CN110068690A - A kind of hand-held glycosylated hemoglobin detector - Google Patents

A kind of hand-held glycosylated hemoglobin detector Download PDF

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Publication number
CN110068690A
CN110068690A CN201910475159.1A CN201910475159A CN110068690A CN 110068690 A CN110068690 A CN 110068690A CN 201910475159 A CN201910475159 A CN 201910475159A CN 110068690 A CN110068690 A CN 110068690A
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detection
sealing cover
upper casing
glycosylated hemoglobin
held
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CN110068690B (en
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邵伟
刘新星
肖锦涛
项帅
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Yantai Baibo Automation Technology Co Ltd
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Yantai Baibo Automation Technology Co Ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721Haemoglobin
    • G01N33/723Glycosylated haemoglobin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721Haemoglobin
    • G01N33/726Devices

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  • Urology & Nephrology (AREA)
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Abstract

The present invention relates to detection technique field, specifically a kind of hand-held glycosylated hemoglobin detector, including upper casing and lower casing;The upper casing and lower casing are clamped and form a reception space, the detection components for glycosylated hemoglobin detection are provided in reception space, the upper end of the upper casing is provided with the reagent card detection mouth for placing when the detection of HbAc reagent card, and the upper end of upper casing is slidably fitted with the sealing cover for sealing and connecting by elastic component with upper casing when the detection of reagent card detection mouth, the sealing cover controls the lockup state of sealing cover folding by locking structure, the solution lock set with locking structure cooperation is additionally provided in the reception space, when solving lock set triggering, the lockup state of sealing cover changes.Of the invention novel in design, structure is simple, it can be achieved that hand-held, and when detection can effectively ensure the leakproofness of detection process, it is ensured that testing result is accurate, and the solution lock set cooperation locking structure of setting realizes the folding of sealing cover, easy to control.

