CN114366795B - Traditional Chinese medicine composition and medicine for irritable bowel syndrome and preparation method and application thereof - Google Patents

Traditional Chinese medicine composition and medicine for irritable bowel syndrome and preparation method and application thereof Download PDF

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Publication number
CN114366795B
CN114366795B CN202011100290.9A CN202011100290A CN114366795B CN 114366795 B CN114366795 B CN 114366795B CN 202011100290 A CN202011100290 A CN 202011100290A CN 114366795 B CN114366795 B CN 114366795B
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China
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traditional chinese
chinese medicine
bowel syndrome
irritable bowel
chinese medicines
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CN114366795A (en
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吴相君
常丽萍
王靖霞
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Shijiazhuang Yiling Pharmaceutical Co Ltd
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Shijiazhuang Yiling Pharmaceutical Co Ltd
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Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for irritable bowel syndrome, a medicine, a preparation method and application. The traditional Chinese medicine composition comprises qi-tonifying spleen-strengthening traditional Chinese medicines, dampness-eliminating spleen-strengthening traditional Chinese medicines, liver-softening pain-relieving traditional Chinese medicines, liver-regulating spleen-regulating traditional Chinese medicines, liver-soothing and depression-relieving traditional Chinese medicines, middle-warming pain-relieving traditional Chinese medicines, blood-cooling dysentery-relieving traditional Chinese medicines, food retention-removing stagnation-eliminating traditional Chinese medicines and pain-relieving traditional Chinese medicines, can correct intestinal peristalsis dysfunction, has good effect of improving clinical symptoms of irritable bowel syndrome, and has remarkable treatment effect. The composition can be made into medicine for treating diarrhea type irritable bowel syndrome.

Description

Traditional Chinese medicine composition and medicine for irritable bowel syndrome and preparation method and application thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for irritable bowel syndrome, a medicine, a preparation method and application.
Background
Irritable Bowel Syndrome (IBS) is a common bio-psychological-social disorder, which is a gastrointestinal dysfunction disease. The pathogenic causes are complex, including genetic factors, mental factors, dietary factors, infectious factors and the like. IBS is classified into four clinical types of diarrhea type, constipation type, mixed type and amorphous type according to the characteristics of stool, and IBS patients in China are more frequently seen with diarrhea IBS.
The diarrhea type irritable bowel syndrome clinically manifests as continuous or intermittent diarrhea, but lacks definite basis of morphological and laboratory abnormal changes and the like, and can occur in various states such as emotional stress, stay up, dietary stimulation and the like. Any minor irritation during the period of onset may cause significant clinical symptoms, severely affecting the quality of life of the affected population.
The existing treatment method for diarrhea type irritable bowel syndrome mainly aims at symptomatic diarrhea, but antidiarrheal medicines only have temporary effects, have short acting time and poor treatment effect, and can aggravate intestinal motility dysfunction if being improperly used.
Disclosure of Invention
Aiming at the technical problems that the existing antidiarrheal medicine for diarrhea type irritable bowel syndrome has poor treatment effect and possibly aggravates intestinal peristalsis dysfunction, the invention provides a traditional Chinese medicine composition for diarrhea type irritable bowel syndrome, a medicine and a preparation method and application thereof.
In order to achieve the above purpose, the embodiment of the invention adopts the following technical scheme:
On one hand, the embodiment of the invention provides a traditional Chinese medicine composition for treating irritable bowel syndrome, which comprises the following traditional Chinese medicines in parts by weight: 15-20 parts of qi-tonifying spleen-strengthening traditional Chinese medicine, 15-20 parts of dampness-eliminating spleen-strengthening traditional Chinese medicine, 20-30 parts of liver-soothing pain-relieving traditional Chinese medicine, 7-12 parts of liver-regulating spleen-soothing liver-qi depression-relieving traditional Chinese medicine, 10-15 parts of middle-warming pain-relieving traditional Chinese medicine, 4-8 parts of blood-cooling dysentery-relieving traditional Chinese medicine, 10-15 parts of stagnation-removing traditional Chinese medicine and 4-8 parts of acute pain-relieving traditional Chinese medicine.
