CN207832803U - A kind of fluorescence immunoassay detection analysis instrument - Google Patents
A kind of fluorescence immunoassay detection analysis instrument Download PDFInfo
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- CN207832803U CN207832803U CN201820246649.5U CN201820246649U CN207832803U CN 207832803 U CN207832803 U CN 207832803U CN 201820246649 U CN201820246649 U CN 201820246649U CN 207832803 U CN207832803 U CN 207832803U
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Abstract
The utility model is related to field of immunodetection, disclose a kind of fluorescence immunoassay detection analysis instrument, including Instrument shell, the Instrument shell is equipped with Yun Kong mechanisms, the optical de-tection means to detection reagent fluorescence signal are equipped on the upside of the Yun Kong mechanisms, the Yun Kong mechanisms are connect with control system with the optical de-tection means, and the Instrument shell upper surface is equipped with the human-computer interaction part being connect with the control system.Excitation optical channel and reception optical channel realize excitation, conduction, collection and the opto-electronic conversion of fluorescence signal, improve the detection sensitivity of analyzer, using sealing detection storehouse, reduce interference of the ambient noise to detection optical signal；The setting of handle, facilitates user to carry, and meets more scene use demands；The user-friendly instrument of human-computer interaction part reads detection information, realizes the friendly of human-computer interaction；Data transmission interface, for facilitating data transmission and storage.
Description
Technical field
The utility model is related to field of immunodetection, more particularly to a kind of fluorescence immunoassay detection analysis instrument.
Background technology
Fluorescence radiation is the Electron absorption energy in substance, from base when high-energy short wavelength light injects Cucumber
State transits to energy more high orbit, i.e., from ground state to excitation state；It, will be from high level track since electronics is unstable in excitation state
It is reduced to low-lying level, fluorescence is sent out to give off energy.Since immunofluorence technic has high sensitivity, easy to operate, nothing
The advantages that radioactive pollution, wide standard curve range, is widely used in clinical medicine and examines field, and becomes clinical medicine
Common analysis method during milligram ammonia is examined.
Immunoassay is reacted based on antigen and antibody characteristic, using the probe materials mark such as fluorescein, enzyme or isotope
Antibody (or antigen) is remembered, by the marker determination in immune complex, reaching a kind of analysis being detected to immune response
Technology.
With quasi-instrument optical detection structure design is simple, sensitivity is not high, it is poorly sealed to concentrate on optical detection room, swashs
Luminous road and light path do not have optical device support, or some only uses optical texture, but exciting light in transmitting light path
Road does not use optical device, reduces instrument detection sensitivity.
Most products are operated in man-machine interaction mode by mechanical button, with the development of embedded hardware, software, especially
It is the universal of the embedded development platforms tool such as Android, Qt, market gradually requires human-computer interaction convenient, apparatus structure design
Simply, detecting instrument system is more stablized, and existing product does not solve the above problems, and still 51 chip microcontrollers is used to control, nothing
Convenient man-machine interactive platform.
Existing a plurality of types of fluorescence immunoassay detection analysis instruments, internal structure are almost the same；But with application scenarios
Most of constantly variation, portable, micromation have become a kind of main trend of fluorescence immunity analyzer, currently on the market
Detecting instrument can not portable use.
Utility model content
(1) technical problems to be solved
The purpose of this utility model is to provide a kind of fluorescence immunoassay detection analysis instrument, to solve existing instrument detection sensitivity
Problem that is low, convenient can not realizing human-computer interaction and carry difficulty.
(2) technical solution
In order to solve the above-mentioned technical problem, the utility model provides a kind of fluorescence immunoassay detection analysis instrument, including instrument shell
Body, the Instrument shell are equipped with Yun Kong mechanisms, and the Yun Kong mechanisms include placing the detection storehouse of reagent strip, the fortune control
It is equipped with the optical de-tection means to detection reagent fluorescence signal on the upside of mechanism, the optical de-tection means include mating use
To conduct the excitation light path channel of exciting light and to conduct the receiving light path channel of fluorescence emission, the Yun Kong mechanisms and institute
It states optical de-tection means to connect with control system, the Instrument shell upper surface is man-machine equipped with connecting with the control system
Interaction part.
