CN114404518A - Spleen-tonifying and lung-benefiting paste formula and preparation process thereof - Google Patents
Spleen-tonifying and lung-benefiting paste formula and preparation process thereof Download PDFInfo
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- CN114404518A CN114404518A CN202210118442.0A CN202210118442A CN114404518A CN 114404518 A CN114404518 A CN 114404518A CN 202210118442 A CN202210118442 A CN 202210118442A CN 114404518 A CN114404518 A CN 114404518A
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Abstract
The invention relates to a paste formula for reinforcing spleen and benefiting lung and a preparation process thereof, the main components of the paste formula for reinforcing spleen and benefiting lung are lotus seed, medlar, dogwood fruit, alcohol solomonseal rhizome, gordon euryale seed, tuckahoe, liquorice, yam, Chinese date, dried orange peel, ginseng, crystal sugar and white honey; the components are medicinal and edible traditional Chinese medicines and are composed of the following components in parts by weight in parts by dry weight: 10-20 parts of lotus seed, 10-20 parts of medlar, 5-15 parts of dogwood fruit, 5-15 parts of wine sealwort, 10-20 parts of gordon euryale seed, 10-20 parts of tuckahoe, 2-8 parts of liquorice, 15-25 parts of yam, 10-15 parts of Chinese date, 10-20 parts of dried orange peel, 5-10 parts of ginseng, 10-20 parts of rock candy and 10-30 parts of white honey. The preparation method of the ointment formula for tonifying spleen and benefiting lung comprises the following steps: cleaning main components, air drying, weighing, mixing, crushing and grinding in groups, decocting and extracting in three sections, standing, filtering, concentrating, adding crystal sugar and white honey, heating for refining, filtering to remove foams, cooling and bottling. The components can be prepared into the traditional Chinese medicine composition paste which has the effects of tonifying spleen and benefiting lung and is homologous in medicine and food by a preparation process, and the traditional Chinese medicine composition paste can be directly taken or taken with warm water.
Description
Technical Field
The invention relates to a formula and a preparation process of a health-care medicine for tonifying spleen and lung, in particular to a component formula of a paste formula for tonifying spleen and lung and a whole preparation process of the paste, belonging to the technical field of health-care products.
Background
The treatment of spleen-lung deficiency is also called earth-growing jin (earth, spleen; jin, lung), which means a treatment for spleen-lung deficiency with a prescription with qi-tonifying, spleen-invigorating and lung-nourishing effects. The spleen is the origin of hematopoiesis, the spleen is the mother of the lung, and the spleen and stomach mainly transport, transform and absorb, so food essence is upward. Aiming at the defects of fast-paced life style and self-conditioning consciousness of modern people, the health state of the people is changed, and the spleen and the lung are firstly supplemented to the end of the body, so that the resistance and the immunity can be enhanced, and the conditioning of the spleen and the lung is the key.
Disclosure of Invention
The invention aims to provide a formula of a paste for tonifying spleen and benefiting lung and a preparation method thereof, so that people can condition their bodies more conveniently and tonify the spleen and the lung.
The technical purpose of the invention is realized by the following technical scheme:
the formula of the ointment for tonifying spleen and benefiting lung mainly comprises the following components: semen Nelumbinis, fructus Lycii, Corni fructus, rhizoma Polygonati preparata, semen euryales, Poria, Glycyrrhrizae radix, rhizoma Dioscoreae, fructus Jujubae, pericarpium Citri Tangerinae, crystal sugar, and Mel.
Preferably, the formula of the ointment for tonifying spleen and benefiting lung comprises the following components in parts by weight: 10-20 parts of lotus seed, 10-20 parts of medlar, 5-15 parts of dogwood fruit, 5-15 parts of wine sealwort, 10-20 parts of gordon euryale seed, 10-20 parts of tuckahoe, 2-8 parts of liquorice, 15-25 parts of yam, 10-15 parts of Chinese date, 10-20 parts of dried orange peel, 5-10 parts of ginseng, 10-20 parts of rock candy and 10-30 parts of white honey.
The action mechanism of the traditional Chinese medicine involved in the spleen-tonifying and lung-benefiting plaster formula is as follows:
lotus seed meat: sweet, astringent and neutral in nature. It enters spleen, kidney and heart meridians. Has effects of invigorating spleen, relieving diarrhea, invigorating kidney, arresting seminal emission, nourishing heart, and tranquilizing mind.
Medlar: sweet in nature and mild in nature. It enters liver and kidney meridians. Has effects in invigorating kidney, nourishing liver, improving eyesight, promoting salivation, quenching thirst, moistening lung, and tranquilizing mind.
Cornus officinalis: slightly warm in nature, sour and astringent in taste. It enters liver and kidney meridians. Has the effects of tonifying liver and kidney, and inducing astringency to arrest depletion.
Wine sealwort: after being roasted with yellow wine, the sealwort has the effects of treating spleen and stomach qi deficiency, tiredness and hypodynamia, stomach yin deficiency, dry mouth and poor appetite, lung deficiency and dry cough, over-strained cough and hemoptysis, and essence and blood deficiency.
Gorgon fruit: mild in nature, sweet and astringent in taste. It enters spleen and kidney meridians. Has effects in invigorating kidney, stopping nocturnal emission, invigorating spleen, relieving diarrhea, eliminating dampness, and stopping leukorrhagia.