Description

A kind of hand-held glycosylated hemoglobin detector
Technical field
The present invention relates to detection technique field, specifically a kind of hand-held glycosylated hemoglobin detector.
Background technique
Improvement of living standard, the change of dietary structure, the rhythm of life being becoming tight day and few dynamic life sides sat more The factors such as formula, so that global diabetes morbidity rapid development, diabetes have become after tumour, cardiovascular pathological changes The third-largest chronic disease for seriously threatening human health.For global diabetic more than 1.2 hundred million people, China patients occupy generation Boundary second, 1994 just up to 20,000,000.According to the World Health Organization, it is expected that by 2025, global maturity-onset diabetes patient numbers 300,000,000 will be increased to, and diabetes mellitus in China patient numbers are up to 40,000,000, diabetes will be that one, China is serious in future 50 years Public health problem.
The cause of disease and pathogenesis of diabetes are not yet completely understood.Clinical carried out extensively detects patient blood glucose's work, but ASSOCIATE STATISTICS shows that the glycemic control compliance rate of China type 2 diabetic patient connects 30% less than one for causing this phenomenon Major reason is that many doctors and patient only pay attention to the monitoring of blood glucose and ignore the monitoring of glycosylated hemoglobin, because of blood glucose Measurement only represents blood glucose level at once, can not be as the index of evaluation disease control degree.
In recent years, the detection of glycosylated hemoglobin (HbA1c) is just being increasingly subject to clinical great attention.Glycosylated hemoglobin Refer to that a part of hemoglobin that in blood and glucose combines.Its principal mode is HbA1c, since protein concentration is protected Hold relatively stable, saccharification level depends mainly on concentration of glucose, and also and protein is related with the length of time of glucose exposure. When the concentration of glucose in blood is higher, human body is formed by saccharification hemoglobin content also can be relatively high.So saccharification blood Lactoferrin ratio, can 1-2 months average blood glucose levels before reaction assay.The measurement result of glycosylated hemoglobin is with percentage table Show, refer to that the hemoglobin combined with glucose accounts for the ratios of whole hemoglobins, is that determine that diabetes control for a long time good Good index.
The detection for carrying out glycosylated hemoglobin has great significance.Glycosylated hemoglobin and because diabetes cause painstaking effort The death rate caused by pipe complication has close association.According to medical college, univ cambridge uk studies have shown that glycosylated hemoglobin 1 white branch of every increase, the probability that type 2 diabetic patient merges Cardial or cerebral vascular diseases are increased by 15% to 18%, and the death rate increases Add 20% to 30%.The suggestion for the treatment of diabetes is just proposed early in American Diabetes Association in 2002, specifies measurement HbA1c Importance, and using it as diabetes monitoring golden index, expressly provide that all diabetics should conventional detection HbA1c。
Traditional glycosylated hemoglobin detector volume is big, quality weight, it has not been convenient to it carries, it is expensive.
Summary of the invention
The purpose of the present invention is to provide a kind of hand-held glycosylated hemoglobin detectors, to solve in above-mentioned background technique The problem of proposition.
To achieve the above object, the invention provides the following technical scheme:
A kind of hand-held glycosylated hemoglobin detector, including upper casing and lower casing;The upper casing and lower casing are clamped and are formed One reception space is provided with the detection components for glycosylated hemoglobin detection in reception space, and the upper end of the upper casing is set It is equipped with the reagent card detection mouth for placing when the detection of HbAc reagent card, and the upper end of upper casing is slidably fitted with and examines for reagent card The sealing cover for sealing and connecting by elastic component with upper casing when mouth detection is surveyed, the sealing cover controls sealing cover by locking structure The lockup state of folding is additionally provided with the solution lock set with locking structure cooperation in the reception space, when solution lock set triggering When, the lockup state of sealing cover changes.
As a further solution of the present invention: the locking structure is the self-locking slideway being arranged on sealing cover, Xie Suoji Structure includes the export key being slidably mounted in upper casing and lower casing junction through slot, and the upper end of the export key is provided with and oneself Lock the fixture block of slideway cooperation clamping, fixture block is fixedly connected with export key, export key also with for drive its carry out reset and The elastic reset component of location conflicts connects.
As further scheme of the invention: the elastic component is export tension spring.
