CN117871846A - Handheld fluorescence immunoassay device - Google Patents
Handheld fluorescence immunoassay device Download PDFInfo
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- CN117871846A CN117871846A CN202410277421.2A CN202410277421A CN117871846A CN 117871846 A CN117871846 A CN 117871846A CN 202410277421 A CN202410277421 A CN 202410277421A CN 117871846 A CN117871846 A CN 117871846A
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- 238000003018 immunoassay Methods 0.000 title claims abstract description 35
- 238000001514 detection method Methods 0.000 claims abstract description 149
- 238000001917 fluorescence detection Methods 0.000 claims abstract description 21
- 230000007306 turnover Effects 0.000 claims description 34
- 238000007789 sealing Methods 0.000 claims description 10
- 239000000428 dust Substances 0.000 abstract description 42
- 238000004043 dyeing Methods 0.000 abstract description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 54
- 238000000034 method Methods 0.000 description 11
- 239000000126 substance Substances 0.000 description 7
- 230000005284 excitation Effects 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 230000003749 cleanliness Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000004078 waterproofing Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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- Biotechnology (AREA)
- Microbiology (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The invention relates to the technical field of medical detection, and particularly discloses a handheld fluorescence immunoassay device which comprises an LED display screen and a detection mechanism, wherein the detection mechanism comprises a lower cover, an upper cover, a control module, a fluorescence detection assembly, a detection platform, a telescopic electric cylinder and a negative pressure assembly, the LED display screen is fixedly connected with the upper cover, the control module is fixedly connected with the upper cover, the upper cover is arranged at the upper end of the lower cover, the upper cover covers the lower cover, the fluorescence detection assembly is fixedly connected with the lower cover, each telescopic electric cylinder is respectively and fixedly connected with the lower cover, the detection platform is fixedly connected with the output ends of the telescopic electric cylinders and is positioned at the upper ends of the telescopic electric cylinders, the negative pressure assembly is arranged between the lower cover and the upper cover, and the input end of the negative pressure assembly penetrates through the detection platform. Can effectually prevent dust and spot entering upper cover's inside, avoid fluorescence signal's detection efficiency to reduce, reduce simultaneously to dyeing quality and detection structure's influence, improve detection accuracy.
Description
Technical Field
The invention relates to the technical field of medical detection, in particular to a handheld fluorescence immunoassay device.
Background
At present, a fluorescence immunoassay analyzer is an instrument capable of measuring and analyzing trace substances, can convert the structure and characteristics of the substances into measurable spectrum signals, has the characteristics of high detection sensitivity, strong specificity, rapidness, accuracy and convenient operation, is not influenced by the characteristics of the detected substances, is a method for analyzing and detecting the substances by utilizing the specific fluorescence characteristics of the substances, and can emit fluorescence when the substances are exposed to light source irradiation with certain energy, the fluorescence is called excitation fluorescence, the wavelength of the fluorescence is generally higher than the wavelength energy of the excitation light, and the fluorescence immunoassay analyzer also consists of a plurality of parts such as an excitation source, a detection system, an amplification system and a display system for realizing the detection of the substances.
The medical handheld fluorescence immunoassay instrument is provided in the prior art CN109900894A, can meet the requirements of batch detection, multi-item detection, reduction of labor intensity of detection personnel, high-efficiency and accuracy detection and the like, and is small in size, convenient to carry, convenient for the detection personnel to carry out operation and flexible to use.
However, in the prior art, the reagent card slot is in an open state under the use and unused states, so that dust and dirt easily enter the fluorescent immunoassay analyzer, the dust and dirt can accumulate on the optical component, the detection efficiency of fluorescent signals is reduced, the view is blocked during observation, and the dyeing quality and the definition of detection results are affected.
Disclosure of Invention
The invention aims to provide a handheld fluorescence immunoassay device, which aims to solve the technical problems that in the prior art, a reagent clamping groove is in an open state in a used state and an unused state, so that dust and dirt easily enter a fluorescence immunoassay device, the dust and dirt can accumulate on an optical component, the detection efficiency of a fluorescence signal is reduced, the visual field is blocked during observation, and the dyeing quality and the definition of a detection result are affected.
