CN114287628A - Health product for delaying senility and improving memory function - Google Patents
Health product for delaying senility and improving memory function Download PDFInfo
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Abstract
The invention discloses a health-care product with functions of delaying senility and improving memory, and mainly relates to the field of health-care food. The paint comprises the following components in parts by weight: 20-60 parts of fish oil; 2-10 parts of ginseng extract; 2-10 parts of grape seed extract; 2-10 parts of ginkgo leaf extract; 2-10 parts of medlar fine powder. The invention has the functions of delaying senility and improving memory.
Description
Technical Field
The invention relates to the field of health-care food, in particular to a health-care product for delaying senility and improving memory function.
Background
Aging, also known as aging, is the manifestation of the combined actions of various biochemical reactions of the body and is the result of the interaction between various factors (including the surrounding environment and social factors, etc.) in vivo and in vitro. Modern medical research shows that the essence of aging refers to an irreversible process that after the organism develops and matures under normal conditions, the organism has reduced functions along with the increase of age, the stability and the stress capability of the environment in the organism are reduced, and the structure and the function are gradually degenerated.
The memory as the basic function is related to the aspects of human life. Memory is the most important and fundamental neurological process of the brain, which is intensively studied in modern neuroscience, psychology and neurology fields. Modern psychophysiology considers that memory is the storage and extraction of empirical information. In traditional Chinese medicine, there is a history of memory decline in the morning, for example, the book "Bian Bing Zhi Mi Men" describes that people are old and forgetful, and are at present too memorable, and even though people are at a glance, they are at a glance, which is the most of true forgetfulness.
At present, although the prior art for delaying senescence and the health care products for improving memory are reported more, the health care products with the functions of delaying senescence and improving memory are not reported yet.
Disclosure of Invention
The invention aims to provide a health care product with functions of delaying senility and improving memory, which has the functions of delaying senility and improving memory.
In order to achieve the purpose, the invention is realized by the following technical scheme:
a health product for delaying senility and improving memory function comprises the following components in parts by weight:
20-60 parts of fish oil;
2-10 parts of ginseng extract;
2-10 parts of grape seed extract;
2-10 parts of ginkgo leaf extract;
2-10 parts of medlar fine powder.
The antioxidant also comprises an antioxidant component, wherein the antioxidant component comprises any one or combination of any several of vitamin E, ascorbyl palmitate, rosmarinic acid and vitamin C.
The suspending agent comprises any one or the combination of beeswax, glyceryl monostearate and lecithin.
Also comprises a diluent, wherein the diluent comprises any one of soybean oil, sunflower seed oil, olive oil and coconut oil or the combination of any several of the above.
In specific application, capsule shells processed by vegetable gum or animal gum are injected to prepare soft capsules.
The preparation method comprises the following steps:
adding the fish oil into the ginseng extract, the grape seed extract, the ginkgo leaf extract and the medlar fine powder, and uniformly mixing to obtain a mixed medicine;
glue melting: adding purified water and glycerol into a gelatin melting tank, heating to 65 + -5 deg.C, stirring, adding gelatin, maintaining the pressure above-0.05 MPa, keeping the temperature at 68 + -5 deg.C for 30-40min, vacuumizing, and stopping vacuumizing when the vacuum degree is not lower than-0.07 MPa to obtain capsule shell gelatin;
pelleting: the soft capsule is prepared by mixing the above materials with capsule shell gelatin and making into soft capsule.
The preparation method comprises the following steps:
adding the fish oil into the ginseng extract, the grape seed extract, the ginkgo leaf extract and the medlar fine powder, and uniformly mixing to obtain a mixed medicine;
glue melting: adding purified water and glycerol into a gelatin melting tank, heating to 95 + -5 deg.C, stirring, adding vegetable gelatin, maintaining the pressure above-0.06 MPa, keeping the temperature at 95 + -5 deg.C for 40-60min, vacuumizing, and stopping vacuumizing when the vacuum degree is not lower than-0.08 MPa to obtain capsule shell gelatin;
pelleting: the soft capsule is prepared by mixing the above materials with capsule shell gelatin and making into soft capsule.
Compared with the prior art, the invention has the beneficial effects that:
1. the health food for delaying senility and improving memory is prepared by compounding fish oil, ginseng extract, grape seed extract, ginkgo leaf extract and medlar fine powder, and realizes the effect of the bifunctional health food for delaying senility and improving memory through the synergistic effect of the raw materials.