The invention takes qi-tonifying spleen-strengthening traditional Chinese medicines as monarch medicines, and has the effects of invigorating primordial qi and strengthening spleen and stomach; taking traditional Chinese medicines with the functions of eliminating dampness and strengthening spleen as ministerial medicines, strengthening spleen to prevent diarrhea by taking the wood as a guide, and eliminating dampness to stop diarrhea; the liver-softening and pain-relieving traditional Chinese medicine is used for relieving abdominal pain, the liver-regulating and spleen-smoothing traditional Chinese medicine is used for preventing liver qi from being taken by spleen, and the dampness-eliminating and spleen-invigorating traditional Chinese medicine is used for eliminating dampness and relieving diarrhea, the liver-soothing and depression-relieving traditional Chinese medicine is used for relieving emotion, and the liver-soothing and pain-relieving traditional Chinese medicine, the blood-cooling and diarrhea-relieving traditional Chinese medicine and the stagnation-removing traditional Chinese medicine are used together as adjuvant drugs; takes the traditional Chinese medicines of the group of slow-release pain-relieving medicines as guiding drugs. The whole formula is prepared by combining the traditional Chinese medicines with the functions through monarch, minister, assistant and guide, and the obtained traditional Chinese medicine composition can correct the intestinal motility dysfunction, has good effect of improving the clinical symptoms of diarrhea type irritable bowel syndrome, and can avoid recurrence.
In actual use, 1g of the medicine is used in an amount of 1-2 doses per day according to the illness state.
Preferably, the qi-tonifying spleen-invigorating traditional Chinese medicine is selected from at least one of radix codonopsis pilosulae, radix pseudostellariae, radix astragali, ginseng, chinese yam, chinese date and poria cocos, and more preferably at least one of radix codonopsis pilosulae, radix astragali, ginseng and poria cocos is adopted.
Preferably, the dampness-eliminating spleen-invigorating traditional Chinese medicine is selected from at least one of coix seed, polyporus, rhizoma alismatis, stir-fried rhizoma atractylodis macrocephalae, fructus amomi, pawpaw, dried orange peel, pericarpium arecae and cortex mori, and more preferably at least one of coix seed, polyporus, stir-fried rhizoma atractylodis macrocephalae and pawpaw is adopted.
Preferably, the liver softening and pain relieving traditional Chinese medicine is selected from at least one of angelica sinensis, ligusticum wallichii, evodia rutaecarpa, fried white paeony root and szechwan chinaberry fruit, and further preferably at least one of ligusticum wallichii, evodia rutaecarpa and fried white paeony root is adopted;
the liver-regulating spleen-soothing traditional Chinese medicine is at least one selected from radix sileris, radix aucklandiae and green tangerine peel, and at least one selected from radix sileris and green tangerine peel is further preferably adopted;
the liver-soothing and depression-relieving traditional Chinese medicine is at least one selected from radix curcumae, rhizoma cyperi, radix bupleuri, akebia stem and fingered citron, and at least one selected from radix curcumae, rhizoma cyperi and radix bupleuri is further preferably adopted;
the Chinese medicine for warming middle-jiao and relieving pain is selected from at least one of Perillae herba, rhizoma Zingiberis Preparatum, rhizoma Alpiniae Officinarum and fructus Zanthoxyli, and preferably at least one of rhizoma Zingiberis Preparatum and rhizoma Alpiniae Officinarum;
the blood cooling and dysentery stopping traditional Chinese medicine is selected from at least one of eclipta, purslane, pulsatilla chinensis, indigo naturalis and brucea javanica, and at least one of eclipta, purslane and pulsatilla chinensis is further preferably adopted;
The Chinese medicinal materials for resolving food stagnation and removing stagnation are selected from at least one of fructus Aurantii, endothelium corneum Gigeriae Galli, rhizoma Zingiberis recens, parched Raphani semen, fructus crataegi preparata, fructus Hordei Germinatus, parched Massa Medicata Fermentata, herba Agastaches, semen Alpiniae Katsumadai and semen Myristicae, and more preferably at least one of fructus Aurantii, rhizoma Zingiberis recens, parched Raphani semen and semen Myristicae;
the Chinese medicinal materials for relieving spasm and pain are selected from at least one of Oletum Trogopterori, radix Glycyrrhizae Preparata and Curcuma rhizome, and more preferably at least one of radix Glycyrrhizae Preparata and Curcuma rhizome.
