CN114306180B - Ultraviolet sunburn repairing agent capable of being placed for long time and preparation method thereof - Google Patents
Ultraviolet sunburn repairing agent capable of being placed for long time and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an ultraviolet sunburn repairing agent capable of being placed for a long time and a preparation method thereof, wherein the ultraviolet sunburn repairing agent comprises the following raw materials: radix Ophiopogonis, radix asparagi, carbomer, cera flava, sodium alginate, tween, betaine, and corn starch; mixing cleaned radix asparagi with radix Ophiopogonis, decocting in water, concentrating, mixing with carbomer, corn starch, sodium alginate, and betaine, stirring, adding Cera flava, homogenizing, emulsifying to obtain repairing agent, and maintaining stability of the medicine on altitude, high temperature difference, thin air, and strong radiation.
Description
Technical Field
The invention relates to the technical field of medicament preparation, in particular to an ultraviolet sunburn repairing agent capable of being placed for a long time and a preparation method thereof.
Background
Offshore training and altitude training are two special environments for army training at present, and ultraviolet injury belongs to common diseases and frequently-occurring diseases under the two special environments. The climate in the plateau area is characterized by strong solar radiation and more ultraviolet radiation. The total annual radiation value of Qinghai-Tibet plateau in China is up to 5850-7950 megajoules per square meter, and the number of sunshine hours in the year is more than 2000 hours. Due to the topography, the ultraviolet rays reaching the land surface in the Qinghai-Tibet plateau area are significantly higher than those in other areas. Because the wavelength of ultraviolet radiation is positively related to the penetrability of the ultraviolet radiation, the medium-wave ultraviolet radiation and the long-wave ultraviolet radiation can cause damage to the surface layer and the dermal tissue of the skin, cause skin erythema, pigmentation, sunburn of cells, immunosuppression, photoaging, tumor and the like, and cause serious harm to the physical health of basic officials and soldiers.
The ultraviolet-proof products sold in the market at present are mainly prepared from inorganic salts with a scattering effect on ultraviolet rays and organic sunscreens with an absorbing effect on ultraviolet rays, and mainly have the function of sun-proof, but the sun-proof behavior of basic-level officers and soldiers is extremely lack, and skin injury caused by the ultraviolet rays cannot be repaired due to separate sun-proof. At present, no effective repairing method exists, and only medicines with functions of disinfection, itching relieving and relieving can be simply used for relieving symptoms, and ultraviolet injury cannot be repaired. Radix Ophiopogonis and radix asparagi belong to the liliaceae traditional Chinese medicine, have the effects of nourishing yin, promoting the production of body fluid, moistening lung, relieving cough and the like, and are not used for preparing medicines for treating sunburn repair. Therefore, the method has wide research prospect, but experiments show that the layering phenomenon of the medicine is serious after the medicine is prepared into the sunburn repairing agent for a long time, and the medicine effect is reduced, so that the medicine is urgently needed to be improved, and the sunburn repairing agent which can be prepared into the sunburn repairing agent without layering and reducing the medicine effect after being placed for a long time is used for daily training and driving protection of basic-level officers and soldiers.
Disclosure of Invention
Therefore, the invention aims to provide the ultraviolet sunburn repairing agent capable of being placed for a long time and the preparation method thereof, and the prepared repairing agent can not generate the conditions of layering and reduced drug effect and can maintain the stability of the drug on the high altitude, large temperature difference, thin air and strong radiation plateau.
The invention solves the technical problems by the following technical means:
an ultraviolet sunburn repairing agent capable of being placed for a long time, wherein the repairing agent comprises the following raw materials:
radix Ophiopogonis, radix asparagi, carbomer, cera flava, sodium alginate, tween, betaine, and corn starch.
Further, the repairing agent comprises the following raw materials in parts by weight:
20-70 parts of dwarf lilyturf tuber, 20-70 parts of asparagus, 5-8 parts of carbomer, 5-8 parts of bee wax, 4-6 parts of sodium alginate, 8-15 parts of tween and 0.5-1 part of betaine.