Wherein, the Yun Kong mechanisms include the bottom plate being fixed on the Instrument shell and are installed on the bottom plate
Driving motor and guide rail, the guide rail are equipped with to the sliding block in the fixation detection storehouse, and the driving motor passes through synchronous belt
The sliding block is driven to move.
Wherein, the guide rail both ends be respectively equipped with to monitor it is described detection storehouse shift position the first optoelectronic switch and
Second optoelectronic switch, the detection storehouse are equipped with the photoelectricity being adapted to first optoelectronic switch and second optoelectronic switch
Catch.
Wherein, the optical de-tection means are fixed by the bracket on the bottom plate, and the optical de-tection means further include
To scan the barcode scanner of bar code on reagent strip.
Wherein, the optical de-tection means include fastening the left cover body and right cover body of adaptation, in the optical de-tection means
Side is equipped with the first excitation light path channel, the second excitation light path channel and receiving light path channel, first excitation light path channel
The one end in one end and second excitation light path channel is connected to the one end in the receiving light path channel, first exciting light
The other end of the other end of paths, the other end in second excitation light path channel and the receiving light path channel is equipped with electricity
Road plate, first excitation light path channel and second excitation light path channel folder between the receiving light path channel respectively
Angle is 45 degree, is all provided in first excitation light path channel, second excitation light path channel and the receiving light path channel
There is optical device mounting groove.
Wherein, first excitation light path channel and one end close to the circuit board in second excitation light path channel
It is equipped with excitation light source, cylindrical mirror is equipped in the middle part of first excitation light path channel and the second excitation light path channel.
Wherein, the first convex lens, the second convex lens, filter are equipped in the receiving light path channel successively along fluorescence direction of illumination
Color chips and photoelectric converter.
Wherein, the Instrument shell is equipped with handle, and the handle is integrally formed with the Instrument shell, and the handle includes
Handle arm, the arm surface that carries are equipped with power-assisted frictional layer.
Wherein, the Instrument shell is equipped with to install the installing port of printer, installing the peace of power control switch
Dress hole, the installation window to install the human-computer interaction part are inserted to the mounting hole, injection port, power supply of mount message indicator light
Hole and data transmission interface.
Wherein, the human-computer interaction part manipulates entire detection analysis instrument by the control system and runs.
(3) advantageous effect
A kind of fluorescence immunoassay detection analysis instrument provided by the utility model, the excitation optical channel of optical detection structure and reception
Path channels realize excitation, conduction, collection and the opto-electronic conversion of fluorescence signal, improve the detection sensitivity of analyzer, adopt
With bidifly luminous road, detection multi-wavelength's fluorescence signal is realized, using sealing detection storehouse, reduce ambient noise and detection light is believed
Number interference；The setting of the analyzer cooperation handle of micromation, facilitates user to carry, meets more scene use demands；Man-machine friendship
The user-friendly instrument of mutual part reads detection information, improves work efficiency, and realizes the friendly of human-computer interaction, improves
The accuracy of testing result；Data transmission interface, for facilitating data transmission and storage.
Description of the drawings
Fig. 1 is the structural schematic diagram of the utility model embodiment；
Fig. 2 is the structural schematic diagram of the utility model embodiment Yun Kong mechanisms；
Fig. 3 is the structural schematic diagram of the utility model embodiment optical de-tection means；
Fig. 4 is the cross-sectional view of the structure of the utility model embodiment optical de-tection means；
Fig. 5 is the structural schematic diagram of the utility model embodiment Instrument shell；
Fig. 6 is the vertical view of the utility model embodiment；
Fig. 7 is the front view of the utility model embodiment；
Fig. 8 is the left view of the utility model embodiment；
Fig. 9 is the rearview of the utility model embodiment.
