CN114404557A - Child constitution consolidating formula and preparation method thereof - Google Patents

Child constitution consolidating formula and preparation method thereof Download PDF

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Publication number
CN114404557A
CN114404557A CN202210058727.XA CN202210058727A CN114404557A CN 114404557 A CN114404557 A CN 114404557A CN 202210058727 A CN202210058727 A CN 202210058727A CN 114404557 A CN114404557 A CN 114404557A
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rhizoma
formula
consolidating
mixing
preparation
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涂毛毛
王楠
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Chengdu Southwest Children's Hospital Co ltd
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Beijing Yikangyuan Pharmaceutical Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention provides a child constitution-consolidating formula and a preparation method thereof, wherein the formula comprises the following raw materials: 156g of codonopsis pilosula, 156g of fried bighead atractylodes rhizome, 209g of poria cocos, 146g of hawthorn, 261g of medicated leaven, 156g of dried orange peel, 104g of costustoot, 156g of mangnolia officinalis, 156g of rhizoma pinelliae preparata, 104g of dried ginger, 104g of rhizoma corydalis and 42g of indigo naturalis. The preparation method comprises the following specific steps: 1) decocting radix Codonopsis, Atractylodis rhizoma, fructus crataegi, rhizoma Pinelliae and Zingiberis rhizoma for 3 times; 2) mixing decoctions, filtering, and concentrating the filtrate; 3) cleaning Poria, pericarpium Citri Tangerinae, radix aucklandiae, cortex Magnolia officinalis, Zingiberis rhizoma and rhizoma corydalis; 4) adding medicated leaven and indigo naturalis into the raw materials in the step 3), drying, crushing, sieving by a 100-mesh sieve, and uniformly mixing for later use; 5) mixing the powder and the fluid extract, and making into granule. The invention has the advantages that: all the materials are Chinese patent medicines, the traditional Chinese medicine is safe and free of side effects, and the product can be made into granules through a series of operations such as decoction, granulation and the like, so that the product can be swallowed more easily, and the traditional Chinese medicine can help children to consolidate the body.