In a second aspect, the embodiment of the invention also provides a preparation method of the traditional Chinese medicine composition for irritable bowel syndrome, which comprises the following operations: weighing the traditional Chinese medicines according to the weight part ratio in the traditional Chinese medicine composition for treating irritable bowel syndrome, mixing, decocting with water, extracting, filtering and collecting the obtained filtrate.
In a third aspect, the embodiment of the invention also provides a preparation method of the traditional Chinese medicine composition for treating irritable bowel syndrome, which comprises the following operations: weighing the traditional Chinese medicines according to the weight part ratio of the traditional Chinese medicine composition for treating irritable bowel syndrome, respectively decocting and extracting the traditional Chinese medicines with water, filtering the decoction, collecting the obtained filtrate, and mixing the obtained filtrate.
The filtrate obtained by the two preparation methods can be further concentrated, dried and the like according to the actual clinical requirements, and then is processed into oral dosage forms such as syrup, oral liquid, powder, granules, capsules, tablets, big honeyed pills and the like.
In a fourth aspect, the embodiment of the invention also provides an application of the traditional Chinese medicine composition for treating the irritable bowel syndrome in preparing a medicine for treating the diarrhea type irritable bowel syndrome.
In a fifth aspect, the embodiment of the invention also provides a medicament for treating diarrhea type irritable bowel syndrome, wherein the medicament comprises the traditional Chinese medicine composition for treating the irritable bowel syndrome.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention. The experimental methods used in the following examples are conventional in the art unless otherwise specified.
The radix codonopsis pilosulae, radix pseudostellariae, radix astragali, ginseng, chinese yam, jujube, poria cocos, coix seed, grifola, rhizoma alismatis, fried bighead atractylodes rhizome, fructus amomi, pawpaw, dried orange peel, areca peel, cortex mori radicis, angelica sinensis, ligusticum wallichii, fructus evodiae, fried white paeony root, szechwan chinaberry fruit, radix sileris, costustoot, green tangerine peel, radix curcumae, rhizoma cyperi, radix bupleuri, akebia stem, fingered citron, perilla, baked ginger, galangal, pricklyash peel, eclipta, purslane, pulsatilla chinensis, natural indigo, brucea javanica, fructus aurantii, chicken's gizzard-skin, ginger, fried radish seed, fried hawthorn fruit, malt, fried medicated leaven, wrinkled gianthyssop herb, katsumadai seed, nutmeg seed, trogopterus dung, honey-fried licorice root and turmeric all conform to the relevant rules under a part of the text of each medicinal material item of Chinese pharmacopoeia (2015).
The raw materials, reagents and the like used in the following examples were obtained from commercial sources unless otherwise specified.
Example 1
The embodiment of the invention provides a traditional Chinese medicine composition for treating irritable bowel syndrome, wherein each dose of the traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
18g of codonopsis pilosula, 5g of polyporus umbellatus, 10g of rhizoma alismatis, 10g of angelica sinensis, 20g of ligusticum wallichii, 12g of green tangerine peel, 15g of radix curcumae, 4g of perilla, 15g of eclipta alba, 15g of ginger and 8g of trogopterus dung.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting with water for 2 times, each time for 20min, filtering, mixing filtrates, concentrating the filtrate, and drying.
Example 2
The embodiment of the invention provides a traditional Chinese medicine composition for treating irritable bowel syndrome, wherein each dose of the traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
15g of radix pseudostellariae, 20g of coix seed, 25g of evodia rutaecarpa, 7g of elecampane, 10g of nutgrass galingale rhizome, 8g of galangal, 10g of Chinese pulsatilla root, 12g of chicken's gizzard-skin and 8g of turmeric.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting with water for 2 times, each time for 20min, filtering, mixing filtrates, concentrating the filtrate, and drying.
Example 3
The embodiment of the invention provides a traditional Chinese medicine composition for treating irritable bowel syndrome, wherein each dose of the traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
18g of astragalus, 18g of stir-fried bighead atractylodes rhizome, 25g of evodia rutaecarpa, 12g of green tangerine peel, 10g of nutgrass galingale rhizome, 8g of galangal, 15g of eclipta, 5g of ginger, 5g of stir-fried radish seed and 8g of turmeric.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting with water for 2 times, each time for 20min, filtering, mixing filtrates, concentrating the filtrate, and drying.