Further, the method comprises the following steps:
(1) Mixing the washed radix asparagi with radix Ophiopogonis, decocting in water for 2 times, mixing decoctions, and concentrating under heating;
(2) Mixing the concentrated decoction with carbomer, stirring, standing overnight for swelling, adjusting pH to 7-8, adding corn starch, stirring gel and corn starch with high-speed stirrer, aging at room temperature for 10-12 hr, drying, and pulverizing into powder;
(3) Melting sodium alginate with soft water at 75-80deg.C, cooling to 25-30deg.C, adding betaine, stirring, adding the powder and Cera flava obtained in step (2) into sodium alginate solution, stirring, heating, homogenizing, adding tween, emulsifying, and storing at 2-4deg.C overnight;
(4) And (3) heating the cream subjected to the low-temperature treatment again for secondary emulsification to obtain the repairing agent.
Further, the step (2) is carried out at 45-55 ℃ for homogenization, and the homogenization pressure is 40Mpa.
Further, the step (2) is carried out at 60-65 ℃.
Further, the temperature of the secondary emulsification in the step (4) is 35-45 ℃.
Further, in the step (1), the radix asparagi and the radix ophiopogonis are decocted for 2 times and then heated and concentrated to 100-300 parts by weight.
Further, the sodium alginate and soft water are prepared into sodium alginate solution with the concentration of 1 percent.
Further, the preservation temperature of the repairing agent is-20-55 ℃.
The beneficial effects are that:
the ultraviolet injury resistant repairing agent prepared by the invention can relieve sunburn after ultraviolet radiation treatment by repairing skin collagen and fibroblast injury, and meanwhile, the repairing agent prepared by the invention is mild and does not irritate. The prepared repairing agent can not generate the conditions of layering and reduced drug effect, and can also keep the stability of the drug on the high altitude, large temperature difference, thin air and strong radiation plateau.
Drawings
Fig. 1: the ultraviolet sunburn restoration agent prepared in example 1.
Detailed Description
The present invention will be described in detail with reference to the following specific examples:
example 1: preparation of repairing agent
(1) Mixing the cleaned 20g of radix asparagi with 20g of dwarf lilyturf tuber, adding water for 2 times, merging the decoctions after the decoction is completed, and then heating and concentrating to 100g of the decoction;
(2) Mixing the concentrated decoction with 5g carbomer ground into particles-free carbomer, uniformly stirring, standing at normal temperature overnight for swelling, regulating pH=8 after swelling to obtain gel, adding 8g corn starch, uniformly stirring the gel and the corn starch by a high-speed stirrer until the corn starch is uniformly dispersed in the gel, covering the surface with a preservative film, aging at normal temperature for 10 hours, drying by a low-temperature drying method, pulverizing into powder after drying, and sieving with a 200-mesh sieve;
(3) Melting sodium alginate into 1% sodium alginate solution with soft water at 75-80deg.C, cooling to 25deg.C, adding 0.5g betaine, stirring, adding the powder in step (2) and 5g bee wax into sodium alginate solution, stirring, heating to 45deg.C for homogenizing under 40Mpa, adding 8g Tween 80, heating to 60deg.C for emulsification, stirring at 60r/min for 50min, and storing at 2-4deg.C overnight;
(4) And (3) heating the emulsifiable paste subjected to low-temperature treatment to 35 ℃ again for secondary emulsification, wherein the emulsification condition is a frame stirrer, the speed is 40r/min, the stirring time is 30min, and the repairing agent is obtained after the secondary emulsification is completed, as shown in figure 1.
