CN114269950A - 检测膀胱及泌尿道上皮癌的尿液小rna指纹图谱及其应用 - Google Patents
检测膀胱及泌尿道上皮癌的尿液小rna指纹图谱及其应用 Download PDFInfo
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Abstract
提供一种涉及miRNA指纹图谱在人膀胱及泌尿道上皮癌(包括膀胱癌、肾盂癌、输尿管癌、排尿管癌等)诊断和治疗中的应用,由miRNA组成的多个指纹图谱能够非常有效地区分膀胱及泌尿道上皮癌的尿液样本与非膀胱及泌尿道上皮癌的尿液样本,灵敏度高,特异性强。可有效地用于膀胱及泌尿道上皮癌的检测,早期诊断与筛查,及膀胱及泌尿道上皮癌药物的筛选。
Description
PCT国内申请,说明书已公开。
Claims (25)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
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CN201910776393 | 2019-08-19 | ||
CN2019107763938 | 2019-08-19 | ||
PCT/CN2020/109710 WO2021032077A1 (zh) | 2019-08-19 | 2020-08-18 | 检测膀胱及泌尿道上皮癌的尿液小rna指纹图谱及其应用 |
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CN114269950A true CN114269950A (zh) | 2022-04-01 |
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CN202080058592.6A Pending CN114269950A (zh) | 2019-08-19 | 2020-08-18 | 检测膀胱及泌尿道上皮癌的尿液小rna指纹图谱及其应用 |
CN202010829801.4A Pending CN112391467A (zh) | 2019-08-19 | 2020-08-18 | 检测膀胱及泌尿道上皮癌的尿液小rna指纹图谱及其应用 |
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US (1) | US20220372578A1 (zh) |
CN (2) | CN114269950A (zh) |
WO (1) | WO2021032077A1 (zh) |
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CN114150063A (zh) * | 2021-12-09 | 2022-03-08 | 觅瑞(杭州)生物科技有限公司 | 膀胱癌诊断用尿液miRNA标志物、诊断试剂及试剂盒 |
Citations (4)
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CN101386848A (zh) * | 2008-08-12 | 2009-03-18 | 南京大学 | 细胞微粒子所载微小核糖核酸及其制备研究方法和应用 |
CN103476947A (zh) * | 2011-03-02 | 2013-12-25 | 格路福生物制药公司 | 寡聚体的增强的生物分布 |
CN105779641A (zh) * | 2016-05-21 | 2016-07-20 | 陈亮 | 用于膀胱癌诊断的miRNA生物标志物及检测试剂盒 |
CN108728439A (zh) * | 2017-04-19 | 2018-11-02 | 上海翔琼生物技术有限公司 | 小rna组成的指纹图谱及其在膀胱癌诊断中的应用 |
Family Cites Families (9)
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US20080076674A1 (en) * | 2006-07-06 | 2008-03-27 | Thomas Litman | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of non coding RNAs associated with cancer |
EP2188395A4 (en) * | 2007-08-17 | 2010-10-13 | Catalyst Assets Llc | USE OF MICRO-RNA ASSOCIATED WITH CANCER OF THE HUMAN BLADDER FOR DIAGNOSIS AND PROGNOSIS |
WO2013040251A2 (en) * | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
WO2014085666A1 (en) * | 2012-11-27 | 2014-06-05 | Board Of Regents, The University Of Texas System | Methods of characterizing and treating molecular subset of muscle-invasive bladder cancer |
CN103320504A (zh) * | 2013-01-28 | 2013-09-25 | 深圳市人民医院 | 检测排泄物中microRNAs作为肺癌、结直肠癌和膀胱癌早期诊断生物标志 |
JP6443889B2 (ja) * | 2013-08-08 | 2018-12-26 | 国立大学法人大阪大学 | 尿路上皮癌の診断または治療剤 |
CN104975019B (zh) * | 2014-04-01 | 2019-07-12 | 上海翔琼生物技术有限公司 | 小rna组成的指纹图谱在人卵巢癌诊断和治疗中的应用 |
CN109706146B (zh) * | 2017-10-25 | 2023-06-06 | 上海翔琼生物技术有限公司 | 小rna组成的指纹图谱在人的癌性胸腔积液诊断和治疗中的应用 |
EP3492607A3 (en) * | 2017-11-30 | 2019-08-14 | Università Degli Studi Di Torino | Urinary mirnas for the in vitro diagnosis of bladder cancer |
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2020
- 2020-08-18 CN CN202080058592.6A patent/CN114269950A/zh active Pending
- 2020-08-18 WO PCT/CN2020/109710 patent/WO2021032077A1/zh active Application Filing
- 2020-08-18 CN CN202010829801.4A patent/CN112391467A/zh active Pending
- 2020-08-18 US US17/636,902 patent/US20220372578A1/en active Pending
Patent Citations (4)
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CN101386848A (zh) * | 2008-08-12 | 2009-03-18 | 南京大学 | 细胞微粒子所载微小核糖核酸及其制备研究方法和应用 |
CN103476947A (zh) * | 2011-03-02 | 2013-12-25 | 格路福生物制药公司 | 寡聚体的增强的生物分布 |
CN105779641A (zh) * | 2016-05-21 | 2016-07-20 | 陈亮 | 用于膀胱癌诊断的miRNA生物标志物及检测试剂盒 |
CN108728439A (zh) * | 2017-04-19 | 2018-11-02 | 上海翔琼生物技术有限公司 | 小rna组成的指纹图谱及其在膀胱癌诊断中的应用 |
Non-Patent Citations (1)
Title |
---|
柯建波等: "miR-151-5p在肿瘤中的研究进展", 国际肿瘤学杂志, vol. 44, no. 6, pages 445 - 447 * |
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US20220372578A1 (en) | 2022-11-24 |
CN112391467A (zh) | 2021-02-23 |
WO2021032077A1 (zh) | 2021-02-25 |
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