In figure, 100：Instrument shell；111：Installing port；112：Mounting hole；113：Handle arm；114：Plane power-assisted friction
Layer；115：It is bent power-assisted frictional layer；116：Window is installed；117：Mounting hole；118：Injection port；120：Detect door；131：Nameplate
Position；132：Supply hub；140：Data transmission interface；150：Rubber washer；200：Yun Kong mechanisms；210：Bottom plate；220：Driving
Motor；221：Synchronous belt；222：Guide rail；223：First optoelectronic switch；224：Second optoelectronic switch；230：Holder；240：Detection
Storehouse；250：Sliding block；260：Bar code surface sweeping device；300：Optical de-tection means；310：Left cover body；320：Right cover body；331：Photoelectricity turns
Parallel operation；332：Colour filter；333：First convex lens；334：Second convex lens；341：Excitation light source；342：Light bar；343：Cylinder
Mirror；350：First excitation light path channel；360：Receiving light path channel；370：Second excitation light path channel；400：Control system；
500：Printer；600：Human-computer interaction part；700：Data transmission module；710：USB interface；720：Network interface；800：Power supply
Control switch；900：Information indicator light.
Specific implementation mode
With reference to the accompanying drawings and examples, specific embodiment of the present utility model is described in further detail.Below
Example is not intended to limit the scope of the present invention for illustrating the utility model.
As shown in Figures 1 to 9, the utility model embodiment provides a kind of fluorescence immunoassay detection analysis instrument, including instrument shell
Body 100, Instrument shell 100 are equipped with handle, and Instrument shell 100 is equipped with Yun Kong mechanisms 200, and Yun Kong mechanisms 200 include putting
The detection storehouse 240 of reagent strip is set, 200 upside of Yun Kong mechanisms is equipped with the optical de-tection means to detection reagent fluorescence signal
300, optical de-tection means 300 are conducted the first, second excitation light path channel 350,370 of exciting light including mating and are used
To conduct the receiving light path channel 360 of fluorescence emission, the reagent strip in exciting light irradiating and detecting storehouse 240 excites reagent strip
Fluorescent material emits fluorescence emission, and receiving light path channel 360 receives and transmitting light is converted to electric signal, Yun Kong mechanisms 200
It is connect with control system 400 with optical de-tection means 300,100 upper surface of Instrument shell is equipped with and is connect with control system 400
Human-computer interaction part 600, realizes the friendly of human-computer interaction, and user-friendly instrument reads detection information, improves work
Efficiency improves the accuracy of testing result.
Further, the side of Instrument shell 100 is equipped with handle, and handle and Instrument shell 100 are integrally formed, handle with it is micro-
Type analysis instrument coordinates, and is convenient for carrying, meets more scene functional needs, handle includes handle arm 113, and the surface of handle arm 113 is set
There are plane power-assisted frictional layer 114 and bending power-assisted frictional layer 115, increasing friction force, safety when improving mobile.
Wherein, Instrument shell 100 is equipped with Yun Kong mechanisms 200, to transport reagent strip to be detected, Yun Kong mechanisms 200
Including the bottom plate 210 being fixed on Instrument shell 100 and the driving motor 220 being installed on bottom plate 210 and guide rail 222.
Further, guide rail 222 is equipped with freely slidable sliding block 250, and detection storehouse 240, inspection are fixed on sliding block 250
It surveys 240 inside of storehouse and is set as the close luminous environment of black, and load reagent strip to be detected, driving motor 220 is driven by synchronous belt 221
Movable slider 250 moves, and realizes that driving detection storehouse 240 moves back and forth on guide rail 222.
Wherein, 222 both ends of guide rail be respectively equipped with to monitor detection 240 shift position of storehouse the first optoelectronic switch 223
With the second optoelectronic switch 224, detection storehouse 240 is equipped with the light being adapted to the first optoelectronic switch 223 and the second optoelectronic switch 224
Electric catch.
Wherein, it when photoelectricity catch triggers the first optoelectronic switch 223, indicates that detection storehouse 240 is moved to origin position, drives
Motor 220 stops driving detection storehouse 240 and moves backward；When photoelectricity catch triggers the second optoelectronic switch 224, detection storehouse is indicated
240 are moved to out bin location, and driving motor 220 is stopped, and reagent strip is placed or taken out into detection storehouse 240.