Tuckahoe, poria cocos: sweet and bland in flavor and mild in nature. It enters heart, lung, spleen and kidney meridians. Has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart.
Licorice root: has the effects of tonifying middle-jiao and Qi, clearing away heat and toxic material, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the drugs.
Chinese yam: sweet, warm, mild and nontoxic. Mainly treats the diseases of impairment of middle energizer, deficiency, cold and heat, pathogenic qi, middle energizer and energy reinforcing.
Chinese date: the red dates are warm in nature and sweet in taste, and have the effects of tonifying qi and blood, strengthening spleen and stomach and dispelling wind.
Dried orange peel: bitter and pungent in flavor and warm in nature. It enters lung and spleen meridians. Has the effects of regulating qi, strengthening spleen, eliminating dampness and phlegm.
Ginseng: has effects of enhancing cardiovascular function and immunity, invigorating spleen and qi, warming spleen and stomach, and dispelling cold.
Crystal sugar and white honey: the compatible sugar in the paste formula not only can reduce the bitter taste of the medicine, and ensure that the paste taste is better and is beneficial to taking, but also has certain tonifying effect. Meanwhile, the combination of sugar and medical glue is more beneficial to the fixation and formation of the soft extract preparation.
Preferably, the preparation method of the cream formula for tonifying spleen and benefiting lung comprises the steps of cleaning main components, air drying, weighing and proportioning, crushing and grinding in groups, decocting and extracting in three sections, standing and filtering, concentrating, adding crystal sugar and white honey, heating and refining, filtering to remove foams, cooling and bottling, and vacuumizing.
Preferably, the preparation method of the cream formula for tonifying spleen and benefiting lung comprises the steps of cleaning the main components for 1-3 times, and drying in an air drying mode.
Preferably, the preparation method of the cream formula for tonifying spleen and lung comprises the steps of drying, weighing the traditional Chinese medicine components according to the formula (dry weight) of the cream formula, grinding the crystal sugar and the white honey, grinding the ginseng alone, and mixing and grinding all the other components.
Preferably, in the preparation method of the ointment formula for tonifying spleen and benefiting lung, ginseng is completely ground to pass through 150 meshes to 200 meshes when being independently ground, and the ginseng does not enter dregs but remains in a decoction liquid after being filtered; the other traditional Chinese medicine components are ground by 80-120 meshes so as to more effectively extract useful components.
Preferably, the preparation method of the ointment formula for tonifying spleen and benefiting lung is characterized in that the extraction rate of useful components is low because the traditional Chinese medicines are decocted and not ground; the concentration of the useful components is reduced and the drug effect is unstable in one time compared with one time due to repeated decoction of water in the conventional traditional Chinese medicine, and the effective components can be effectively extracted and the drug effect is controlled to be stable by adopting three-section decoction and mixed concentration.
Preferably, the preparation method of the ointment formula for tonifying spleen and benefiting lung adopts three-section decoction for decocting the traditional Chinese medicine components; decocting for the first time, controlling the weight ratio of the rest ingredients except the ginseng medicinal powder to water to be 1:2, decocting for 2-5 minutes after boiling, decocting for 4 hours with slow fire, standing and filtering to obtain 1 time of decoction, and reserving the 1 st time of filter residue; second stage of decoction, wherein the weight ratio of the 1 st filter residue to water is controlled to be 1:1, the mixture is boiled for 2-5 minutes, the mixture is decocted for 3 hours by soft fire, then the mixture is kept stand and filtered to obtain 2 times of decoction liquid, and the 2 nd filter residue is reserved; and (3) third-stage decoction, namely controlling the weight ratio of the 2 nd filter residue to water to be 2:1, boiling for 2-5 minutes, decocting for 1 hour with slow fire, standing, filtering, removing the medicinal residues, adding 5-10 parts of ginseng powder into the filtrate, boiling for 2-5 minutes, decocting for 1 hour with slow fire, and cooling to obtain 3 times of decoction.
Preferably, the preparation method of the ointment formula for tonifying spleen and lung comprises the steps of uniformly mixing the decoction for 1 st, 2 nd and 3 rd times at a stirrer rotating speed of 100-.
Preferably, the preparation method of the ointment formula for tonifying spleen and benefiting lung is to adopt strong fire for 10-20 minutes and then to change middle fire and slow fire for slowly concentrating until 1/3 of the volume of the mixed solution.
Preferably, the preparation method of the cream formula for tonifying spleen and benefiting lung comprises the steps of adding 10-20 parts of rock candy and 10-30 parts of white honey according to the formula proportion when the mixture is concentrated to 1/3 parts by volume of the mixed solution, heating and slightly refining the mixture with soft fire until the solution is thick, and then filtering the mixture to remove surface foams; cooling, loading into sealed bottle, and vacuumizing.
Preferably, the device for preparing the cream formula for tonifying the spleen and benefiting the lung comprises a concentration tank, wherein a foam collecting box is welded at the top of one side of the outer part of the concentration tank, a communicating port is horizontally formed between the concentration tank and the foam collecting box, an L-shaped mounting frame is horizontally inserted in the foam collecting box, a filter screen is horizontally embedded in the L-shaped mounting frame, the bottom of the foam collecting box is communicated with the concentration tank through a communicating pipe, a push plate is horizontally arranged above one side of the inner part of the concentration tank, a moving mechanism for driving the push plate to move is arranged on the outer side of the concentration tank, a mounting box is horizontally welded above one side of the inner part of the concentration tank, one end of the bottom of the mounting box is vertically and rotatably connected with a driven shaft, a driving mechanism for driving the driven shaft to rotate is arranged in the mounting box, sleeves are horizontally welded at the top and the bottom of the periphery of the driven shaft, and two telescopic rods are inserted in the sleeves, telescopic link and sleeve sliding connection, horizontal welding has the spring between telescopic link one end and the sleeve inner wall, two vertical welding has the puddler between the telescopic link, the equal horizontal installation in middle part of driven shaft periphery has the stirring leaf.
