CN114252421A - Hand-held type fluorescence detector - Google Patents
Hand-held type fluorescence detector Download PDFInfo
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- CN114252421A CN114252421A CN202111570674.1A CN202111570674A CN114252421A CN 114252421 A CN114252421 A CN 114252421A CN 202111570674 A CN202111570674 A CN 202111570674A CN 114252421 A CN114252421 A CN 114252421A
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- 230000007246 mechanism Effects 0.000 claims abstract description 42
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 35
- 230000003287 optical effect Effects 0.000 claims abstract description 29
- 238000012545 processing Methods 0.000 claims abstract description 28
- 230000005540 biological transmission Effects 0.000 claims description 8
- 238000003780 insertion Methods 0.000 claims description 7
- 230000037431 insertion Effects 0.000 claims description 7
- 238000012360 testing method Methods 0.000 claims description 5
- 238000001514 detection method Methods 0.000 abstract description 10
- 239000003814 drug Substances 0.000 description 13
- 229940079593 drug Drugs 0.000 description 13
- 238000010586 diagram Methods 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000012921 fluorescence analysis Methods 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The invention discloses a handheld fluorescence detector which comprises a shell, a card inserting mechanism, a touch screen, a power supply module, a control module, a light source, an optical module, a photoelectric sensor and a processing module, wherein the power supply module, the control module, the light source, the optical module, the photoelectric sensor and the processing module are arranged in the shell, the card inserting mechanism is connected with the shell in a sliding mode, the touch screen is fixed outside the shell, the power supply module supplies power to the control module, the light source, the photoelectric sensor and the processing module, the control module is respectively connected with the card inserting mechanism, the light source, the processing module and the touch screen, and the light source, the optical module, the photoelectric sensor and the processing module are sequentially connected. The invention has reasonable structure, is convenient to carry, can conveniently detect in real time on site, quickly output results and display the results through the touch screen; a plurality of detection cards can be put into to card inserting mechanism simultaneously, and control module control multiaspect fixture autogiration to this detects a plurality of reagent cards, improves detection efficiency.
Description
Technical Field
The invention relates to the field of handheld fluorescence detectors, in particular to a handheld fluorescence detector.
Background
The detection of drugs, the hairs of drug addicts and the like is an essential important component in the drug prohibition work, and at present, due to the fact that the drug case is difficult to obtain evidence, the drug case is difficult to severely punish drug-related criminals, deterrent and attack drug crimes, meanwhile, the difficulty in preventing drug crimes and reducing drug addicts is increased, and the spread of drug crimes is difficult to effectively inhibit. Therefore, detection techniques and equipment capable of rapidly, real-timely and accurately acquiring drug evidence are very urgently needed for controlling the increase of drug addicts and preventing and fighting drug crimes.
The fluorescence analysis method is widely applied due to the characteristics of high sensitivity, high accuracy, strong selectivity, high detection speed, real-time online measurement and the like. The fluorescence signal measuring light path is simple, and the instrument development cost is low. Most of the existing fluorescence detectors are inconvenient to carry, and only a single reagent card slot is provided, so that the efficiency is not high.
Disclosure of Invention
The invention aims to provide a handheld fluorescence detector aiming at the defects in the prior art.
In order to achieve the above object, the present invention provides a handheld fluorescence detector, which includes a housing, a card insertion mechanism, a touch screen, and a power module, a control module, a light source, an optical module, a photoelectric sensor, and a processing module disposed in the housing, wherein the card insertion mechanism is slidably connected to the housing, the touch screen is fixed outside the housing, the power module provides power to the control module, the light source, the photoelectric sensor, and the processing module, the control module is respectively connected to the card insertion mechanism, the light source, the processing module, and the touch screen, the light source, the optical module, the photoelectric sensor, and the processing module are sequentially connected, the card insertion mechanism includes a bracket slidably connected to the housing, a circular rail fixedly connected to the bracket, a clamp rotating in the circular rail, and a multi-surface clamp drivingly connected to the multi-surface clamp, and a first motor connected to the control module, the power module provides power to the first motor, when the reagent card is inserted into the multi-surface fixture and the card inserting mechanism is pushed into the shell to be in place, the card pushing mechanism connected with the control module is arranged on the shell below the multi-surface fixture, and the optical module is arranged on the shell corresponding to the position of the test line on the reagent card.
