CN114364969A - Phantom and fluorescence detection device - Google Patents
Phantom and fluorescence detection device Download PDFInfo
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- CN114364969A CN114364969A CN202080061148.XA CN202080061148A CN114364969A CN 114364969 A CN114364969 A CN 114364969A CN 202080061148 A CN202080061148 A CN 202080061148A CN 114364969 A CN114364969 A CN 114364969A
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- 238000001917 fluorescence detection Methods 0.000 title claims abstract description 48
- 230000005284 excitation Effects 0.000 claims abstract description 112
- 230000004044 response Effects 0.000 claims abstract description 91
- 238000006243 chemical reaction Methods 0.000 claims abstract description 29
- 239000000463 material Substances 0.000 claims abstract description 10
- 238000009792 diffusion process Methods 0.000 claims description 6
- 230000006866 deterioration Effects 0.000 abstract description 4
- 238000012986 modification Methods 0.000 description 35
- 230000004048 modification Effects 0.000 description 35
- 238000010586 diagram Methods 0.000 description 26
- 230000003287 optical effect Effects 0.000 description 14
- 239000000126 substance Substances 0.000 description 11
- 238000012937 correction Methods 0.000 description 10
- 230000009467 reduction Effects 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 7
- 230000035945 sensitivity Effects 0.000 description 7
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 4
- 229960004657 indocyanine green Drugs 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 3
- 239000007850 fluorescent dye Substances 0.000 description 3
- QUCHWTCTBHQQDU-UHFFFAOYSA-N 2-amino-4-oxopentanoic acid Chemical class CC(=O)CC([NH3+])C([O-])=O QUCHWTCTBHQQDU-UHFFFAOYSA-N 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 210000005005 sentinel lymph node Anatomy 0.000 description 2
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 description 1
- 229940043215 aminolevulinate Drugs 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6434—Optrodes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/127—Calibration; base line adjustment; drift compensation
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Abstract
The present invention is less susceptible to deterioration with age when a device for obtaining fluorescence is tested. The phantom (1) is provided with an electric signal output unit (2) that receives excitation light and outputs an electric signal corresponding to the intensity of the excitation light, and a response light generation unit (4) that receives an electric signal (current signal I) and generates response light corresponding to the electric signal. The wavelength of the response light is equal to the wavelength of fluorescence generated when the fluorescent material receives the excitation light emitted from the fluorescence detection device 8. The electric signal output unit (2) has a photosensor (photodiode) (24), and the response light generation unit (4) has: a voltage conversion unit (42) that converts an electrical signal (current signal I) into a voltage signal (V); a drive circuit (44) that drives the electronic circuit element (26) based on the voltage signal (V); and an electronic circuit element (LED) (26).
Description
Technical Field
The present invention relates to testing of devices for obtaining fluorescence.
Background
Conventionally, a fluorescent phantom (phantom) containing a fluorescent dye is known (see the abstract of patent document 1). Calibration of fluorescence measuring apparatuses is also known (see patent documents 2 to 5).
Documents of the prior art
Patent document
Patent document 1: japanese patent laid-open publication No. 2013-96920
Patent document 2: japanese Kokai publication No. 2009-540327
Patent document 3: japanese laid-open patent publication No. 2007-212478
Patent document 4: japanese patent laid-open publication No. 2016-29401
Patent document 5: japanese patent application laid-open publication No. 2011-17721
Disclosure of Invention
Problems to be solved by the invention
However, according to the above-described conventional techniques, the fluorescent dye of the fluorescent phantom deteriorates with time.
Therefore, an object of the present invention is to provide a fluorescent substance that is less susceptible to deterioration with age when a device for obtaining fluorescent light is tested.
Means for solving the problems
The phantom according to the present invention includes: an electric signal output unit that receives the excitation light and outputs an electric signal corresponding to the intensity of the excitation light; and a response light generating unit that receives the electric signal and generates response light corresponding to the electric signal, the response light having a wavelength equal to a wavelength of fluorescence generated by the fluorescent material receiving the excitation light.
According to the phantom configured as described above, the electric signal output unit receives the excitation light and outputs an electric signal corresponding to the intensity of the excitation light. The response light generating unit receives the electrical signal and generates response light corresponding to the electrical signal. The wavelength of the response light is equal to the wavelength of fluorescence generated by the fluorescent body receiving the excitation light.
In the phantom according to the present invention, the electric signal output unit may have an optical sensor, and the responsive light generating unit may have an electronic circuit element.
In the phantom according to the present invention, the light sensor may be a photodiode, and the electronic circuit element may be an LED.
In the phantom according to the present invention, the electric signal may be a current signal, and the responsive light generating unit may include: a voltage conversion unit that converts the electric signal into a voltage signal; and a driving section that drives the electronic circuit element in accordance with the voltage signal.
In the phantom according to the present invention, the electric signal may be a voltage signal, and the responsive light generating unit may include a driving unit that drives the electronic circuit element based on the voltage signal.
In the phantom according to the present invention, the electric signal may be a digital signal, and the phantom may include a driving unit for driving the electronic circuit element based on the digital signal.
In addition, the phantom according to the present invention may be configured such that the responsive light generating unit includes: a white light source that generates white light; and a filter that receives the white light, transmits light of a predetermined wavelength, and outputs the light as the response light.
In addition, the phantom according to the present invention may be configured such that the responsive light generating unit includes: a light source generating light of a predetermined wavelength; and a light reducing section that receives and attenuates the light of the predetermined wavelength, and outputs the light as the response light.