As the present invention further scheme: the elastic reset component includes be fixed on lower casing inside bottom self-locking Locating piece slides the sliding bar for running through lock-bit block and abutting with export key, is arranged with self-locking pressure spring on the sliding bar, One end of self-locking pressure spring is abutted with lock-bit block, and the other end is fixed on sliding bar by E type circlip.
As further scheme of the invention: the detection components include power switch, induction self-starting component, display Screen and control circuit board, display screen are mounted on upper casing by display screen fixed plate, and control circuit board is mounted under display screen Side and be electrically connected with display screen, control circuit board and power switch and the lithium battery group being mounted on the inside of lower casing at closed circuit, The control circuit board is also established with induction self-starting component and the Photoelectric Detection module being arranged in below reagent card detection mouth logical News connection.
As the present invention further scheme: the induction self-starting component include the magnet being fixed on sealing cover and Hall sensor on upper casing is installed, after reagent card detection mouth is built in sealing cover sliding, magnet is in above Hall sensor.
As further scheme of the invention: the detection components further include the RC sense being mounted below control circuit board Answer device.
As further scheme of the invention: being additionally provided with the mini being electrically connected with control circuit board on the upper casing Usb interface and indicator light.
Compared with prior art, the beneficial effects of the present invention are: the present invention is novel in design, structure is simple, low in cost, can Realize hand-held, when detection can effectively ensure the leakproofness of detection process, it is ensured that testing result is accurate, the solution lock set of setting Locking structure is cooperated to realize the folding of sealing cover, it is easy to control, it is practical.
Detailed description of the invention
Fig. 1 is the explosive view of hand-held glycosylated hemoglobin detector.
Fig. 2 is structural schematic diagram of the hand-held glycosylated hemoglobin detector in sealing cover opening state.
Fig. 3 is structural schematic diagram of the hand-held glycosylated hemoglobin detector in sealing cover closed state.
Fig. 4 is the explosive view of upper casing in hand-held glycosylated hemoglobin detector.
Fig. 5 is sealing cover and solution lock set connection status diagram in hand-held glycosylated hemoglobin detector.
Fig. 6 is the structural schematic diagram of sealing cover in hand-held glycosylated hemoglobin detector.
In figure: 1- upper casing, 2- lower casing, 3- sealing cover, 4- power switch, 5-HbA1c reagent card, 6- reagent card detection mouth, 7-RC522 inductor, 8- lithium battery, 9- Photoelectric Detection module, the self-locking slideway of 10-, 11- magnet, 12- export tension spring, 13- export Key, 14- lock-bit block, 15-E type circlip, the self-locking pressure spring of 16-, 17- sliding bar, 18- Hall sensor, 19- display screen, 20- display screen fixed plate, 21- control circuit board, 22-mini usb interface, 23- indicator light.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall within the protection scope of the present invention.
Embodiment one
Please refer to Fig. 1~6, in the embodiment of the present invention, a kind of hand-held glycosylated hemoglobin detector, including 1 He of upper casing Lower casing 2;The upper casing 1 is clamped with lower casing 2 and is formed a reception space, is provided in reception space for glycosylated hemoglobin The detection components of detection, the upper end of the upper casing 1 are provided with the reagent card detection mouth placed when detecting for HbA1c reagent card 5 6, and the upper end of upper casing 1 is slidably fitted with when detecting for reagent card detection mouth 6 and seals and pass through what elastic component was connect with upper casing 1 Sealing cover 3, the sealing cover 3 are controlled the lockup state that sealing cover 3 opens and closes by locking structure, also set up in the reception space There is the solution lock set with locking structure cooperation, when solving lock set triggering, the lockup state of sealing cover 3 changes, thus real The folding control of existing sealing cover 3.
Above-mentioned hand-held glycosylated hemoglobin detector can effectively ensure the leakproofness of detection process when in use, it is ensured that inspection Survey result is accurate, and the solution lock set cooperation locking structure of setting realizes the folding of sealing cover 3, easy to control, practical.
Above-mentioned elastic component is preferably that other elastic components can also be used certainly in export tension spring 12 in this application, as long as meeting Demand, the application are not construed as limiting this.
