CN108618798A - A kind of preparation method and its body mould of CT body mould - Google Patents
A kind of preparation method and its body mould of CT body mould Download PDFInfo
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- CN108618798A CN108618798A CN201810261183.0A CN201810261183A CN108618798A CN 108618798 A CN108618798 A CN 108618798A CN 201810261183 A CN201810261183 A CN 201810261183A CN 108618798 A CN108618798 A CN 108618798A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000000463 material Substances 0.000 claims abstract description 27
- 239000004014 plasticizer Substances 0.000 claims abstract description 17
- 238000002156 mixing Methods 0.000 claims abstract description 15
- 239000000314 lubricant Substances 0.000 claims abstract description 11
- 239000012760 heat stabilizer Substances 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 239000004800 polyvinyl chloride Substances 0.000 claims description 12
- 210000003734 kidney Anatomy 0.000 claims description 11
- 210000000056 organ Anatomy 0.000 claims description 10
- 239000003063 flame retardant Substances 0.000 claims description 9
- 238000002591 computed tomography Methods 0.000 claims description 5
- OEIWPNWSDYFMIL-UHFFFAOYSA-N dioctyl benzene-1,4-dicarboxylate Chemical compound CCCCCCCCOC(=O)C1=CC=C(C(=O)OCCCCCCCC)C=C1 OEIWPNWSDYFMIL-UHFFFAOYSA-N 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 claims description 2
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 claims description 2
- ZFMQKOWCDKKBIF-UHFFFAOYSA-N bis(3,5-difluorophenyl)phosphane Chemical compound FC1=CC(F)=CC(PC=2C=C(F)C=C(F)C=2)=C1 ZFMQKOWCDKKBIF-UHFFFAOYSA-N 0.000 claims description 2
- 238000004364 calculation method Methods 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 229920001596 poly (chlorostyrenes) Polymers 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 claims 4
- ULGYAEQHFNJYML-UHFFFAOYSA-N [AlH3].[Ca] Chemical compound [AlH3].[Ca] ULGYAEQHFNJYML-UHFFFAOYSA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000004575 stone Substances 0.000 claims 1
- 210000001835 viscera Anatomy 0.000 abstract description 7
- 206010028980 Neoplasm Diseases 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 229910052750 molybdenum Inorganic materials 0.000 abstract 1
- 239000011733 molybdenum Substances 0.000 abstract 1
- 239000008037 PVC plasticizer Substances 0.000 description 14
- 229920000915 polyvinyl chloride Polymers 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 10
- 230000005855 radiation Effects 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 238000010146 3D printing Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000005075 mammary gland Anatomy 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/032—Transmission computed tomography [CT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/58—Testing, adjusting or calibrating thereof
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- High Energy & Nuclear Physics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Theoretical Computer Science (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Abstract
The invention discloses a kind of CT body mold materials and preparation method thereof.The phantom material is made of Corvic, plasticizer, hydrocalumite, atoleine.Change the mixing ratio of PVC and plasticizer, PVC heat stabilizer, the content of lubricant can adjust the CT values of the phantom material, realize that CT values are adjustable between 20HU~100HU.The present invention can be used in CT detection body moulds or simulated humanbody internal organs/tumor phantom.The phantom material production method is simple, and material has elasticity, can be imaged at molybdenum target, CT.
Description
Technical field
The present invention relates to phantom material, body mould, radiophotography and its analysis fields, and in particular to a kind of preparation of body mould
Method and its body mould, and the method by these body moulds for radiophotography.
Background technology
In order to ensure that the safety of radiotherapy and patient and operating personnel during diagnosis, various radiotherapies diagnosis are set
Standby and security protection instrument must periodically be demarcated using Anthropomorphic radiant phantom.Anthropomorphic radiant phantom is except requiring and people
Outside the similar formalness of body and internal structure, it is often more important that under certain energy with human body radiation characteristic having the same,
Therefore the design of tissue radiation equivalent material is to manufacture one of the key technology of Anthropomorphic radiant phantom.
CT values are substances in computed tomography image corresponding to each pixel to X-ray linear averaging attenuation
The expression of size.In practical application, using the linear attenuation coefficient of water as benchmark, therefore CT values can be expressed as, measured matter
The relative difference of the linear attenuation coefficient of linear attenuation coefficient and water, unit are Hu (Hounsfield Unit).
CT values can preferably reflect radiation comprehensive effect of the ray (X or gamma-rays) to tissue and organ.Common
The standard substance CT value differences that CT standard value body moulds are included are different huge, can not correctly estimate at deviation is corrected, and CT standard values
Discontinuously so that CT values deviation without standard measure, it is linear must obtain, accurately correct foundation and quantitative target to cause to lack.