Preferably, the top center department of concentrated jar has seted up the feed inlet, one side bottom intercommunication of concentrated jar has the discharging pipe, and installs the valve on the discharging pipe, one side mid-mounting of concentrated jar has the control box.
Preferably, collection foam case and L type mounting bracket hookup location bond and have sealed the pad, L type mounting bracket horizontal part's tip is inlayed and is had first magnet, collection foam incasement wall has seted up the slot, and the slot is inside to be inlayed and to have the second magnet, first magnet and second magnet magnetism attract mutually.
Preferably, a check valve is arranged in the communicating pipe, and the push plate and the communicating port are arranged in parallel and have the same size.
Preferably, moving mechanism includes electric telescopic handle, electric telescopic handle horizontal installation is in concentrated jar outside one side top, electric telescopic handle's flexible end stretch into concentrated jar inside and with concentrated jar sliding connection, electric telescopic handle's flexible end and the one side middle part fixed connection of push pedal.
Preferably, actuating mechanism includes the rotating electrical machines, rotating electrical machines horizontal installation is in the top in concentrated jar outside one side, the output shaft of rotating electrical machines stretches into the mounting box inside and rotates with concentrated jar to be connected, the output shaft horizontal fixed mounting of rotating electrical machines has the driving shaft.
Preferably, a driving bevel gear is installed at the top end of the driving shaft, the top end of the driven shaft extends into the installation box, a driven bevel gear is installed at the top of the driven shaft, and the driving bevel gear is meshed with the driven bevel gear.
Preferably, the sleeve is equipped with a plurality ofly, and is a plurality of the sleeve is circumference evenly distributed at the top and the bottom of periphery, the stirring leaf is equipped with a plurality ofly, and is a plurality of the stirring leaf is at the middle part evenly distributed of driven shaft periphery.
The paste preparation device provided by the invention has the following beneficial effects:
1. by arranging the push plate and the froth collecting box, when the cream stock solution is concentrated in the concentrating tank to generate froth, the electric telescopic rod is started to drive the push plate to move forwards so that the push plate can slowly push the froth on the surface of the liquid to the communicating port, and the froth enters the froth collecting box from the communicating port to wait for uniform cleaning, so that the froth can be automatically skimmed, manual operation is not needed, time and labor are saved, workers are prevented from being scalded by steam, and the paste concentrate concentrating tank is safer;
2. the stirring blade, the sleeve, the telescopic rod and the stirring rod are arranged, the driven shaft drives the stirring blade when rotating, the sleeve and the telescopic rod rotate to stir the paste side stock solution, the telescopic rod drives the stirring rod to rotate to stir the paste side stock solution, meanwhile, the rotation of the driven shaft provides centrifugal force for the telescopic rod, so that the telescopic rod is thrown out of the sleeve for a certain distance from the inside of the sleeve, the telescopic rod stretches out and stretches the spring, the spring generates pulling force to pull the telescopic rod back to the inside of the sleeve, the telescopic rod is repeatedly stretched out and retracted in the sleeve in a reciprocating mode, the stirring rod moves horizontally while rotating, the paste side stock solution forms turbulent flow, and the stirring effect is better;
3. through being provided with filter screen and communicating pipe, fall on the filter screen surface after floating the foam and getting into collection foam case, when partial cream side stoste gets into collection foam case along with floating the foam, float the foam and be held back by the filter screen, and cream side stoste gets back to concentrated jar inside once more through communicating pipe through the filter screen to prevent that cream side stoste from producing extravagantly, only get rid of pure superficial foam.
The ointment for tonifying spleen and benefiting lung prepared by the formula and the preparation process can be taken directly or mixed with warm water.
The ointment for tonifying spleen and benefiting lung prepared by the formula and the preparation process has the best effect, and the dosage of the ointment for one time is not less than 10mL and not more than 30 mL.
In conclusion, the invention has the following beneficial effects: has the effects of regulating spleen and lung and enhancing resistance and immunity, and can be taken for a long time because the components are all traditional Chinese medicines with homology of medicine and food.
Drawings
FIG. 1 is a process flow for preparing a paste formula for invigorating spleen and benefiting lung;
FIG. 2 is an overall top cross-sectional view of a paste preparation apparatus of the invention;
FIG. 3 is an overall external view of a paste preparation apparatus according to the present invention;
FIG. 4 is a sectional view of a paste preparation apparatus according to the present invention;
FIG. 5 is an enlarged view of the paste preparation apparatus of the present invention at A.
In the figure: 1. a communication port; 2. mounting a box; 3. pushing the plate; 4. an electric telescopic rod; 5. a rotating electric machine; 6. a concentration tank; 7. a sleeve; 8. a telescopic rod; 9. a foam collecting box; 10. stirring blades; 11. a spring; 12. a driven shaft; 13. a drive shaft; 14. a drive bevel gear; 15. a driven bevel gear; 16. a stirring rod; 17. a communicating pipe; 18. a non-return valve; 19. filtering with a screen; 20. a first magnet; 21. a second magnet; 22. a gasket; 23. an L-shaped mounting rack.