Example 2: preparation of repairing agent II
(1) Mixing the washed 70g of radix asparagi with 70g of dwarf lilyturf tuber, adding water for 2 times, merging the decoctions after the decoction is completed, and then heating and concentrating to 300g of the decoction;
(2) Mixing the concentrated decoction with 8g carbomer ground into particles-free carbomer, stirring uniformly, standing at normal temperature overnight for swelling, regulating pH=7 after swelling to obtain gel, adding 15g corn starch, stirring the gel and the corn starch uniformly by a high-speed stirrer until the corn starch is uniformly dispersed in the gel, covering the surface with a preservative film, aging at normal temperature for 12h, drying, optionally drying at low temperature, pulverizing into powder after drying, and sieving with a 180-mesh sieve;
(3) Melting sodium alginate into 1% sodium alginate solution with soft water at 75-80deg.C, cooling to 25deg.C, adding 1g betaine, stirring, adding the powder in step (2) and 8g bee wax into sodium alginate solution, stirring, heating to 55deg.C, homogenizing under 40Mpa, adding 15g Tween 80, heating to 65deg.C, emulsifying with frame stirrer at 60r/min for 50min, and preserving at 2-4deg.C overnight;
(4) And (3) heating the emulsifiable paste subjected to low-temperature treatment to 45 ℃ again for secondary emulsification, wherein the emulsification condition is a frame stirrer, the speed is 40r/min, the stirring time is 30min, and the repairing agent is obtained after the secondary emulsification is completed.
Example 3: preparation of repairing agent three
(1) Mixing the washed 40g of radix asparagi with 40g of dwarf lilyturf tuber, adding water for 2 times, merging the decoctions after the decoction is completed, and then heating and concentrating to 200g of the decoction;
(2) Mixing the concentrated decoction with 6g carbomer ground into particles-free carbomer, uniformly stirring, standing at normal temperature overnight for swelling, regulating pH=7.5 after swelling to obtain gel, adding 10g corn starch, uniformly stirring the gel and the corn starch by a high-speed stirrer until the corn starch is uniformly dispersed in the gel, covering the surface with a preservative film, aging at normal temperature, aging for 11h, drying, optionally drying at low temperature, pulverizing into powder after drying, and sieving with a 200-mesh sieve;
(3) Melting sodium alginate into 1% sodium alginate solution with soft water at 75-80deg.C, cooling to 30deg.C, adding 0.8g betaine, stirring, adding the powder in step (2) and 6g bee wax into sodium alginate solution, stirring, heating to 50deg.C, homogenizing under 40Mpa, adding 12g Tween 80, heating to 63deg.C, emulsifying with frame stirrer at 60r/min for 50min, and storing at 2-4deg.C overnight;
(4) And (3) heating the emulsifiable paste subjected to low-temperature treatment to 40 ℃ again for secondary emulsification, wherein the emulsification condition is a frame stirrer, the speed is 40r/min, the stirring time is 30min, and the repairing agent is obtained after the secondary emulsification is completed.
Comparative example 1: contrast restorative 1
The comparative example was formed with the restorative agent prepared in example 1, except that no corn starch was added in step (2), and the specific procedure was as follows:
(2) Mixing the concentrated decoction with 5g carbomer ground into granule-free powder, stirring, standing at normal temperature overnight for swelling, adjusting pH=8 after swelling to obtain gel, covering the surface with preservative film, aging at normal temperature for 10 hr, drying, optionally drying at low temperature, pulverizing into powder, and sieving with 200 mesh sieve.
Comparative example 2: contrast repair agent 2
Comparative example was formed with the restorative prepared in example 1, except that no aging operation was performed in step (2), and the specific operation was as follows:
(2) Mixing the concentrated decoction with 5g carbomer ground into granule-free powder, stirring, standing at normal temperature overnight for swelling, adjusting pH=8 after swelling to obtain gel, adding 8g corn starch, stirring gel and corn starch with high-speed stirrer until corn starch is uniformly dispersed in gel, drying, and sieving with 200 mesh sieve.
Comparative example 3: contrast repair agent 3
Comparative example was formed with the restorative prepared in example 1, except that no homogenization operation was performed in step (3), as follows:
(3) Melting sodium alginate into 1% sodium alginate solution with 75-80deg.C soft water, cooling to 25deg.C, adding 0.5g betaine, stirring, adding the powder in step (2) and 5g bee wax into sodium alginate solution, stirring, adding 8g Tween 80, heating to 60deg.C for emulsification, stirring at 60r/min for 50min, and storing at 2-4deg.C overnight.
Comparative example 4: contrast repair agent 4
Comparative example was formed with the restorative agent prepared in example 1, except that no cryopreservation was performed in step (3), specifically as follows:
(3) Melting sodium alginate into 1% sodium alginate solution with soft water at 75-80deg.C, cooling to 25deg.C, adding 0.5g betaine, stirring, adding the powder in step (2) and 5g bee wax into sodium alginate solution, stirring, heating to 45deg.C, homogenizing under 40Mpa, adding 8g Tween 80, heating to 60deg.C, emulsifying with frame stirrer at 60r/min for 50min, and emulsifying again.
