CN114366795A - Traditional Chinese medicine composition and medicine for irritable bowel syndrome, and preparation method and application thereof - Google Patents

Traditional Chinese medicine composition and medicine for irritable bowel syndrome, and preparation method and application thereof Download PDF

Info

Publication number
CN114366795A
CN114366795A CN202011100290.9A CN202011100290A CN114366795A CN 114366795 A CN114366795 A CN 114366795A CN 202011100290 A CN202011100290 A CN 202011100290A CN 114366795 A CN114366795 A CN 114366795A
Authority
CN
China
Prior art keywords
traditional chinese
chinese medicine
bowel syndrome
irritable bowel
medicine composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202011100290.9A
Other languages
Chinese (zh)
Other versions
CN114366795B (en
Inventor
吴相君
常丽萍
王靖霞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shijiazhuang Yiling Pharmaceutical Co Ltd
Original Assignee
Shijiazhuang Yiling Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shijiazhuang Yiling Pharmaceutical Co Ltd filed Critical Shijiazhuang Yiling Pharmaceutical Co Ltd
Priority to CN202011100290.9A priority Critical patent/CN114366795B/en
Publication of CN114366795A publication Critical patent/CN114366795A/en
Application granted granted Critical
Publication of CN114366795B publication Critical patent/CN114366795B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/732—Chaenomeles, e.g. flowering quince
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/754—Evodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for irritable bowel syndrome, a medicine, a preparation method and application. The traditional Chinese medicine composition comprises qi-tonifying and spleen-tonifying traditional Chinese medicines, dampness-eliminating and spleen-tonifying traditional Chinese medicines, liver-softening and pain-relieving traditional Chinese medicines, liver-regulating and spleen-soothing traditional Chinese medicines, liver-soothing and depression-relieving traditional Chinese medicines, middle-jiao-warming and pain-relieving traditional Chinese medicines, blood-cooling and dysentery-relieving traditional Chinese medicines, stagnation-removing and stasis-removing traditional Chinese medicines and acute pain-relieving traditional Chinese medicines, can correct intestinal motility dysfunction, has a good effect of improving clinical symptoms of irritable bowel syndrome, and has a remarkable treatment effect. The composition can be made into medicine for treating diarrhea type irritable bowel syndrome.