Furthermore, the number of the surfaces of the multi-surface fixture is at least three, a rotating shaft is fixedly connected to the inner side of the multi-surface fixture through a fixing frame, a first motor fixed with the round rail is connected to the lower side of the rotating shaft through gear transmission, sliding blocks in sliding connection with the round rail are arranged at the top and bottom corners of the multi-surface fixture, a sliding groove matched with the reagent card is formed in each surface of the multi-surface fixture, a supporting block is arranged at the lower end of the sliding groove, and a groove matched with the card pushing mechanism is formed in the middle of the supporting block.
Further, push away card mechanism include with casing rotatable coupling's screw rod, with casing fixed connection's guide bar, with screw rod threaded connection's push rod, with screw rod transmission connection's second motor, second motor and casing fixed connection and with control module electric connection, the push rod lower extreme is equipped with the sand grip with guide bar sliding connection.
Further, the optical module comprises a diaphragm, a first plano-convex lens, a dichroic mirror, a second plano-convex lens, an optical filter and a third plano-convex lens, the photoelectric sensor is arranged above the third plano-convex lens, the light source is arranged on the left side of the first plano-convex lens, the diaphragm and the first plano-convex lens are vertically arranged, the dichroic mirror is inclined by 45 degrees, the second plano-convex lens, the optical filter and the third plano-convex lens are horizontally arranged, light emitted by the light source passes through the diaphragm, penetrates through the first plano-convex lens to the dichroic mirror, and penetrates through the second plano-convex lens through reflection of the dichroic mirror, a long-strip light spot is formed on the reagent card, and fluorescence excited by the reagent card reaches the photoelectric sensor through the second plano-convex lens, the dichroic mirror, the optical filter and the third plano-convex lens.
Further, a handle is arranged on the outer side of the shell, and a power switch is arranged on the lower side of the touch screen.
Furthermore, a card pushing empty groove matched with the card inserting mechanism is formed in the shell, and a spring plate is arranged in the card pushing empty groove and used for returning the reagent card.
Has the advantages that: the fluorescent detector has a reasonable structure, main functional elements of the fluorescent detector are selected from smaller elements and integrated in the shell, the fluorescent detector is convenient to carry and carry, real-time detection can be conveniently carried out on site, a result is rapidly obtained, and the result is displayed through the touch screen; the card inserting mechanism can be used for simultaneously placing a plurality of detection cards, and the control module controls the multi-surface fixture to automatically rotate so as to detect a plurality of reagent cards and improve the detection efficiency.
Drawings
FIG. 1 is a schematic diagram of a hand-held fluorescence detector according to an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of a card insertion mechanism according to an embodiment of the present invention;
FIG. 3 is a schematic structural diagram of a card pushing mechanism according to an embodiment of the present invention;
FIG. 4 is a schematic structural view of a push-card empty slot and a spring plate of an embodiment of the present invention;
FIG. 5 is a schematic structural diagram of an optical module according to an embodiment of the present invention;
fig. 6 is a schematic block diagram of the structure of an embodiment of the present invention.
In the figure: 1. a housing; 2. a card insertion mechanism; 3. a touch screen; 4. a power supply module; 5. a control module; 6. a light source; 7. an optical module; 8. a photosensor; 9. a processing module; 10. a support; 11. a circular rail; 12. a multi-faced fixture; 13. a first motor; 14. a fixed mount; 15. a rotating shaft; 16. a slider; 17. a chute; 18. a support block; 19. grooving; 20. a screw; 21. a guide bar; 22. a push rod; 23. a second motor; 24. a convex strip; 25. a diaphragm; 26. a first plano-convex lens; 27. a dichroic mirror; 28. a second plano-convex lens; 29. an optical filter; 30. a third plano-convex lens; 31. a handle; 32. a power switch; 33. pushing the card empty slot; 34. a spring plate.
Detailed Description
The present invention will be further illustrated with reference to the accompanying drawings and specific examples, which are carried out on the premise of the technical solution of the present invention, and it should be understood that these examples are only for illustrating the present invention and are not intended to limit the scope of the present invention.