Comparative example 5: contrast repair agent 5
Comparative example was formed with the restorative preparation prepared in example 1, differing only in the operating temperatures in step (3) and step (4), and the specific operations were as follows:
(3) Melting sodium alginate into 1% sodium alginate solution with soft water at 75-80deg.C, cooling to 25deg.C, adding 0.5g betaine, stirring, adding the powder in step (2) and 5g bee wax into sodium alginate solution, stirring, homogenizing at normal temperature under 40Mpa, adding 8g Tween 80, emulsifying at normal temperature, stirring at 60r/min for 50min, and storing at low temperature of 2-4deg.C overnight;
(4) And (3) performing secondary emulsification on the emulsifiable paste subjected to the low-temperature treatment under the condition of a frame stirrer at the speed of 40r/min for 30min, and obtaining the repairing agent after the secondary emulsification is completed.
Experiments are carried out on the prepared repairing agent, and the specific process is as follows:
1. centrifugal experiment
10g of each repairing agent is taken and placed in a centrifuge tube, and the results obtained by centrifugation for 15min at different rotational speeds of 3000r/min, 3500r/min, 4000r/min, 5000r/min and 7000r/min per minute are shown in Table 1:
TABLE 1 influence of rotational speed on restorative
"-" is unchanged, "+" is thick, "++" is layered, and "++ + +" is water layer accounts for about 1/10 of the total volume.
As can be seen from the results in Table 1, the repairing agent prepared by the method disclosed by the invention is unchanged under high-speed centrifugation at 7000r/min, has no demulsification and oil-water separation phenomena, and has good stability. At 4000r/min, the coarsening phenomenon of the repairing agent prepared in the comparative example 3 only occurs, at 5000r/min, the coarsening phenomenon of the comparative examples 2 and 5 occurs, the layering phenomenon of the comparative example 3 occurs, at 7000r/min, the coarsening phenomenon of the comparative examples 4 and 5 occurs, the layering phenomenon of the comparative examples 1 and 2 occurs, and the serious layering phenomenon of the aqueous layer of the comparative example 3 accounts for more than about 1/10 of the total volume. The situation of comparative example 3 in the repairing agent is serious, which is probably due to incomplete embedding of the water oil caused by non-homogenizing operation, the delamination phenomenon is caused by light centrifugation, and the phenomenon of water oil separation is caused by both comparative example 1 and comparative example 2, which indicates that corn starch and non-aging operation also cause the phenomenon of water oil separation.
2. Temperature (Cold and heat resistance) test
(1) Taking 10g of each repairing agent, placing the repairing agents in an ointment box, respectively placing the ointment box in a refrigerator or an incubator with constant temperature, storing the ointment box in a hot constant temperature mode for 6 hours at different temperatures, and placing the ointment box in a low temperature mode for 24 hours;
(2) Taking 10g of repairing agent, storing and observing at natural room temperature, placing in a sample-keeping cabinet, observing and comparing month by month, and taking out after half a year, wherein the temperature is 20+/-5 ℃;
(3) Experiments were repeated 3 times; the results obtained are shown in tables 2 and 3:
TABLE 2 influence of temperature on restorative
"-" is unchanged, 1 or 2 times of coarsening, "+" coarsening and "++" layering are performed in the "+ -" experiment.
TABLE 3 variation of restorative at natural room temperature
"-" is unchanged, 1 or 2 times of coarsening, "+" coarsening and "++" layering are performed in the "+ -" experiment.
As can be seen from the data in tables 2 and 3, the restorative prepared by the method of the invention has no delamination or coarsening phenomenon at low temperature, high temperature and natural storage. The results of comparative examples 4, 5 and 2 are poor in low temperature, high temperature and natural storage, and the phenomena of thickening and layering occur earlier, probably because the three materials act cooperatively during the preparation process, so that the materials in the repairing agent are fused and emulsified with each other in advance, and dispersed more uniformly, and the gel material is better wrapped on the appearance of the easily layered materials, which is different from the single emulsification or homogenization operation, so that layering phenomenon does not occur in the examples.