In addition, the phantom according to the present invention may be configured such that the responsive light generating unit includes: a light source generating light of a predetermined wavelength; and a light ring section that receives the light of the predetermined wavelength, reduces the light, and outputs the light as the response light.
In addition, the phantom according to the present invention may be configured such that the responsive light generating unit includes: a light source generating light of a predetermined wavelength; and a diffusion section that receives and diffuses the light of the predetermined wavelength and outputs the light as the response light.
In the phantom according to the present invention, the response light generating unit may generate the response light when it is determined that the intensity of the excitation light exceeds a predetermined intensity based on the electric signal.
The phantom according to the present invention may further include a determination light generating unit configured to generate determination light different from the response light when it is determined that the intensity of the excitation light exceeds a predetermined intensity based on the electric signal.
In the phantom according to the present invention, the responsive light generating unit may change the intensity of the responsive light based on a ratio of the intensity of the fluorescence to the intensity of the excitation light.
In addition, the phantom according to the present invention may be provided with an excitation light intensity output unit that outputs the intensity of the excitation light based on the electrical signal.
The fluorescence detection device of the present invention is configured to emit excitation light and detect fluorescence generated by a fluorescent material receiving the excitation light, and includes an intensity correction unit configured to correct the intensity of the excitation light based on the intensity of the excitation light received from the phantom of the present invention.
Drawings
Fig. 1 is a diagram showing the structure of a phantom 1 according to a first embodiment.
Fig. 2 is a diagram showing the structure of the phantom 1 according to modification 1 of the first embodiment.
Fig. 3 is a diagram showing the structure of the phantom 1 according to modification 2 of the first embodiment.
Fig. 4 is a diagram showing the structure of the phantom 1 according to the second embodiment.
Fig. 5 is a diagram showing the structure of the phantom 1 according to the third embodiment.
Fig. 6 is a diagram showing the structure of the phantom 1 according to the fourth embodiment.
Fig. 7 is a diagram showing the structure of the phantom 1 according to the fifth embodiment.
Fig. 8 is a diagram showing the structure of the phantom 1 according to the sixth embodiment.
Fig. 9 is a diagram showing the structure of the phantom 1 according to the seventh embodiment.
Fig. 10 is a diagram showing the structure of a phantom 1 according to the eighth embodiment.
Fig. 11 is a diagram showing the structure of a phantom 1 according to a modification of the eighth embodiment.
Fig. 12 is a diagram showing the structure of the phantom 1 according to the ninth embodiment.
Fig. 13 is a diagram showing the structure of a phantom 1 according to a modification of the ninth embodiment.
Detailed Description
Hereinafter, embodiments of the present invention will be described with reference to the drawings.
First embodiment
Fig. 1 is a diagram showing the structure of a phantom 1 according to a first embodiment. The phantom 1 of the first embodiment receives excitation light from the fluorescence detection device 8.
The fluorescence detection device 8 emits excitation light to the fluorescent material. Fluorescent substances are present in the phosphor. When the phosphor receives the excitation light, fluorescence is generated. The fluorescence detection device 8 receives fluorescence from the fluorescent material and detects the fluorescence. The fluorescent substance is, for example, Sentinel lymph node (Sentinel lymph node). Examples of fluorescent substances are ICG (Indocyanine green), but in addition to this, fluorescein or aminolevulinic acid salts can also be considered. Of course, other various known phosphors and fluorescent substances are also conceivable.
The wavelength of the excitation light and the wavelength of the fluorescence are determined by the fluorescent substance. For example, when the fluorescent substance is ICG, the wavelength of the excitation light is 785nm, and the wavelength of the fluorescence is near 805 nm. For example, in the case where the fluorescent substance is fluorescein, the wavelength of the excitation light is 494nm, and the wavelength of the fluorescence is in the vicinity of 521 nm. For example, when the fluorescent substance is aminolevulinic acid salt, the wavelength of the excitation light is 400 to 410nm, and the wavelength of the fluorescence is about 635 nm.
When the phantom 1 receives excitation light from the fluorescence detection device 8, response light equal to the wavelength of the fluorescence is generated. By observing the operation of the fluorescence detection device 8 when the response light is received, the fluorescence detection device 8 can be tested.
For example, if the operation of the fluorescence detection device 8 when emitting the excitation light to the phantom 1 is the same as the operation of the fluorescence detection device 8 when emitting the excitation light to the phosphor, it can be determined that the fluorescence detection device 8 is operating normally. For example, if the response light cannot be detected even if the fluorescence detection device 8 emits the excitation light to the phantom 1, it is known that the emission function of the excitation light or the detection function of the response light by the fluorescence detection device 8 has a problem.
The phantom 1 according to the first embodiment includes an electric signal output unit 2 and a responsive light generating unit 4.
The electric signal output unit 2 receives the excitation light and outputs an electric signal corresponding to the intensity of the excitation light. The electric signal output unit 2 has a light attenuation plate 22 and a light sensor 24. The light attenuation panel 22 attenuates the excitation light and provides it to the light sensor 24. The optical sensor 24 receives the excitation light via the optical attenuation panel 22 and converts the excitation light into an electrical signal. Wherein the electrical signal is a current signal I. The light sensor 24 is, for example, a photodiode. A bandpass filter (e.g., in the case where the fluorescent substance is fluorescein or aminolevulinate) may be disposed between the optical attenuation plate 22 and the optical sensor 24. However, it is also contemplated that the light attenuating panel 22 may not be needed due to the intensity of the excitation light.
