CN114375197A - 治疗kras突变癌症的方法 - Google Patents

治疗kras突变癌症的方法 Download PDF

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Publication number
CN114375197A
CN114375197A CN202080063707.0A CN202080063707A CN114375197A CN 114375197 A CN114375197 A CN 114375197A CN 202080063707 A CN202080063707 A CN 202080063707A CN 114375197 A CN114375197 A CN 114375197A
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cntfr
clcf1
leu
kras
amino acid
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CN202080063707.0A
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Chinese (zh)
Inventor
埃里克·亚历杭德罗·斯威特-科尔德罗
詹妮弗·R·科克伦
金准宇
塞萨尔·P·马克斯
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University of California San Diego UCSD
Leland Stanford Junior University
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University of California San Diego UCSD
Leland Stanford Junior University
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CN202080063707.0A 2019-09-10 2020-09-10 治疗kras突变癌症的方法 Pending CN114375197A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962898249P 2019-09-10 2019-09-10
US62/898,249 2019-09-10
US201962931608P 2019-11-06 2019-11-06
US62/931,608 2019-11-06
PCT/US2020/050206 WO2021050732A1 (en) 2019-09-10 2020-09-10 Methods of treating kras mutant cancers

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Publication Number Publication Date
CN114375197A true CN114375197A (zh) 2022-04-19

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US (1) US20220331401A1 (https=)
EP (1) EP4028044A4 (https=)
JP (2) JP2022547167A (https=)
KR (1) KR20220061997A (https=)
CN (1) CN114375197A (https=)
AU (1) AU2020346820A1 (https=)
CA (1) CA3149872A1 (https=)
WO (1) WO2021050732A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11932633B2 (en) 2018-05-07 2024-03-19 Mirati Therapeutics, Inc. KRas G12C inhibitors
JP2022500385A (ja) 2018-09-10 2022-01-04 ミラティ セラピューティクス， インコーポレイテッド 組み合わせ療法
WO2020055761A1 (en) 2018-09-10 2020-03-19 Mirati Therapeutics, Inc. Combination therapies
SMT202500028T1 (it) 2018-09-10 2025-03-12 Mirati Therapeutics Inc Terapie combinate
CA3112043A1 (en) 2018-09-10 2020-03-19 Mirati Therapeutics, Inc. Combination therapies
CN113164418A (zh) 2018-12-05 2021-07-23 米拉蒂治疗股份有限公司 组合疗法
WO2020146613A1 (en) 2019-01-10 2020-07-16 Mirati Therapeutics, Inc. Kras g12c inhibitors
WO2021041671A1 (en) 2019-08-29 2021-03-04 Mirati Therapeutics, Inc. Kras g12d inhibitors
CN114761012B (zh) 2019-09-24 2025-03-21 米拉蒂治疗股份有限公司 组合疗法
PH12022551513A1 (en) 2019-12-20 2023-04-24 Mirati Therapeutics Inc Sos1 inhibitors
WO2022056307A1 (en) 2020-09-11 2022-03-17 Mirati Therapeutics, Inc. Crystalline forms of a kras g12c inhibitor
WO2022132200A1 (en) 2020-12-15 2022-06-23 Mirati Therapeutics, Inc. Azaquinazoline pan-kras inhibitors
EP4262803A4 (en) 2020-12-16 2025-03-12 Mirati Therapeutics, Inc. Tetrahydropyridopyrimidine pan-kras inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018106790A1 (en) * 2016-12-06 2018-06-14 The Board Of Trustees Of The Leland Stanford Junior University Ciliary neurotrophic factor receptor ligand-binding agents and methods of using the same
WO2018128745A1 (en) * 2017-01-06 2018-07-12 The Board Of Trustees Of The Leland Stanford Junior University Ciliary neurotrophic factor receptor ligands and methods of using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018106790A1 (en) * 2016-12-06 2018-06-14 The Board Of Trustees Of The Leland Stanford Junior University Ciliary neurotrophic factor receptor ligand-binding agents and methods of using the same
WO2018128745A1 (en) * 2017-01-06 2018-07-12 The Board Of Trustees Of The Leland Stanford Junior University Ciliary neurotrophic factor receptor ligands and methods of using the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOHN C. HUNTER等: "Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations", MOL CANCER RES, vol. 13, no. 9, 1 September 2018 (2018-09-01), pages 1325 - 1335, XP093074232, DOI: 10.1158/1541-7786.MCR-15-0203 *

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EP4028044A1 (en) 2022-07-20
US20220331401A1 (en) 2022-10-20
JP2022547167A (ja) 2022-11-10
CA3149872A1 (en) 2021-03-18
AU2020346820A1 (en) 2022-04-21
WO2021050732A1 (en) 2021-03-18
KR20220061997A (ko) 2022-05-13
JP2025138641A (ja) 2025-09-25
EP4028044A4 (en) 2023-09-27

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