Detailed Description
Example 1:
the formula of the cream formula adopted by the invention in the embodiment is as follows: 10 parts of lotus seed, 10 parts of medlar, 5 parts of dogwood fruit, 5 parts of wine sealwort, 10 parts of gordon euryale seed, 10 parts of tuckahoe, 2 parts of liquorice, 15 parts of yam, 10 parts of Chinese date, 10 parts of dried orange peel, 5 parts of ginseng, 10 parts of rock candy and 10 parts of white honey. Cleaning with important components for 1 time; then air-drying; weighing the air-dried components according to dry weight of the formula; crushing and grinding by groups by using a traditional Chinese medicine crusher, wherein the ginseng powder is 150 meshes in fineness, and the rest ingredients are 80 meshes in fineness to prepare medicinal powder. Three-stage boiling is respectively as follows: decocting for the first time, controlling the weight ratio of the rest ingredients except the ginseng medicinal powder to water to be 1:2, decocting for 2 minutes after boiling with soft fire for 4 hours, standing and filtering to obtain 1 time of decoction liquid, and reserving the 1 st time of filter residue; second stage decocting, controlling the weight ratio of the 1 st filter residue to water to be 1:1, decocting for 2 minutes after boiling, decocting for 3 hours with slow fire, standing and filtering to obtain 2 times of decoction liquid, and reserving the 2 nd filter residue; and (3) third-stage decoction, namely controlling the weight ratio of the 2 nd filter residue to water to be 2:1, boiling for 5 minutes, decocting for 1 hour with slow fire, standing, filtering, removing the residues, adding 5-10 parts of ginseng powder into the filtrate, boiling for 2 minutes, decocting for 1 hour with slow fire, and cooling to obtain 3 times of decoction.
When concentrating, the 1 st, 2 nd and 3 rd decocted liquids are mixed together and then concentrated, wherein when concentrating, the mixture is slowly concentrated to 1/3 of the volume of the mixed liquid by a medium and small fire after 10 minutes by a big fire. When the mixed solution is concentrated to 1/3 parts by volume, 10 parts of rock sugar and 10 parts of white honey are added according to the formula proportion, the mixture is heated and slightly refined by small fire until the solution is thick, and then the mixture is filtered to remove surface foams; cooling, loading into sealed bottle, and vacuumizing.
The obtained ointment is taken by taking 10mL of the ointment once, three times a day and 15 days as a treatment course in a mode of direct taking or warm water mixing.
Example 2:
the formula of the cream formula adopted by the invention in the embodiment is as follows: 15 parts of lotus seed, 15 parts of medlar, 10 parts of dogwood fruit, 10 parts of wine-processed rhizoma polygonati, 15 parts of gordon euryale seed, 15 parts of tuckahoe, 3 parts of liquorice, 20 parts of yam, 15 parts of Chinese date, 10 parts of dried orange peel, 8 parts of ginseng, 20 parts of rock candy and 10 parts of white honey. Cleaning with important components for 1 time; then air-drying; weighing the air-dried components according to dry weight of the formula;
crushing and grinding by groups by using a traditional Chinese medicine crusher, wherein the ginseng powder is sieved by 180 meshes, and the rest ingredients are sieved by 100 meshes to prepare powder. Three-stage boiling is respectively as follows: decocting for the first time, controlling the weight ratio of the rest ingredients except the ginseng medicinal powder to water to be 1:2, decocting for 2 minutes after boiling with soft fire for 4 hours, standing and filtering to obtain 1 time of decoction liquid, and reserving the 1 st time of filter residue; second stage decocting, controlling the weight ratio of the 1 st filter residue to water to be 1:1, decocting for 2 minutes after boiling, decocting for 3 hours with slow fire, standing and filtering to obtain 2 times of decoction liquid, and reserving the 2 nd filter residue; and (3) third-stage decoction, namely controlling the weight ratio of the 2 nd filter residue to water to be 2:1, boiling for 5 minutes, decocting for 1 hour with slow fire, standing, filtering, removing the residues, adding 5-10 parts of ginseng powder into the filtrate, boiling for 5 minutes, decocting for 1 hour with slow fire, and cooling to obtain 3 times of decoction.
When in concentration, the 1 st, the 2 nd and the 3 rd decocted liquids are mixed together and then concentrated, wherein the mixture is slowly concentrated to 1/3 of the volume of the mixed liquid by medium and small fire after 15 minutes of strong fire. When the mixed solution is concentrated to 1/3 parts by volume, 20 parts of rock candy and 10 parts of white honey are added according to the formula proportion, the mixture is heated and slightly refined by small fire until the solution is thick, and then the mixture is filtered to remove surface foams; cooling, loading into sealed bottle, and vacuumizing.
The obtained ointment is taken by taking 15mL of the ointment once, three times a day and 15 days as a treatment course in a mode of direct taking or warm water mixing.