Description

Traditional Chinese medicine composition and medicine for irritable bowel syndrome, and preparation method and application thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for irritable bowel syndrome, a medicine, a preparation method and application.
Background
Irritable Bowel Syndrome (IBS) is a common bio-psycho-social disorder, and is a disorder of gastrointestinal dysfunction. The pathogenic factors of the traditional Chinese medicine are complex and comprise genetic factors, mental factors, dietary factors, infection factors and the like. According to the characteristics of the stool, IBS is divided into four clinical types of diarrhea type, constipation type, mixed type and indeterminate type, and IBS patients in China are more common in diarrhea IBS.
The diarrhea-predominant irritable bowel syndrome is clinically manifested by persistent or intermittent diarrhea, but the diarrhea-predominant irritable bowel syndrome lacks exact basis such as morphological and laboratory abnormal changes and can occur in various states such as emotional stress, staying up night, dietary stimulation and the like. Any slight stimulation in the onset period may cause obvious clinical symptoms, which seriously affect the quality of life of the affected people.
At present, the treatment method for diarrhea-predominant irritable bowel syndrome is mainly symptomatic diarrhea checking, but the antidiarrheal drug only has temporary effect, short action time and poor treatment effect, and the antidiarrheal drug can aggravate the functional disorder of intestinal peristalsis if not used properly.
Disclosure of Invention
Aiming at the technical problems that the existing antidiarrheal medicines for diarrhea-predominant irritable bowel syndrome have poor treatment effect and are likely to aggravate functional disorder of intestinal peristalsis, the invention provides a traditional Chinese medicine composition and a medicine for treating the irritable bowel syndrome, and a preparation method and application thereof.
In order to achieve the purpose of the invention, the embodiment of the invention adopts the following technical scheme:
on one hand, the embodiment of the invention provides a traditional Chinese medicine composition for irritable bowel syndrome, which comprises the following traditional Chinese medicines in parts by weight: 15-20 parts of qi-tonifying and spleen-tonifying traditional Chinese medicine, 15-20 parts of dampness-eliminating and spleen-tonifying traditional Chinese medicine, 20-30 parts of liver-softening and pain-relieving traditional Chinese medicine, 7-12 parts of liver-regulating and spleen-soothing traditional Chinese medicine, 10-15 parts of liver-soothing and depression-relieving traditional Chinese medicine, 4-8 parts of middle-warming and pain-relieving traditional Chinese medicine, 10-15 parts of blood-cooling and dysentery-stopping traditional Chinese medicine, 10-15 parts of stagnation-removing and stagnation-removing traditional Chinese medicine and 4-8 parts of acute pain-relieving traditional Chinese medicine.
The invention takes the traditional Chinese medicines for tonifying qi and spleen as monarch medicines, benefits primordial qi and strengthens spleen and stomach; traditional Chinese medicines with dampness eliminating and spleen strengthening functions are used as ministerial medicines, the spleen strengthening function is achieved by dispelling wood, and the dampness eliminating function is achieved by stopping diarrhea; the traditional Chinese medicines for softening liver and relieving pain relieve abdominal spasm and pain, the traditional Chinese medicines for regulating liver and dispersing spleen enable liver qi to reach the state of no longer riding spleen, the traditional Chinese medicines for eliminating dampness and strengthening spleen have the effect of eliminating dampness and relieving diarrhea, the traditional Chinese medicines for soothing liver and relieving depression reach liver qi, and the traditional Chinese medicines for relieving emotion are taken as adjuvant medicines together with the traditional Chinese medicines for warming middle-jiao and relieving pain, the traditional Chinese medicines for cooling blood and stopping dysentery and the traditional Chinese medicines for removing food retention and removing food stagnation; uses the traditional Chinese medicines with the functions of relieving spasm and pain as guiding medicines. The whole formula is prepared by the compatibility of the traditional Chinese medicines with the functions through monarch, minister, assistant and guide, and the obtained traditional Chinese medicine composition can correct the functional disorder of intestinal peristalsis, has good effect of improving the clinical symptoms of diarrhea-type irritable bowel syndrome, and can avoid relapse.
In the practical use of the traditional Chinese medicine, 1g of the traditional Chinese medicine is used as each dose, and 1-2 doses are used every day according to the state of illness.
Preferably, the qi-tonifying and spleen-invigorating traditional Chinese medicine is at least one selected from codonopsis pilosula, radix pseudostellariae, astragalus membranaceus, ginseng, dioscorea opposita thumb, Chinese date and poria cocos, and further preferably at least one selected from codonopsis pilosula, astragalus membranaceus, ginseng and poria cocos.
