CN1248712C - Medicine composition for curing splenomegaly - Google Patents

Abstract

The present invention relates to a pharmaceutical composition for treating splenomegaly and a preparation method thereof, and the pharmaceutical composition comprises red honey, small date, cinnabar, glutinous millet, anhydrous sodium sulfate, peach seed, cape jasmine fruit, musk, almond and borneol. The preparation method comprises the steps: the peach seed, the almond and the cape jasmine fruit are ground and sieved; the anhydrous sodium sulfate is ground and sieved; the small date and the glutinous millet are added to water to be decocted until cores of the small date is removed; the borneol is added to the small date fresh to be ground; the substances are mixed, then the cinnabar, the musk and the red honey are added to the mixture to be uniformly mixed, and the mixture is stirred into paste which is prepared into a pasty medicaments; or the paste is added to water to be decocted for 30 to 60 minutes; the decoction solution is prepared into external dosage form, such as liquor or a spraying agent. The pharmaceutical composition has obvious treatment effect on treating spleen and liver diseases, particularly the initial stage and the middle stage of spleen and liver tumescence, and no toxic or side effect.

Description

A kind of pharmaceutical composition for the treatment of splenomegaly and preparation method thereof

Technical field

The present invention relates to a kind of pharmaceutical composition for the treatment of splenomegaly and preparation method thereof.

Background technology

At present, that sell on the market or common to treatment spleen disease, especially the medicine of spleen enlargement initial stage and intermediate period treatment, have following shortcoming to a certain extent: 1, Western medicine is taken toxic and side effects in various degree: 2, the Chinese medicine uncertain therapeutic efficacy is cut: 3, dosage form mostly is for oral administration, and taking to the patient for a long time makes troubles.

Summary of the invention

The purpose of this invention is to provide a kind of pharmaceutical composition for the treatment of splenomegaly and preparation method thereof, overcome present Drug therapy spleen disease, especially the medicine of spleen enlargement initial stage and intermediate period treatment has toxic and side effects in various degree, the Chinese medicine uncertain therapeutic efficacy is cut, it is for oral administration that dosage form mostly is, and takes the shortcoming of making troubles to the patient for a long time.

The objective of the invention is to finish by the following technical programs:

A kind of pharmaceutical composition for the treatment of splenomegaly of the present invention comprises following parts by weight of component: red sweet 150-300, XIAOZAO 50-150, Cinnabaris 10-35, Semen setariae 500-1500, Matrii Sulfas Exsiccatus 500-1500, Semen Persicae 40-60, Fructus Gardeniae 40-60, Moschus 1-5, Semen Armeniacae Amarum 40-60, Borneolum Syntheticum 10-35.

Described component is preferably following parts by weight of component: red sweet 250, and XIAOZAO 100, Cinnabaris 25, Semen setariae 1000, Matrii Sulfas Exsiccatus 1000, Semen Persicae 50, Fructus Gardeniae 50, Moschus 3, Semen Armeniacae Amarum 50, Borneolum Syntheticum 25.

Described pharmaceutical composition is a said exterior-applied formulation on any pharmaceutics.

Described pharmaceutical composition is preferably unguentum, solution or spray.

A kind of preparation of drug combination method for the treatment of splenomegaly of the present invention may further comprise the steps: get Semen Persicae, Semen Armeniacae Amarum, Fructus Gardeniae grinding, sieve; Getting the Matrii Sulfas Exsiccatus grinding sieves; Get XIAOZAO, Semen setariae decocts with water to the XIAOZAO freestone, gets little jujube pulp, adds borneol and grinding: above-mentioned thing is mixed, adds Cinnabaris, Moschus, red sweet mix homogeneously, stir, become thick, make unguentum; Or above-mentioned thick thing decocted with water 30-60 minute, decoction liquor is filtered, and concentrates, and makes exterior-applied formulations such as solution or spray.

Described Semen Persicae, Semen Armeniacae Amarum can be used the clear water maceration, take out and grind; Described little jujube pulp can grind a little and put into container: described sieving is 200 mesh sieves; Described 120 sieves that are filtered into filter.

Solution of the present invention is based on motherland's medical science to treatment spleen disease, especially the understanding and the Therapeutic Principle of spleen enlargement initial stage and intermediate period treatment mechanism, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out the natural plant of strengthening the body resistance, by the monarch prescription of theory of Chinese medical science, make exterior-applied formulation, make it infiltrate through the effect that spleen is brought into play its treatment.

XIAOZAO, the medicine for nourishing blood thing, sweet in the mouth, warm in nature.Go into lung, liver, kidney channel.Can enrich blood, YIN nourishing.Semen Persicae, QI regulating medicine is Rosaceae or mountain peach mature seed.Bitter in the mouth, sweet, property is flat.Go into the heart, Liver Channel.The laxation of moisturizing effect can and be arranged.