Example 3:
the formula of the cream formula adopted by the invention in the embodiment is as follows: 20 parts of lotus seed, 10 parts of medlar, 15 parts of dogwood fruit, 10 parts of wine-processed rhizoma polygonati, 15 parts of gordon euryale seed, 15 parts of poria cocos, 3 parts of liquorice, 20 parts of Chinese yam, 15 parts of Chinese date, 15 parts of dried orange peel, 10 parts of ginseng, 20 parts of rock candy and 20 parts of white honey. Cleaning with important components for 1 time; then air-drying; weighing the air-dried components according to dry weight of the formula;
crushing and grinding by groups by using a traditional Chinese medicine crusher, wherein the ginseng powder is 200 meshes in fineness, and the rest medicinal powder is 120 meshes in fineness to prepare medicinal powder. Three-stage boiling is respectively as follows: decocting for the first time, controlling the weight ratio of the rest ingredients except the ginseng medicinal powder to water to be 1:2, decocting for 2 minutes after boiling with soft fire for 4 hours, standing and filtering to obtain 1 time of decoction liquid, and reserving the 1 st time of filter residue; second stage decocting, controlling the weight ratio of the 1 st filter residue to water to be 1:1, decocting for 2 minutes after boiling, decocting for 3 hours with slow fire, standing and filtering to obtain 2 times of decoction liquid, and reserving the 2 nd filter residue; and (3) third-stage decoction, namely controlling the weight ratio of the 2 nd filter residue to water to be 2:1, boiling for 5 minutes, decocting for 1 hour with slow fire, standing, filtering, removing the residues, adding 5-10 parts of ginseng powder into the filtrate, boiling for 2 minutes, decocting for 1 hour with slow fire, and cooling to obtain 3 times of decoction.
When in concentration, the 1 st, the 2 nd and the 3 rd decocted liquids are mixed together and then concentrated, wherein the mixture is slowly concentrated to 1/3 of the volume of the mixed liquid by medium and small fire after the mixture is heated for 20 minutes by big fire. When the mixed solution is concentrated to 1/3 parts by volume, 20 parts of rock candy and 20 parts of white honey are added according to the formula proportion, the mixture is heated and slightly refined by small fire until the solution is thick, and then the mixture is filtered to remove surface foams; cooling, loading into sealed bottle, and vacuumizing.
The obtained ointment is taken by taking 20mL of the ointment once, three times a day and 15 days as a treatment course in a mode of direct taking or warm water mixing.
In order to prove the beneficial effects of the invention, the following experiments are compared between the traditional boiling method and the invention (under the same formula):
TABLE 1 comparison of conventional and inventive methods
As can be seen from Table 1, the traditional Chinese medicine is not ground and has large blocks, the main ingredients in the traditional Chinese medicine are extracted less and are not mixed, the concentration of the main ingredients is gradually reduced, and the efficacy is reduced. After the traditional Chinese medicine adopted by the invention is ground, decocted in three sections and mixed, the concentration of the components is stable to be about 30.0%, and the higher the grinding fineness, the higher the concentration of the components.
In order to prove the necessity of group crushing and fine grinding and three-stage boiling, the following experimental comparisons (under the same formula) are carried out:
TABLE 2 comparative experiment of group crushing and three-stage decoction
As can be seen from Table 2, the three-stage decoction methods C1 and C2 adopted in the invention without the group grinding are listed in the final product, wherein the human reference is 0.7-0.9% because the too long decoction time affects the drug effect of the ginseng and most of the ginseng enters the dregs. By adopting the method, the ginseng powder with higher fineness is added only in the third stage during three-stage decoction and extraction, so that the proportion of ginseng in the final product can be improved, and the effect is higher.
Example 4
The same as embodiment 3, except that the dosage form of the medicinal and edible old square product containing resistant starch is a cream formula, as shown in the attached drawings 2-5, the cream formula preparation device comprises a concentration tank 6, a heating system is arranged in the concentration tank 6, a foam collecting tank 9 is welded at the top of one side outside the concentration tank 6, a communication port 1 is horizontally formed between the concentration tank 6 and the foam collecting tank 9, an L-shaped mounting rack 23 is horizontally inserted in the foam collecting tank 9, a filter screen 19 is horizontally embedded in the L-shaped mounting rack 23, the bottom of the foam collecting tank 9 is communicated with the concentration tank 6 through a communication pipe 17, when floating foam enters the foam collecting tank 9, the floating foam falls on the surface of the filter screen 19, when partial cream formula raw liquid enters the foam collecting tank 9 along with the floating foam, the floating foam is intercepted by the filter screen 19, the cream formula raw liquid returns to the interior of the concentration tank 6 through the filter screen 19 again through the communication pipe 17, so that the waste of the formula raw liquid is prevented, and only pure floating foam is removed, a push plate 3 is horizontally arranged above one side inside a concentration tank 6, a moving mechanism for driving the push plate 3 to move is arranged outside the concentration tank 6, a mounting box 2 is horizontally welded above the middle of one side inside the concentration tank 6, one end of the bottom of the mounting box 2 is vertically and rotatably connected with a driven shaft 12, a driving mechanism for driving the driven shaft 12 to rotate is arranged in the mounting box 2, sleeves 7 are horizontally welded at the top and the bottom of the periphery of the driven shaft 12, telescopic rods 8 are inserted in the two sleeves 7, the telescopic rods 8 are slidably connected with the sleeves 7, a spring 11 is horizontally welded between one end of each telescopic rod 8 and the inner wall of each sleeve 7, a stirring rod 16 is vertically welded between the two telescopic rods 8, stirring blades 10 are horizontally arranged in the middle of the periphery of the driven shaft 12, the telescopic rods 8 drive the stirring rods 16 to rotate to stir paste stock solution, meanwhile, the rotation of the driven shaft 12 provides a centrifugal force for the telescopic rods 8, and accordingly, one distance is thrown out of the telescopic rods 8 from the insides of the sleeves 7, extension spring 11 after telescopic link 8 stretches out, inside spring 11 produced the pulling force and pull back sleeve 7 with telescopic link 8, so reciprocal messenger telescopic link 8 is at the inside reciprocal withdrawal that stretches out of sleeve 7 to make 16 limits of puddler rotate the limit horizontal to removing, make cream side stoste form the turbulent flow, stirring effect is better.