2. The soft capsule of the invention has the advantages of high bioavailability, convenient taking, convenient storage and carrying.
3. The components of the invention are easy to obtain, the preparation of the soft capsule formulation is simple, the process is mature, and the invention is convenient for production and transformation application.
Drawings
FIG. 1 is a photograph of the process of the present invention.
FIG. 2 is a report cover of the inspection report for the product of example 1.
FIG. 3 is the first page of the inspection report pages for the delivery of the product of example 1.
Figure 4 is the second page of the inspection report for the product submission of example 1.
FIG. 5 is the third page of the inspection report for the product submission of example 1.
FIG. 6 is the fourth page of the inspection report for the product submission of example 1.
Detailed Description
The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and these equivalents also fall within the scope of the present application.
The instruments, reagents, materials and the like used in the following examples are conventional instruments, reagents, materials and the like in the prior art and are commercially available in a normal manner unless otherwise specified. Unless otherwise specified, the experimental methods, detection methods, and the like described in the following examples are conventional experimental methods, detection methods, and the like in the prior art.
The invention mainly relates to a health product with functions of delaying senility and improving memory, which mainly comprises the following components in parts by weight:
20-60 parts of fish oil;
2-10 parts of ginseng extract;
2-10 parts of grape seed extract;
2-10 parts of ginkgo leaf extract;
2-10 parts of medlar fine powder.
Among the above components, the functions of each component are as follows:
fish oil: the fish oil rich in the DHA can improve the memory of people, and the fish oil rich in the DHA can be fully supplemented. Research shows that along with the increase of age, the DHA content in human body blood platelets and erythrocyte membrane lipid is reduced, and the SOD activity is reduced; after 12 old people take the preparation for 4 weeks, the DHA content in erythrocyte membrane lipid is increased, and the SOD activity is enhanced. Research work also suggests that DHA has antioxidant and anti-aging effects.
The ginseng extract: is extracted from root, stem and leaf of Panax ginseng C.A. Meyer of Araliaceae family, and is rich in eighteen ginsenoside monomer. It has effects in delaying nerve cell aging, reducing memory injury of the elderly, stabilizing membrane structure, increasing protein synthesis, and improving memory of the elderly. Is available on the market.
Grape seed extract: is a novel high-efficiency natural antioxidant substance which can not be synthesized in human body and is extracted from grape seeds. The antioxidant and free radical scavenging substance is a substance which is found in nature and has the strongest capacity of resisting oxidation and scavenging free radicals, the antioxidant activity of the antioxidant and free radical scavenging substance is 50 times that of vitamin E and 20 times that of vitamin C, the antioxidant and free radical scavenging substance can effectively scavenge redundant free radicals in vivo, and the antioxidant and free radical scavenging substance has the super-strong functions of delaying senility, enhancing immunity, improving hypomnesis and the like. Is available on the market.
Ginkgo leaf extract: the effective components of the ginkgo leaf extract are mainly ginkgetin and terpene lactone, and clinical tests prove that the ginkgo leaf extract has the effects of scavenging free radicals, resisting stress reaction, protecting myocardial damage of diabetic rats and resisting fatigue. Is available on the market.
Medlar fine powder: the main component is lycium barbarum polysaccharide. Modern aging theory considers that the main reason for the immune function deterioration of the body in the aging process is that the thymus is atrophied along with the increase of age, and the thymus is the main link of aging. The lycium barbarum polysaccharides in the wolfberry fruits have a main selective effect on thymus T cells in a human body, can capture and increase the number of mature cells, enhance the emptying function, increase the transfer of the thymocytes to the periphery and reverse the aging thymus degeneration. Lycium barbarum polysaccharides can also enhance bone marrow hemopoiesis, so Lycium barbarum has antiaging effect.
The health product is not limited to the components, and the following components can be further added:
1) any one or more of vitamin E, ascorbyl palmitate, rosmarinic acid and vitamin C, so that the health-care product has the effects of resisting oxidation and improving immunity.
2) Any one or more of beeswax, glyceryl monostearate and lecithin as suspending agent.
3) Any one or combination of any several of soybean oil, sunflower seed oil, olive oil and coconut oil as diluent.
Based on the components, the health care product can be mixed with a pharmaceutically acceptable carrier, matrix or auxiliary material to prepare an oral health care product when being applied specifically. Can be made into soft capsule. And the capsule shell can be made of plant gum or animal gum according to the requirements of customers, so that the requirements of different customers are met.