Description

Child constitution consolidating formula and preparation method thereof
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a child constitution-consolidating formula and a preparation method thereof.
Background
"consolidating foundation and cultivating essence" is the essence of the traditional Chinese medicine theory, and as the name suggests, "essence is both original spirit and root is the foundation, that is, the meaning of consolidating the original spirit is cultivated fundamentally. The traditional Chinese medicine considers that: the kidney and the spleen and stomach are the basic of life, namely, the kidney and the spleen and stomach are maintained and regulated, and the kidney, the spleen and the stomach are tonified to replenish and recover original qi, enhance immunity and improve physical functions. The infant has a poor constitution in the growth stage, and needs to be subjected to the effects of strengthening the body resistance and building the body foundation.
Disclosure of Invention
The invention aims to solve the problems in the background art, and provides a child constitution consolidating formula and a preparation method thereof.
In order to solve the technical problems, the technical scheme provided by the invention is as follows:
the child constitution consolidating formula comprises the following raw materials: 156g of codonopsis pilosula, 156g of fried bighead atractylodes rhizome, 209g of poria cocos, 146g of hawthorn, 261g of medicated leaven, 156g of dried orange peel, 104g of costustoot, 156g of mangnolia officinalis, 156g of rhizoma pinelliae preparata, 104g of dried ginger, 104g of rhizoma corydalis and 42g of indigo naturalis.
As an improvement, the hawthorn is dry hawthorn slices without seeds.
A preparation method of a child constitution-consolidating formula comprises the following specific steps:
1) decocting radix Codonopsis, Atractylodis rhizoma, fructus crataegi, rhizoma Pinelliae and Zingiberis rhizoma for half amount in water for 3 times, adding 3500ml of water for the first time, decocting for 3 hr, adding 3000ml of water for the second and third times, and decocting for 2 hr;
2) mixing decoctions, filtering, and concentrating the filtrate to obtain fluid extract with relative density of 1.15-1.2;
3) cleaning Poria, pericarpium Citri Tangerinae, radix aucklandiae, cortex Magnolia officinalis, Zingiberis rhizoma and rhizoma corydalis, and draining;
4) adding medicated leaven and indigo naturalis into the raw materials in the step 3), drying, crushing, sieving by a 100-mesh sieve, and uniformly mixing for later use;
5) mixing the powder obtained in step 4) with the fluid extract obtained in step 2), granulating, making into 1000 granules, and drying.
As a modification, the concentration temperature in step 2) is 65 ℃.
The invention has the beneficial effects that:
the codonopsis pilosula is sweet in taste and neutral in nature, has the effects of tonifying middle-jiao and Qi, is suitable for patients with deficiency of Qi, and is commonly used for treating diseases such as short breath, palpitation, deficiency of both qi and blood, tiredness and weakness, rectocele and the like in clinic; the parched Atractylodis rhizoma has effects of invigorating qi and spleen, and can be used for treating weakness of spleen and stomach, anorexia, loose stool, listlessness and qi deficiency; poria has effects of invigorating heart and spleen, calming heart, tranquilizing mind, and enhancing immunity; haw is slightly warm and not hot, has good effect of promoting digestion and relieving stagnation, and can be used as an essential herb for treating various food stagnation, especially for digesting greasy meat food stagnation; the medicated leaven has the effects of strengthening the spleen and stomach, and helping digestion and regulating the middle warmer, and is mainly used for treating symptoms such as weakness of the spleen and the stomach, diet stagnation, chest fullness and abdominal distension, dyspepsia, infantile indigestion and the like; the dried orange peel, pungent in flavor and warm in nature, has the effects of promoting qi circulation, relieving pain, invigorating spleen and regulating stomach; cortex Magnolia officinalis can be used for treating damp obstruction of middle warmer, abdominal distention, dyspepsia, abdominal distention, constipation, lung qi deficiency, phlegm retention, asthma, cough, damp turbidity, cholera, diarrhea, seven emotions, depression, and globus hystericus due to stagnation of phlegm and qi; rhizoma Pinelliae has effects of relieving swelling and pain, clearing throat, lowering adverse qi, relieving vomit, and rhizoma corydalis has effects of promoting blood circulation, activating qi-flowing, and relieving pain; qing Dai can cool blood, remove macula, clear liver-fire and fix convulsion. The whole formula is the traditional Chinese medicine, and the product can be prepared into granules through a series of operations such as decoction, granulation and the like, so that the product is easier to swallow.
Detailed Description
The invention is illustrated below by means of specific examples, without being restricted thereto.
Example one
The child constitution consolidating formula comprises the following raw materials: 156g of codonopsis pilosula, 156g of fried bighead atractylodes rhizome, 209g of poria cocos, 146g of hawthorn (seed-removed dry hawthorn slices), 261g of medicated leaven, 156g of dried orange peel, 104g of elecampane, 156g of mangnolia officinalis, 156g of rhizoma pinelliae preparata, 104g of dried ginger, 104g of rhizoma corydalis and 42g of indigo naturalis. The preparation method of the children's constitution consolidating formula comprises the following specific steps:
1) decocting radix Codonopsis, Atractylodis rhizoma, fructus crataegi, rhizoma Pinelliae and Zingiberis rhizoma for half amount in water for 3 times, adding 3500ml of water for the first time, decocting for 3 hr, adding 3000ml of water for the second and third times, and decocting for 2 hr;
2) mixing decoctions, filtering, and concentrating the filtrate to obtain fluid extract with relative density of 1.15 (concentration temperature of 65 deg.C);
3) cleaning Poria, pericarpium Citri Tangerinae, radix aucklandiae, cortex Magnolia officinalis, Zingiberis rhizoma and rhizoma corydalis, and draining;
4) adding medicated leaven and indigo naturalis into the raw materials in the step 3), drying, crushing, sieving by a 100-mesh sieve, and uniformly mixing for later use;
5) mixing the powder obtained in step 4) with the fluid extract obtained in step 2), granulating, making into 1000 granules, and drying.
Example two
The child constitution consolidating formula comprises the following raw materials: 156g of codonopsis pilosula, 156g of fried bighead atractylodes rhizome, 209g of poria cocos, 146g of dried hawthorn (without seeds), 261g of medicated leaven, 156g of dried orange peel, 104g of costustoot, 156g of mangnolia officinalis, 156g of rhizoma pinelliae preparata, 104g of dried ginger, 104g of rhizoma corydalis and 42g of indigo naturalis.
A preparation method of a child constitution-consolidating formula comprises the following specific steps:
1) decocting radix Codonopsis, Atractylodis rhizoma, fructus crataegi, rhizoma Pinelliae and Zingiberis rhizoma for half amount in water for 3 times, adding 3500ml of water for the first time, decocting for 3 hr, adding 3000ml of water for the second and third times, and decocting for 2 hr;
2) mixing decoctions, filtering, and concentrating the filtrate to obtain fluid extract with relative density of 1.2;
3) cleaning Poria, pericarpium Citri Tangerinae, radix aucklandiae, cortex Magnolia officinalis, Zingiberis rhizoma and rhizoma corydalis, and draining;
4) adding medicated leaven and indigo naturalis into the raw materials in the step 3), drying, crushing, sieving by a 100-mesh sieve, and uniformly mixing for later use;
5) mixing the powder obtained in step 4) with the fluid extract obtained in step 2), granulating, making into 1000 granules, and drying.
The concentration temperature in step 2) was 65 ℃.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (4)