Example 4
The embodiment of the invention provides a traditional Chinese medicine composition for treating irritable bowel syndrome, wherein each dose of the traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
10g of radix codonopsis pilosulae, 5g of ginseng, 18g of stir-fried white atractylodes rhizome, 24g of stir-fried white peony root, 9g of divaricate saposhnikovia root, 12g of bupleurum, 6g of baked ginger, 12g of purslane, 12g of fructus aurantii and 6g of honey-fried licorice root.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting with water for 2 times, each time for 20min, filtering, mixing filtrates, concentrating the filtrate, and drying.
Example 5
The embodiment of the invention provides a traditional Chinese medicine composition for treating irritable bowel syndrome, wherein each dose of the traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
12g of codonopsis pilosula, 6g of poria cocos, 18g of fried bighead atractylodes rhizome, 24g of fried white peony root, 9g of divaricate saposhnikovia root, 12g of bupleurum, 6g of baked ginger, 12g of purslane, 12g of fructus aurantii and 6g of honey-fried licorice root.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting with water for 2 times, each time for 20min, filtering, mixing filtrates, concentrating the filtrate, and drying.
Example 6
The embodiment of the invention provides a traditional Chinese medicine composition for treating irritable bowel syndrome, wherein each dose of the traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
18g of astragalus, 18g of stir-fried bighead atractylodes rhizome, 24g of stir-fried white paeony root, 9g of divaricate saposhnikovia root, 12g of Chinese thorowax root, 6g of baked ginger, 12g of purslane, 12g of fructus aurantii and 6g of honey-fried liquorice.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting with water for 2 times, each time for 20min, filtering, mixing filtrates, concentrating the filtrate, and drying.
Example 7
The embodiment of the invention provides a traditional Chinese medicine composition for treating irritable bowel syndrome, wherein each dose of the traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
8g of codonopsis pilosula, 10g of astragalus, 10g of Polyporus, 8g of fried bighead atractylodes rhizome, 24g of fried white peony root, 9g of divaricate saposhnikovia root, 12g of radix bupleuri, 6g of baked ginger, 12g of purslane, 12g of fructus aurantii and 6g of honey-fried licorice root.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting with water for 2 times, each time for 20min, filtering, mixing filtrates, concentrating the filtrate, and drying.
Example 8
The embodiment of the invention provides a traditional Chinese medicine composition for treating irritable bowel syndrome, wherein each dose of the traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
18g of astragalus, 18g of stir-fried bighead atractylodes rhizome, 24g of evodia rutaecarpa, 24g of stir-fried white peony root, 6g of divaricate saposhnikovia root and green tangerine peel, 12g of bupleurum, 6g of baked ginger, 12g of purslane, 5g of fructus aurantii, 10g of stir-fried radish seed, 2g of stir-fried liquorice and 2g of turmeric.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting with water for 2 times, each time for 20min, filtering, mixing filtrates, concentrating the filtrate, and drying.
Example 9
The embodiment of the invention provides a traditional Chinese medicine composition for treating irritable bowel syndrome, wherein each dose of the traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
18g of astragalus, 18g of stir-fried bighead atractylodes rhizome, 10g of szechuan lovage rhizome, 10g of evodia rutaecarpa, 12g of green tangerine peel, 5g of nutgrass galingale rhizome, 7g of turmeric, 8g of galangal, 10g of Chinese pulsatilla root, 12g of ginger and 6g of honey-fried licorice root.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting with water for 2 times, each time for 20min, filtering, mixing filtrates, concentrating the filtrate, and drying.
Example 10
The embodiment of the invention provides a traditional Chinese medicine composition for treating irritable bowel syndrome, wherein each dose of the traditional Chinese medicine composition comprises the following traditional Chinese medicines in parts by weight:
10g of codonopsis pilosula, 10g of poria cocos, 10g of Polyporus umbellatus, 8g of papaya, 24g of fried white peony root, 9g of radix sileris, 12g of radix bupleuri, 6g of baked ginger, 12g of purslane, 12g of fructus aurantii and 6g of honey-fried licorice root.