In order to achieve the above object, the handheld fluorescence immunoassay device comprises an LED display screen and a detection mechanism, wherein the detection mechanism comprises a lower cover, an upper cover, a control module, a fluorescence detection assembly, a detection platform, telescopic electric cylinders and a negative pressure assembly, the LED display screen is fixedly connected with the upper cover and embedded in one side of the upper cover, the control module is fixedly connected with the upper cover and embedded in one side of the upper cover, the upper cover is arranged at the upper end of the lower cover, the upper cover covers the lower cover, the fluorescence detection assembly is fixedly connected with the lower cover and is positioned between the lower cover and the upper cover, the number of the telescopic electric cylinders is multiple, each telescopic electric cylinder is respectively fixedly connected with the lower cover and is respectively positioned between the lower cover and the upper cover, the detection platform is fixedly connected with the output ends of the telescopic electric cylinders and is positioned at the upper ends of the telescopic electric cylinders, and the negative pressure assembly is arranged between the lower cover and the upper cover and the detection platform, and the negative pressure assembly penetrates through the input end.
The negative pressure assembly comprises a plurality of negative pressure nozzles, negative pressure pipes and miniature negative pressure pumps, wherein the negative pressure nozzles are fixedly connected with the detection platform and are respectively positioned at the upper ends of the detection platform, the input ends of the negative pressure pipes are respectively communicated with the corresponding negative pressure nozzles and are respectively positioned at the lower ends of the negative pressure nozzles, the miniature negative pressure pumps are fixedly connected with the lower cover and are positioned between the lower cover and the upper cover, and the input ends of the miniature negative pressure pumps are communicated with the output ends of the negative pressure pipes.
The fluorescent detection assembly comprises two guide rails, a sliding block, a screw rod group, a micro servo motor, a detection frame, a fluorescent detection module and an amplifying circuit module, wherein the number of the guide rails is two, the two guide rails are respectively fixedly connected with the lower cover and are respectively positioned at the upper end of the lower cover, the screw rod group is fixedly connected with the lower cover and is positioned at one side of the guide rails, the number of the sliding blocks is two, the two groups of the sliding blocks are respectively sleeved on the corresponding screw rod group and the outer surface wall of the screw rod group, the two groups of the sliding blocks are respectively in sliding connection with the corresponding guide rails, the micro servo motor is arranged at the upper end of the lower cover, the output end of the micro servo motor is fixedly connected with the screw rod group, the detection frame is fixedly connected with the two groups of the sliding blocks and is positioned at the upper ends of the sliding blocks, the fluorescent detection module is fixedly connected with the detection frame and is positioned at the upper end of the detection frame and the amplifying circuit module.
The fluorescent detection assembly further comprises a scanning module, wherein the scanning module is fixedly connected with the detection frame and is positioned on one side of the detection frame.
The detection mechanism further comprises a sealing rubber ring, wherein the sealing rubber ring is fixedly connected with the upper cover and is positioned at the lower end of the upper cover.
The handheld fluorescence immunoassay device further comprises a dustproof mechanism, and the dustproof mechanism is arranged at the upper end of the upper cover.
The dustproof mechanism comprises a turnover seat, a turnover plate, a lifting sliding block and a dustproof cover, wherein the turnover seat is fixedly connected with the upper cover and is positioned at the upper end of the upper cover, the turnover plate is rotationally connected with the turnover seat and is arranged at the upper end of the turnover seat, the lifting sliding block is in sliding connection with the turnover plate and is positioned at one side of the turnover plate, and the dustproof cover is fixedly connected with the lifting sliding block and is positioned at one side of the lifting sliding block.
The dustproof mechanism further comprises an inner rubber ring and an outer rubber ring, the inner rubber ring is fixedly connected with the upper cover and embedded in the inner side of the upper cover, the outer rubber ring is fixedly connected with the upper cover and located in the inner side of the upper cover, and the outer rubber ring and the inner rubber ring are oppositely arranged.
According to the handheld fluorescence immunoassay device, the reagent card to be detected is placed on the detection platform, the negative pressure component is used for sucking the lower end of the reagent card, the reagent card is stably fixed on the detection platform in a vacuum negative pressure mode, the telescopic electric cylinder is started to retract downwards, the detection platform and the reagent card are retracted to the inside of the upper cover, when the telescopic electric cylinder is retracted to the lowest point, the fluorescence detection component is started to scan and perform fluorescence detection on the reagent card, the fluorescence detection component can reciprocate at the upper end of the reagent card in the detection process until detection is completed, the fluorescence detection component is reset after detection of the reagent card is completed, and meanwhile the telescopic electric cylinder extends, so that the detection platform is attached to the upper cover, fluorescence immunoassay of the reagent card is completed, the control module is used for controlling and operating the handheld fluorescence immunoassay device, the LED display screen is used for displaying operation setting and detection data, the handheld fluorescence immunoassay device is not provided with the detection cover, the detection efficiency is improved through the detection cover, and the detection efficiency is improved, and the detection efficiency is prevented from being influenced by the detection cover, and the detection structure is prevented from entering the inside of the detection platform.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural view of a first embodiment of the present invention.