Semen Armeniacae Amarum for the kernel that the maturation of Rosaceae apricot is made, is got Semen Armeniacae Amarum, and bitter in the mouth is warm in nature.Go into lung, large intestine channel, and the effect of loosening bowel to relieve constipation is arranged.

Moschus is awaking drug, is the secretions dry product in the male body note capsule of animal in deer family Moschus moschiferous.Acrid in the mouth, warm in nature.Go into the heart, spleen channel.Can the have one's ideas straightened out refreshment and the effects such as silt, evacuation of pus of dispelling.

Fructus Gardeniae has another name called Fructus Gardeniae core, is the mature fruit of Maguireothamnus speciosus.Bitter in the mouth, cold in nature, go into the heart, lung, liver, stomach warp.Energy heat clearing away, dampness removing, removing heat from blood.

Borneolum Syntheticum has another name called Borneolum Syntheticum, the processing crystallization product of flavor Dipterocarpaceae aiphyllium vateria fat.Acrid in the mouth, hardship, cold nature.Go into the heart, spleen, lung crystalline substance.The refreshment of having one's ideas straightened out, and effects such as pain relieving are arranged.

Cinnabaris is the fabricated product of natural occasion Ore.Sweet in the mouth, cold nature.Go into the heart, spleen channel.The arresting convulsion of calming the nerves, and the antidotal effect is arranged.

Medicine material of the present invention all can be buied from market, selects the top grade raw material for use.

Effect of the present invention and indication: have the effect of moisturizing hemostasis, temperature compensation spleen, activating blood and removing stasis, be used for the treatment of treatment spleen disease, especially splenomegaly.

Using method: external application or be sprayed on spleen affected part body surface.During use, avoid greasy, raw and cold.

The present invention has the following advantages:

1, determined curative effect, therapeutic effect is remarkable.

2, overcome present treatment treatment spleen disease, especially the spleen enlargement initial stage and mid-term dosage form mostly be for oral administration, take the shortcoming of making troubles for a long time to the patient.

3, medicament sources is easy to get, at the bottom of the cost.

4, select natural plant for use, have no side effect.

For proof medicine of the present invention described therapeutic effect, from year April in March, 1997-2002, choose splenomegaly 345 routine clinical observations, age 21-60 year.Stochastic sampling is divided into two groups, this medicine group 184 examples wherein, and M-F is 3: 1.Its mild or moderate splenomegaly person 92 examples, moderate splenomegaly person 70 examples, severe splenomegaly person 22 examples.Matched group placebo medicine group 120 examples.

Curative effect is passed judgment on and is divided level Four: cures, produce effects is effectively, invalid.The therapeutic outcome contrast, of the present invention group obviously is better than matched group.Effective percentage 100% to initial stage patient cure rate 100%, to patient 98% in mid-term, has mitigation to patients with terminal, statistical analysis P value＜0.01.

Diagnosis: spleen is positioned at left upper abdomen, as lying on the back or lateral position is touched the edge of spleen, then can think splenomegaly.In the time of splenauxe 2-3 times, can under costal margin, touch the edge.When splenomegaly is obvious, can contact splenic notch, and visible spleen moves to middle below with breathing.Voiced sound circle of percussion spleen (normally between left midaxillary line 9-11 rib, width 4-7cm, the place ahead is no more than the anterior axillary line), help to judge whether spleen increases.

Also can obtain diagnosis from age of onset, sex, epidemiological history, state of an illness process and simultaneous phenomenon.

When touching splenomegaly, note its degree, surface and edge situation, hardness, have or not tenderness and friction sound etc.

Clinically, dark when air-breathing according to the patient, the size of touching spleen under costal margin is divided the degree of splenomegaly: spleen-Bu Yuan and is no more than 2-30n person under the left costal margin, is called silght enlargement; Surpass 30n to umbilicus horizontal line person, be called moderate swelling; Surpass umbilicus horizontal line person, be called heavy swelling.

Concrete case

Liang Chunmei, the woman, 37 years old, suffered from splenomegaly in 1997, with heating, obvious tenderness, splenomegaly character softness is examined to due to the viral infection, recovers normally through treating after.

Li Guosheng, the man, 57 years old, splenomegaly due to the chronic infection, with heating, the uncomfortable pain in spleen district and friction sound person, chronic splenomegaly hardening, the often level and smooth and regular shape in its surface.Routine is done chest X-ray regulating liver-QI, gallbladder, spleen ultrasonic examination.Examine and be splenic infarction.After treating 2 months, recover normal.

Chang Lin, the man, 28 years old, because of 2002 because of wound causes splenomegaly, examine and be the spleen hematoma.After treating 8 days, recover normal.

Wang Jun, the woman, 50 years old, spleen district pain and friction sound person checked and found esophageal varicosis in July, 1999, routine is done chest X-ray regulating liver-QI, gallbladder, spleen ultrasonic examination, is diagnosed as the height splenomegaly.Through taking effect, the 4th day takes effect, and appetite is arranged, and sensation is strong, the complexion commentaries on classics of getting better, back hepatitis interstitialis chronica death.

