CN114402080B - 人巨细胞病毒的ul18对t细胞应答的调节 - Google Patents

人巨细胞病毒的ul18对t细胞应答的调节 Download PDF

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CN114402080B
CN114402080B CN202080064753.2A CN202080064753A CN114402080B CN 114402080 B CN114402080 B CN 114402080B CN 202080064753 A CN202080064753 A CN 202080064753A CN 114402080 B CN114402080 B CN 114402080B
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mhc
cells
seq
vector
recombinant hcmv
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CN114402080A (zh
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克劳斯·J·弗吕
斯克特·G·汉森
丹尼尔·马卢利
路易斯·J·皮克
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Oregon Health and Science University
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C12N2710/16011—Herpesviridae
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    • C12N2710/16141—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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CN202080064753.2A 2019-08-20 2020-08-19 人巨细胞病毒的ul18对t细胞应答的调节 Active CN114402080B (zh)

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US201962889310P 2019-08-20 2019-08-20
US62/889,310 2019-08-20
PCT/US2020/047050 WO2021034964A1 (en) 2019-08-20 2020-08-19 Modulation of t cell responses by ul18 of human cytomegalovirus

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CN114402080B true CN114402080B (zh) 2024-09-13

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US (1) US20220307054A1 (https=)
EP (1) EP4017985A4 (https=)
JP (2) JP7693651B2 (https=)
KR (1) KR20220047619A (https=)
CN (1) CN114402080B (https=)
AU (1) AU2020334061A1 (https=)
BR (1) BR112022003159A2 (https=)
CA (1) CA3148642A1 (https=)
CL (1) CL2022000398A1 (https=)
CO (1) CO2022002922A2 (https=)
CR (1) CR20220093A (https=)
DO (1) DOP2022000041A (https=)
EC (1) ECSP22013145A (https=)
IL (1) IL290748A (https=)
MX (1) MX2022002154A (https=)
MY (1) MY210519A (https=)
PE (1) PE20220648A1 (https=)
PH (1) PH12022550439A1 (https=)
WO (1) WO2021034964A1 (https=)

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JP2024534189A (ja) * 2021-08-31 2024-09-18 ヴィア・バイオテクノロジー・インコーポレイテッド 組換えｈｃｍｖベクター及びその使用
WO2024059635A2 (en) * 2022-09-13 2024-03-21 Oregon Health And Science University Universal t cell-based, cmv-vectored vaccine for influenza

Citations (1)

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CN110036112A (zh) * 2016-10-18 2019-07-19 俄勒冈健康与科学大学 引发受主要组织相容性复合体e分子限制的t细胞的巨细胞病毒载体

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US1410314A (en) 1920-11-04 1922-03-21 Edgar B Hyatt Garage-door control
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US20020069244A1 (en) 1999-11-24 2002-06-06 John Blair Message delivery system billing method and apparatus
CA2437201C (en) * 2001-02-02 2008-11-18 Chemocentryx, Inc. Methods and compositions useful for stimulating an immune response
WO2008039148A1 (en) 2006-09-28 2008-04-03 Packetfront Sweden Ab Method for automatically providing a customer equipment with the correct service
WO2014135209A1 (en) 2013-03-06 2014-09-12 SiEVA Apparatus for high side transistor bridge driver
US10752902B2 (en) * 2014-09-23 2020-08-25 Board Of Trustees Of Michigan State University Compositions comprising fusion proteins useful for modulating an immune response
JP6816031B2 (ja) * 2015-02-10 2021-01-20 オレゴン ヘルス アンド サイエンス ユニバーシティ 非標準的なｃｄ８＋ｔ細胞応答を生成するのに有用な方法および組成物
CN108474003A (zh) 2015-11-20 2018-08-31 俄勒冈健康与科学大学 包含微小rna识别元件的cmv载体
CN109843321A (zh) 2016-06-22 2019-06-04 国际艾滋病疫苗行动组织公司 作为结核病疫苗的重组巨细胞病毒载体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110036112A (zh) * 2016-10-18 2019-07-19 俄勒冈健康与科学大学 引发受主要组织相容性复合体e分子限制的t细胞的巨细胞病毒载体

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MX2022002154A (es) 2022-03-17
KR20220047619A (ko) 2022-04-18
CL2022000398A1 (es) 2023-03-17
IL290748A (en) 2022-04-01
AU2020334061A1 (en) 2022-03-10
CO2022002922A2 (es) 2022-04-19
DOP2022000041A (es) 2022-08-15
ECSP22013145A (es) 2022-04-29
WO2021034964A1 (en) 2021-02-25
CA3148642A1 (en) 2021-02-25
CN114402080A (zh) 2022-04-26
PH12022550439A1 (en) 2023-03-13
BR112022003159A2 (pt) 2022-05-17
JP7693651B2 (ja) 2025-06-17
EP4017985A4 (en) 2023-09-27
NZ785288A (en) 2025-09-26
US20220307054A1 (en) 2022-09-29
JP2022544704A (ja) 2022-10-20
JP2025131719A (ja) 2025-09-09
MY210519A (en) 2025-09-29
PE20220648A1 (es) 2022-04-28
EP4017985A1 (en) 2022-06-29
CR20220093A (es) 2022-06-15

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