As shown in fig. 1 to 6, an embodiment of the present invention provides a handheld fluorescence detector, which includes a housing 1, a card-inserting mechanism 2, a touch screen 3, and a power module 4, a control module 5, a light source 6, an optical module 7, a photoelectric sensor 8 and a processing module 9 that are disposed in the housing 1, wherein the card-inserting mechanism 2 is slidably connected to the housing 1, the touch screen 3 is fixed outside the housing 1, a handle 31 is disposed outside the housing 1, a power switch 32 is disposed under the touch screen 3, the power switch 32 is connected between the power module 4 and the control module 5 to control the fluorescent detector to be turned on and off, the control module 5 is respectively connected to the card-inserting mechanism 2, the light source 6, the processing module 9 and the touch screen 3, the power module 4 provides power for the control module 5, the light source 6, the photoelectric sensor 8 and the processing module 9 in the fluorescence detector, and the light source 6, the optical module 7, the photoelectric sensor 8, the photoelectric sensor 9, The processing modules 9 are connected in sequence. The reagent card can be inserted after the card inserting mechanism 2 is drawn out, when the card inserting mechanism 2 is pushed into the shell 1 to be in place, the card pushing mechanism connected with the control module 5 is arranged on the shell 1 below the card inserting mechanism 2, the optical module 7 is arranged on the shell 1 corresponding to the position of the test line on the reagent card, the optical module 7 is connected with the photoelectric sensor 8, the photoelectric sensor 8 transmits signals to the processing module 9, the processing module 9 transmits the processing result to the control module 5 after processing, and finally the processing result is displayed on the touch screen 3.
The card inserting mechanism 2 comprises a bracket 10 connected with the shell 1 in a sliding manner, a circular rail 11 fixedly connected with the bracket 10, a multi-face fixture 12 rotating in the circular rail 11, and a first motor 13 connected with the multi-face fixture 12 in a transmission manner and connected with the control module 5, wherein the power module 4 supplies power to the first motor 13, the bracket 10 is provided with a limiting block, so that the card inserting mechanism 2 cannot be completely pulled out of the shell 1, the wiring of the first motor 13 is not influenced, the number of the faces of the multi-face fixture 12 is at least three, the multi-face fixture 12 in the embodiment is a three-face fixture, the number of the faces can be four faces and more according to actual requirements, the size of the fluorescence detector can be increased unless the size of a reagent card is reduced while the number of the faces is increased, the inner side of the multi-face fixture 12 is fixedly connected with a rotating shaft 15 through a fixing frame 14, the lower side of the rotating shaft 15 is connected with the first motor 13 fixed with the circular rail 11 through a gear transmission manner, and the top corners of the upper end and the lower end of the multi-face fixture 12 are provided with sliders 16 slidably connected with the circular rail 11, each side of the multi-surface fixture 12 is provided with a sliding groove 17 matched with the reagent card, the lower end of the sliding groove 17 is provided with a support block 18, and the middle part of the support block 18 is provided with a slot 19 matched with the card pushing mechanism. The fixing frames 14 on the inner sides of the multi-face clamps 12 are uniformly arranged, if the fixing frames 14 extend out from each triangle angle of the multi-face clamps 12 to be connected with the rotating shaft 15 in the embodiment, the first limit switch is further arranged on the shell 1 at the lower ends of the multi-face clamps 12, when one face of each multi-face clamp 12 is aligned with the optical module 7, the first limit switch just senses one of the fixing frames 14, the control module 5 controls the multi-face clamps 12 to change the faces, the first motor 13 is started, the multi-face clamps stop when the first limit switch senses the fixing frames 14 when the multi-face clamps rotate, and the multi-face clamps rotate again until the face changing instructions are given.
The card pushing mechanism comprises a screw rod 20 rotatably connected with the shell 1, a guide rod 21 fixedly connected with the shell 1, a push rod 22 in threaded connection with the screw rod 20, a second motor 23 in transmission connection with the screw rod 20, the second motor 23 is fixedly connected with the shell 1 and is electrically connected with the control module 5, the power module 4 provides power for the second motor 23, a convex strip 24 in sliding connection with the guide rod 21 is arranged at the lower end of the push rod 22, two limit switches and a third limit switch are respectively arranged on the shell 1 on the left side of the guide rod 21, the convex strip 24 enables the second limit switch to generate signals when the push rod 22 reaches the top, and the convex strip 24 enables the third limit switch to generate signals when the push rod 22 reaches the bottom. The inside card pushing empty groove 33 matched with the card inserting mechanism 2 is arranged in the shell 1, the card pushing empty groove 33 is specifically arranged on the upper side of the card inserting mechanism 2, a spring plate 34 for returning the reagent card is arranged in the card pushing empty groove 33, and the spring plate 34 can press the reagent card back to the original position when the push rod 22 descends after the reagent card is pushed up. When the detection is carried out, the reagent card needs to move back and forth due to scanning detection, and when the card needs to be pushed, the control module 5 controls the second motor 23 to start to drive the screw rod 20 to rotate, the push rod 22 moves upwards to push the reagent card upwards, the second motor 23 rotates reversely, the push rod 22 moves downwards, and the spring plate 34 presses the reagent card back to the original position.