In this embodiment, as shown in fig. 1-3, a feed inlet has been seted up at the top center of concentration tank 6, and one side bottom intercommunication of concentration tank 6 has the discharging pipe, and installs the valve on the discharging pipe, and one side mid-mounting of concentration tank 6 has the control box, adds the cream side stoste into concentration tank 6 from the feed inlet and concentrates, opens the valve after the concentration and follows the discharging pipe ejection of compact, and each power equipment is controlled to the control box.
In this embodiment, as shown in fig. 3-4, a sealing gasket 22 is bonded to a connection position of the foam collecting box 9 and the L-shaped mounting frame 23, the sealing gasket 22 prevents liquid leakage, a first magnet 20 is embedded in an end portion of a horizontal portion of the L-shaped mounting frame 23, a slot is formed in an inner wall of the foam collecting box 9, a second magnet 21 is embedded in the slot, the first magnet 20 and the second magnet 21 attract each other magnetically, and the first magnet 20 and the second magnet 21 attract each other to fix the L-shaped mounting frame 23 in the foam collecting box 9.
In this embodiment, as shown in fig. 1, 3 and 4, a check valve 18 is installed in the communicating pipe 17, the push plate 3 and the communicating port 1 are arranged in parallel and have the same size, and the check valve 18 prevents the liquid inside the concentration tank 6 from entering the foam collecting tank 9.
In this embodiment, as shown in fig. 1 and 3, moving mechanism includes electric telescopic handle 4, 4 horizontal installation of electric telescopic handle is in concentrated 6 outside one sides tops of jar, electric telescopic handle 4's flexible end stretch into concentrated 6 inside and with concentrated 6 sliding connection of jar, electric telescopic handle 4's flexible end and one side middle part fixed connection of push pedal 3, when concentrated production froth, start electric telescopic handle 4 and drive push pedal 3 and move forward and make push pedal 3 slowly promote the froth on liquid surface to intercommunication mouth 1 forward, it is unified to wait for in the foam collecting box 9 to clear up from intercommunication mouth 1, thereby can skim the froth automatically, need not manual operation, time saving and labor saving, and avoid vapor scald the staff, and is comparatively safe.
In this embodiment, as shown in fig. 1 and 3, the driving mechanism includes a rotating electrical machine 5, the rotating electrical machine 5 is horizontally installed in the upper portion of one side outside the concentration tank 6, the output shaft of the rotating electrical machine 5 extends into the mounting box 2 and is rotatably connected with the concentration tank 6, a driving shaft 13 is horizontally and fixedly installed on the output shaft of the rotating electrical machine 5, and the rotating electrical machine 5 is started to drive the driving shaft 13 to rotate.
In this embodiment, as shown in fig. 3, a driving bevel gear 14 is installed at the top end of the driving shaft 13, the top end of the driven shaft 12 extends into the mounting box 2, a driven bevel gear 15 is installed at the top end of the driven shaft 12, the driving bevel gear 14 is engaged with the driven bevel gear 15, the driving shaft 13 drives the driving bevel gear 14 to rotate, and the driving bevel gear 14 drives the driven shaft 12 to rotate through the driven bevel gear 15.
In this embodiment, as shown in fig. 3, sleeve 7 is equipped with a plurality ofly, and a plurality of sleeves 7 are circumference evenly distributed at the top and the bottom of periphery, and stirring leaf 10 is equipped with a plurality ofly, and a plurality of stirring leaves 10 are at the middle part evenly distributed of driven shaft 12 periphery, and driven shaft 12 drives stirring leaf 10, sleeve 7 and telescopic link 8 when rotating and rotates and stir the cream side stoste.
The working principle of the invention is as follows: adding the paste stock solution into a concentration tank 6 from a feed inlet for concentration, starting a rotating motor 5 to drive a driving shaft 13 to rotate, driving the driving shaft 13 to drive a driving bevel gear 14 to rotate, driving the driving bevel gear 14 to drive a driven shaft 12 to rotate through a driven bevel gear 15, driving a stirring blade 10, a sleeve 7 and a telescopic rod 8 to stir the paste stock solution when the driven shaft 12 rotates, driving a stirring rod 16 to rotate by the telescopic rod 8 to stir the paste stock solution, and simultaneously, the rotation of the driven shaft 12 gives a centrifugal force to the telescopic rod 8, so that the telescopic rod 8 is thrown out a certain distance from the interior of the sleeve 7, the spring 11 is stretched after the telescopic rod 8 is stretched out, the spring 11 generates pulling force to pull the telescopic rod 8 back to the interior of the sleeve 7, the telescopic rod 8 is repeatedly stretched out and retracted in the interior of the sleeve 7 in such a reciprocating way, thereby enabling the stirring rod 16 to horizontally move while rotating, enabling the paste stock solution to form turbulent flow and achieving better stirring effect; when froth is generated by concentration, the electric telescopic rod 4 is started to drive the push plate 3 to move forwards, so that the push plate 3 slowly pushes the froth on the surface of the liquid to the communication port 1 forwards, and the froth enters the froth collecting box 9 from the communication port 1 to wait for uniform cleaning, so that the froth can be skimmed automatically, manual operation is not needed, time and labor are saved, workers are prevented from being scalded by steam, and the device is safe; drop on 19 surfaces of filter screen after floating the foam and getting into collection foam case 9, when partial cream side stoste gets into collection foam case 9 along with floating the foam, float the foam and be held back by filter screen 19, and cream side stoste gets back to concentrated jar 6 inside once more through communicating pipe 17 through filter screen 19 to prevent that cream side stoste from producing extravagantly, only get rid of pure superficial foam.