Fig. 2 is a partial structural schematic diagram of a first embodiment of the present invention.
Fig. 3 is a bottom view of the upper cover of the first embodiment of the present invention.
Fig. 4 is a schematic structural view of a second embodiment of the present invention.
Fig. 5 is a front view of a third embodiment of the present invention.
Fig. 6 is a cross-sectional view of the A-A line structure of fig. 5 in accordance with the present invention.
Fig. 7 is a cross-sectional view of the B-B line structure of fig. 5 according to the present invention.
Fig. 8 is a cross-sectional view of the internal structure of the electromagnetic assembly of the present invention.
The device comprises a 101-LED display screen, a 102-lower cover, a 103-upper cover, a 104-control module, a 105-guide rail, a 106-sliding block, a 107-screw rod group, a 108-polished rod group, a 109-miniature servo motor, a 110-detection frame, a 111-fluorescence detection module, a 112-amplifying circuit module, a 113-detection platform, a 114-telescopic electric cylinder, a 115-negative pressure nozzle, a 116-negative pressure pipe, a 117-miniature negative pressure pump, a 118-scanning module, a 119-sealing rubber ring, a 201-turning seat, a 202-turning plate, a 203-lifting sliding block, a 204-dustproof cover, a 205-inner rubber ring, a 206-outer rubber ring, a 301-first proximity sensor, a 302-second proximity sensor, a 303-sensing block, a 304-magnetic attraction block, a 305-electromagnetic sleeve, a 306-insulating layer, a 307-electrifying coil and a 308-magnetic core.
Detailed Description
The first embodiment of the application is as follows:
referring to fig. 1 to 3, fig. 1 is a schematic structural view of a first embodiment of the present invention, fig. 2 is a schematic partial structural view of the first embodiment of the present invention, and fig. 3 is a bottom view of an upper cover of the first embodiment of the present invention.
The invention provides a handheld fluorescence immunoassay device, which comprises: the LED display screen 101 and detection mechanism are included, the detection mechanism includes lower cover 102, upper cover 103, control module 104, fluorescence detection subassembly, testing platform 113, flexible jar 114, negative pressure subassembly and sealed rubber ring 119, the negative pressure subassembly includes negative pressure mouth 115, negative pressure pipe 116 and miniature negative pressure pump 117, the fluorescence detection subassembly includes guide rail 105, slider 106, lead screw group 107, polished rod group 108, miniature servo motor 109, detection frame 110, fluorescence detection module 111, amplifying circuit module 112 and scanning module 118.
Wherein the LED display screen 101 is fixedly connected with the upper cover 103 and embedded in one side of the upper cover 103, the control module 104 is fixedly connected with the upper cover 103 and embedded in one side of the upper cover 103, the upper cover 103 is arranged at the upper end of the lower cover 102, the upper cover 103 covers the lower cover 102, the fluorescence detection assembly is fixedly connected with the lower cover 102 and positioned between the lower cover 102 and the upper cover 103, the number of the telescopic electric cylinders 114 is multiple, each telescopic electric cylinder 114 is respectively fixedly connected with the lower cover 102 and respectively positioned between the lower cover 102 and the upper cover 103, the detection platform 113 is fixedly connected with the output ends of the telescopic electric cylinders 114 and positioned at the upper ends of the telescopic electric cylinders 114, the negative pressure assembly is arranged between the lower cover 102 and the upper cover 103, the input ends of the negative pressure assembly penetrate through the detection platform 113, the reagent card to be detected is placed on the detection platform 113, the lower end of the reagent card is sucked by the negative pressure component, the reagent card is stably fixed on the detection platform 113 in a vacuum negative pressure mode, the telescopic electric cylinder 114 is started to retract downwards, the detection platform 113 and the reagent card are contracted into the upper cover 103, when the telescopic electric cylinder 114 is contracted to the lowest point, the fluorescent detection component is started to scan and perform fluorescent detection on the reagent card, the fluorescent detection component can reciprocate at the upper end of the reagent card in the detection process until the detection is completed, the fluorescent detection component is reset after the detection of the reagent card is completed, meanwhile, the telescopic electric cylinder 114 extends, so that the detection platform 113 is attached to the upper cover 103, and the fluorescent immunoassay on the reagent card is completed, the control module 104 controls and operates the handheld fluorescence immunoassay device, and the LED display screen 101 displays operation setting and detection data, and the handheld fluorescence immunoassay device seals the opening of the upper cover 103 through the detection platform 113 when no reagent card is detected.