The optical module 7 includes a diaphragm 25, a first plano-convex lens 26, a dichroic mirror 27, a second plano-convex lens 28, an optical filter 29, and a third plano-convex lens 30. The photosensor 8 is disposed above the third plano-convex lens 30, the light source 6 is disposed on the left side of the first plano-convex lens 26, the diaphragm 25 and the first plano-convex lens 26 are disposed vertically, the dichroic mirror 27 is disposed at an inclination of 45 °, and the second plano-convex lens 28, the optical filter 29, and the third plano-convex lens 30 are disposed horizontally. In this embodiment, the light source 6 is an ultraviolet lamp, the light source 6 is connected to and controlled by the control module 5, light emitted from the light source 6 passes through the diaphragm 25, passes through the first plano-convex lens 26 and onto the dichroic mirror 27, and is reflected by the dichroic mirror 27 and passes through the second plano-convex lens 28, so that a long light spot is formed on the reagent card, the light spot irradiates on a test area of the reagent card, fluorescence excited on the reagent card passes through the second plano-convex lens 28, the dichroic mirror 27, the optical filter 29 and the third plano-convex lens 30 and reaches the photoelectric sensor 8, the photoelectric sensor 8 transmits a photoelectric signal to the processing module 9, and the processing module 9 performs analysis processing.
When the device is used, the power switch 32 is pressed to turn on the device, the card inserting mechanism 2 is pulled out, a plurality of reagent cards are placed into the device, one surface of each reagent card is pushed into the card inserting mechanism 2, the touch screen 3 is clicked to start detection, the control module 5 controls the first motor 13 to rotate, when the first limit switch senses that the reagent cards are in place, the first motor 13 stops, the reagent cards are right opposite to the optical module 7 at the moment, the control module 5 controls the light source 6 to be turned on to form a strip light spot in a test area of the reagent cards, the card pushing mechanism is started, the reagent cards move back and forth, generated photoelectric signals are transmitted to the processing module 9 and are analyzed, after the reagent cards are processed, an analysis processing result is transmitted to the control module 5, a face changing instruction is simultaneously excited, face changing is detected, and a final result is displayed on the touch screen 3.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that other parts not specifically described are within the prior art or common general knowledge to those of ordinary skill in the art. Without departing from the principle of the invention, several improvements and modifications can be made, and these improvements and modifications should also be construed as the scope of the invention.
Claims (6)
1. A hand-held fluorescence detector is characterized by comprising a shell, a card inserting mechanism, a touch screen, a power module, a control module, a light source, an optical module, a photoelectric sensor and a processing module, wherein the power module, the control module, the light source, the optical module, the photoelectric sensor and the processing module are arranged in the shell, the card inserting mechanism is connected with the shell in a sliding manner, the touch screen is fixed outside the shell, the power module supplies power to the control module, the light source, the photoelectric sensor and the processing module, the control module is respectively connected with the card inserting mechanism, the light source, the optical module, the photoelectric sensor and the touch screen, the light source, the optical module, the photoelectric sensor and the processing module are sequentially connected, the card inserting mechanism comprises a bracket in sliding connection with the shell, a circular rail fixedly connected with the bracket, a multi-face fixture rotating in the circular rail, a first motor in transmission connection with the fixture and connected with the control module, and the power module supplies power to the first motor, when the reagent card is inserted into the multi-surface fixture and the card inserting mechanism is pushed into the shell to be in place, the card pushing mechanism connected with the control module is arranged on the shell below the multi-surface fixture, and the optical module is arranged on the shell corresponding to the position of the test line on the reagent card.