The specific processing method comprises the following steps:
(1) preparing materials: pumping qualified fish oil and diluent into a dispensing tank, adding suspending agent, melting, adding Ginseng radix extract, grape seed extract, folium Ginkgo extract, fructus Lycii fine powder and antioxidant, respectively, and mixing for 20-60 min.
(2) Glue melting: transfer animal glue and vegetable glue:
animal glue:
adding purified water and glycerol into gelatin melting tank, heating to 65 + -5 deg.C, stirring, adding gelatin, maintaining pressure above-0.05 MPa, and keeping the temperature at 68 + -5 deg.C; sol is carried out for 30-40 min; vacuumizing, and stopping vacuumizing when the vacuum degree is not lower than-0.07 MPa.
Vegetable gum:
adding purified water and glycerol into a gelatin melting tank, heating to 95 + -5 deg.C, stirring, adding vegetable gelatin, maintaining the pressure at-0.06 MPa, and keeping the temperature at 95 + -5 deg.C; sol is carried out for 40-60 min; vacuumizing, and stopping vacuumizing when the vacuum degree is not lower than-0.08 MPa.
(3) Pelleting: pressing soft capsules with different loading according to a pill pressing process.
Example 1: health product for delaying senility and improving memory function
A health food with functions of delaying senility and improving memory comprises the following raw material components:
40% of fish oil, 2% of ginseng extract, 2% of grape seed extract, 5% of ginkgo leaf extract, 3% of medlar fine powder, 0.5% of vitamin E, 4% of beeswax and 43.5% of sunflower seed oil.
The health food components are prepared by the following method:
adding 10Kg of water and 4Kg of glycerol into a gelatin melting tank, heating to 65 +/-5 ℃, stirring, adding 11Kg of gelatin and sol with pressure of more than 0.05MPa, and keeping the temperature at 68 +/-5 ℃; sol is carried out for 30-40 min; vacuumizing, and stopping vacuumizing when the vacuum degree is not lower than-0.07 MPa.
Pelleting: pressing soft capsules with different loading quantities according to the requirements of customers.
Example 2: health product for delaying senility and improving memory function
A health food with functions of delaying senility and improving memory comprises the following raw material components:
45% of fish oil, 2% of ginseng extract, 2% of grape seed extract, 5% of ginkgo leaf extract, 3% of medlar fine powder, 0.5% of vitamin E, 4% of beeswax and 38.5% of sunflower seed oil.
The health food components are prepared by the following method:
adding 12kg of purified water and 6kg of glycerol into a gelatin melting tank, heating to 95 +/-5 ℃, stirring, adding 12kg of vegetable gelatin, keeping the pressure of the gelatin solution at more than-0.06 MPa, and keeping the temperature at 95 +/-5 ℃; sol is carried out for 40-60 min; vacuumizing, and stopping vacuumizing when the vacuum degree is not lower than-0.08 MPa.
Pelleting: pressing soft capsules with different loading quantities according to the requirements of customers.
Example 3: animal experiments (with respect to delaying aging) Using the capsules obtained in example 1
Experimental animals: oregon K wild type Drosophila melanogaster (Drosophila melanogaster) was provided by Shanghai university of railway medical school.
Fruit fly survival experiment:
the test dose is as follows: the soft capsules prepared in example 1 were used, and the recommended intake of human body was 2.0g/d, and four concentration groups were set, respectively: 0.022%, 0.067%, 0.200%, 0.600%, and blank control group was added.
Test reagents and instruments: biochemical incubator (25 + -1 deg.C, humidity 45-75%), culture finger tube (flat bottom) 2.5 × 10cm, electronic balance, diethyl ether, and propionic acid.
The experimental process comprises the following steps: collecting newly emerged fruit fly imagoes within eight hours, and randomly grouping the divided males and females under ether anesthesia. 200 drosophila hermitica flies per concentration group are distributed in 10 culture finger tubes, and 20 drosophila hermitica flies per tube. Adults were weighed and given the test subjects starting 2 weeks after nest splitting. The experiment is formally started after the fruit flies are placed in the culture medium of the test object, the control group is given with the common corn starch culture medium, and the experiment group is given with the culture medium containing 0.022 percent, 0.067 percent, 0.200 percent and 0.600 percent of the test object respectively. The experimental conditions are as follows: the temperature is 25 +/-1 ℃, and the relative humidity is 54-66%. The death number of the fruit flies was recorded by regular observation every day, and the medium was changed every 4 days until all the flies were observed to die. At the end of the experiment, half the number of death days, the mean life-span and the mean maximum life-span were calculated (the mean number of surviving days for the last dead 20 flies in each group was the maximum life-span of the group).
