CN1143680C - 增强非索非那定及其衍生物之生物利用度的方法 - Google Patents

增强非索非那定及其衍生物之生物利用度的方法 Download PDF

Info

Publication number
CN1143680C
CN1143680C CNB988081598A CN98808159A CN1143680C CN 1143680 C CN1143680 C CN 1143680C CN B988081598 A CNB988081598 A CN B988081598A CN 98808159 A CN98808159 A CN 98808159A CN 1143680 C CN1143680 C CN 1143680C
Authority
CN
China
Prior art keywords
glycoprotein
peg
antihistamine
fexofenadine
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB988081598A
Other languages
English (en)
Chinese (zh)
Other versions
CN1267221A (zh
Inventor
ƽ
黄金凯
H
丹尼斯·H·吉辛
盖尔·H·赫斯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Auin Thurber Holding Co
Auin Thurber Ltd By Share Ltd
Aventis Saab LLC
Original Assignee
AWANDIS PHARMACEUTICAL CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AWANDIS PHARMACEUTICAL CORP filed Critical AWANDIS PHARMACEUTICAL CORP
Publication of CN1267221A publication Critical patent/CN1267221A/zh
Application granted granted Critical
Publication of CN1143680C publication Critical patent/CN1143680C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/745—Polymers of hydrocarbons
    • A61K31/75—Polymers of hydrocarbons of ethene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
CNB988081598A 1997-08-14 1998-07-21 增强非索非那定及其衍生物之生物利用度的方法 Expired - Lifetime CN1143680C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91156397A 1997-08-14 1997-08-14
US08/911,563 1997-08-14

Publications (2)

Publication Number Publication Date
CN1267221A CN1267221A (zh) 2000-09-20
CN1143680C true CN1143680C (zh) 2004-03-31

Family

ID=25430473

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988081598A Expired - Lifetime CN1143680C (zh) 1997-08-14 1998-07-21 增强非索非那定及其衍生物之生物利用度的方法

Country Status (29)

Country Link
EP (1) EP1003528B1 (enExample)
JP (1) JP4295913B2 (enExample)
KR (1) KR100522985B1 (enExample)
CN (1) CN1143680C (enExample)
AR (1) AR018505A1 (enExample)
AT (1) ATE224721T1 (enExample)
AU (1) AU725965C (enExample)
BR (1) BR9811937A (enExample)
CA (1) CA2301267C (enExample)
CZ (1) CZ293666B6 (enExample)
DE (1) DE69808303T2 (enExample)
DK (1) DK1003528T3 (enExample)
EE (1) EE04263B1 (enExample)
ES (1) ES2179523T3 (enExample)
HU (1) HU226823B1 (enExample)
ID (1) ID24463A (enExample)
IL (1) IL134521A (enExample)
NO (1) NO325148B1 (enExample)
NZ (1) NZ502133A (enExample)
OA (1) OA11287A (enExample)
PL (1) PL191607B1 (enExample)
PT (1) PT1003528E (enExample)
RU (1) RU2197967C2 (enExample)
SK (1) SK283868B6 (enExample)
TR (1) TR200000419T2 (enExample)
TW (1) TWI240633B (enExample)
UA (1) UA64765C2 (enExample)
WO (1) WO1999008690A1 (enExample)
ZA (1) ZA987221B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2213700C (en) 1995-02-28 2002-04-02 Hoechst Marion Roussel, Inc. Pharmaceutical composition for piperidinoalkanol compounds
PT998272E (pt) * 1997-08-26 2003-09-30 Aventis Pharma Inc Composicao farmaceutica para combinacao do descongestionante piperidinoalcanol
GB9822170D0 (en) * 1998-10-13 1998-12-02 Danbioyst Uk Ltd Novel formulations of fexofenadine
WO2003101437A2 (en) * 2002-05-29 2003-12-11 Aventis Pharmaceuticals Holdings Inc. Method of treating asthma using fexofenadine
GB0319935D0 (en) * 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
AR050043A1 (es) * 2004-08-03 2006-09-20 Novartis Ag Metodos para mejorar la biodisponibilidad y composicion farmaceutica para trastornos cardiovasculares
JP2008120684A (ja) * 2005-03-07 2008-05-29 Kumamoto Univ 抗アレルギー薬
KR101106374B1 (ko) 2009-06-05 2012-01-19 민병욱 고체연료에 의한 가연성 가스 발생 장치
KR101117014B1 (ko) * 2009-09-09 2012-06-14 민병욱 부패성 폐기물의 바이오매스 처리에 의한 폐자원 재활용 방법 및 장치
CN101843616B (zh) * 2010-06-04 2011-07-27 西安万隆制药有限责任公司 一种盐酸非索非那定与微晶纤维素组合物及其制备方法
RU2453315C2 (ru) * 2010-08-17 2012-06-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтическая композиция для лечения аллергических заболеваний
BR112013029778A2 (pt) 2011-05-20 2017-01-17 Aventis Pharma Inc composição farmacêutica que compreende fexofenadina
RU2504018C1 (ru) * 2012-05-28 2014-01-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения и социального развития Российской Федерации Способ моделирования состояния индукции функциональной активности гликопротеина-р финастеридом в эксперименте
RU2553362C1 (ru) * 2014-01-09 2015-06-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ моделирования состояния ингибирования функциональной активности гликопротеина-р линестренолом в эксперименте
CN104188998A (zh) * 2014-09-18 2014-12-10 中山大学 一种柚皮苷与盐酸非索非那丁药物组合物及其制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
NO900427L (no) * 1989-01-31 1990-08-01 Int Pharma Agentur Erosjonsregulert frigjoeringssystem for aktive stoffer og en fremgangsmaate for deres fremstilling.
US5567592A (en) * 1994-02-02 1996-10-22 Regents Of The University Of California Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal
WO1996040792A1 (en) * 1995-06-07 1996-12-19 Novo Nordisk A/S Modification of polypeptides
WO1996040192A1 (en) * 1995-06-07 1996-12-19 Avmax, Inc. Use of essential oils to increase bioavailability of oral pharmaceutical compounds