The response light generating section 4 receives the electric signal and generates response light corresponding to the electric signal. Wherein the wavelength of the response light is equal to the wavelength of the fluorescence. The response light generating section 4 includes a voltage converting section 42, a drive circuit (drive section) 44, and an electronic circuit element 46. The voltage conversion section 42 converts the electric signal (current signal I) into a voltage signal V. The drive circuit 44 drives the electronic circuit element 46 based on the voltage signal V. The electronic circuit element 46 receives the voltage signal V via the drive circuit 44 and converts the voltage signal V into response light. The electronic circuit element 46 is, for example, an LED.
Next, the operation of the first embodiment will be described.
The electrical signal output 2 of the phantom 1 receives excitation light from the fluorescence detection device 8. The excitation light is supplied to the photosensor 24 via the light attenuation panel 22, and is converted into an electric signal (current signal I) by the photosensor 24. The current signal I is supplied to the response light generating section 4. The current signal I is converted into a voltage signal V by the voltage conversion section 42, and is supplied to the electronic circuit element 46 via the drive circuit 44. The electronic circuit element 46 emits response light. The fluorescence detection means 8 detects the response light.
According to the first embodiment, the electric signal output unit 2 and the responsive light generating unit 4 are electronic circuits using electric signals, and thus are less susceptible to deterioration with age than fluorescent dyes (e.g., ICG). Therefore, according to the first embodiment, the fluorescence detection device 8 can be tested without being affected by the aged deterioration.
In the first embodiment, the following modifications are considered.
Modification example 1
Fig. 2 is a diagram showing the structure of the phantom 1 according to modification 1 of the first embodiment. Modification 1 of the first embodiment replaces the photosensor 24 and the voltage conversion section 42 of the first embodiment with the photosensor (voltage output) 25 and the amplifier circuit 43.
The photosensor (voltage output) 25 receives the excitation light via the optical attenuator panel 22 and converts the excitation light into an electrical signal. Wherein the electrical signal is a voltage signal V1. The amplifying circuit 43 amplifies the voltage signal V1 into a voltage signal V2. The driving circuit 44 drives the electronic circuit element 46 based on the voltage signal V2. Here, since the voltage signal V2 is a signal based on the voltage signal V1, the driving circuit 44 drives the electronic circuit element 46 based on the voltage signal V1.
Fig. 3 is a diagram showing the structure of the phantom 1 according to modification 2 of the first embodiment. Modification 2 of the first embodiment replaces the optical sensor 24 of the first embodiment with an optical sensor (digital output) 26. The responsive light generating unit 4 of the phantom 1 according to modification 2 of the first embodiment includes an FPGA41, a DAC (digital-to-analog converter) 45, and an electronic circuit element 46.
The optical sensor (digital output) 26 receives the excitation light via the optical attenuation panel 22 and converts the excitation light into an electrical signal. Wherein the electrical signal is a digital signal. The FPGA41 and the DAC45 drive the electronic circuit element 46 based on a digital signal, and function in the same manner as the drive circuit 44 of the first embodiment. The FPGA41 receives a digital signal from the optical sensor (digital output) 26 and outputs a signal corresponding to the output of the drive circuit 44 of the first embodiment, which is digitally converted. The DAC45 converts the output (digital) of the FPGA41 into analog, makes it the same as the output of the drive circuit 44 of the first embodiment, and supplies it to the electronic circuit element 46.
Second embodiment
The phantom 1 of the second embodiment is different from the phantom 1 of the first embodiment in that it includes a white light source 47 and a band pass filter 48.
Fig. 4 is a diagram showing the structure of the phantom 1 according to the second embodiment. The phantom 1 according to the second embodiment includes an electric signal output unit 2 and a responsive light generating unit 4. Hereinafter, the same portions as those of the first embodiment are denoted by the same reference numerals, and description thereof is omitted.
The fluorescence detection device 8 and the electric signal output unit 2 of the second embodiment are the same as those of the first embodiment, and therefore, the description thereof is omitted.
The response light generating unit 4 includes a voltage converting unit 42, a drive circuit (drive unit) 44, a white light source 47, and a band pass filter 48. The voltage conversion unit 42 and the drive circuit 44 are the same as those of the first embodiment, and therefore, description thereof is omitted. The white light source 47 generates white light. The bandpass filter 48 receives white light, transmits light of a predetermined wavelength, and outputs the light as response light. Wherein the predetermined wavelength is the same as the wavelength of the fluorescence.
Next, the operation of the second embodiment will be described.
The electrical signal output 2 of the phantom 1 receives excitation light from the fluorescence detection device 8. The excitation light is supplied to the photosensor 24 via the light attenuation panel 22, and is converted into an electric signal (current signal I) by the photosensor 24. The current signal I is supplied to the response light generating section 4. The current signal I is converted into a voltage signal V by the voltage conversion section 42, and supplied to the white light source 47 via the drive circuit 44. White light is emitted from the white light source 47, and light of a predetermined wavelength is extracted by the band pass filter 48 to be response light. The fluorescence detection means 8 detects the response light.
According to the second embodiment, the same effects as those of the first embodiment are obtained. Even if there is no light source (for example, LED) that generates light having a wavelength equal to that of the fluorescent light, by providing the band-pass filter 48 that transmits light having a wavelength equal to that of the fluorescent light, light having a wavelength equal to that of the fluorescent light can be extracted from the white light, and response light can be generated.
In addition, in modification 1 (see fig. 2) and modification 2 (see fig. 3) of the first embodiment, a white light source 47 and a band pass filter 48 may be similarly provided instead of the electronic circuit element 46.
Third embodiment
The phantom 1 of the third embodiment is different from the phantom 1 of the first embodiment in that it includes a light reduction plate (light reduction part) 49 a.
