CN114401946A - Magl抑制剂及其制备方法、用途 - Google Patents
Magl抑制剂及其制备方法、用途 Download PDFInfo
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- CN114401946A CN114401946A CN202080061346.6A CN202080061346A CN114401946A CN 114401946 A CN114401946 A CN 114401946A CN 202080061346 A CN202080061346 A CN 202080061346A CN 114401946 A CN114401946 A CN 114401946A
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- aryl
- alkyl
- maglz
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- radical
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Classifications
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Abstract
本发明属于药物领域,涉及一种作为MAGL抑制剂的式(Ⅰ)化合物及其药学上可接受的盐,及其制备方法、用途,和用于制备其的中间体。
Description
PCT国内申请,说明书已公开。
Claims (21)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910836454.5A CN111518020A (zh) | 2019-02-01 | 2019-09-05 | Magl抑制剂及其制备方法、用途 |
CN2019108364545 | 2019-09-05 | ||
CN201910856962X | 2019-09-10 | ||
CN201910856962.XA CN112552229A (zh) | 2019-09-10 | 2019-09-10 | Magl抑制剂及制备方法和用途 |
CN201910854235X | 2019-09-10 | ||
CN201910854235.XA CN112552228A (zh) | 2019-09-10 | 2019-09-10 | Magl抑制剂及其用途 |
PCT/CN2020/104989 WO2021042911A1 (zh) | 2019-09-05 | 2020-07-27 | Magl抑制剂及其制备方法、用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114401946A true CN114401946A (zh) | 2022-04-26 |
Family
ID=74853072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202080061346.6A Pending CN114401946A (zh) | 2019-09-05 | 2020-07-27 | Magl抑制剂及其制备方法、用途 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230090255A1 (zh) |
EP (1) | EP4043436A4 (zh) |
JP (1) | JP2022546958A (zh) |
KR (1) | KR20220058553A (zh) |
CN (1) | CN114401946A (zh) |
AU (1) | AU2020343737A1 (zh) |
BR (1) | BR112022004068A2 (zh) |
CA (1) | CA3150147A1 (zh) |
MX (1) | MX2022002720A (zh) |
WO (1) | WO2021042911A1 (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101128427A (zh) * | 2004-12-24 | 2008-02-20 | 阿斯利康(瑞典)有限公司 | 用作ccr2b拮抗剂的杂环化合物 |
CN105916841A (zh) * | 2013-11-25 | 2016-08-31 | 诺沃根公司 | 作为抗癌药物的功能化的和取代的吲哚 |
US20180079756A1 (en) * | 2015-03-30 | 2018-03-22 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
CN109593089A (zh) * | 2019-01-24 | 2019-04-09 | 西南大学 | 二氮杂螺癸烷哌啶甲酰胺类化合物制备和应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012170098A2 (en) * | 2011-03-31 | 2012-12-13 | The Regents Of The University Of Michigan | Arbovirus inhibitors and uses thereof |
WO2015048567A1 (en) * | 2013-09-26 | 2015-04-02 | Sanford-Burnham Medical Research Institute | Spirocyclic ebi2 modulators |
US10525048B2 (en) * | 2015-09-18 | 2020-01-07 | Memorial Sloan Kettering Cancer Center | Methods and compositions of inhibiting DCN1-UBC12 interaction |
CA3008171A1 (en) * | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
AR108326A1 (es) * | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
CN106279136B (zh) * | 2016-08-15 | 2019-06-21 | 中山大学 | 治疗中枢神经系统退行性疾病或脑肿瘤的化合物及其应用 |
JP2020503363A (ja) * | 2017-01-06 | 2020-01-30 | ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド | チューブリン結合化合物およびその治療的使用 |
WO2019105915A1 (en) * | 2017-11-28 | 2019-06-06 | F. Hoffmann-La Roche Ag | New heterocyclic compounds |
TW201930300A (zh) * | 2017-12-15 | 2019-08-01 | 瑞士商赫孚孟拉羅股份公司 | 新雜環化合物 |
DK3837263T3 (da) * | 2018-08-13 | 2024-09-09 | Hoffmann La Roche | Nye heterocykliske forbindelser som monoacylglycerollipasehæmmere |
-
2020
- 2020-07-27 US US17/640,785 patent/US20230090255A1/en active Pending
- 2020-07-27 BR BR112022004068A patent/BR112022004068A2/pt unknown
- 2020-07-27 CN CN202080061346.6A patent/CN114401946A/zh active Pending
- 2020-07-27 AU AU2020343737A patent/AU2020343737A1/en active Pending
- 2020-07-27 WO PCT/CN2020/104989 patent/WO2021042911A1/zh unknown
- 2020-07-27 KR KR1020227007788A patent/KR20220058553A/ko unknown
- 2020-07-27 JP JP2022513078A patent/JP2022546958A/ja active Pending
- 2020-07-27 MX MX2022002720A patent/MX2022002720A/es unknown
- 2020-07-27 EP EP20861878.5A patent/EP4043436A4/en active Pending
- 2020-07-27 CA CA3150147A patent/CA3150147A1/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101128427A (zh) * | 2004-12-24 | 2008-02-20 | 阿斯利康(瑞典)有限公司 | 用作ccr2b拮抗剂的杂环化合物 |
CN105916841A (zh) * | 2013-11-25 | 2016-08-31 | 诺沃根公司 | 作为抗癌药物的功能化的和取代的吲哚 |
US20180079756A1 (en) * | 2015-03-30 | 2018-03-22 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
CN109593089A (zh) * | 2019-01-24 | 2019-04-09 | 西南大学 | 二氮杂螺癸烷哌啶甲酰胺类化合物制备和应用 |
Non-Patent Citations (1)
Title |
---|
"《STN,Registry》", 《STN,REGISTRY》, 28 June 2019 (2019-06-28), pages 1 - 24 * |
Also Published As
Publication number | Publication date |
---|---|
EP4043436A4 (en) | 2023-08-30 |
BR112022004068A2 (pt) | 2022-05-31 |
JP2022546958A (ja) | 2022-11-10 |
MX2022002720A (es) | 2022-08-10 |
US20230090255A1 (en) | 2023-03-23 |
WO2021042911A1 (zh) | 2021-03-11 |
AU2020343737A1 (en) | 2022-03-31 |
KR20220058553A (ko) | 2022-05-09 |
EP4043436A1 (en) | 2022-08-17 |
CA3150147A1 (en) | 2021-03-11 |
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