasonic cholelithiasis (a large amount of, the be full of maximum calculus 2.2cm) cholecystitis that turns out to be.The equal expectant treatment of each outbreak, outbreak by the initial 5-6 month once, transfer the 1-2 month gradually to once.Rise June nineteen ninety-five, takes medicine of the present invention, takes the medicine three times that the present invention treats cholelithiasis every day, and taking medicine before meal is used, each 1 bag and use 1 bottle of oral liquid of being joined to take after mixing it with water, after beginning certainly to take, the clinical symptoms complete obiteration, took altogether 5 months, and 10 years so far, the clinical symptoms recurrence was not arranged again.Do not have significant change but repeatedly B ultrasonic therebetween confirms calculus quantity shape, do not reduce, do not increase yet.
Claims (4)
1. a medicine for the treatment of cholelithiasis is characterized in that, crude drug and weight proportion thereof are:
Rhizoma Curcumae Longae 5-30, Radix Curcumae 5-20, Radix Paeoniae Alba 6-20, Fructus Aurantii 0-25, Rhizoma Curcumae 2-20,
Fructus Toosendan 0-20, Radix Astragali 0-20, Herba Artemisiae Scopariae 0-10, Radix Bupleuri 0-15, Fructus Crataegi 0-20,
Sal Nitri 1-8, Melanteritum 1-10, artificial Calculus Bovis 2-10, Endothelium Corneum Gigeriae Galli powder 0-15, Indigo Naturalis 0-20;
Rhizoma Curcumae in the above-mentioned raw materials medicine, Fructus Toosendan, the Radix Astragali, Herba Artemisiae Scopariae, Radix Bupleuri and Fructus Crataegi only are used for decoction; Sal Nitri in the above-mentioned raw materials medicine, Melanteritum, artificial Calculus Bovis, Endothelium Corneum Gigeriae Galli powder and Indigo Naturalis only are used for powder;
Rhizoma Curcumae Longae in the above-mentioned raw materials medicine, Radix Curcumae, the Radix Paeoniae Alba and Fructus Aurantii partly are used for decoction, and part is used for powder, and the percentage by weight that every flavor Chinese medicine is used for decoction, powder is respectively:
Rhizoma Curcumae Longae: decoction 50-60%, powder 40-50%,
Radix Curcumae: decoction 50-60%, powder 40-50%,
The Radix Paeoniae Alba: decoction 70-80%, powder 20-30%,
Fructus Aurantii: decoction 60-70%, powder 30-40%.
2. medicine for the treatment of cholelithiasis according to claim 1; it is characterized in that the weight proportion of described crude drug is: Rhizoma Curcumae Longae 11, Radix Curcumae 10, the Radix Paeoniae Alba 17, Fructus Aurantii 9, Rhizoma Curcumae 12, Fructus Toosendan 10, the Radix Astragali 11, Herba Artemisiae Scopariae 10, Radix Bupleuri 7, Fructus Crataegi 9, Sal Nitri 2, Melanteritum 1, artificial Calculus Bovis 7, Endothelium Corneum Gigeriae Galli powder 5, Indigo Naturalis 2.
3. preparation method for the treatment of the medicine of cholelithiasis as claimed in claim 1 or 2, its step is as follows:
1) required decoction crude drug Rhizoma Curcumae Longae, Radix Curcumae, the Radix Paeoniae Alba, Fructus Aurantii, Rhizoma Curcumae, Fructus Toosendan, the Radix Astragali, Herba Artemisiae Scopariae, Radix Bupleuri and Fructus Crataegi are added water to do not have, decoct, waited to boil back 1-2 hour, incline and decoction liquor, residue adds water and continues and boil 1-1.5 hour, and inclining two decocting liquids, is merged into decoct with preceding decocting liquid, the volume of decoct is joined 10ml by per 2.4 gram powder crude drug and is calculated, and makes every bottle of 10ml of oral liquid; Or decoct filtered, is concentrated into the weight of 4-6 the weight portion that is equivalent to crude drug, obtain the concentrated juice of frying in shallow oil;
2) required powder crude drug Rhizoma Curcumae Longae, Radix Curcumae, the Radix Paeoniae Alba, Fructus Aurantii, Sal Nitri, Melanteritum, artificial Calculus Bovis, Endothelium Corneum Gigeriae Galli powder and Indigo Naturalis are pulverized and fine ground powder, crossed 50 orders, obtain the powder of powder crude drug with top sieve;
3) with the powder packing of above-mentioned powder crude drug, every bag 2.4 gram is mixed for every bag and is stated 1 bottle of oral liquid, the medicine of the cholelithiasis that obtains medical treatment;
4) be 50-130 ℃ drying in oven with above-mentionedly concentrating the powder mixes fry in shallow oil juice and powder crude drug, stir, putting into temperature, to water content less than 3%, fine ground again mistake 50 orders are with top sieve, the drug powder of the cholelithiasis that obtains medical treatment; Incapsulate 0.4g gram/grain then; Or compacting in flakes, 0.4 gram/sheet.
4. the preparation method as the medicine of treatment cholelithiasis as described in the claim 3 is characterized in that, in the 4th step, the temperature in the baking oven is 80-110 ℃.
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|---|---|---|---|---|
| CN1418682A (en) * | 2002-11-29 | 2003-05-21 | 张慧芳 | Medicine compositions for treating biliary calculus, and its prepn. method |
| CN1593601A (en) * | 2004-07-12 | 2005-03-16 | 张成军 | Chinese medicinal composition for cholecystitis and preparing method thereof |
-
2005
- 2005-09-21 CN CNB2005100864527A patent/CN100340285C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1418682A (en) * | 2002-11-29 | 2003-05-21 | 张慧芳 | Medicine compositions for treating biliary calculus, and its prepn. method |
| CN1593601A (en) * | 2004-07-12 | 2005-03-16 | 张成军 | Chinese medicinal composition for cholecystitis and preparing method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 中医、中西医结合治疗胆石症进展 范天福，山东中医学院学报，第18卷第3期 1994 * |
| 胆石方治疗胆总管结石45例 张士敏，南京中医药大学学报，第14卷第4期 1998 * |
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| CN1739773A (en) | 2006-03-01 |
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