2. The handheld fluorescence detector of claim 1, wherein the multi-surface fixture has at least three surfaces, the inner side of the multi-surface fixture is fixedly connected with a rotating shaft through a fixing frame, the lower side of the rotating shaft is connected with a first motor fixed with the circular rail through gear transmission, the top corners of the upper and lower ends of the multi-surface fixture are provided with sliding blocks slidably connected with the circular rail, each surface of the multi-surface fixture is provided with a sliding groove matched with the reagent card, the lower end of the sliding groove is provided with a support block, and the middle part of the support block is provided with a slot matched with the card pushing mechanism.
3. The handheld fluorescence detector of claim 1, wherein the pushing and clamping mechanism comprises a screw rotatably connected to the housing, a guide rod fixedly connected to the housing, a push rod in threaded connection with the screw, and a second motor in transmission connection with the screw, the second motor is fixedly connected to the housing and electrically connected to the control module, and a protruding strip slidably connected to the guide rod is disposed at a lower end of the push rod.
4. The hand-held fluorescence detector of claim 1, wherein the optical module comprises a diaphragm, a first plano-convex lens, a dichroic mirror, a second plano-convex lens, a filter, and a third plano-convex lens, the photoelectric sensor is disposed above the third plano-convex lens, the light source is disposed on the left side of the first plano-convex lens, the diaphragm and the first plano-convex lens are disposed vertically, the dichroic mirror is disposed at an angle of 45 °, the second plano-convex lens, the filter, and the third plano-convex lens are disposed horizontally, light emitted from the light source passes through the diaphragm, passes through the first plano-convex lens onto the dichroic mirror, and is reflected by the dichroic mirror through the second plano-convex lens to form a strip light spot on the reagent card, and fluorescence excited by the reagent card passes through the second plano-convex lens, the dichroic mirror, the filter, and the third plano-convex lens to reach the photoelectric sensor.
5. The hand-held fluorescence detector of claim 1, wherein the housing has a handle on an outside thereof, and a power switch is disposed on an underside of the touch screen.
6. The hand-held fluorescence detector of claim 1, wherein the housing defines a card pushing recess therein for engaging the card insertion mechanism, and wherein the card pushing recess defines a spring plate for returning the reagent card.
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CN202111570674.1A CN114252421B (en) | 2021-12-21 | 2021-12-21 | Handheld fluorescence detector |
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CN202111570674.1A CN114252421B (en) | 2021-12-21 | 2021-12-21 | Handheld fluorescence detector |
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CN114252421B CN114252421B (en) | 2024-04-19 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117871846A (en) * | 2024-03-12 | 2024-04-12 | 南京长健生物科技有限公司 | Handheld fluorescence immunoassay device |
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CN206684046U (en) * | 2017-04-27 | 2017-11-28 | 南京微测生物科技有限公司 | The quantitative quick analytic instrument of portable food safety fluorescent |
CN206756842U (en) * | 2017-05-21 | 2017-12-15 | 苏州和迈精密仪器有限公司 | A kind of handhold portable immunochromatographiassays assays instrument |
CN210401442U (en) * | 2019-07-10 | 2020-04-24 | 郑州科蒂亚生物技术有限公司 | Reagent card feeding device of fluorescence immunoassay appearance |
CN112630204A (en) * | 2020-12-31 | 2021-04-09 | 奥谱天成(厦门)光电有限公司 | Hand-held fluorescence detector |
CN112748245A (en) * | 2020-12-30 | 2021-05-04 | 浙江省智能诊疗设备制造业创新中心 | Multi-channel fluorescence immunochromatography quantitative detector and detection method thereof |
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2021
- 2021-12-21 CN CN202111570674.1A patent/CN114252421B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN206684046U (en) * | 2017-04-27 | 2017-11-28 | 南京微测生物科技有限公司 | The quantitative quick analytic instrument of portable food safety fluorescent |
CN206756842U (en) * | 2017-05-21 | 2017-12-15 | 苏州和迈精密仪器有限公司 | A kind of handhold portable immunochromatographiassays assays instrument |
CN210401442U (en) * | 2019-07-10 | 2020-04-24 | 郑州科蒂亚生物技术有限公司 | Reagent card feeding device of fluorescence immunoassay appearance |
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CN112630204A (en) * | 2020-12-31 | 2021-04-09 | 奥谱天成(厦门)光电有限公司 | Hand-held fluorescence detector |
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CN117871846A (en) * | 2024-03-12 | 2024-04-12 | 南京长健生物科技有限公司 | Handheld fluorescence immunoassay device |
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