The preparation method comprises the following steps: weighing the above Chinese medicinal materials, mixing, decocting with water for 2 times, each time for 20min, filtering, mixing filtrates, concentrating the filtrate, and drying.
Effect example 1
The effect example provides the influence of the traditional Chinese medicine composition for treating the irritable bowel syndrome on the diarrhea type irritable bowel syndrome of the mice.
1. Material
1.1 Animals
ICR mice, male, body weight at the start of experiment: 18-23 g. Purchased from beijing vernalia laboratory animal technology limited, license number: SCXK (Beijing) 2016-0006.
1.2 Medicine
The traditional Chinese medicine composition for treating irritable bowel syndrome obtained in the examples 1-10.
The clinical dosage of the adult is 1.95g crude drug/kg calculated by 60kg of body weight.
1.3 Feed stuff
SPF-class rats maintained feed, supplied by Australian feed Co., beijing, feed production license number was Beijing feed (2018) 06073. The clean water of the ROA50 experimental animal drinking system is drunk daily, the drinking bottle is filled for animals to drink freely, the drinking bottle is washed and changed once daily, and the water bottle and the water nozzle are changed 2 times per week.
2. Method of
2.1 Grouping and administration of laboratory animals
Animals were randomly divided into 12 groups, namely, normal group, model group, and examples 1-10. The dose of the group of examples 1 to 10 was 19.5g crude drug/kg (ICR mice had a clinical equivalent dose of about 10 times the clinical dose of adults). Each group had a dosage volume of 1ml/100g body weight and was administered by intragastric administration daily for 7 consecutive days.
2.2 Experimental animal modeling method
8% Senna leaf powder is administrated by lavage according to the dosage of 1g crude drug/kg, and an animal model of diarrhea type irritable bowel syndrome is established.
2.3 Experimental procedure
The newly received experimental animals are numbered and adaptively fed for 5 days, and are randomly divided into the above 12 groups according to the weight. Administration is started after quarantine is completed, the traditional Chinese medicine composition for irritable bowel syndrome obtained in the examples 1-10 is respectively administered by stomach irrigation in the examples 1-10 each day, deionized water with the same volume is administered in the normal group and the model group, and the administration is carried out 1 time each day for 7 continuous days. After the last administration for 30min, 8% senna powder was administered by gavage to the model group and the mice of examples 1 to 10 according to the dose of 1g crude drug/kg, and the same volume of deionized water was administered to the normal group. The rare rate, rare grade and diarrhea index of each group of mice were observed within 6 hours.
2.4 Statistical analysis
Single factor analysis of variance (One-Way ANOVA) was performed using SPSS 22.0 statistical software, first with level's for variance alignment (P > 0.05), with Dunnett t test for group comparison test; if the variance is not uniform (P.ltoreq.0.05), then the inter-group comparison test is performed with Dunnett T3. All statistical tests were double-sided t-test, with significance levels set at 0.05 and 0.01.
3. Results
The rare rate, rare grade and diarrhea index were significantly reduced (P < 0.05) in the mice of examples 1-10 as compared to the model group, as shown in table 1.
4. Conclusion(s)
The traditional Chinese medicine composition for treating the irritable bowel syndrome can effectively improve the diarrhea type irritable bowel syndrome of ICR mice.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, or alternatives falling within the spirit and principles of the invention.

Claims (2)

1. The traditional Chinese medicine composition for treating diarrhea type irritable bowel syndrome is characterized by comprising the following raw materials in parts by weight: 18g of astragalus, 18g of stir-fried bighead atractylodes rhizome, 10g of szechuan lovage rhizome, 10g of evodia rutaecarpa, 12g of green tangerine peel, 5g of nutgrass galingale rhizome, 7g of turmeric root-tuber, 8g of galangal, 10g of Chinese pulsatilla root, 12g of ginger and 6g of honey-fried licorice root.
2. The method for preparing a traditional Chinese medicine composition for diarrhea type irritable bowel syndrome according to claim 1, comprising the following operations: weighing the above Chinese medicinal materials, mixing, decocting with water for 2 times, each time for 20min, filtering, mixing filtrates, concentrating the filtrate, and drying.
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