TABLE 1 Drosophila survival test statistical table
Note: p < 0.05, P < 0.01, compared to control
As can be seen from Table 1, the growth of each group of Drosophila was good in the Drosophila survival test. Half death days of male fruit flies in 0.200% and 0.600% concentration groups are respectively prolonged by 6 days and 7 days compared with those of the control group, and the average life and the average maximum life of the male fruit flies in 0.067%, 0.200% and 0.600% concentration groups are respectively prolonged than those of the control group, and the difference is significant (P is less than 0.05); the half death days of the female drosophila melanogaster 0.200% and 0.600% concentration groups are respectively prolonged by 7 days and 9 days compared with the control group, the average life and the average maximum life are both prolonged compared with the control group, and the difference is uniform and significant (P is less than 0.05).
Example 4: animal experiments (regarding memory) performed using the capsules obtained in example 1
1, sample: example 1.
2 subjects:
adult volunteers healthy and in line with the following conditions were selected as subjects. The first test is carried out before sample taking, the test is divided into groups according to the memory quotient of the test, and the second test is carried out 30 days after the test. The subjects were taken from a college. And satisfies the following conditions:
2.1 received no similar tests;
2.2 the medicine or health care product related to the memory improvement is not taken within one year;
2.3 the culture degree is the same;
2.4 same age group (20-28 years old).
And 3, a grouping method: 104 persons are tested for the first time, and are queued according to the memory quotient height, divided into two groups according to the odd number and the even number, after the two groups of memory quotient are tested to be balanced, one group is randomly selected to be a test group (52 persons), and the other group is selected to be a control group (52 persons).
4, taking samples: test groups: the sample prepared in example 1; control group: a placebo was administered.
TABLE 2 comparison of test and memory quotient for test and control groups before sample taking
| Test items | Control group | Test group |
| Number of people (n) | 52 | 52 |
| Memory of direction | 15.3±5.7 | 15.8±4.1 |
| Associative learning | 17.6±4.7 | 18.3±5.8 |
| Free memory of image | 14.7±5.2 | 14.3±4.3 |
| Re-recognition of meaningless figures | 8.5±9.4 | 6.3±7.7 |
| Human image feature contact memory | 13.6±4.8 | 13.5±4.8 |
| Memory Quotient (MQ) | 70.2±10.4 | 69.1±11.4 |
As can be seen from Table 2, the test scale and memory quotient of each component of the test group before sample taking are compared with those of the control group, and the difference is not significant (P is more than 0.05). It indicates that the memory levels of the two groups are balanced before taking the sample.
TABLE 3 test group test before and after test comparing test points with memory quotient
| Test items | Before testing | After the test |
| Number of people (n) | 52 | 52 |
| Memory of direction | 15.8±4.1 | 19.6±4.6** |
| Associative learning | 18.3±5.8 | 23.4±5.7** |
| Free memory of image | 14.3±4.3 | 20.9±4.9** |
| Re-recognition of meaningless figures | 6.3±7.7 | 16.8±7.9** |
| Human image feature contact memory | 13.5±4.8 | 18.5±6.3** |
| Memory Quotient (MQ) | 69.1±11.4 | 92.0±13.8** |
Note: p < 0.01, compared to before experiment
As can be seen from Table 3, after the test group takes the sample, the indexes of the test table and the memory quotient are obviously higher than those before the test and the difference is significant (P is less than 0.01).
TABLE 4 comparison of test points and memory quotient for each test point before and after the control group test
| Test items | Before testing | After the test |
| Number of people (n) | 52 | 52 |
| Memory of direction | 15.3±5.7 | 19.2±5.4** |
| Associative learning | 17.6±4.7 | 18.7±6.4 |
| Free memory of image | 14.7±5.2 | 15.6±6.0 |
| Re-recognition of meaningless figures | 8.5±9.4 | 15.2±7.9** |
| Human image feature contact memory | 13.6±4.8 | 15.4±5.5 |
| Memory Quotient (MQ) | 70.2±10.4 | 79.4±14.2** |
Note: p < 0.01, compared to before experiment
As can be seen from Table 4, after the control group was tested, the score of the index memory and meaningless graph recognition test and the memory quotient were higher than those before the test, and the difference was significant (P < 0.01).