Secondly, the number of the negative pressure nozzles 115 is a plurality, each negative pressure nozzle 115 is fixedly connected with the detection platform 113 and is respectively located at the upper end of the detection platform 113, the input end of the negative pressure pipe 116 is respectively communicated with the corresponding negative pressure nozzle 115 and is respectively located at the lower end of the negative pressure nozzle 115, the micro negative pressure pump 117 is fixedly connected with the lower cover 102 and is located between the lower cover 102 and the upper cover 103, the input end of the micro negative pressure pump 117 is communicated with the output end of the negative pressure pipe 116, among the negative pressure assemblies, the negative pressure nozzle 115 penetrates through the detection platform 113, when the reagent card is placed on the detection platform 113, the micro negative pressure pump 117 operates, air at the upper end of each negative pressure nozzle 115 is sucked through the negative pressure pipe 116, and when the reagent card is placed at the upper end of the detection platform 113, the reagent card is adsorbed at the upper ends of the negative pressure nozzle 115 and the detection platform 113 in a negative pressure mode.
Simultaneously, the number of the guide rails 105 is two, the two groups of the guide rails 105 are respectively and fixedly connected with the lower cover 102 and are respectively positioned at the upper end of the lower cover 102, the polish rod group 108 is fixedly connected with the lower cover 102 and is positioned at one side of the guide rails 105, the polish rod group 107 is fixedly connected with the lower cover 102 and is positioned at one side of the guide rails 105, the number of the slide blocks 106 is two, the two groups of the slide blocks 106 are respectively sleeved on the corresponding outer surface walls of the polish rod group 107 and the polish rod group 108, the two groups of the slide blocks 106 are respectively and slidably connected with the corresponding guide rails 105, the micro servo motor 109 is arranged at the upper end of the lower cover 102, the output end of the micro servo motor 109 is fixedly connected with the polish rod group 107, the detection frame 110 is fixedly connected with the two groups of the slide blocks 106 and is positioned at the upper ends of the two groups of the slide blocks 106, the fluorescent detection module 111 is fixedly connected with the detection frame 110 and is positioned at the upper ends of the detection frame 110, the detection frame 110 is respectively sleeved on the corresponding slide blocks 107 and the slide blocks, the detection frame 110 is rotatably driven by the micro servo motor 109 and the detection frame 110, the detection frame 105 is rotatably driven by the micro servo motor 109, the detection frame 110 is rotatably driven by the detection frame 110, the detection frame 105 is horizontally driven by the slide block 110, the detection frame 105 is rotatably, the detection frame is rotatably and the detection frame is horizontally driven by the slide frame 105, the micro servo motor 109 rotationally controls the detection frame 110 to reset.
In addition, the scanning module 118 is fixedly connected with the detection frame 110 and is located at one side of the detection frame 110, and bar code information or two-dimensional code information on the reagent card can be rapidly identified in the detection process through the scanning module 118.
Furthermore, the sealing rubber ring 119 is fixedly connected with the upper cover 103 and is located at the lower end of the upper cover 103, and the sealing rubber ring 119 can improve the sealing strength between the detection platform 113 and the upper cover 103.
When the hand-held fluorescence immunoassay device of the embodiment is used, a reagent card to be detected is placed on the detection platform 113, the lower end of the reagent card is sucked by the negative pressure component, the reagent card is stably fixed on the detection platform 113 in a vacuum negative pressure mode, the telescopic cylinder 114 is started to retract downwards, the detection platform 113 and the reagent card are retracted into the upper cover 103, when the telescopic cylinder 114 is retracted to the lowest point, the fluorescence detection component is started to scan and perform fluorescence detection on the reagent card, the fluorescence detection component can reciprocate at the upper end of the reagent card in the detection process until the detection is completed, the fluorescence detection component is reset after the detection of the reagent card is completed, and meanwhile the telescopic cylinder 114 extends, so that the detection platform 113 is attached to the upper cover 103, thus, the control module 104 controls and operates the hand-held fluorescence immunoassay device, the LED display screen 101 displays operation setting and detection data, the hand-held fluorescence immunoassay device seals the opening of the upper cover 103 through the detection platform 113 when the reagent card is not detected, the negative pressure nozzle 115 penetrates through the detection platform 113 in the negative pressure assembly, when the reagent card is placed on the detection platform 113, the micro negative pressure pump 117 operates, the air at the upper end of each negative pressure nozzle 115 is sucked through the negative pressure pipe 116, when the reagent card is placed on the upper end of the detection platform 113, the reagent card is adsorbed on the negative pressure nozzle 115 and the upper end of the detection platform 113 in a negative pressure mode, in the fluorescence detection assembly, the guide rail 105 supports the slider 106, the micro servo motor 109 drives the screw rod group 107, the slider 106 is driven to move on the guide rail 105 by the rotation of the screw rod group 107, so as to drive the detection frame 110 to horizontally move along the guide rail 105, the polish rod group 108 carries out auxiliary support and auxiliary movement, the detection frame 110 detects a reagent card by the fluorescent detection module 111 and the amplifying circuit module 112 in the moving process, after detection is completed, the detection frame 110 is controlled to reset by the rotation of the micro servo motor 109, bar code information or two-dimensional code information on the reagent card can be rapidly identified in the detection process by the scanning module 118, and the sealing rubber ring 119 can improve the sealing strength between the detection platform 113 and the upper cover 103.