Preferably, the traditional Chinese medicine for drying dampness and strengthening spleen is selected from at least one of coix seed, polyporus umbellatus, rhizoma alismatis, fried rhizoma atractylodis macrocephalae, fructus amomi, pawpaw, dried orange peel, areca peel and cortex mori radicis, and further preferably at least one of coix seed, polyporus umbellatus, fried rhizoma atractylodis macrocephalae and pawpaw.
Preferably, the liver-softening pain-relieving traditional Chinese medicine is selected from at least one of angelica sinensis, ligusticum wallichii, fructus evodiae, fried white paeony root and fructus toosendan, and further preferably at least one of ligusticum wallichii, fructus evodiae and fried white paeony root;
the liver-regulating and spleen-soothing traditional Chinese medicine is selected from at least one of divaricate saposhnikovia root, costustoot and green tangerine orange peel, and is further preferably selected from at least one of divaricate saposhnikovia root and green tangerine orange peel;
the traditional Chinese medicine for soothing liver-qi stagnation is selected from at least one of radix curcumae, rhizoma cyperi, radix bupleuri, akebia seed and fingered citron, and further preferably at least one of radix curcumae, rhizoma cyperi and radix bupleuri;
the middle-warmer warming and pain relieving traditional Chinese medicine is selected from at least one of perilla, baked ginger, galangal and pepper, and is further preferably selected from at least one of baked ginger and galangal;
the traditional Chinese medicine for cooling blood and stopping dysentery is at least one selected from eclipta, purslane, Chinese pulsatilla root, indigo naturalis and brucea javanica, and at least one selected from eclipta, purslane and Chinese pulsatilla root is further preferably adopted;
the traditional Chinese medicine for removing food stagnation is selected from at least one of fructus Aurantii, endothelium corneum Gigeriae Galli, rhizoma Zingiberis recens, parched Raphani semen, fructus crataegi preparata, fructus Hordei Germinatus, parched Massa Medicata Fermentata, herba Agastaches, semen Alpiniae Katsumadai and semen Myristicae, and preferably at least one of fructus Aurantii, rhizoma Zingiberis recens, parched Raphani semen and semen Myristicae;
the traditional Chinese medicine for relieving spasm and pain is selected from at least one of trogopterus dung, honey-fried licorice root and turmeric, and further preferably at least one of honey-fried licorice root and turmeric.
In a second aspect, the embodiment of the present invention also provides a preparation method of the above traditional Chinese medicine composition for irritable bowel syndrome, which includes the following operations: weighing the traditional Chinese medicines according to the weight part ratio in the traditional Chinese medicine composition for irritable bowel syndrome, mixing, decocting with water for extraction, filtering, and collecting the obtained filtrate.
In a third aspect, an embodiment of the present invention further provides another preparation method of the above traditional Chinese medicine composition for irritable bowel syndrome, including the following operations: weighing the traditional Chinese medicines according to the weight part ratio in the traditional Chinese medicine composition for irritable bowel syndrome, respectively decocting and extracting the traditional Chinese medicines with water, filtering, collecting obtained filtrate, and mixing.
According to the actual needs of clinical use, the filtrates obtained by the two preparation methods can be further concentrated, dried and the like, and then processed into oral dosage forms such as syrup, oral liquid, powder, granules, capsules, tablets, big honeyed pills and the like.
In a fourth aspect, the embodiment of the invention also provides application of the traditional Chinese medicine composition for treating irritable bowel syndrome in preparation of a medicine for treating diarrhea-predominant irritable bowel syndrome.
In a fifth aspect, the embodiment of the present invention further provides a medicament for treating diarrhea-predominant irritable bowel syndrome, wherein the medicament comprises the above traditional Chinese medicine composition for treating irritable bowel syndrome.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. The experimental procedures used in the following examples are all conventional in the art unless otherwise specified.
The codonopsis pilosula, the heterophylly falsestarwort root, the astragalus root, the ginseng, the Chinese yam, the Chinese date, the poria cocos, the coix seed, the polyporus umbellatus, the rhizoma alismatis, the fried bighead atractylodes rhizome, the fructus amomi, the pawpaw, the dried orange peel, the areca peel, the white mulberry root-bark, the Chinese angelica, the ligusticum wallichii, the fructus evodiae, the fried white peony root, the toosendan fruit, the ledebouriella root, the elecampane, the green tangerine peel, the radix curcumae, the rhizoma cyperi, the radix bupleuri, the akebia stem seed, the fingered citron, the perilla, the baked ginger, the galangal, the pepper, the eclipta, the purslane, the Chinese pulsatilla root, the indigo naturalis, the brucea javanica, the fructus aurantii, the endothelium corneum gigeriae galli, the ginger, the fried radish seed, the scorched hawthorn fruit, the malt, the fried medicated leaven, the wrinkled gianthyssop, the katsumada, the nutmeg, the trogopterus dung, the radix glycyrrhizae and the turmeric all accord with relevant regulations under the item of each medicinal material in the pharmacopoeia of China (2015 edition).