Fig. 5 is a diagram showing the structure of the phantom 1 according to the third embodiment. The phantom 1 according to the third embodiment includes an electric signal output unit 2 and a responsive light generating unit 4. Hereinafter, the same portions as those of the first embodiment are denoted by the same reference numerals, and description thereof is omitted.
The fluorescence detection device 8 and the electric signal output unit 2 of the third embodiment are the same as those of the first embodiment, and therefore, the description thereof is omitted.
The response light generator 4 includes a voltage converter 42, a drive circuit (drive unit) 44, an electronic circuit element 46, and a light reduction plate (light reduction unit) 49 a. The voltage conversion unit 42, the drive circuit 44, and the electronic circuit element 46 are the same as those of the first embodiment, and therefore, the description thereof is omitted. Wherein the electronic circuit element 46 is a light source that generates light of a predetermined wavelength. The predetermined wavelength is equal to the wavelength of the fluorescence. The light reduction plate (light reduction section) 49a receives and attenuates light of a predetermined wavelength, and outputs the light as response light.
Next, the operation of the third embodiment will be described.
The electrical signal output 2 of the phantom 1 receives excitation light from the fluorescence detection device 8. The excitation light is supplied to the photosensor 24 via the light attenuation panel 22, and is converted into an electric signal (current signal I) by the photosensor 24. The current signal I is supplied to the response light generating section 4. The current signal I is converted into a voltage signal V by the voltage conversion section 42, and is supplied to the electronic circuit element 46 via the drive circuit 44. Light of a predetermined wavelength is emitted from the electronic circuit element 46, attenuated by the light reduction plate 49a, and becomes response light. The fluorescence detection means 8 detects the response light.
According to the third embodiment, the same effects as those of the first embodiment are obtained. Further, since the response light is attenuated by the light attenuation plate 49a, it is possible to perform an experiment in which the fluorescence detection device 8 is used for a fluorescent substance having a small fluorescence output.
In addition, in modification 1 (see fig. 2) and modification 2 (see fig. 3) of the first embodiment, a light reduction plate (light reduction portion) 49a may be provided in front of the electronic circuit element 46 in the same manner.
Fourth embodiment
The phantom 1 of the fourth embodiment is different from the phantom 1 of the first embodiment in that it includes a coil portion 49 b.
Fig. 6 is a diagram showing the structure of the phantom 1 according to the fourth embodiment. The phantom 1 according to the fourth embodiment includes an electric signal output unit 2 and a responsive light generating unit 4. Hereinafter, the same portions as those of the first embodiment are denoted by the same reference numerals, and description thereof is omitted.
The fluorescence detection device 8 and the electric signal output unit 2 of the fourth embodiment are the same as those of the first embodiment, and therefore, the description thereof is omitted.
The response light generating section 4 includes a voltage converting section 42, a drive circuit (drive section) 44, an electronic circuit element 46, and an aperture section 49 b. The voltage conversion unit 42, the drive circuit 44, and the electronic circuit element 46 are the same as those of the first embodiment, and therefore, the description thereof is omitted. Wherein the electronic circuit element 46 is a light source that generates light of a predetermined wavelength. The predetermined wavelength is equal to the wavelength of the fluorescence. The diaphragm portion 49b receives light of a predetermined wavelength, narrows the received light, and outputs the narrowed light as response light. The diaphragm 49b is, for example, a pinhole or a slit.
Next, the operation of the fourth embodiment will be described.
The electrical signal output 2 of the phantom 1 receives excitation light from the fluorescence detection device 8. The excitation light is supplied to the photosensor 24 via the light attenuation panel 22, and is converted into an electric signal (current signal I) by the photosensor 24. The current signal I is supplied to the response light generating section 4. The current signal I is converted into a voltage signal V by the voltage conversion section 42, and is supplied to the electronic circuit element 46 via the drive circuit 44. Light of a predetermined wavelength is emitted from the electronic circuit element 46, and is narrowed by the diaphragm portion 49b, thereby becoming response light. The fluorescence detection means 8 detects the response light.
According to the fourth embodiment, the same effects as those of the first embodiment are obtained. Further, since the response light is reduced by the aperture portion 49b, a test can be performed assuming that the fluorescence detection device 8 is used for a small fluorescent material.
In addition, in modification 1 (see fig. 2) and modification 2 (see fig. 3) of the first embodiment, the diaphragm portion 49b may be provided in front of the electronic circuit element 46 in the same manner.
Fifth embodiment
The phantom 1 of the fifth embodiment is different from the phantom 1 of the first embodiment in that it includes a diffuser plate (diffuser) 49 c.
Fig. 7 is a diagram showing the structure of the phantom 1 according to the fifth embodiment. The phantom 1 according to the fifth embodiment includes an electric signal output unit 2 and a responsive light generating unit 4. Hereinafter, the same portions as those of the first embodiment are denoted by the same reference numerals, and description thereof is omitted.
The fluorescence detection device 8 and the electric signal output unit 2 of the fifth embodiment are the same as those of the first embodiment, and therefore, the description thereof is omitted.
The response light generating section 4 includes a voltage converting section 42, a drive circuit (drive section) 44, an electronic circuit element 46, and a diffusion plate (diffusion section) 49 c. The voltage conversion unit 42, the drive circuit 44, and the electronic circuit element 46 are the same as those of the first embodiment, and therefore, the description thereof is omitted. Wherein the electronic circuit element 46 is a light source that generates light of a predetermined wavelength. The predetermined wavelength is equal to the wavelength of the fluorescence. The diffusion plate 49c receives light of a predetermined wavelength, diffuses it, and outputs it as response light.