The second embodiment of the present application is:
on the basis of the first embodiment, please refer to fig. 4, wherein fig. 4 is a schematic structural diagram of a second embodiment of the present invention.
The invention provides a handheld fluorescence immunoassay device, which comprises: the dustproof mechanism comprises a turnover seat 201, a turnover plate 202, a lifting sliding block 203, a dustproof cover 204, an inner rubber ring 205 and an outer rubber ring 206.
Wherein, dustproof mechanism set up in the upper end of upper cover 103, when detecting reagent card, because detection platform 113 can retract to the inside of upper cover 103 leads to the opening part of upper cover 103 is in unoccluded state, and easy in-process dust that detects gets into wherein, through dustproof mechanism can avoid the entering of dust and spot at the in-process that detects.
The turnover seat 201 is fixedly connected with the upper cover 103, and is located at the upper end of the upper cover 103, the turnover plate 202 is rotatably connected with the turnover seat 201, and is disposed at the upper end of the turnover seat 201, the lifting slide block 203 is slidably connected with the turnover plate 202, and is located at one side of the turnover plate 202, the dust cover 204 is fixedly connected with the lifting slide block 203, and is located at one side of the lifting slide block 203, the turnover plate is fixedly installed through the turnover seat 201, meanwhile, the turnover plate 202 can rotate on the turnover seat 201, when a reagent card is detected, the opening of the upper cover 103 is covered by the dust cover 204, so that dust and dirt are prevented from entering, when the reagent card needs to be taken and placed, the dust cover 204 is moved upwards, the dust cover 204 is moved to enable the lifting slide block 203 to lift along the turnover plate 202, and after the dust cover 204 is separated from the upper cover 103, the dust cover 202 can be turned over, and the dust cover 204 can be opened.
Secondly, the inner rubber ring 205 is fixedly connected with the upper cover 103 and is embedded in the inner side of the upper cover 103, the outer rubber ring 206 is fixedly connected with the upper cover 103 and is located in the inner side of the upper cover 103, the outer rubber ring 206 and the inner rubber ring 205 are oppositely arranged, and when the dust cover 204 covers the upper cover 103, the gap between the dust cover 204 and the upper cover 103 is sealed by extrusion of the outer rubber ring 206 and the inner rubber ring 205, so that the dust and water proofing effects can be effectively achieved.
When the handheld fluorescence immunoassay device of the embodiment is used, during detection of a reagent card, as the detection platform 113 is retracted to the inside of the upper cover 103, the opening of the upper cover 103 is in an unsealed state, dust is easy to enter the detection platform, the dust and dirt can be prevented from entering the detection platform in the detection process through the dust prevention mechanism, the turnover cover is fixed by the turnover seat 201, meanwhile, the turnover plate 202 can rotate on the turnover seat 201, when the reagent card is detected, the dust cover 204 covers the opening of the upper cover 103, the dust and dirt are prevented from entering the detection platform, when the reagent card is required to be taken and placed, the dust cover 204 is moved upwards, the lifting slider 203 is lifted along the turnover plate 202, the dust cover 204 can be turned over after the dust cover 204 is separated from the upper cover 103, so that the dust cover 204 is opened, and the dust cover 204 is closed by the upper cover 103, the dust cover is pressed by the dust cover 204 and the dust cover 204, and the dust cover 103 can be sealed by the dust cover 204, and the dust cover can be effectively pressed by the dust cover 103.