The specific embodiment

Embodiment 1

Take by weighing each component (g) by following proportioning: red sweet 250, XIAOZAO 100, Cinnabaris 25, Semen setariae 1000, Matrii Sulfas Exsiccatus 1000, Semen Persicae 50, Fructus Gardeniae 50, Moschus 3, Semen Armeniacae Amarum 50, Borneolum Syntheticum 25 is made unguentum.

Preparation method is: get Semen Persicae, Semen Armeniacae Amarum clear water maceration, taking-up adds Fructus Gardeniae grinds, and 200 orders sieve: get Matrii Sulfas Exsiccatus and grind, 200 orders sieve; Get XIAOZAO, Semen setariae decocts with water to the XIAOZAO freestone, gets little jujube pulp, grinds a little, adds borneol and grinding; Above-mentioned thing is mixed, add Cinnabaris, Moschus, red sweet mix homogeneously, stir, become thick, make unguentum, fill, the ultraviolet sterilization, promptly.

Embodiment 2

Take by weighing each component (g) by following proportioning: red sweet 150, XIAOZAO 50, Cinnabaris 10, Semen setariae 500, Matrii Sulfas Exsiccatus 500, Semen Persicae 40, Fructus Gardeniae 40, Moschus 3, Semen Armeniacae Amarum 40, Borneolum Syntheticum 10 is made solution.

Preparation method is: embodiment 1 is decocted with water 30 minutes, and decoction liquor 120 mesh sieves filter, concentrate, and fill, solution is made in logical 100 ℃ of sterilizations of steam.

Embodiment 3

Take by weighing each component (g) by following proportioning: red sweet 300, XIAOZAO 150, Cinnabaris 35, Semen setariae 1500, Matrii Sulfas Exsiccatus 1500, Semen Persicae 60, Fructus Gardeniae 60, Moschus 5, Semen Armeniacae Amarum 60, Borneolum Syntheticum 35 is made spray.

Preparation method is: get Semen Persicae, Semen Armeniacae Amarum and grind: other gets Cinnabaris, Matrii Sulfas Exsiccatus, Moschus, gardenia florida, Borneolum Syntheticum and grinds respectively, and with aforementioned abrasive material mix homogeneously, 200 orders sieve; Get XIAOZAO, Semen setariae decocts with water to the XIAOZAO freestone, gets little jujube pulp, grind a little; Above-mentioned sieving and XIAOZAO abrasive material are put into container, stir, decoct with water 40 minutes, decoction liquor 120 mesh sieves filter, concentrate, and the fill spray bottle, spray bottle is made in logical 100 ℃ of sterilizations of steam.

Claims (6)

1, a kind of pharmaceutical composition for the treatment of splenomegaly is characterized in that being made up of following components in part by weight: red sweet 150-300, XIAOZAO 50-150, Cinnabaris 10-35, Semen setariae 500-1500, Matrii Sulfas Exsiccatus 500-1500, Semen Persicae 40-60, Fructus Gardeniae 40-60, Moschus 1-5, Semen Armeniacae Amarum 40-60, Borneolum Syntheticum 10-35.

2, according to the pharmaceutical composition of the treatment splenomegaly of claim 1, it is characterized in that forming by following components in part by weight: red sweet 250, XIAOZAO 100, Cinnabaris 25, Semen setariae 1000, Matrii Sulfas Exsiccatus 1000, Semen Persicae 50, gardenia florida 50, Moschus 3, Semen Armeniacae Amarum 50, Borneolum Syntheticum 25.

3, according to the pharmaceutical composition of the treatment splenomegaly of claim 1 or 2, described pharmaceutical composition is a said exterior-applied formulation on any pharmaceutics.

4, according to the pharmaceutical composition of the treatment splenomegaly of claim 3, described pharmaceutical composition is unguentum, solution or spray.

5, a kind of method for preparing the pharmaceutical composition of treatment splenomegaly as claimed in claim 1 may further comprise the steps: get Semen Persicae, Semen Armeniacae Amarum, Fructus Gardeniae grinding, sieve; Getting Matrii Sulfas Exsiccatus grinds and to sieve: get XIAOZAO, Semen setariae decocts with water to the XIAOZAO freestone, gets little jujube pulp, adds borneol and grinding; Above-mentioned thing is mixed, add Cinnabaris, Moschus, red sweet mix homogeneously, stir, become thick, make unguentum; Or above-mentioned thick thing decocted with water 30-60 minute, decoction liquor is filtered, and concentrates, and makes exterior-applied formulation.

6, according to the preparation of drug combination method of the treatment splenomegaly of claim 5, described Semen Persicae, Semen Armeniacae Amarum clear water maceration takes out and grinds; Described little jujube pulp grinds a little puts into container; Described sieving is 200 mesh sieves: described 120 mesh sieves that are filtered into filter.