Next, the operation of the fifth embodiment will be described.
The electrical signal output 2 of the phantom 1 receives excitation light from the fluorescence detection device 8. The excitation light is supplied to the photosensor 24 via the light attenuation panel 22, and is converted into an electric signal (current signal I) by the photosensor 24. The current signal I is supplied to the response light generating section 4. The current signal I is converted into a voltage signal V by the voltage conversion section 42, and is supplied to the electronic circuit element 46 via the drive circuit 44. Light of a predetermined wavelength is emitted from the electronic circuit element 46, and is diffused by the diffuser plate 49c to become response light. The fluorescence detection means 8 detects the response light.
According to the fifth embodiment, the same effects as those of the first embodiment are obtained. Further, since the response light is diffused by the diffusion plate 49c, a test can be performed assuming that the fluorescence detection device 8 is used for a large phosphor.
In modification 1 (see fig. 2) and modification 2 (see fig. 3) of the first embodiment, a diffuser plate 49c may be provided in front of the electronic circuit element 46 in the same manner.
Sixth embodiment
The phantom 1 of the sixth embodiment is different from the phantom 1 of the first embodiment in that it includes a threshold value recording unit 40a and a comparator 40 b.
Fig. 8 is a diagram showing the structure of the phantom 1 according to the sixth embodiment. The phantom 1 according to the sixth embodiment includes an electric signal output unit 2 and a responsive light generating unit 4. Hereinafter, the same portions as those of the first embodiment are denoted by the same reference numerals, and description thereof is omitted.
The fluorescence detection device 8 and the electric signal output unit 2 according to the sixth embodiment are the same as those of the first embodiment, and therefore, the description thereof is omitted.
The response light generating section 4 includes a voltage converting section 42, a drive circuit (drive section) 44, an electronic circuit element 46, a threshold recording section 40a, and a comparator 40 b. The voltage conversion unit 42, the drive circuit 44, and the electronic circuit element 46 are the same as those of the first embodiment, and therefore, the description thereof is omitted.
The threshold value recording section 40a records the value of the voltage signal V as a threshold value when the intensity of the excitation light is a predetermined intensity. For example, when the predetermined intensity is 10mW, 1V is recorded as the threshold value in the case where the voltage signal V output from the voltage converting section 42 is 1V.
The comparator 40b compares the voltage signal V output from the voltage conversion section 42 with the threshold value recorded by the threshold value recording section 40 a. When the voltage signal V exceeds the threshold, the comparator 40b supplies the drive signal V3 to the drive circuit 44. In addition, the comparator 40b does not supply a signal to the drive circuit 44 when the voltage signal V is smaller than the threshold value. Therefore, in a case where the comparator 40b determines that the intensity of the excitation light exceeds the predetermined intensity based on the electric signal (voltage signal V) (i.e., in a case where the voltage signal V exceeds the threshold), the drive signal V3 is supplied to the drive circuit 44, and thus the response light is generated.
The comparator 40b is disposed between the voltage conversion unit 42 and the drive circuit 44. More specifically, the output terminal of the comparator 40b is connected to the input terminal of the drive circuit 44, and the input terminal of the comparator 40b is connected to the output terminal of the voltage conversion unit 42 and the threshold value recording unit 40 a.
Next, the operation of the sixth embodiment will be described.
The electrical signal output 2 of the phantom 1 receives excitation light from the fluorescence detection device 8. The excitation light is supplied to the photosensor 24 via the light attenuation panel 22, and is converted into an electric signal (current signal I) by the photosensor 24. The current signal I is supplied to the response light generating section 4. The current signal I is converted into a voltage signal V by the voltage conversion unit 42. The voltage signal V is supplied to the comparator 40b, and it is determined whether the threshold is exceeded.
If it is determined that the voltage signal V exceeds the threshold value, the drive signal V3 is supplied to the electronic circuit element 46 via the drive circuit 44. The electronic circuit element 46 emits response light. The fluorescence detection means 8 detects the response light.
On the other hand, if it is determined that the voltage signal V does not exceed the threshold value, the drive signal V3 is not supplied to the drive circuit 44, and therefore the electronic circuit element 46 does not emit response light.
According to the sixth embodiment, the same effects as those of the first embodiment are obtained. In addition, when the intensity of the excitation light is insufficient, the response light is not detected, and therefore, the insufficient intensity of the excitation light can be easily determined.
In modification 1 (see fig. 2) of the first embodiment, the threshold value recording unit 40a and the comparator 40b may be provided in the same manner. In this case, the comparator 40b is disposed between the amplifier circuit 43 and the driver circuit 44. More specifically, the output terminal of the comparator 40b is connected to the input terminal of the drive circuit 44, and the input terminal of the comparator 40b is connected to the output terminal of the amplifier circuit 43 and the threshold value recording unit 40 a. The threshold value recording unit 40a records the value of the voltage signal V2 when the intensity of the excitation light is a predetermined intensity as the threshold value.
In modification 2 (see fig. 3) of the first embodiment, the same functions as those of the sixth embodiment can be achieved. In this case, the FPGA41 records the value of the electric signal (digital signal) when the intensity of the excitation light is a predetermined intensity as the threshold value. The FPGA41 determines whether or not the electrical signal (digital signal) exceeds a threshold value, and if so, transmits the electrical signal (digital signal) to the DAC45, and if not, does not transmit the signal to the DAC 45.