The third embodiment of the present application is:
on the basis of the second embodiment, please refer to fig. 5 to 8, wherein fig. 5 is a front view of a third embodiment of the present invention, fig. 6 is a sectional view of the A-A line structure of fig. 5 of the present invention, fig. 7 is a sectional view of the B-B line structure of fig. 5 of the present invention, and fig. 8 is a sectional view of the internal structure of the electromagnetic assembly of the present invention.
The invention provides a handheld fluorescence immunoassay device, which comprises: also included are a first proximity sensor 301, a second proximity sensor 302, an inductive block 303, a magnetic attraction block 304, and an electromagnetic assembly comprising an electromagnetic sleeve 305, an insulating layer 306, an energizing coil 307, and a magnetic core 308.
Wherein the first proximity sensor 301 is fixedly connected to the detection platform 113 and embedded in the upper end of the detection platform 113, the second proximity sensor 302 is fixedly connected to the upper cover 103 and embedded in the upper end of the upper cover 103, the sensing block 303 is fixedly connected to the dust cover 204 and embedded in one side of the dust cover 204, the number of the magnetic blocks 304 is two, the two magnetic blocks 304 are respectively fixedly connected to the dust cover 204 and embedded in one side of the dust cover 204, the number of the electromagnetic components is two, the two groups of the electromagnetic components are respectively fixedly connected to the upper cover 103 and embedded in one side of the upper cover 103, each group of the electromagnetic components is respectively matched with the corresponding magnetic block 304, the first proximity sensor 301 detects whether the detection platform 113 has a reagent card, when the dust cover 204 is covered on the upper end of the upper cover 103, the second proximity sensor 302 senses the existence of the sensing block 303, when the first proximity sensor 301 senses that the reagent card is arranged above and the second proximity sensor 302 senses that the sensing block 303 is arranged above, the handheld fluorescence immunoassay device is started to check the reagent card, if any one of the first proximity sensor 301 and the second proximity sensor 302 does not receive the sensing, the reagent card is not checked, the detection of the reagent card in a sealed state can be forced, the cleanliness of the handheld fluorescence immunoassay device is improved, the protection intensity of the handheld fluorescence immunoassay device is improved, and meanwhile, when the reagent card is detected, the electromagnetic assembly is electrified, the dust cover 204 is magnetically engaged by the magnetic assembly and the magnetic block 304.
Next, the electromagnetic sleeve 305 is fixedly connected to the upper cover 103 and is embedded in one side of the upper cover 103, the insulating layer 306 is disposed inside the electromagnetic sleeve 305, the magnetic core 308 is fixedly connected to the electromagnetic sleeve 305, the magnetic core 308 covers the electromagnetic sleeve 305, one end of the magnetic core 308 penetrates through the magnetic core 307, the electromagnetic sleeve 305 houses the insulating layer 306, the insulating layer 306 insulates and protects the magnetic core 307, and when the magnetic attraction is fixed, the magnetic core 308 is electrified, so that the magnetic core 308 has electromagnetic force, the magnetic core 308 and the magnetic attraction block 304 are magnetically connected by the electromagnetic force, and after the magnetic core 308 is powered off, no electromagnetic force exists between the magnetic core 308 and the magnetic attraction block 304.
When the handheld fluorescence immunoassay device of the present embodiment is used, the first proximity sensor 301 detects whether a reagent card is present on the detection platform 113, when the dust cover 204 is covered on the upper end of the upper cover 103, the second proximity sensor 302 senses the existence of the induction block 303, when the first proximity sensor 301 senses that a reagent card is present above and the second proximity sensor 302 senses that the induction block 303 is present above, the handheld fluorescence immunoassay device is started to check the reagent card, if any one of the first proximity sensor 301 and the second proximity sensor 302 does not receive induction, the reagent card is not checked, the reagent card can be forcedly detected in a sealed state, the cleanliness of the handheld fluorescence immunoassay device is improved, the protection intensity of the handheld fluorescence immunoassay device is improved, simultaneously, when the reagent card is sensed to be detected, the electromagnetic assembly is electrified, the electromagnetic assembly and the magnetic attraction block 304 are connected with the magnetic core 308 through the electromagnetic assembly and the electromagnetic attraction block 306, the electromagnetic force layer 307 is not electrically insulated from the magnetic core 308, and the magnetic core 308 is electrically insulated from the magnetic core 308, and the electromagnetic assembly is electrically insulated from the magnetic core 308, and the magnetic core 307 is electrically insulated from the magnetic core 308.
The above disclosure is only a preferred embodiment of the present invention, and it should be understood that the scope of the invention is not limited thereto, and those skilled in the art will appreciate that all or part of the procedures described above can be performed according to the equivalent changes of the claims, and still fall within the scope of the present invention.