Comparative example 1
The same as example 1 except that lotus seed pulp, wolfberry fruit and polygonatum kingianum were not contained therein.
Comparative example 2
The same as example 2, except that cornus fruit, gorgon fruit and licorice were not contained.
Test example 1 acute toxicity test
Test materials:
animals: 60 mice are taken, each mouse weighs 18 g-22 g, and the male and female halves are respectively.
Medicine preparation: the invention relates to a pulverized traditional Chinese medicine composition powder.
Mice were randomly divided into 6 groups of 10 mice each, each half male and female. The cream formulation was adjusted to be pasty (maximum concentration is standard), each mouse was perfused with a maximum amount of the drug administered twice a day for 14 consecutive days and the animals were observed. In the observation period of 14 days, the mice were normal in appetite, activity, hair color, mental status, etc., developed normally, and had no death. The medicine of the present invention has high safety, no obvious side effect and very low acute toxicity.
Test example 2 drug efficacy test
The influence of the traditional Chinese medicine composition on the mouse cough model is as follows:
the mice were randomly divided into a model control group, and a blank control group, an example group and a comparative example group were set. The administration is carried out by intragastric administration for 5 days every day, and after the last administration for 2h, the mice are placed in a bell jar, and concentrated ammonia water is uniformly sprayed for 5s to stimulate the mice to cause cough, and the cough frequency of the mice within 10min is observed.
TABLE 3 Effect of examples and comparative examples on mouse cough model
The experimental result shows that the components of the paste formula prepared by the raw materials have the effect of inhibiting the cough caused by strong ammonia water, namely the effect of tonifying middle-jiao and Qi; however, the formula of the traditional Chinese medicine composition in examples 1 to 4 of the invention has a more obvious inhibiting effect on cough caused by strong ammonia, the effect of examples 1 to 4 is better than that of comparative examples 1 to 2, wherein the effect of example 3 is better than that of examples 1 and 2, and the effect of example 4 is better than that of example 3.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.
Claims (10)
1. The formula of the ointment for tonifying spleen and benefiting lung is characterized in that: the formula comprises lotus seed, medlar, dogwood fruit, wine-processed rhizoma polygonati, gordon euryale seed, tuckahoe, liquorice, yam, Chinese date, dried orange peel, ginseng, crystal sugar and white honey.
2. The spleen-tonifying and lung-benefiting paste formulation of claim 1, wherein: the traditional Chinese medicine composition comprises the following components in parts by weight (based on dry weight): 10-20 parts of lotus seed, 10-20 parts of medlar, 5-15 parts of dogwood fruit, 5-15 parts of wine sealwort, 10-20 parts of gordon euryale seed, 10-20 parts of tuckahoe, 2-8 parts of liquorice, 15-25 parts of yam, 10-15 parts of Chinese date, 10-20 parts of dried orange peel, 5-10 parts of ginseng, 10-20 parts of rock candy and 10-30 parts of white honey.
3. A process for preparing the spleen-tonifying and lung-benefiting paste formulation of any one of claims 1-2, which is characterized in that: the method comprises the steps of cleaning main components, air drying, weighing and batching, crushing and fine grinding in groups, decocting and extracting in three sections, standing, filtering, concentrating, adding crystal sugar and white honey, heating and refining slightly, filtering to remove foams, cooling and bottling.
4. The preparation process of the paste formula for tonifying spleen and benefiting lung according to claim 3, characterized by comprising the following steps: the main component is washed for 1-3 times; then air-drying; weighing the air-dried components according to dry weight of the formula; crushing and grinding into powder by group with a traditional Chinese medicine crusher.
5. The preparation process of the paste formula for tonifying spleen and benefiting lung according to claim 4, characterized by comprising the following steps: when the ginseng is crushed and ground in groups, the ginseng needs to be ground separately to pass through a 150-200-mesh target standard sample sieve, and the rest components are mixed and ground to pass through a 80-120-mesh sample sieve.
6. The preparation process of the paste formula for tonifying spleen and benefiting lung according to claim 5, characterized by comprising the following steps: the three-stage decoction and extraction respectively comprises the following steps: decocting for the first time, controlling the weight ratio of the rest ingredients except the ginseng medicinal powder to water to be 1:2, decocting for 2-5 minutes after boiling, decocting for 4 hours with slow fire, standing and filtering to obtain 1 time of decoction, and reserving the 1 st time of filter residue; second stage of decoction, wherein the weight ratio of the 1 st filter residue to water is controlled to be 1:1, the mixture is boiled for 2-5 minutes, the mixture is decocted for 3 hours by soft fire, then the mixture is kept stand and filtered to obtain 2 times of decoction liquid, and the 2 nd filter residue is reserved; and (3) third-stage decoction, namely controlling the weight ratio of the 2 nd filter residue to water to be 2:1, boiling for 2-5 minutes, decocting for 1 hour with slow fire, standing, filtering, removing the medicinal residues, adding 5-10 parts of ginseng powder into the filtrate, boiling for 2-5 minutes, decocting for 1 hour with slow fire, and cooling to obtain 3 times of decoction.