Seventh embodiment
The phantom 1 according to the seventh embodiment is different from the phantom 1 according to the sixth embodiment in that it includes a determination light generating unit 5.
Fig. 9 is a diagram showing the structure of the phantom 1 according to the seventh embodiment. The phantom 1 according to the seventh embodiment includes an electric signal output unit 2, a responsive light generating unit 4, and a determination light generating unit 5. Hereinafter, the same portions as those of the sixth embodiment are denoted by the same reference numerals, and description thereof is omitted.
The fluorescence detection device 8, the electric signal output unit 2, and the response light generation unit 4 according to the seventh embodiment are the same as those according to the sixth embodiment, and therefore, the description thereof is omitted.
The determination light generating section 5 includes a comparator 50b, a drive circuit 54, and an electronic circuit element 56.
The comparator 50b compares the voltage signal V output from the voltage conversion section 42 with the threshold value recorded by the threshold value recording section 40 a. When the voltage signal V exceeds the threshold, the comparator 50b supplies the drive signal V4 to the drive circuit 54. In addition, the comparator 40b does not supply a signal to the drive circuit 54 when the voltage signal V is smaller than the threshold value.
The comparator 50b is disposed between the voltage conversion unit 42 and the drive circuit 54. More specifically, the output terminal of the comparator 50b is connected to the input terminal of the drive circuit 54, and the input terminal of the comparator 50b is connected to the output terminal of the voltage conversion unit 42 and the threshold value recording unit 40 a.
The drive circuit 54 drives the electronic circuit element 56 based on the drive signal V4.
The electronic circuit element 56 receives the drive signal V4 via the drive circuit 54, and converts the drive signal V4 into determination light. The electronic circuit element 56 is, for example, an LED.
When the comparator 50b determines that the intensity of the excitation light exceeds the predetermined intensity based on the electrical signal (voltage signal V) (that is, when the voltage signal V exceeds the threshold), the drive signal V4 is supplied to the drive circuit 54, and therefore the electronic circuit element 56 generates the determination light. The determination light is light different from the response light.
Next, the operation of the seventh embodiment will be described. However, the same portions as the operation of the sixth embodiment will not be described.
The voltage signal V output from the voltage conversion unit 42 is supplied to the comparator 50b, and it is determined whether or not the threshold is exceeded.
If it is determined that the voltage signal V exceeds the threshold value, a drive signal V4 is supplied to the electronic circuit element 56 via the drive circuit 54. The electronic circuit element 56 emits determination light.
On the other hand, if it is determined that the voltage signal V does not exceed the threshold value, the drive signal V4 is not supplied to the drive circuit 54, and therefore the electronic circuit element 56 does not emit the determination light.
According to the seventh embodiment, the same effects as those of the sixth embodiment are obtained. In addition, since the determination light is not emitted when the intensity of the excitation light is insufficient, the insufficient intensity of the excitation light can be easily determined.
In modification 1 (see fig. 2) of the first embodiment, the threshold value recording unit 40a, the comparator 50b, the drive circuit 54, and the electronic circuit element 56 may be similarly provided. In this case, the comparator 50b is disposed between the amplification circuit 43 and the drive circuit 54. More specifically, the output terminal of the comparator 50b is connected to the input terminal of the drive circuit 54, and the input terminal of the comparator 50b is connected to the output terminal of the amplifier circuit 43 and the threshold value recording unit 40 a. The threshold value recording unit 40a records the value of the voltage signal V2 when the intensity of the excitation light is a predetermined intensity as the threshold value.
In modification 2 (see fig. 3) of the first embodiment, the same functions as those of the seventh embodiment can be achieved. In this case, the electronic circuit element 56 is provided, and the value of the electric signal (digital signal) when the intensity of the excitation light is a predetermined intensity is recorded as the threshold value in the FPGA 41. The FPGA41 determines whether or not the electrical signal (digital signal) exceeds a threshold value, and if so, transmits the electrical signal (digital signal) to the determination optical DAC (disposed between the FPGA41 and the electronic circuit element 56, converts the digital output of the FPGA41 into analog and supplies the analog to the electronic circuit element 56), and if not, does not transmit the signal to the determination optical DAC.
Eighth embodiment
The phantom 1 according to the eighth embodiment is different from the phantom 1 according to the first embodiment in that it includes a variable resistor 42 a.
Fig. 10 is a diagram showing the structure of a phantom 1 according to the eighth embodiment. The phantom 1 according to the eighth embodiment includes an electric signal output unit 2 and a responsive light generating unit 4. Hereinafter, the same portions as those of the first embodiment are denoted by the same reference numerals, and description thereof is omitted.
The fluorescence detection device 8 and the electric signal output unit 2 according to the eighth embodiment are the same as those of the first embodiment, and therefore, the description thereof is omitted.
The response light generating section 4 includes a voltage converting section 42, a variable resistor 42a, a drive circuit (drive section) 44, and an electronic circuit element 46. The drive circuit 44 and the electronic circuit element 46 are the same as those of the first embodiment, and therefore, the description thereof is omitted.
The voltage conversion unit 42 is, for example, an operational amplifier, and receives the electric signal (current signal I) by inverting the positive and negative of the signal at one end of the input side, and the other end of the input side is grounded, as in the first embodiment. One end of the input side of the voltage conversion unit 42 is connected to the output side via a variable resistor 42 a. By changing the resistance of the variable resistor 42a, the value of the voltage signal V can be changed, and the intensity of the response light can be changed. The resistance of the variable resistor 42a is changed based on the ratio (i.e., sensitivity) of the intensity of the fluorescence generated by the phosphor to the intensity of the excitation light. Therefore, the intensity of the response light is changed based on the sensitivity.
