CN114302712B - 一种阿昔莫司多单元缓释微丸片及其制备方法 - Google Patents

一种阿昔莫司多单元缓释微丸片及其制备方法 Download PDF

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Publication number
CN114302712B
CN114302712B CN201980038416.3A CN201980038416A CN114302712B CN 114302712 B CN114302712 B CN 114302712B CN 201980038416 A CN201980038416 A CN 201980038416A CN 114302712 B CN114302712 B CN 114302712B
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China
Prior art keywords
acipimox
release
pellets
parts
sustained
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Active
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CN201980038416.3A
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English (en)
Chinese (zh)
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CN114302712A (zh
Inventor
刘阿利
徐同强
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Lunnan Better Pharmaceutical Co ltd
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Lunnan Better Pharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
CN201980038416.3A 2019-09-04 2019-09-04 一种阿昔莫司多单元缓释微丸片及其制备方法 Active CN114302712B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2019/104272 WO2021042278A1 (fr) 2019-09-04 2019-09-04 Comprimé de granulés d'acipimox à libération prolongée à unités multiples et méthode de préparation associée

Publications (2)

Publication Number Publication Date
CN114302712A CN114302712A (zh) 2022-04-08
CN114302712B true CN114302712B (zh) 2023-08-04

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CN201980038416.3A Active CN114302712B (zh) 2019-09-04 2019-09-04 一种阿昔莫司多单元缓释微丸片及其制备方法

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CN (1) CN114302712B (fr)
WO (1) WO2021042278A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115039888B (zh) * 2022-07-25 2023-11-21 安徽九春堂药业有限公司 一种维生素c片及其制备方法
CN117462516A (zh) * 2023-08-04 2024-01-30 青岛海洋生物医药研究院 一种新型缓释微丸及其制备方法和其微丸片剂
CN117323305B (zh) * 2023-11-07 2024-06-07 杭州沐源生物医药科技有限公司 溴隐亭片剂及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6475521B1 (en) * 1998-03-19 2002-11-05 Bristol-Myers Squibb Co. Biphasic controlled release delivery system for high solubility pharmaceuticals and method
CN102123699A (zh) * 2008-06-16 2011-07-13 生物血管公司 降低血小板循环水平的药剂的控释组合物及其制备方法
CN103211785A (zh) * 2012-01-18 2013-07-24 北京天衡药物研究院 阿昔莫司膜控缓释微丸胶囊

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201003766D0 (en) * 2010-03-05 2010-04-21 Univ Strathclyde Pulsatile drug release

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6475521B1 (en) * 1998-03-19 2002-11-05 Bristol-Myers Squibb Co. Biphasic controlled release delivery system for high solubility pharmaceuticals and method
CN102123699A (zh) * 2008-06-16 2011-07-13 生物血管公司 降低血小板循环水平的药剂的控释组合物及其制备方法
CN103211785A (zh) * 2012-01-18 2013-07-24 北京天衡药物研究院 阿昔莫司膜控缓释微丸胶囊

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
The assessment of human regional drug absorption of free acid and sodium salt forms of acipimox, in healthy volunteers, to direct modified release formulation strategy;Menon, R. , Cefali, E. , Wilding, I. , Wray, H. , & Connor, A.;Biopharmaceutics & Drug Disposition;第30卷(第9期);508-516 *

Also Published As

Publication number Publication date
CN114302712A (zh) 2022-04-08
WO2021042278A1 (fr) 2021-03-11

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