Specifically, the locking structure is the self-locking slideway 10 being arranged on sealing cover 3, and unlocking mechanism includes sliding peace Export key 13 in upper casing 1 and 2 junction through slot of lower casing, the upper end of the export key 13 is provided with and self-locking slideway The fixture block of 10 cooperation clampings, fixture block is fixedly connected with export key 13, export key 13 also with for drive its carry out reset and The elastic reset component of location conflicts connects, and when pressing export key 13, squeezes elastic reset component, while driving fixture block de- From self-locking slideway 10, the lockup state of sealing cover 3 changes at this time, automatically opens under the elastic force effect of export tension spring 12, When needing closing seam lid 3, only need to press sealing cover 3 reaches lock position, and fixture block can be in elastic reset component elastic force at this time It is caught in automatically under effect in self-locking slideway 10, realizes the fixation of sealing cover 3, it is easy to operate.
Furthermore, it is understood that the elastic reset component includes the lock-bit block 14 for being fixed on 2 inside bottom of lower casing, sliding Through lock-bit block 14 and the sliding bar 17 that abuts with export key 13, it is arranged with self-locking pressure spring 16 on the sliding bar 17, One end of self-locking pressure spring 16 is abutted with lock-bit block 14, and the other end is fixed on sliding bar 17 by E type circlip 15, when pressing When export key 13, export key 13 drives sliding bar 17 mobile, squeezes self-locking pressure spring 16 at this time, while fixture block being taken away self-locking Slideway 10, sealing cover 3 unlocks, and when unclamping export key 13, sliding bar 17 resets under the elastic force effect of self-locking pressure spring 16 again And export key 13 is driven to reset.
Embodiment two
In the embodiment of the present invention, it is also proposed that the structure of detection components is described in detail in another embodiment, specifically It is as follows:
The detection components include power switch 4, induction self-starting component, display screen 19 and control circuit board 21, display Screen 19 is mounted on upper casing 1 by display screen fixed plate 20, control circuit board 21 be mounted on the lower section of display screen 19 and with display 19 electrical connection of screen, control circuit board 21 and power switch 4 and the lithium battery 8 for being mounted on 2 inside of lower casing form closed circuit, work as electricity When source switch 4 starts, control circuit board 21 is powered, and display screen 19 is for visualizingre agent card information and data analysis as a result, described Control circuit board 21 is also established with induction self-starting component and the Photoelectric Detection module 9 being arranged in below reagent card detection mouth 6 logical News connection, induction self-starting component sending enable signals to control circuit board 21, and control circuit board 21 issues work order to light Electro-detection module 9 realizes detection.
Above-mentioned induction self-starting component includes the hall sensing on the magnet 11 being fixed on sealing cover 3 and installation upper casing 1 Device 18, after reagent card detection mouth 6 is built in the sliding of sealing cover 3, magnet 11 is in 18 top of Hall sensor, Hall sensor 18 Control circuit board 21 is issued a signal to, to realize the starting of detection work.
The detection components further include the RC522 inductor 7 for being mounted on 21 lower section of control circuit board.
Preferably, the mini usb interface 22 being electrically connected with control circuit board 21 and instruction are additionally provided on the upper casing 1 Lamp 23, indicator light 23 are used for display working condition.
Working principle: power switch 4 to instrument is clicked first and is switched on, then clicks export key 13, sealing cover 3 exists It is popped up along the slideway of upper cover 1 to reagent card detection mouth 6 is exposed, by added sample under the action of export tension spring 12 HbA1c reagent card 5 is put into reagent card detection mouth 6, and sealing cover 3 is pushed back machine to self-locking mechanism by its locking, at this time later Hall sensor 18 senses magnet 11, and the software interface appearance of display screen 19 indicates that click starts to detect, and instrument passes through in place Photoelectric Detection module 9 detects HbA1c reagent card 5, the software carried by instrument to the volume reflection of the light of different wave length into Row analysis, and be compared with level threshold value, the saccharification hemoglobin content of the reagent card is obtained, finally, display screen 19 is shown The results such as reagent card information and analysis data out.Detection finishes, and clicking export key 13 pops up sealing cover 3, will test Reagent card take down discarding.
Wherein, self-locking mechanism is mainly by self-locking slideway 10, export key 13, lock-bit block 14, E type circlip 15, self-locking Pressure spring 16, sliding bar 17 are constituted.When sealing cover 3 pushes back machine, sliding bar 17 can catch on close under the action of self-locking pressure spring 16 The self-locking slideway 10 of capping 3, to make its positioning.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims Variation is included within the present invention.Any reference signs in the claims should not be construed as limiting the involved claims.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art The other embodiments being understood that.