The raw materials, reagents and the like used in the following examples were obtained commercially unless otherwise specified.
Example 1
The embodiment of the invention provides a traditional Chinese medicine composition for irritable bowel syndrome, and each traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
18g of codonopsis pilosula, 5g of grifola, 10g of rhizoma alismatis, 10g of angelica sinensis, 20g of ligusticum wallichii, 12g of pericarpium citri reticulatae viride, 15g of radix curcumae, 4g of perilla, 15g of herba ecliptae, 15g of ginger and 8g of trogopterus dung.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting in water for 2 times, each for 20min, filtering, mixing filtrates, concentrating, and drying.
Example 2
The embodiment of the invention provides a traditional Chinese medicine composition for irritable bowel syndrome, and each traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
15g of radix pseudostellariae, 20g of semen coicis, 25g of fructus evodiae, 7g of elecampane, 10g of rhizoma cyperi, 8g of galangal, 10g of Chinese pulsatilla root, 12g of endothelium corneum gigeriae galli and 8g of turmeric.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting in water for 2 times, each for 20min, filtering, mixing filtrates, concentrating, and drying.
Example 3
The embodiment of the invention provides a traditional Chinese medicine composition for irritable bowel syndrome, and each traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
18g of astragalus, 18g of fried bighead atractylodes rhizome, 25g of fructus evodiae, 12g of green tangerine peel, 10g of rhizoma cyperi, 8g of galangal, 15g of eclipta, 5g of ginger, 5g of fried radish seed and 8g of turmeric.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting in water for 2 times, each for 20min, filtering, mixing filtrates, concentrating, and drying.
Example 4
The embodiment of the invention provides a traditional Chinese medicine composition for irritable bowel syndrome, and each traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
10g of codonopsis pilosula, 5g of ginseng, 18g of fried bighead atractylodes rhizome, 24g of fried white paeony root, 9g of divaricate saposhnikovia root, 12g of radix bupleuri, 6g of baked ginger, 12g of purslane, 12g of fructus aurantii and 6g of honey-fried licorice root.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting in water for 2 times, each for 20min, filtering, mixing filtrates, concentrating, and drying.
Example 5
The embodiment of the invention provides a traditional Chinese medicine composition for irritable bowel syndrome, and each traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
12g of codonopsis pilosula, 6g of poria cocos, 18g of fried bighead atractylodes rhizome, 24g of fried white paeony root, 9g of divaricate saposhnikovia root, 12g of radix bupleuri, 6g of baked ginger, 12g of purslane, 12g of fructus aurantii and 6g of honey-fried licorice root.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting in water for 2 times, each for 20min, filtering, mixing filtrates, concentrating, and drying.
Example 6
The embodiment of the invention provides a traditional Chinese medicine composition for irritable bowel syndrome, and each traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
18g of astragalus, 18g of fried bighead atractylodes rhizome, 24g of fried white peony root, 9g of divaricate saposhnikovia root, 12g of radix bupleuri, 6g of baked ginger, 12g of purslane, 12g of fructus aurantii and 6g of honey-fried licorice root.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting in water for 2 times, each for 20min, filtering, mixing filtrates, concentrating, and drying.
Example 7
The embodiment of the invention provides a traditional Chinese medicine composition for irritable bowel syndrome, and each traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
8g of codonopsis pilosula, 10g of astragalus membranaceus, 10g of polyporus umbellatus, 8g of fried bighead atractylodes rhizome, 24g of fried white peony root, 9g of divaricate saposhnikovia root, 12g of radix bupleuri, 6g of baked ginger, 12g of purslane, 12g of fructus aurantii and 6g of honey-fried licorice root.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting in water for 2 times, each for 20min, filtering, mixing filtrates, concentrating, and drying.
Example 8
The embodiment of the invention provides a traditional Chinese medicine composition for irritable bowel syndrome, and each traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
18g of astragalus, 18g of fried bighead atractylodes rhizome, 18g of evodia, 24g of fried white peony root, 6g of divaricate saposhnikovia root, 4g of green tangerine peel, 12g of radix bupleuri, 6g of baked ginger, 12g of purslane, 5g of fructus aurantii, 10g of fried radish seed, 2g of honey-fried licorice root and 2g of turmeric.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting in water for 2 times, each for 20min, filtering, mixing filtrates, concentrating, and drying.