Also Published As

Publication number Publication date
EP1003528A1 (en) 2000-05-31
TWI240633B (en) 2005-10-01
NO20000706D0 (no) 2000-02-11
SK1842000A3 (en) 2000-08-14
PL338579A1 (en) 2000-11-06
CZ293666B6 (cs) 2004-06-16
ZA987221B (en) 1999-02-15
AU8505098A (en) 1999-03-08
TR200000419T2 (tr) 2000-09-21
SK283868B6 (sk) 2004-03-02
AU725965B2 (en) 2000-10-26
HUP0003189A2 (en) 2001-03-28
DE69808303T2 (de) 2003-05-22
KR20010022845A (ko) 2001-03-26
DE69808303D1 (de) 2002-10-31
CA2301267C (en) 2004-07-13
OA11287A (en) 2003-10-22
RU2197967C2 (ru) 2003-02-10
EE04263B1 (et) 2004-04-15
KR100522985B1 (ko) 2005-10-21
HUP0003189A3 (en) 2001-04-28
WO1999008690A1 (en) 1999-02-25
AR018505A1 (es) 2001-11-28
EE200000069A (et) 2000-10-16
HU226823B1 (hu) 2009-11-30
IL134521A (en) 2005-07-25
ATE224721T1 (de) 2002-10-15
CA2301267A1 (en) 1999-02-25
JP4295913B2 (ja) 2009-07-15
BR9811937A (pt) 2000-09-05
PL191607B1 (pl) 2006-06-30
NO325148B1 (no) 2008-02-11
ID24463A (id) 2000-07-20
IL134521A0 (en) 2001-04-30
HK1025901A1 (en) 2000-12-01
UA64765C2 (uk) 2004-03-15
NZ502133A (en) 2002-03-28
CN1267221A (zh) 2000-09-20
JP2001515041A (ja) 2001-09-18
NO20000706L (no) 2000-04-13
DK1003528T3 (da) 2003-02-03
EP1003528B1 (en) 2002-09-25
CZ2000522A3 (cs) 2000-09-13
ES2179523T3 (es) 2003-01-16
AU725965C (en) 2004-04-22
PT1003528E (pt) 2003-02-28

Similar Documents

Publication Publication Date Title
US6451815B1 (en) Method of enhancing bioavailability of fexofenadine and its derivatives
CN1143680C (zh) 增强非索非那定及其衍生物之生物利用度的方法
ZA200307684B (en) Antifungal composition with enhanced bioavailability
US20150190413A1 (en) Compositions and methods for the treatment of bladder cancer
JP2001515041A5 (enExample)
CN1191061C (zh) 药用组合物
US20040198646A1 (en) Menthol solutions of drugs
MXPA00001515A (en) Method of enhancing bioavailability of fexofenadine and its derivatives
HK1025901B (en) Method of enhancing bioavailability of fexofenadine and its derivatives
AU2010338249B2 (en) Oral liquid pharmaceutical composition of nifedipine
US20060141028A1 (en) Cyclosporin formulations
US20210386720A1 (en) Methods of treating cns tumors with tesetaxel
HK1092459A (en) Compositions and methods for preventing and treating endotoxin-related diseases and conditions
CN1164189A (zh) 含有gf120918a的非肠道药物组合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: AVENTIS SAAB CO., LTD.

Free format text: FORMER OWNER: AVENTIS HOLDINGS INC.

Effective date: 20100928

Owner name: AVENTIS HOLDINGS INC.

Free format text: FORMER OWNER: HMR PHARMACEUTICAL CO., LTD.

Effective date: 20100928

Owner name: HMR PHARMACEUTICAL CO., LTD.

Free format text: FORMER OWNER: AWANDIS PHARMACEUTICAL CORP.

Effective date: 20100928

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20100928

Address after: Delaware

Patentee after: Aventis Holdings, Inc.

Address before: Delaware

Patentee before: Avant Holdings

Effective date of registration: 20100928

Address after: Delaware

Patentee after: Avant Holdings

Address before: Delaware

Patentee before: HMR Pharmaceutical Co.

Effective date of registration: 20100928

Address after: Delaware

Patentee after: HMR Pharmaceutical Co.

Address before: New jersey, USA

Patentee before: AVENTIS PHARMACEUTICALS Inc.

C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee
CP01 Change in the name or title of a patent holder

Address after: Delaware

Patentee after: Aventis Saab LLC

Address before: Delaware

Patentee before: Auin Thurber Limited by Share Ltd.

TR01 Transfer of patent right

Effective date of registration: 20160809

Address after: Delaware

Patentee after: Auin Thurber Limited by Share Ltd.

Address before: Delaware

Patentee before: Auin Thurber holding Co.

Effective date of registration: 20160809

Address after: Delaware

Patentee after: Auin Thurber holding Co.

Address before: Delaware

Patentee before: Aventis Holdings, Inc.

CX01 Expiry of patent term

Granted publication date: 20040331

CX01 Expiry of patent term