Next, the operation of the eighth embodiment will be described.
The electrical signal output 2 of the phantom 1 receives excitation light from the fluorescence detection device 8. The excitation light is supplied to the photosensor 24 via the light attenuation panel 22, and is converted into an electric signal (current signal I) by the photosensor 24. The current signal I is supplied to the response light generating section 4. The current signal I is converted into a voltage signal V by the voltage conversion section 42, and is supplied to the electronic circuit element 46 via the drive circuit 44. However, by changing the resistance of the variable resistor 42a based on the sensitivity, the value of the voltage signal V (further, the intensity of the response light) can be changed. The electronic circuit element 46 emits response light. The fluorescence detection means 8 detects the response light.
According to the eighth embodiment, the same effects as those of the first embodiment are obtained. Further, since the intensity of the response light can be changed by changing the resistance of the variable resistor 42a based on the sensitivity of the fluorescent material, it is possible to perform a test assuming that the fluorescence detection device 8 is used for fluorescent materials of various sensitivities.
In the eighth embodiment, the following modifications are considered.
Fig. 11 is a diagram showing the structure of a phantom 1 according to a modification of the eighth embodiment. A modification of the eighth embodiment does not include the variable resistor 42a of the eighth embodiment, and the drive circuit 44 of the eighth embodiment is replaced with a variable drive circuit 44 a. The variable drive circuit 44a can change the drive voltage supplied to the electronic circuit element 46 based on the sensitivity of the phosphor, thereby changing the intensity of the response light.
The same effects are also obtained by replacing the photosensor 24 and the voltage converter 42 of the eighth embodiment and the modifications thereof with the photosensor (voltage output) 25 and the amplifier circuit 43 (see modifications 1 and 2 of the first embodiment).
In modification 2 (see fig. 3) of the first embodiment, the same functions as those of the eighth embodiment can be achieved. In this case, the FPGA41 changes the output to the DAC45 based on the sensitivity of the phosphor.
Ninth embodiment
The phantom 1 of the ninth embodiment is different from the phantom 1 of the first embodiment in that it includes an excitation light intensity output unit 6.
Fig. 12 is a diagram showing the structure of the phantom 1 according to the ninth embodiment. The phantom 1 according to the ninth embodiment includes an electric signal output unit 2, a responsive light generating unit 4, and an excitation light intensity output unit 6. Hereinafter, the same portions as those of the first embodiment are denoted by the same reference numerals, and description thereof is omitted.
The electric signal output section 2 and the response light generating section 4 of the ninth embodiment are the same as those of the first embodiment, and therefore, the description thereof is omitted. However, the drive circuit 44 may be replaced with a variable drive circuit 44a (see fig. 11 and a modification of the eighth embodiment).
The excitation light intensity output section 6 outputs the intensity of the excitation light based on the electric signal. The excitation light intensity output section 6 includes an ADC (analog-to-digital converter) 62 and an FPGA 64. The ADC62 converts the voltage signal V (analog) output from the voltage conversion section 42 into digital. The FPGA64 receives the output of the ADC62 and outputs the intensity of the excitation light.
The fluorescence detection device 8 is similar to the first embodiment, but includes a target value recording unit 82, an intensity correction unit 84, and an excitation light source 86. The target value recording unit 82 records an output target value (for example, 10mW) of the excitation light. The intensity correction unit 84 corrects the intensity of the excitation light based on the intensity of the excitation light received from the FPGA64 of the excitation light intensity output unit 6. Specifically, the intensity correction unit 84 receives the target value (for example, 10mW) from the target value recording unit 82, and receives the intensity of the excitation light (for example, 9mW) from the FPGA64 of the excitation light intensity output unit 6. The intensity correction unit 84 supplies (target value) × (target value)/(intensity of excitation light) (10 × 10/9 — 11.1mW) to the excitation light source 86 as a new target value, thereby correcting the intensity of the excitation light. The excitation light source 86 outputs excitation light in accordance with the new target value supplied from the intensity correction section 84.
Next, the operation of the ninth embodiment will be described. However, the same portions as the operation of the first embodiment will not be described.
It is assumed that the output of the excitation light should be 10mW (target value) originally, but only 9mW is output. The voltage signal V output from the voltage conversion unit 42 is converted into digital by the ADC62 and supplied to the FPGA 64. The FPGA64 supplies the intensity of the excitation light (9mW) to the intensity correction unit 84 of the fluorescence detection device 8.
Then, it was found that the output of the excitation light was 0.9 times as large as the target value of 9mW/10 mW. Therefore, it is found that if the target value of 10mW is 1/0.9 to 1.11 times, the output of the excitation light is exactly 10 mW. Therefore, the intensity correction unit 84 supplies (target value) × (target value)/(intensity of excitation light) (10 × 10/9 ═ 11.1mW) to the excitation light source 86 as a new target value, thereby correcting the intensity of the excitation light. The excitation light source 86 outputs excitation light in accordance with the new target value of 11.1mW supplied from the intensity correcting section 84. Then, the output of the excitation light is 11.1mW × 0.9 ═ 10 mW.
According to the ninth embodiment, the same effects as those of the first embodiment are obtained. The output of the excitation light from the fluorescence detection device 8 can be automatically corrected by the output of the excitation light intensity output unit 6.
In addition, in modification 1 (see fig. 2) of the first embodiment, the excitation light intensity output unit 6 can be connected to the output of the amplifier circuit 43 in the same manner.
In the ninth embodiment, the following modifications are considered.