3. Plateau environment simulation experiment
(1) Taking 10g of each repairing agent, placing the repairing agents in an ointment box, respectively placing the repairing agents in an incubator simulating the plateau environment for 1 month, and observing and comparing the repairing agents month by month;
(2) Simulating a plateau environment: temperature: heating to 20 ℃ at the initial temperature of-20 ℃ every day at 5 ℃/h, and keeping the rest constant temperature at 20 ℃; pressure intensity: maintaining at 500-600 mmHg; radiation amount/day: 20MJ/m 2
(3) Experiments were repeated 3 times; the results obtained are shown in Table 4.
TABLE 4 variation of restorative in plateau environments
"-" is unchanged, 1 or 2 times of coarsening, "+" coarsening and "++" layering are performed in the "+ -" experiment.
According to the data in Table 4, the repairing agent prepared by the method of the invention has the best performance in the simulated plateau environment, and samples in comparative examples 2, 3, 4 and 5 all show the phenomenon of coarsening within 5-10 days, so that the repairing agent has more severe plateau environment, and the stability is reduced due to the comprehensive factors of large temperature difference, strong irradiation, low pressure and the like. If the dispersion is poor or the emulsification is not correct in the earlier preparation process, the temperature difference can lead to water-oil separation, and meanwhile, the pressure drop and the irradiation improvement can lead to the acceleration of the separation of the repairing agent which is stable originally, so that the layering phenomenon is shown. Therefore, the repairing agent prepared by the invention is more suitable for being used on the high altitude, large temperature difference and strong radiation plateau.
The above embodiments are only for illustrating the technical solution of the present invention and not for limiting the same, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made thereto without departing from the spirit and scope of the technical solution of the present invention, which is intended to be covered by the scope of the claims of the present invention. The technology, shape, and construction parts of the present invention, which are not described in detail, are known in the art.
Claims (4)
1. The ultraviolet sunburn repairing agent capable of being placed for a long time is characterized by comprising the following raw materials in parts by weight:
20-70 parts of dwarf lilyturf tuber, 20-70 parts of asparagus, 5-8 parts of carbomer, 5-8 parts of beeswax, 4-6 parts of sodium alginate, 8-15 parts of tween, 0.5-1 part of betaine and 8-15 parts of corn starch; the preparation of the repairing agent comprises the following steps:
(1) Mixing the washed radix asparagi with radix Ophiopogonis, decocting in water for 2 times, mixing decoctions, and concentrating under heating;
(2) Mixing and stirring the concentrated decoction with carbomer uniformly, standing for overnight for swelling, adjusting pH=7-8, adding corn starch, stirring gel and corn starch uniformly by a high-speed stirrer, aging at normal temperature for 10-12h, drying, and pulverizing into powder;
(3) Melting sodium alginate with soft water at 75-80 ℃, cooling to 25-30 ℃, adding betaine, stirring uniformly, adding the powder obtained in the step (2) and beeswax into sodium alginate solution, stirring uniformly, heating and homogenizing, adding tween for heating and emulsifying after homogenizing, and storing at a low temperature of 2-4 ℃ overnight after emulsifying;
(4) Heating the low-temperature treated cream again for secondary emulsification to obtain a repairing agent;
homogenizing at 45-55 ℃ under the homogenizing pressure of 40Mpa; the step (3) is carried out emulsification at 60-65 ℃; the temperature of the secondary emulsification in the step (4) is 35-45 ℃.
2. The ultraviolet sunburn restoration agent capable of being placed for a long time according to claim 1, wherein in the step (1), radix asparagi and radix ophiopogonis are decocted with water for 2 times and then heated and concentrated to 100-300 parts by weight.
3. The ultraviolet sunburn restoration agent capable of being placed for a long time according to claim 2, wherein said sodium alginate and soft water are prepared into a sodium alginate solution with a concentration of 1%.
4. The ultraviolet sunburn restoration agent capable of being placed for a long time according to claim 3, wherein the preservation temperature of the restoration agent is-20-55 ℃.
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