1. The infant constitution consolidating formula is characterized by comprising the following raw materials: 156g of codonopsis pilosula, 156g of fried bighead atractylodes rhizome, 209g of poria cocos, 146g of hawthorn, 261g of medicated leaven, 156g of dried orange peel, 104g of costustoot, 156g of mangnolia officinalis, 156g of rhizoma pinelliae preparata, 104g of dried ginger, 104g of rhizoma corydalis and 42g of indigo naturalis.
2. The pediatric formula for consolidating basis according to claim 1, wherein the hawthorn is dry hawthorn slices without seeds.
3. The preparation method of the children's constitution consolidating formula is characterized by comprising the following specific steps of:
1) decocting radix Codonopsis, Atractylodis rhizoma, fructus crataegi, rhizoma Pinelliae and Zingiberis rhizoma for half amount in water for 3 times, adding 3500ml of water for the first time, decocting for 3 hr, adding 3000ml of water for the second and third times, and decocting for 2 hr;
2) mixing decoctions, filtering, and concentrating the filtrate to obtain fluid extract with relative density of 1.15-1.2;
3) cleaning Poria, pericarpium Citri Tangerinae, radix aucklandiae, cortex Magnolia officinalis, Zingiberis rhizoma and rhizoma corydalis, and draining;
4) adding medicated leaven and indigo naturalis into the raw materials in the step 3), drying, crushing, sieving by a 100-mesh sieve, and uniformly mixing for later use;
5) mixing the powder obtained in step 4) with the fluid extract obtained in step 2), granulating, making into 1000 granules, and drying.
4. The method for preparing a pediatric formula for consolidating basis according to claim 3, wherein the concentration temperature in the step 2) is 65 ℃.
CN202210058727.XA 2022-01-15 2022-01-15 Child constitution consolidating formula and preparation method thereof Pending CN114404557A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824240A (en) * 2006-01-12 2006-08-30 北京阜康仁生物制药科技有限公司 Shenshu Jianpi medicinal preparation for invigorating spleen and its new preparation method
CN105362906A (en) * 2015-11-29 2016-03-02 王宁 Traditional Chinese medicine for treating spleen-stomach deficiency and food stagnation symptoms of children and method for preparing traditional Chinese medicine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824240A (en) * 2006-01-12 2006-08-30 北京阜康仁生物制药科技有限公司 Shenshu Jianpi medicinal preparation for invigorating spleen and its new preparation method
CN105362906A (en) * 2015-11-29 2016-03-02 王宁 Traditional Chinese medicine for treating spleen-stomach deficiency and food stagnation symptoms of children and method for preparing traditional Chinese medicine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
杨建平,等: "理中汤加青黛治疗小儿虚寒腹泻30例", 《福建中医药》 *

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