CN114269723A - 吡嗪-2(1h)-酮类化合物的d晶型及其制备方法 - Google Patents

吡嗪-2(1h)-酮类化合物的d晶型及其制备方法 Download PDF

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Publication number
CN114269723A
CN114269723A CN202080054561.3A CN202080054561A CN114269723A CN 114269723 A CN114269723 A CN 114269723A CN 202080054561 A CN202080054561 A CN 202080054561A CN 114269723 A CN114269723 A CN 114269723A
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CN114269723B (zh
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陈志亮
罗志毅
庄毅超
林锦霞
高龙辉
付志飞
罗妙荣
张杨
黎健
陈曙辉
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Zhangzhou Pientzehuang Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

公开了一种吡嗪‑2(1H)‑酮类化合物的晶型及其制备方法，具体公开了式(ⅠI)化合物及其晶型的制备方法。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080054561.3A 2019-08-08 2020-08-04 吡嗪-2(1h)-酮类化合物的d晶型及其制备方法 Active CN114269723B (zh)

Applications Claiming Priority (5)

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CN2019107311061 2019-08-08
CN201910731106 2019-08-08
CN2019110599426 2019-11-01
CN201911059942 2019-11-01
PCT/CN2020/106901 WO2021023195A1 (zh) 2019-08-08 2020-08-04 吡嗪-2（1h）-酮类化合物的d晶型及其制备方法

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US (1) US11597722B2 (zh)
EP (1) EP4011869B1 (zh)
JP (1) JP7200437B2 (zh)
CN (1) CN114269723B (zh)
ES (1) ES2968388T3 (zh)
WO (1) WO2021023195A1 (zh)

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Publication number Priority date Publication date Assignee Title
WO2021023192A1 (zh) * 2019-08-08 2021-02-11 漳州片仔癀药业股份有限公司 吡嗪-2(1h)-酮类化合物的a晶型和b晶型及其制备方法
CN114174271B (zh) * 2019-08-08 2023-09-12 漳州片仔癀药业股份有限公司 吡嗪-2(1h)-酮类化合物的c晶型和e晶型及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101468965A (zh) * 2003-03-24 2009-07-01 默克公司 联芳基取代的6元杂环钠通道阻滞剂
CN104540809A (zh) * 2012-07-11 2015-04-22 蓝印药品公司 成纤维细胞生长因子受体的抑制剂
WO2017070708A1 (en) * 2015-10-23 2017-04-27 Array Biopharma, Inc. 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases
CN107438607A (zh) * 2015-02-20 2017-12-05 因赛特公司 作为fgfr抑制剂的双环杂环

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2936627T3 (es) 2018-02-08 2023-03-21 Zhangzhou Pien Tze Huang Pharm Compuesto de pirazina-2(1H)-cetona como inhibidor de FGFR
WO2021023193A1 (zh) * 2019-08-08 2021-02-11 漳州片仔癀药业股份有限公司 吡嗪-2(1h)-酮类化合物的制备方法
WO2021023192A1 (zh) * 2019-08-08 2021-02-11 漳州片仔癀药业股份有限公司 吡嗪-2(1h)-酮类化合物的a晶型和b晶型及其制备方法
CN114174271B (zh) * 2019-08-08 2023-09-12 漳州片仔癀药业股份有限公司 吡嗪-2(1h)-酮类化合物的c晶型和e晶型及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101468965A (zh) * 2003-03-24 2009-07-01 默克公司 联芳基取代的6元杂环钠通道阻滞剂
CN104540809A (zh) * 2012-07-11 2015-04-22 蓝印药品公司 成纤维细胞生长因子受体的抑制剂
CN107438607A (zh) * 2015-02-20 2017-12-05 因赛特公司 作为fgfr抑制剂的双环杂环
WO2017070708A1 (en) * 2015-10-23 2017-04-27 Array Biopharma, Inc. 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases

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ES2968388T3 (es) 2024-05-09
EP4011869B1 (en) 2023-11-15
JP2022535625A (ja) 2022-08-09
CN114269723B (zh) 2023-09-12
EP4011869A4 (en) 2022-10-12
US20220281853A1 (en) 2022-09-08
WO2021023195A1 (zh) 2021-02-11
JP7200437B2 (ja) 2023-01-06
EP4011869A1 (en) 2022-06-15
US11597722B2 (en) 2023-03-07

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