Invention content
The purpose of the present invention is to provide a kind of preparation method of CT body mould and its body moulds.The preparation of CT body mould of the present invention
Method is with Corvic, plasticizer, and fire retardant, PVC heat stabilizer and lubricant are raw material, by changing polychlorostyrene second
The proportioning of olefine resin and plasticizer obtains the CT values of ranging from -20Hu~100Hu.Method accordingly, the present invention can imitate mammary gland,
The CT body mould with good tissue radiation equivalence is made in the human internal organs such as liver,spleen,kidney.
To achieve the above object, the present invention is realized by following scheme：
One of the object of the invention provides a kind of preparation method of CT body mould, and with Corvic, plasticizer is fire-retardant
Agent, PVC heat stabilizer and lubricant are that raw material measures different CT by changing the proportioning of Corvic and plasticizer
Value, obtains the mixing ratio and CT value variation relations of Corvic and plasticizer；According to the CT values of required simulated organ, meter
The dosage for calculating each raw material, is processed to obtain the final product.
The second aspect of the present invention provides a kind of CT body mould being prepared by the above method.
A certain amount of fire retardant, PVC heat stabilizer and lubricant are added in CT body mold materials of the present invention, can be effectively increased
The range of CT values, such as：A certain amount of hydrocalumite is added, the thermal stability of phantom material can be made to become good, while can drop
Low phantom material CT values；A certain amount of atoleine is added, lubricant can be played the role of, reduces body mould internal friction,
It imparts knowledge to students suitable for puncturing, meanwhile, reduce phantom material CT values.
Compared with prior art, the beneficial effects of the invention are as follows：
1) the present invention provides a kind of preparation method of CT body mould, this method can get the ranging from CT of -20Hu-100Hu
Value, the present invention can imitate the human internal organs such as mammary gland, liver,spleen,kidney, and preparation-obtained mould has good tissue radiation etc.
Effect property；
2) the raw materials used in the present invention have certain deformability and recovery capability, can study adjacent tissue internal organs it
Between deformation relationship and deformability；
3) present invention provide preparation method CT body mould can be processed into various specific shapes and be easy to configuration, density it is uniform
Material.
Description of the drawings
The preparation method flow chart of Fig. 1 phantom materials；
Fig. 2 PVC- plasticizer mixing ratios and CT value relational graphs.
Specific implementation mode
It is noted that described further below be all exemplary, it is intended to provide further instruction to the present invention.Unless
Otherwise indicated, all technical and scientific terms used herein has and general technical staff of the technical field of the invention
Normally understood identical meanings.
It should be noted that term used herein above is merely to describe specific implementation mode, and be not intended to restricted root
According to exemplary embodiments of the present invention.As used herein, unless the context clearly indicates otherwise, otherwise singular shape
Formula is also intended to include plural form, additionally, it should be understood that, when in the present specification use term "comprising" and/or
When " comprising ", existing characteristics, step, operation, component and/or combination thereof are indicated.
To solve the problems, such as described in background technology, the present invention provides a kind of preparation method of CT body mould, with polyvinyl chloride
Resin, plasticizer, fire retardant, PVC heat stabilizer and lubricant are raw material, by changing Corvic and plasticizer
Proportioning, measures different CT values, obtains the mixing ratio and CT value variation relations of Corvic and plasticizer；According to required
The CT values of simulated organ, calculate the dosage of each raw material, process to obtain the final product.
Further, ranging from -20Hu~100Hu of gained CT values.
Further, the plasticizer is in dioctyl terephthalate, dioctyl phthalate, dioctyl adipate
At least one.
Further, the Corvic selects model PVC SG5, and plasticizer is dioctyl terephthalate.
Further, the fire retardant, PVC heat stabilizer dosage are 0-1%, and the lubricant quantity is 0-1%.
Further, the fire retardant, PVC heat stabilizer are hydrocalumite, and the lubricant is atoleine.
Further, the preparation method of the CT body mould, specifically includes following steps：
1) initial data is extracted：Read original DICOM images, extract data, obtain organ mean CT-number to be simulated and
Its three-D profile；
2) it prints：3d prints organ outer profile mold；
3) proportioning is calculated：According to the content needed for straight line and regression equation calculation raw material；
4) it weighs；
5) heating stirring：Load weighted raw material is mixed, is heated, 280 DEG C, 30min, and mixed liquor is stirred continuously；
6) preheated mold：70℃-90℃；
7) it is molded：The solution heated is poured into after vacuum defoamation is handled in mold, then room temperature cools down；
8) cooling：Room temperature cools down, and waits for that solution becomes gel-like state, then kidney phantom material proposed by the invention is completed；
9) CT scan is verified：The kidney body mould that above-mentioned formula is scanned in CT equipment measures its average CT value.