Example 9
The embodiment of the invention provides a traditional Chinese medicine composition for irritable bowel syndrome, and each traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
18g of astragalus, 18g of fried bighead atractylodes rhizome, 10g of ligusticum wallichii, 10g of fructus evodiae, 12g of green tangerine peel, 5g of rhizoma cyperi, 7g of radix curcumae, 8g of galangal, 10g of Chinese pulsatilla root, 12g of ginger and 6g of honey-fried licorice root.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting in water for 2 times, each for 20min, filtering, mixing filtrates, concentrating, and drying.
Example 10
The embodiment of the invention provides a traditional Chinese medicine composition for irritable bowel syndrome, and each traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
10g of codonopsis pilosula, 10g of poria cocos, 10g of polyporus umbellatus, 8g of pawpaw, 24g of fried white peony root, 9g of divaricate saposhnikovia root, 12g of radix bupleuri, 6g of baked ginger, 12g of purslane, 12g of fructus aurantii and 6g of honey-fried licorice root.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting in water for 2 times, each for 20min, filtering, mixing filtrates, concentrating, and drying.
Effect example 1
The effect example provides the effect of the traditional Chinese medicine composition for irritable bowel syndrome on diarrhea-predominant irritable bowel syndrome in mice.
1. Material
1.1 animals
ICR mice, male, body weight at the start of the experiment: 18-23 g. Purchased from Beijing Weitonglihua laboratory animal technology Co., Ltd, license number: SCXK (Kyoto) 2016-.
1.2 medicine
The Chinese medicinal composition for irritable bowel syndrome obtained in examples 1 to 10.
The clinical dose of the adult is 1.95g crude drug/kg calculated according to the body weight of 60 kg.
1.3 feed
The SPF-level rat maintenance feed is provided by Australian cooperative feed limited company of Beijing Ke, and the license number of the feed production is Kyoho feed (2018) 06073. Drinking clean water through the ROA50 experimental animal drinking system every day, filling the drinking bottle for animals to drink freely, flushing the drinking bottle every day and changing water once, and changing the water bottle and the water nozzle 2 times every week.
2. Method of producing a composite material
2.1 grouping and administration of Experimental animals
Animals were randomly divided into 12 groups, i.e., normal group, model group, and examples 1-10 groups. The dose administered in each of the groups of examples 1 to 10 was 19.5g crude drug/kg (ICR mouse clinical equivalent dose was about 10 times the adult clinical dose). The administration volume of each group is 1ml/100g body weight, and the administration is performed by intragastric administration every day for 7 days.
2.2 Experimental animal modeling method
And (3) performing intragastric administration on the 8% senna leaf powder according to the dose of 1g crude drug/kg to establish an animal model of diarrhea-predominant irritable bowel syndrome.
2.3 Experimental procedures
Newly received experimental animals, numbered, adaptively raised for 5 days, and randomly divided into the above 12 groups according to body weight. After the quarantine is completed, the administration is started, the traditional Chinese medicine composition for irritable bowel syndrome obtained in examples 1 to 10 is respectively administered to groups of examples 1 to 10 by intragastric administration every day, and deionized water with the same volume is administered to a normal group and a model group 1 time a day for 7 days continuously. After 30min of the last administration, the model group and the mice of the groups of the examples 1 to 10 were administered 8% senna powder by gavage at a dose of 1g crude drug/kg, and the normal group was administered deionized water of the same volume. The mice in each group were observed for loose stool rate, loose stool grade, and diarrhea index over 6 h.
2.4 statistical analysis
Performing One-Way ANOVA (One-Way ANOVA) by using SPSS 22.0 statistical software, firstly performing homogeneous variance test by using Leven's, performing homogeneous variance test (P > 0.05), and performing comparative test between groups by using Dunnett t test; if the variance is not uniform (P.ltoreq.0.05), a comparison test between groups is carried out with Dunnett T3. All statistical tests were two-sided t-tests with significance levels set at 0.05 and 0.01.
3. Results
Compared with the model group, the mice of the examples 1-10 groups have obviously reduced index of loose stool rate, level of loose stool and diarrhea (P<0.05) as shown in table 1.
Figure 232475DEST_PATH_IMAGE001
4. Conclusion
The traditional Chinese medicine composition for treating irritable bowel syndrome provided by the invention can effectively improve diarrhea-type irritable bowel syndrome of an ICR mouse.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents or improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (10)