Fig. 13 is a diagram showing the structure of a phantom 1 according to a modification of the ninth embodiment. The fluorescence detection device 8 is the same as in the ninth embodiment. The phantom 1 is the same as the phantom of modification 1 (see fig. 2) of the first embodiment. However, the output of the FPGA41 of the phantom 1 is provided to the intensity correction portion 84. The FPGA41 corresponds to the excitation light intensity output unit 6 of the ninth embodiment.
Description of the symbols
1 phantom
2 electric signal output part
22 light attenuation board
24 optical sensor
25 light sensor (Voltage output)
4-responsive light generating section
40a threshold value recording part
40b comparator
41 FPGA
42 voltage conversion part
42a variable resistor
43 amplifier circuit
44 drive circuit (drive part)
44a variable type drive circuit
45 DAC (digital-to-analog converter)
46 electronic circuit element
47 white light source
48 band-pass filter
49a light reduction plate (dimming part)
49b diaphragm part
49c diffuser plate (diffuser)
5 determining the light generating part
50b comparator
54 drive circuit
56 electronic circuit element
6 excitation light intensity output unit
62 ADC (analog-to-digital converter)
64 FPGA
8 fluorescence detection device
82 target value recording part
84 intensity correction part
86 excitation light source
I current signal
V, V1, V2 Voltage Signal
V3, V4 drive signals.
Claims (15)
1. A phantom, comprising:
an electric signal output unit that receives the excitation light and outputs an electric signal corresponding to the intensity of the excitation light; and
and a response light generating unit that receives the electric signal and generates response light corresponding to the electric signal, the response light having a wavelength equal to a wavelength of fluorescence generated by the fluorescent material receiving the excitation light.
2. The phantom according to claim 1,
the electric signal output part is provided with a light sensor,
the response light generating section has an electronic circuit element.
3. The phantom according to claim 2,
the light sensor is a photodiode and the light sensor is,
the electronic circuit element is an LED.
4. The phantom according to claim 2 or 3,
the electrical signal is a current signal and,
the response light generation unit includes:
a voltage conversion unit that converts the electric signal into a voltage signal; and
and a driving unit that drives the electronic circuit element in accordance with the voltage signal.
5. The phantom according to claim 2 or 3,
the electrical signal is a voltage signal and,
the response light generating section has a driving section that drives the electronic circuit element based on the voltage signal.
6. The phantom according to claim 2 or 3,
the electrical signal is a digital signal that is,
the phantom has a driving section that drives the electronic circuit element based on the digital signal.
7. The phantom according to any one of claims 1 to 6,
the response light generation unit includes:
a white light source that generates white light; and
and a filter that receives the white light, transmits light of a predetermined wavelength, and outputs the light as the response light.
8. The phantom according to any one of claims 1 to 6,
the response light generation unit includes:
a light source generating light of a predetermined wavelength; and
and a light attenuation unit that receives and attenuates the light of the predetermined wavelength and outputs the light as the response light.
9. The phantom according to any one of claims 1 to 6,
the response light generation unit includes:
a light source generating light of a predetermined wavelength; and
and a light ring section that receives and reduces the light of the predetermined wavelength and outputs the light as the response light.
10. The phantom according to any one of claims 1 to 6,
the response light generation unit includes:
a light source generating light of a predetermined wavelength; and
and a diffusion section that receives the light of the predetermined wavelength, diffuses the light, and outputs the diffused light as the response light.
11. The phantom according to any one of claims 1 to 10,
the response light generation unit generates the response light when it is determined that the intensity of the excitation light exceeds a predetermined intensity based on the electric signal.
12. The phantom according to claim 11,
the phantom includes a determination light generating unit that generates determination light different from the response light when it is determined that the intensity of the excitation light exceeds a predetermined intensity based on the electric signal.
13. The phantom according to any one of claims 1 to 10,
the response light generation unit changes the intensity of the response light based on a ratio of the intensity of the fluorescence to the intensity of the excitation light.
14. The phantom according to any one of claims 1 to 10,
the phantom includes an excitation light intensity output unit that outputs the intensity of the excitation light based on the power of the electrical signal.
15. A fluorescence detection device for emitting excitation light and detecting fluorescence generated by a fluorescent material receiving the excitation light,
the fluorescence detection device is provided with:
an intensity correcting section that corrects the intensity of the excitation light based on a value of the intensity of the excitation light received from the phantom according to claim 14.
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|---|---|---|---|
| JP2019-168170 | 2019-09-17 | ||
| JP2019168170A JP7240995B2 (en) | 2019-09-17 | 2019-09-17 | Phantom and fluorescence detector |
| PCT/JP2020/022632 WO2021053898A1 (en) | 2019-09-17 | 2020-06-09 | Phantom and fluorescence detection device |
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| CN114364969A true CN114364969A (en) | 2022-04-15 |
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| CN202080061148.XA Pending CN114364969A (en) | 2019-09-17 | 2020-06-09 | Phantom and fluorescence detection device |
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| JP (1) | JP7240995B2 (en) |
| KR (1) | KR20220030296A (en) |
| CN (1) | CN114364969A (en) |
| DE (1) | DE112020003379T5 (en) |
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| WO (1) | WO2021053898A1 (en) |
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| Publication number | Publication date |
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| DE112020003379T5 (en) | 2022-03-31 |
| JP2021047031A (en) | 2021-03-25 |
| KR20220030296A (en) | 2022-03-10 |
| WO2021053898A1 (en) | 2021-03-25 |
| JP7240995B2 (en) | 2023-03-16 |
| TW202113334A (en) | 2021-04-01 |
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