Further, the PVC polymer fluids described in step 7) carry out vacuum defoamation processing before pouring into mold.
Further, the PVC polymer fluids described in step 8) answer room temperature to be cooled to 120-130 DEG C and pour into mold again.
The second aspect of the present invention provides a kind of CT body mould being prepared by the above method.
In order to enable those skilled in the art can clearly understand technical scheme of the present invention, below with reference to
The specific embodiment technical solution that the present invention will be described in detail.
Embodiment 1
1) makes sample：Sample ratio is as shown in table 1 below, makes the PVC- plasticizer samples of 17 kinds of different ratios；
1 different ratio of table (PVC- plasticizer mixing ratio), atoleine and the corresponding phantom material CT of hydrocalumite content
Value
Atoleine or hydrocalumite are not added for "-" expression
2) CT scan：Above-mentioned 17 kinds of different ratios PVC- plasticizer samples are scanned in CT equipment, to each sample point
Not Xuan Qu 5 different level region of interest (region of interest, ROI) record, obtain mean CT-number；
3) it counts：Count PVC- plasticizer mixing ratio and corresponding mean CT-number, obtain scatter plot, Rejection of samples 1,2,5,
6,7 (contain 2 variables), as shown in Fig. 2, PVC- plasticizer mixing ratio and CT values be there are apparent linear relationship,
4) it analyzes：The straight line and regression equation of PVC- plasticizer mixing ratio and the variation of CT values are obtained using SPSS 22.0,
That is y=6.2686x-48.3380.Wherein y is CT values, and x is the mixing ratio of PVC- plasticizer, coefficient R2=0.9493.
Embodiment 2
1) initial data is extracted：Original DICOM images are read, data is extracted, obtains kidney mean CT-number to be simulated
(42.1 ± 5.0) and its three-D profile；
2) it prints：3d prints kidney outer profile mold；
3) proportioning is calculated：According to straight line and regression equation, the content needed for raw material is calculated；
4) it weighs：Corvic PVC SG-5, dioctyl terephthalate, mixed proportion are 13.8 × 10-2g/
mL；
5) heating stirring：Load weighted raw material is mixed, is heated, 280 DEG C, 30min, and mixed liquor is stirred continuously；
6) preheated mold：70℃-90℃；
7) it is molded：The solution heated is poured into after vacuum defoamation is handled in mold, then room temperature cools down；
8) cooling：Room temperature cools down, and waits for that solution becomes gel-like state, then kidney phantom material proposed by the invention is completed；
9) CT scan is verified：The kidney body mould that above-mentioned formula is scanned in CT equipment measures its average CT value.
Test example
It simulates human organ CT value measurement data and derives from a normal adult male, what 5 ROI of selection were measured is averaged
Value, the results are shown in Table 2.
2 human body different organs CT values of table are compared with different ratio (PVC- plasticizer mixing ratio) phantom material CT values
As shown in table 1, the PVC- plasticizer samples of 17 kinds of different ratios, which are placed under CT machines, scans.5 are chosen to same sample
A different level ROI records its CT value, and counts the corresponding mean CT-number of PVC- plasticizer mixing ratios.As shown in Table 1,
Different PVC- plasticizer mixing ratios can produce the phantom material of different CT values, and density is uniform, can simulate human body difference
The absorption coefficient at position；Meanwhile the phantom material different ratio can realize that CT values are adjustable in -20HU~100HU, CT values are adjustable
It is larger to save space, can make and detect body mould or simulated humanbody internal organs/tumor phantom for CT.In conclusion utilizing the formula
It can make and detect body mould or simulated humanbody internal organs/tumor phantom for CT.The body mould prepared using the phantom material, with people
The certain tissues of body have same or analogous absorption coefficient.
As shown in table 2, the phantom material CT values obtained by different PVC- plasticizer mixing ratios meet in embodiment 1
Straight line and regression equation.As shown in Table 1, different PVC- plasticizer mixing ratios can produce the phantom material of different CT values,
Density is uniform, can simulate the absorption coefficient of human body different parts, has good tissue radiation equivalence；Meanwhile the body mould
Material can coordinate 3D printing technique, be processed into various specific shapes, may be implemented good tissue formalness similitude and
Internal structure simulation quality；Therefore, phantom material provided by the invention can simulate human body different parts, different absorption coefficient, no
The human internal organ of similar shape tissue, such as liver,spleen,kidney is dirty, gall-bladder, interverbebral disc.
When making body mould using phantom material proposed by the invention, the method that multiple mould can be used is molten by what is heated
Liquid pours into Mold Making adult mould.In addition, cooperation 3D printing technique, may be implemented good tissue formalness similitude with
And internal structure simulation quality.
Claims (10)
1. a kind of preparation method of CT body mould, which is characterized in that with Corvic, plasticizer, fire retardant, PVC thermostabilizations
Agent and lubricant are that raw material measures different CT values, obtain polychlorostyrene second by changing the proportioning of Corvic and plasticizer
The mixing ratio and CT value variation relations of olefine resin and plasticizer；According to the CT values of required simulated organ, the use of each raw material is calculated
Amount, is processed to obtain the final product.
2. the preparation method of CT body mould according to claim 1, which is characterized in that the ranging from -20Hu of gained CT values~
100Hu。
3. the preparation method of CT body mould according to claim 1, which is characterized in that the plasticizer is that terephthalic acid (TPA) two is pungent
At least one of ester, dioctyl phthalate, dioctyl adipate.
4. CT body mold materials according to claim 1, the Corvic selection model PVCSG5, plasticizer are
Dioctyl terephthalate.
5. the preparation method of CT body mould according to claim 1, which is characterized in that fire retardant, PVC heat stabilizer dosage are 0-
1%, lubricant quantity 0-1%.
6. the preparation method of CT body mould according to claim 5, which is characterized in that fire retardant, PVC heat stabilizer are water aluminium calcium
Stone, lubricant are atoleine.
7. the preparation method of the CT body mould according to claim 1-5, which is characterized in that specifically include following steps：
1) initial data is extracted：Read original DICOM images, extract data, obtain organ mean CT-number to be simulated and thirdly
Tie up profile；
2) it prints：3d prints organ outer profile mold；
3) proportioning is calculated：According to the content needed for straight line and regression equation calculation raw material；
4) it weighs；
5) heating stirring：Load weighted raw material is mixed, is heated, 280 DEG C, 30min, and mixed liquor is stirred continuously；
6) preheated mold：70℃-90℃；
7) it is molded：The solution heated is poured into after vacuum defoamation is handled in mold, then room temperature cools down；
8) cooling：Room temperature cools down, and waits for that solution becomes gel-like state, then kidney phantom material proposed by the invention is completed；
9) CT scan is verified：The kidney body mould that above-mentioned formula is scanned in CT equipment, measures its mean CT-number.
8. the preparation method of CT body mould according to claim 7, which is characterized in that the PVC polymer fluids described in step 7) fill
Vacuum defoamation processing is carried out before entering mold.
9. the preparation method of CT body mould according to claim 7, which is characterized in that the PVC polymer fluids described in step 8) are answered
Room temperature is cooled to 120-130 DEG C and pours into mold again.
10. a kind of CT body mould being prepared by claim 1 method.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810261183.0A CN108618798A (en) | 2018-03-28 | 2018-03-28 | A kind of preparation method and its body mould of CT body mould |
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| CN201810261183.0A CN108618798A (en) | 2018-03-28 | 2018-03-28 | A kind of preparation method and its body mould of CT body mould |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110063740A (en) * | 2019-04-25 | 2019-07-30 | 泰山医学院 | Phantom material, preparation method and application suitable for the detection of CT standard value |
| CN114364969A (en) * | 2019-09-17 | 2022-04-15 | 株式会社爱德万测试 | Phantom and fluorescence detection device |
| CN114441186A (en) * | 2021-12-24 | 2022-05-06 | 中国汽车技术研究中心有限公司 | Method for manufacturing limb skin layer of dummy for automobile crash test |
-
2018
- 2018-03-28 CN CN201810261183.0A patent/CN108618798A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110063740A (en) * | 2019-04-25 | 2019-07-30 | 泰山医学院 | Phantom material, preparation method and application suitable for the detection of CT standard value |
| CN110063740B (en) * | 2019-04-25 | 2020-07-07 | 泰山医学院 | Phantom material suitable for CT standard value detection, preparation method and application |
| WO2020215853A1 (en) * | 2019-04-25 | 2020-10-29 | 山东第一医科大学(山东省医学科学院) | Phantom material suitable for ct standard value detection, preparation method and application |
| CN114364969A (en) * | 2019-09-17 | 2022-04-15 | 株式会社爱德万测试 | Phantom and fluorescence detection device |
| CN114441186A (en) * | 2021-12-24 | 2022-05-06 | 中国汽车技术研究中心有限公司 | Method for manufacturing limb skin layer of dummy for automobile crash test |
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