1. The traditional Chinese medicine composition for irritable bowel syndrome is characterized by comprising the following traditional Chinese medicines in parts by weight: 15-20 parts of qi-tonifying and spleen-tonifying traditional Chinese medicine, 15-20 parts of dampness-eliminating and spleen-tonifying traditional Chinese medicine, 20-30 parts of liver-softening and pain-relieving traditional Chinese medicine, 7-12 parts of liver-regulating and spleen-soothing traditional Chinese medicine, 10-15 parts of liver-soothing and depression-relieving traditional Chinese medicine, 4-8 parts of middle-warming and pain-relieving traditional Chinese medicine, 10-15 parts of blood-cooling and dysentery-stopping traditional Chinese medicine, 10-15 parts of stagnation-removing and stagnation-removing traditional Chinese medicine and 4-8 parts of acute pain-relieving traditional Chinese medicine.
2. The traditional Chinese medicine composition for irritable bowel syndrome according to claim 1, wherein the qi and spleen invigorating herbs are at least one selected from the group consisting of codonopsis pilosula, pseudostellaria root, astragalus root, ginseng, dioscorea opposita thunb, jujube and poria cocos.
3. The traditional Chinese medicine composition for irritable bowel syndrome according to claim 2, wherein the qi and spleen invigorating class of traditional Chinese medicines is selected from at least one of codonopsis pilosula, astragalus membranaceus, ginseng and poria cocos.
4. The traditional Chinese medicine composition for irritable bowel syndrome according to claim 1, wherein the dampness-drying and spleen-invigorating herbs are at least one selected from the group consisting of coix seed, polyporus umbellatus, alisma orientale, white atractylodes rhizome, amomum villosum, chaenomeles sinensis, dried orange peel, areca peel and white mulberry root-bark.
5. The traditional Chinese medicine composition for irritable bowel syndrome according to claim 4, wherein the dampness-drying and spleen-invigorating herbs are at least one selected from coix seeds, polyporus umbellatus, roasted white atractylodes rhizome and pawpaw.
6. The composition of claim 1, wherein the liver-soothing and pain-relieving herbs are selected from at least one of Dang Gui, Chuan Xiong, Wu Zhu Yu, Shi Zhu, Bai Shao and Chuan Lian Zi; and/or the liver-regulating and spleen-soothing traditional Chinese medicine is selected from at least one of divaricate saposhnikovia root, costustoot and green tangerine orange peel; and/or the traditional Chinese medicine for soothing liver-qi stagnation is selected from at least one of radix curcumae, rhizoma cyperi, radix bupleuri, akebia seed and fingered citron; and/or the middle-warmer warming and pain relieving Chinese medicinal materials are selected from at least one of Perillae herba, rhizoma Zingiberis Preparata, rhizoma Alpiniae Officinarum and fructus Zanthoxyli; and/or the blood-cooling dysentery-stopping traditional Chinese medicine is selected from at least one of eclipta, purslane, pulsatilla root, indigo naturalis and brucea javanica; and/or the traditional Chinese medicines with effects of resolving food stagnation and removing food stagnation are selected from at least one of fructus Aurantii, endothelium corneum Gigeriae Galli, rhizoma Zingiberis recens, parched Raphani semen, fructus crataegi preparata, fructus Hordei Germinatus, parched Massa Medicata Fermentata, herba Agastaches, semen Alpiniae and semen Myristicae; and/or the traditional Chinese medicine for relieving spasm and pain is selected from at least one of trogopterus dung, honey-fried licorice root and turmeric.
7. The method for preparing a traditional Chinese medicine composition for irritable bowel syndrome according to any one of claims 1 to 6, comprising the following steps: weighing the traditional Chinese medicines according to the weight part ratio in the traditional Chinese medicine composition for irritable bowel syndrome, mixing, decocting with water for extraction, filtering, and collecting the obtained filtrate.
8. The method of preparing the traditional Chinese medicine composition for irritable bowel syndrome according to any one of claims 1 to 6, comprising the following operations: weighing the traditional Chinese medicines according to the weight part ratio in the traditional Chinese medicine composition for irritable bowel syndrome, respectively decocting and extracting the traditional Chinese medicines with water, filtering, collecting obtained filtrate, and mixing.
9. Use of the Chinese medicinal composition for irritable bowel syndrome according to any one of claims 1 to 6 for the preparation of a medicament for treating diarrhea-predominant irritable bowel syndrome.
10. A medicament for treating diarrhea-predominant irritable bowel syndrome, which comprises the Chinese medicinal composition for treating the diarrhea-predominant irritable bowel syndrome according to any one of claims 1 to 6.
CN202011100290.9A 2020-10-15 2020-10-15 Traditional Chinese medicine composition and medicine for irritable bowel syndrome and preparation method and application thereof Active CN114366795B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011100290.9A CN114366795B (en) 2020-10-15 2020-10-15 Traditional Chinese medicine composition and medicine for irritable bowel syndrome and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202011100290.9A CN114366795B (en) 2020-10-15 2020-10-15 Traditional Chinese medicine composition and medicine for irritable bowel syndrome and preparation method and application thereof