Claims (8)

1. a kind of hand-held glycosylated hemoglobin detector, including upper casing (1) and lower casing (2);The upper casing (1) and lower casing (2) It is clamped and is formed a reception space, the detection components for glycosylated hemoglobin detection, feature are provided in reception space It is, the upper end of the upper casing (1) is provided with the reagent card detection mouth (6) for placing when HbA1c reagent card (5) detection, and The upper end of upper casing (1) is slidably fitted with for sealing and being connect by elastic component with upper casing (1) when reagent card detection mouth (6) detection Sealing cover (3), the sealing cover (3) by locking structure control sealing cover (3) open and close lockup state, the reception space It is inside additionally provided with the solution lock set with locking structure cooperation, when solving lock set triggering, the lockup state of sealing cover (3) changes Become.
2. a kind of hand-held glycosylated hemoglobin detector according to claim 1, which is characterized in that the locking structure For the self-locking slideway (10) being arranged on sealing cover (3), unlocking mechanism includes being slidably mounted on upper casing (1) to connect with lower casing (2) Locate the export key (13) in through slot, the upper end of the export key (13) is provided with the card with self-locking slideway (10) cooperation clamping Block, fixture block are fixedly connected with export key (13), and export key (13) is also and for driving it reset and location conflicts The connection of elastic reset component.
3. a kind of hand-held glycosylated hemoglobin detector according to claim 1, which is characterized in that the elastic component is Export tension spring (12).
4. a kind of hand-held glycosylated hemoglobin detector according to claim 2, which is characterized in that the elastic reset Component includes the lock-bit block (14) for being fixed on lower casing (2) inside bottom, sliding through lock-bit block (14) and and export The sliding bar (17) that key (13) abuts is arranged with self-locking pressure spring (16) on the sliding bar (17), the one of self-locking pressure spring (16) End is abutted with lock-bit block (14), and the other end is fixed on sliding bar (17) by E type circlip (15).
5. a kind of hand-held glycosylated hemoglobin detector according to claim 1, which is characterized in that the detection components Pass through display including power switch (4), induction self-starting component, display screen (19) and control circuit board (21), display screen (19) Screen fixed plate (20) is mounted on upper casing (1), and control circuit board (21) is mounted on the lower section of display screen (19) and and display screen (19) it is electrically connected, control circuit board (21) and power switch (4) and the lithium battery (8) being mounted on the inside of lower casing (2) composition are closed Circuit, the control circuit board (21) are also examined with induction self-starting component and the photoelectricity being arranged below reagent card detection mouth (6) It surveys module (9) and establishes communication connection.
6. a kind of hand-held glycosylated hemoglobin detector according to claim 5, which is characterized in that the induction is opened certainly Dynamic component includes the Hall sensor (18) on the magnet (11) being fixed on sealing cover (3) and installation upper casing (1), works as sealing cover (3) after reagent card detection mouth (6) are built in sliding, magnet (11) is in above Hall sensor (18).
7. a kind of hand-held glycosylated hemoglobin detector according to claim 5, which is characterized in that the detection components It further include the RC522 inductor (7) being mounted below control circuit board (21).
8. a kind of hand-held glycosylated hemoglobin detector according to claim 5, which is characterized in that the upper casing (1) On be additionally provided with the mini usb interface (22) and indicator light (23) being electrically connected with control circuit board (21).
CN201910475159.1A 2019-06-03 2019-06-03 Handheld glycosylated hemoglobin detector Active CN110068690B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110441534A (en) * 2019-09-07 2019-11-12 烟台德瑞生物科技有限公司 Glycosylated hemoglobin detector
CN117871846A (en) * 2024-03-12 2024-04-12 南京长健生物科技有限公司 Handheld fluorescence immunoassay device

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JPS63117870U (en) * 1987-01-19 1988-07-29
JP2002147096A (en) * 2000-11-09 2002-05-22 Murakoshi Mfg Corp Door opening/closing device
CN201364598Y (en) * 2008-12-11 2009-12-16 深圳市中成汇实业有限公司 Recycling card box
US20110034786A1 (en) * 2009-08-06 2011-02-10 Roche Diagnostics Operations, Inc. Portable handheld medical diagnostic devices
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CN105421902A (en) * 2015-12-03 2016-03-23 美固电子(深圳)有限公司 Self-locking mechanism for box door
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110441534A (en) * 2019-09-07 2019-11-12 烟台德瑞生物科技有限公司 Glycosylated hemoglobin detector
CN117871846A (en) * 2024-03-12 2024-04-12 南京长健生物科技有限公司 Handheld fluorescence immunoassay device

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