Claims (8)
1. A hand-held fluorescence immunoassay device comprises an LED display screen, and is characterized in that,
the device also comprises a detection mechanism;
the detection mechanism comprises a lower cover, an upper cover, a control module, a fluorescence detection assembly, a detection platform, telescopic electric cylinders and a negative pressure assembly, wherein the LED display screen is fixedly connected with the upper cover and embedded in one side of the upper cover, the control module is fixedly connected with the upper cover and embedded in one side of the upper cover, the upper cover is arranged at the upper end of the lower cover, the upper cover covers the lower cover, the fluorescence detection assembly is fixedly connected with the lower cover and is positioned between the lower cover and the upper cover, the number of the telescopic electric cylinders is multiple, each telescopic electric cylinder is respectively fixedly connected with the lower cover and is respectively positioned between the lower cover and the upper cover, the detection platform is fixedly connected with the output ends of the telescopic electric cylinders and is positioned at the upper ends of the telescopic electric cylinders, and the negative pressure assembly is arranged between the lower cover and the upper cover, and the input ends of the negative pressure assembly penetrate through the detection platform.
2. A hand-held fluoroimmunoassay device according to claim 1, wherein,
the negative pressure assembly comprises a plurality of negative pressure nozzles, negative pressure pipes and miniature negative pressure pumps, wherein the negative pressure nozzles are fixedly connected with the detection platform and are respectively positioned at the upper ends of the detection platform, the input ends of the negative pressure pipes are respectively communicated with the corresponding negative pressure nozzles and are respectively positioned at the lower ends of the negative pressure nozzles, the miniature negative pressure pumps are fixedly connected with the lower cover and are positioned between the lower cover and the upper cover, and the input ends of the miniature negative pressure pumps are communicated with the output ends of the negative pressure pipes.
3. A hand-held fluoroimmunoassay device according to claim 2, wherein,
the fluorescent detection assembly comprises two guide rails, sliding blocks, screw rod groups, a micro servo motor, a detection frame, a fluorescent detection module and an amplifying circuit module, wherein the number of the guide rails is two, the two guide rails are respectively fixedly connected with the lower cover and are respectively positioned at the upper end of the lower cover, the screw rod groups are fixedly connected with the lower cover and are positioned at one side of the guide rails, the number of the sliding blocks is two, the two groups of the sliding blocks are respectively sleeved on the corresponding screw rod groups and the outer surface wall of the screw rod groups, the two groups of the sliding blocks are respectively in sliding connection with the corresponding guide rails, the micro servo motor is arranged at the upper end of the lower cover, the output end of the micro servo motor is fixedly connected with the screw rod groups, the detection frame is fixedly connected with the two groups of the sliding blocks and are positioned at the upper ends of the sliding blocks, the fluorescent detection module is fixedly connected with the detection frame and is positioned at the upper end of the amplifying circuit module.
4. A hand-held fluoroimmunoassay device according to claim 3, wherein,
the fluorescence detection assembly further comprises a scanning module, wherein the scanning module is fixedly connected with the detection frame and is positioned on one side of the detection frame.
5. A hand-held fluoroimmunoassay device according to claim 4, wherein,
the detection mechanism further comprises a sealing rubber ring, wherein the sealing rubber ring is fixedly connected with the upper cover and is positioned at the lower end of the upper cover.
6. A hand-held fluoroimmunoassay device according to claim 5, wherein,
the handheld fluorescence immunoassay device further comprises a dustproof mechanism, and the dustproof mechanism is arranged at the upper end of the upper cover.
7. A hand-held fluoroimmunoassay device according to claim 6, wherein,
the dustproof mechanism comprises a turnover seat, a turnover plate, a lifting sliding block and a dustproof cover, wherein the turnover seat is fixedly connected with the upper cover and is positioned at the upper end of the upper cover, the turnover plate is rotationally connected with the turnover seat and is arranged at the upper end of the turnover seat, the lifting sliding block is in sliding connection with the turnover plate and is positioned at one side of the turnover plate, and the dustproof cover is fixedly connected with the lifting sliding block and is positioned at one side of the lifting sliding block.
8. A hand-held fluoroimmunoassay device according to claim 7, wherein,
the dustproof mechanism further comprises an inner rubber ring and an outer rubber ring, the inner rubber ring is fixedly connected with the upper cover and embedded in the inner side of the upper cover, the outer rubber ring is fixedly connected with the upper cover and located in the inner side of the upper cover, and the outer rubber ring and the inner rubber ring are oppositely arranged.
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Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013041007A1 (en) * | 2011-09-21 | 2013-03-28 | 艾康生物技术(杭州)有限公司 | Biochemical analyzer and tester |
| WO2018027930A1 (en) * | 2016-08-12 | 2018-02-15 | Medtrum Technologies Inc. | A one step all‐in‐one apparatus for body fluid sampling and sensing |
| CN108181456A (en) * | 2018-01-18 | 2018-06-19 | 南京岚煜生物科技有限公司 | Hand-held fluorescence immunoassay apparatus |
| CN110068690A (en) * | 2019-06-03 | 2019-07-30 | 烟台百博自动化科技有限公司 | A kind of hand-held glycosylated hemoglobin detector |
| CN110221056A (en) * | 2019-07-22 | 2019-09-10 | 公安部第一研究所 | A kind of hand-held hair illicit drugs inspection all-in-one machine |
| KR20200040417A (en) * | 2018-10-10 | 2020-04-20 | 엘아이에스 주식회사 | Fluorescence reader device and process in the form of insertion strip for the quantitative measurements |
| CN114252421A (en) * | 2021-12-21 | 2022-03-29 | 南京长健生物科技有限公司 | Hand-held type fluorescence detector |
| CN115032404A (en) * | 2022-06-10 | 2022-09-09 | 杨富松 | Vaccine antibody detection card, detection system and detection method thereof |
| CN217466940U (en) * | 2022-05-27 | 2022-09-20 | 广东蓝沛医疗科技有限公司 | Blood glucose and uric acid analyzer with dustproof structure |
| CN115201463A (en) * | 2022-07-15 | 2022-10-18 | 上池诊断科技(深圳)有限公司 | Fluorescence immunoassay instrument convenient to mobile detection |
| CN115290825A (en) * | 2022-08-04 | 2022-11-04 | 陈昌波 | Gas detection device |
| CN116047049A (en) * | 2023-01-31 | 2023-05-02 | 石家庄迪虹生物科技有限公司 | Portable scanning electronic detector |
| CN116106225A (en) * | 2022-12-27 | 2023-05-12 | 重庆艾令达生物医学研究有限公司 | Thyroid stimulating hormone detection device |
-
2024
- 2024-03-12 CN CN202410277421.2A patent/CN117871846B/en active Active
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013041007A1 (en) * | 2011-09-21 | 2013-03-28 | 艾康生物技术(杭州)有限公司 | Biochemical analyzer and tester |
| WO2018027930A1 (en) * | 2016-08-12 | 2018-02-15 | Medtrum Technologies Inc. | A one step all‐in‐one apparatus for body fluid sampling and sensing |
| CN108181456A (en) * | 2018-01-18 | 2018-06-19 | 南京岚煜生物科技有限公司 | Hand-held fluorescence immunoassay apparatus |
| KR20200040417A (en) * | 2018-10-10 | 2020-04-20 | 엘아이에스 주식회사 | Fluorescence reader device and process in the form of insertion strip for the quantitative measurements |
| CN110068690A (en) * | 2019-06-03 | 2019-07-30 | 烟台百博自动化科技有限公司 | A kind of hand-held glycosylated hemoglobin detector |
| CN110221056A (en) * | 2019-07-22 | 2019-09-10 | 公安部第一研究所 | A kind of hand-held hair illicit drugs inspection all-in-one machine |
| CN114252421A (en) * | 2021-12-21 | 2022-03-29 | 南京长健生物科技有限公司 | Hand-held type fluorescence detector |
| CN217466940U (en) * | 2022-05-27 | 2022-09-20 | 广东蓝沛医疗科技有限公司 | Blood glucose and uric acid analyzer with dustproof structure |
| CN115032404A (en) * | 2022-06-10 | 2022-09-09 | 杨富松 | Vaccine antibody detection card, detection system and detection method thereof |
| CN115201463A (en) * | 2022-07-15 | 2022-10-18 | 上池诊断科技(深圳)有限公司 | Fluorescence immunoassay instrument convenient to mobile detection |
| CN115290825A (en) * | 2022-08-04 | 2022-11-04 | 陈昌波 | Gas detection device |
| CN116106225A (en) * | 2022-12-27 | 2023-05-12 | 重庆艾令达生物医学研究有限公司 | Thyroid stimulating hormone detection device |
| CN116047049A (en) * | 2023-01-31 | 2023-05-02 | 石家庄迪虹生物科技有限公司 | Portable scanning electronic detector |
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| Publication number | Publication date |
|---|---|
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