Publications (2)

Publication Number Publication Date
CN114366795A true CN114366795A (en) 2022-04-19
CN114366795B CN114366795B (en) 2024-06-11

Family

ID=81138689

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202011100290.9A Active CN114366795B (en) 2020-10-15 2020-10-15 Traditional Chinese medicine composition and medicine for irritable bowel syndrome and preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN114366795B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118634292A (en) * 2024-08-15 2024-09-13 江中药业股份有限公司 Application of stomach-invigorating digestion-promoting tablet in preparing medicine for treating irritable bowel syndrome

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103751357A (en) * 2014-01-16 2014-04-30 于炳好 Traditional Chinese medicine composition for treating spleen-deficiency-type colonitis
CN103845702A (en) * 2012-12-05 2014-06-11 中国中医科学院西苑医院 Traditional Chinese medicinal composition for treating irritable bowel syndrome and preparation method of composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103845702A (en) * 2012-12-05 2014-06-11 中国中医科学院西苑医院 Traditional Chinese medicinal composition for treating irritable bowel syndrome and preparation method of composition
CN103751357A (en) * 2014-01-16 2014-04-30 于炳好 Traditional Chinese medicine composition for treating spleen-deficiency-type colonitis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
黄霖颖: "痛泻要方加减联合思密达治疗腹泻型肠易激综合征临床疗效的随机对照观察", 《中国医药指南》, vol. 12, no. 3, 30 January 2014 (2014-01-30), pages 173 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118634292A (en) * 2024-08-15 2024-09-13 江中药业股份有限公司 Application of stomach-invigorating digestion-promoting tablet in preparing medicine for treating irritable bowel syndrome

Also Published As

Publication number Publication date
CN114366795B (en) 2024-06-11

Similar Documents

Publication Publication Date Title
CN102416139B (en) Chinese medicine composition for treating breast diseases
CN101254261B (en) Pharmaceutical combination with hypnogenesis, depression resistance and angst resistance effect and method of preparing the same
CN102846866A (en) Chinese medicine composition for prevention and control of porcine circovirus disease and preparation method thereof
CN1679913A (en) Gynecologic rehabilitation capsules for treating gynecopathy
CN102961497A (en) Chinese herbal compound prescription used for treating chronic diarrhea
CN104984297A (en) Application of pharmaceutical composition in preparation of drugs for treating amenorrhea
CN104338044A (en) Drug for treating gynecological abnormal leucorrhea and preparation method thereof
CN104027517A (en) Traditional Chinese medicine for treating acute enteritis
CN102293900A (en) Chinese medicine for treating infantile diarrhea
CN103800795A (en) Traditional Chinese medicine for treating gastric ulcer
CN103495019B (en) A kind of tranquilizing by nourishing the heart Chinese medicine preparation and preparation method thereof
CN102188682B (en) Chinese medicinal composition for treating biliary calculus and preparation method thereof
CN114366795B (en) Traditional Chinese medicine composition and medicine for irritable bowel syndrome and preparation method and application thereof
CN104435246A (en) Compound pomegranate bark dampness-excreting diarrhea-checking tablets and preparation method
CN110742980B (en) Traditional Chinese medicine composition for treating irritable bowel syndrome and preparation method and application thereof
CN106237263A (en) A kind of treat acute icterohepatitis and Chinese medicine composition that chronic hepatitis acute onset raises with bilirubin
CN105412424A (en) Pharmaceutical preparation containing argy wormwood leaves and having bowel relaxing function as well as preparation method of pharmaceutical preparation
CN102488851B (en) Drug for treating recurrent genital herpes and preparation method thereof
CN105727089A (en) Application of medicine composition containing folium artemisiae argyi to preparing medicine for treating irritable bowel syndrome
CN111407860A (en) A Chinese medicinal composition for treating dementia and preparation method thereof
CN104435079A (en) Traditional Chinese medicinal composition for treating gout
CN109364213A (en) A kind of herbal mixture for treating liver fibrosis
CN1195541C (en) Medicine combination for treating chronic hepatitis B
CN103070337A (en) Defaecation-promoting health-care food and preparation method thereof
CN110051770B (en) Compound Chinese herbal medicine immunopotentiator for treating weak piglets and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant