CN114364791A - 通用供体细胞 - Google Patents

通用供体细胞 Download PDF

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Publication number
CN114364791A
CN114364791A CN202080062262.4A CN202080062262A CN114364791A CN 114364791 A CN114364791 A CN 114364791A CN 202080062262 A CN202080062262 A CN 202080062262A CN 114364791 A CN114364791 A CN 114364791A
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cells
cell
mhc
hla
composition
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CN202080062262.4A
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Chinese (zh)
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A·雷扎尼亚
R·拉莫斯-扎亚斯
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CRISPR Therapeutics AG
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CRISPR Therapeutics AG
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • A61K35/37—Digestive system
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    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
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    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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CN202080062262.4A 2019-09-05 2020-09-04 通用供体细胞 Pending CN114364791A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962896477P 2019-09-05 2019-09-05
US62/896,477 2019-09-05
US202062979756P 2020-02-21 2020-02-21
US62/979,756 2020-02-21
PCT/IB2020/058279 WO2021044377A1 (en) 2019-09-05 2020-09-04 Universal donor cells

Publications (1)

Publication Number Publication Date
CN114364791A true CN114364791A (zh) 2022-04-15

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ID=72473592

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Application Number Title Priority Date Filing Date
CN202080062262.4A Pending CN114364791A (zh) 2019-09-05 2020-09-04 通用供体细胞

Country Status (14)

Country Link
US (4) US11116798B2 (https=)
EP (1) EP4025224A1 (https=)
JP (1) JP2022547053A (https=)
KR (1) KR20220058579A (https=)
CN (1) CN114364791A (https=)
AU (1) AU2020340622A1 (https=)
BR (1) BR112022004031A2 (https=)
CA (1) CA3150233A1 (https=)
CO (1) CO2022002570A2 (https=)
IL (1) IL290504A (https=)
MX (1) MX2022002663A (https=)
PH (1) PH12022550542A1 (https=)
SA (1) SA522431817B1 (https=)
WO (1) WO2021044377A1 (https=)

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US12378572B2 (en) 2018-09-07 2025-08-05 Crispr Therapeutics Ag Universal donor cells
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US11104918B2 (en) 2019-09-05 2021-08-31 Crispr Therapeutics Ag Universal donor cells
KR20230146007A (ko) 2020-12-31 2023-10-18 크리스퍼 테라퓨틱스 아게 범용 공여자 세포
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WO2023076994A1 (en) * 2021-10-27 2023-05-04 The Penn State Research Foundation Universal stem cell and uses thereof
WO2025064822A2 (en) * 2023-09-20 2025-03-27 Factor Bioscience Inc. Cells and methods for engineering cells with persistent transgene expression
WO2025202874A1 (en) 2024-03-25 2025-10-02 Crispr Therapeutics Ag Genetically modified cells expressing glp-1 receptor agonist
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