TABLE 5 post-test comparison of test combination control Components test Scale and memory quotient
| Test items | Control group | Test group |
| Number of people (n) | 52 | 52 |
| Memory of direction | 19.2±5.4 | 19.6±4.6 |
| Associative learning | 18.7±6.4 | 23.4±5.7** |
| Free memory of image | 15.6±6.0 | 20.9±4.9** |
| Re-recognition of meaningless figures | 15.2±7.9 | 16.8±7.9 |
| Human image feature contact memory | 15.4±5.5 | 18.5±6.3* |
| Memory Quotient (MQ) | 79.4±14.2 | 92.0±13.8** |
Note: p < 0.05, P < 0.01, compared to control
As shown in Table 5, after the test, the five components of the test group have higher score and memory quotient than the control group, wherein the association learning, the free image memory, the portrait character association memory and the memory quotient and the control group have significant difference (P is less than 0.05).
Claims (7)
1. A health product for delaying senility and improving memory function is characterized by comprising the following components in parts by weight:
2. the health product for delaying aging and improving memory function according to claim 1, further comprising an antioxidant component, wherein the antioxidant component comprises any one or a combination of any several of vitamin E, ascorbyl palmitate, rosmarinic acid and vitamin C.
3. The health product for delaying aging and improving memory according to claim 1, further comprising a suspending agent, wherein the suspending agent comprises any one or a combination of any two of beeswax, glyceryl monostearate and lecithin.
4. The health product for delaying aging and improving memory function according to claim 1, further comprising a diluent, wherein the diluent comprises any one or a combination of any several of soybean oil, sunflower seed oil, olive oil and coconut oil.
5. The health product of claim 1, wherein the capsule shell is prepared by injecting plant gum or animal gum, and making into soft capsule.
6. The health product for delaying aging and improving memory according to claim 1, which is prepared by the following method:
adding the fish oil into the ginseng extract, the grape seed extract, the ginkgo leaf extract and the medlar fine powder, and uniformly mixing to obtain a mixed medicine;
glue melting: adding purified water and glycerol into a gelatin melting tank, heating to 65 + -5 deg.C, stirring, adding gelatin, maintaining the pressure above-0.05 MPa, keeping the temperature at 68 + -5 deg.C for 30-40min, vacuumizing, and stopping vacuumizing when the vacuum degree is not lower than-0.07 MPa to obtain capsule shell gelatin;
pelleting: the soft capsule is prepared by mixing the above materials with capsule shell gelatin and making into soft capsule.
7. The health product for delaying aging and improving memory according to claim 1, which is prepared by the following method:
adding the fish oil into the ginseng extract, the grape seed extract, the ginkgo leaf extract and the medlar fine powder, and uniformly mixing to obtain a mixed medicine;
glue melting: adding purified water and glycerol into a gelatin melting tank, heating to 95 + -5 deg.C, stirring, adding vegetable gelatin, maintaining the pressure above-0.06 MPa, keeping the temperature at 95 + -5 deg.C for 40-60min, vacuumizing, and stopping vacuumizing when the vacuum degree is not lower than-0.08 MPa to obtain capsule shell gelatin;
pelleting: the soft capsule is prepared by mixing the above materials with capsule shell gelatin and making into soft capsule.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101828714A (en) * | 2010-05-13 | 2010-09-15 | 山东森健生物科技发展有限公司 | Health food for delaying senescence |
| CN103238840A (en) * | 2013-05-16 | 2013-08-14 | 汤臣倍健股份有限公司 | Ginkgo biloba extract and fish oil soft capsule and preparation method thereof |
| WO2020233459A1 (en) * | 2019-05-17 | 2020-11-26 | 石家庄以岭药业股份有限公司 | Composition for improving memory and preparation method therefor |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101828714A (en) * | 2010-05-13 | 2010-09-15 | 山东森健生物科技发展有限公司 | Health food for delaying senescence |
| CN103238840A (en) * | 2013-05-16 | 2013-08-14 | 汤臣倍健股份有限公司 | Ginkgo biloba extract and fish oil soft capsule and preparation method thereof |
| WO2020233459A1 (en) * | 2019-05-17 | 2020-11-26 | 石家庄以岭药业股份有限公司 | Composition for improving memory and preparation method therefor |
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