7. The preparation process of the cream formula for tonifying spleen and benefiting lung according to claims 5 and 6, characterized in that: the ginseng medicinal powder is not filtered after being decocted, so that the fineness of the medicinal powder can be controlled to be over 150-200 meshes, and the fineness of the medicinal powder is ensured; the ginseng should not be decocted for too long, so the third stage of decocting is to filter out the residue of other components and then add the ginseng powder for decocting.
8. The preparation process of the paste formula for tonifying spleen and benefiting lung according to claim 7, characterized by comprising the following steps: when concentrating, the 1 st, 2 nd and 3 rd decoction liquids are mixed together and then concentrated, and after the concentration is carried out for 10-20 minutes by adopting a big fire, the mixture is slowly concentrated to 1/3 of the volume of the mixed liquid by changing to a middle and small fire.
9. The preparation process of the paste formula for tonifying spleen and benefiting lung according to claim 8, characterized by comprising the following steps: when the mixed solution is concentrated to 1/3 volumes, 10-20 parts of rock sugar and 10-30 parts of white honey are added according to the formula proportion, the mixture is heated by soft fire and slightly refined until the solution is thick, and then the solution is filtered to remove surface foams; cooling, loading into sealed bottle, and vacuumizing.
10. The preparation process of the paste formula for tonifying spleen and benefiting lung according to claims 1-9, characterized by comprising the following steps: the final finished product is ointment, the single dose is not less than 10mL and not more than 30 mL, and the drug effect is optimal.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116571160A (en) * | 2023-07-14 | 2023-08-11 | 宸光(常州)新材料科技有限公司 | Nozzle, propylene pigment stirring equipment for nozzle and stirring method |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103725573A (en) * | 2014-01-13 | 2014-04-16 | 江苏海昇药业有限公司 | Longan and cinnamon wine and preparation method thereof |
| CN105055853A (en) * | 2015-08-07 | 2015-11-18 | 南京同仁堂黄山精制药业有限公司 | Traditional Chinese medicine composition used for adjusting qi deficiency |
| CN112076298A (en) * | 2020-09-25 | 2020-12-15 | 西安莲湖五朝九体国医馆有限公司 | Ginseng and rhizoma polygonati cream and preparation method and application thereof |
| CN113598381A (en) * | 2021-07-30 | 2021-11-05 | 湖南康润农业科技发展有限公司 | Production equipment of mulberry lily paste |
| CN113827481A (en) * | 2021-10-24 | 2021-12-24 | 和也健康科技有限公司 | Decocting and concentrating device for preparing medicinal and edible ointment |
| CN113855764A (en) * | 2021-11-12 | 2021-12-31 | 北京中医药大学 | Chinese medicinal compound preparation for improving immunity of organism |
| CN216726765U (en) * | 2021-12-06 | 2022-06-14 | 深圳市昌鹏通节能环保科技有限公司 | Defoaming device for diluent concentration equipment |
-
2022
- 2022-02-08 CN CN202210118442.0A patent/CN114404518B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103725573A (en) * | 2014-01-13 | 2014-04-16 | 江苏海昇药业有限公司 | Longan and cinnamon wine and preparation method thereof |
| CN105055853A (en) * | 2015-08-07 | 2015-11-18 | 南京同仁堂黄山精制药业有限公司 | Traditional Chinese medicine composition used for adjusting qi deficiency |
| CN112076298A (en) * | 2020-09-25 | 2020-12-15 | 西安莲湖五朝九体国医馆有限公司 | Ginseng and rhizoma polygonati cream and preparation method and application thereof |
| CN113598381A (en) * | 2021-07-30 | 2021-11-05 | 湖南康润农业科技发展有限公司 | Production equipment of mulberry lily paste |
| CN113827481A (en) * | 2021-10-24 | 2021-12-24 | 和也健康科技有限公司 | Decocting and concentrating device for preparing medicinal and edible ointment |
| CN113855764A (en) * | 2021-11-12 | 2021-12-31 | 北京中医药大学 | Chinese medicinal compound preparation for improving immunity of organism |
| CN216726765U (en) * | 2021-12-06 | 2022-06-14 | 深圳市昌鹏通节能环保科技有限公司 | Defoaming device for diluent concentration equipment |
Non-Patent Citations (2)
| Title |
|---|
| 张敬礼编著: "《寿世补元》", 31 January 2002, 中国医药科技出版社, pages: 508 * |
| 衷敬柏主编: "《实用中医膏方学》", 30 November 2019, 科学技术文献出版社, pages: 310 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116571160A (en) * | 2023-07-14 | 2023-08-11 | 宸光(常州)新材料科技有限公司 | Nozzle, propylene pigment stirring equipment for nozzle and stirring method |
| CN116571160B (en) * | 2023-07-14 | 2023-10-03 | 宸光(常州)新材料科技有限公司 | Nozzle, propylene pigment stirring equipment for nozzle and stirring method |
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