Further, 200 upside of Yun Kong mechanisms is equipped with optical de-tection means 300, and optical de-tection means 300 pass through holder
230 are fixed on Instrument shell 100, and optical de-tection means 300 conduct the first, second excitation of exciting light including mating
Path channels 350,370 and to conduct the receiving light path channel 360 of fluorescence emission, to detect downside by detection storehouse
The fluorescence signal of reagent strip in 240；It further include the barcode scanner 260 for scanning bar code on reagent strip.
Wherein, optical de-tection means 300 include fastening the left cover body 310 and right cover body 320 of adaptation, optical de-tection means
300 insides are equipped with the first excitation light path channel 350, the second excitation light path channel 370 and receiving light path channel 360, the first excitation
The one end in one end of path channels 350 and the second excitation light path channel 370 is connected to the one end in receiving light path channel 360, the
The other end in one excitation light path channel 350, the other end in the second excitation light path channel 370 and receiving light path channel 360 it is another
End is equipped with circuit board, the first excitation light path channel 350 and the second excitation light path channel 370 respectively with receiving light path channel 360
Between angle be 45 degree, in the first excitation light path channel 350, the second excitation light path channel 370 and receiving light path channel 360
It is equipped with optical device mounting groove.
Further, close to one end of circuit board in the first excitation light path channel 350 and the second excitation light path channel 370
It is equipped with excitation light source 341, emits the exciting light to the fluorescent material in excitation-detection reagent strip, the first excitation light path channel
350 and the middle part of the second excitation light path channel 370 optical device mounting groove in be equipped with cylindrical mirror 343, exciting light to be converged
Gather on reagent strip to be detected.
Wherein, it is equipped with successively to collect fluorescent emission optical signal along fluorescence direction of illumination in receiving light path channel 360, and
Convergence is the first convex lens 333 of directional light, the second convex lens 334 optical signal to be pooled to detection hot spot, to mistake
It filters the colour filter 332 of specified wavelength fluorescence signal and the fluorescence signal being collected into is converted to the photoelectric converter 331 of electric signal,
331 preferred photocell of photoelectric converter.
Wherein, excitation light source 341, cylindrical mirror 343, the first convex lens 333, the second convex lens 334, colour filter 332 and light
Electric transducer 331 is fastened in corresponding optical device mounting groove, is easily installed and is safeguarded, optical de-tection means 300
Close brightness cell structure is constituted with detection storehouse 240, reduces influence of the ambient noise to detection light.
Further, Yun Kong mechanisms 200 and optical de-tection means 300 with the control system that is fixed on Instrument shell 100
400 connection of system, control system 400 include the circuit board of embedding operation software, and 100 upper surface of Instrument shell is equipped with and control system
400 connection human-computer interaction parts 600, to data show with the instruction of the working condition of input control analyzer, it is preferably man-machine
Interaction touch screen, user-friendly analyzer read detection information, realize the friendly of human-computer interaction.
Wherein, control system 400 further includes the data transmission module 700 of setting on circuit boards, data transmission module 700
Including multiple USB interfaces 710 and network interface 720, USB interface 710 carries out data and leads to connect USB storage device
Go out, the peripheral components such as mouse, keyboard can also be connected, analyzer is operated, USB flash disk can also be inserted into and carried out to operating software
Upgraded, for network interface 720 to connect network cable, transmission data is mutual into row information with hospital and medical inspection mechanism
Connection.
Further, it is additionally provided with that the installing port 111 of printer 500 is installed on Instrument shell 100, printer 500 is excellent
Mini-printer is selected, to print testing result, to install the mounting hole 112 of power control switch 800, controls entire analysis
The on and off of instrument power supply, the installation window 116 to install human-computer interaction part 600, to the mounting hole of mount message indicator light 900
117, to show whether equipment and data run are normal, reagent strip to be put into injection port 118, the power supply in detection storehouse 240
Jack 132 and data transmission interface 140 to installation data transmission module 700.
Wherein, it is equipped with detection door 120 at injection port 118, is closed, is opened when reagent strip enters or exits
It opens, is automatically closed after the completion；All sides of Instrument shell 100 are equipped with to paste the inscription of display analyzer essential information nameplate
Memorial tablet；The bottom side of Instrument shell 100 is equipped with rubber washer 150, improves the stability of analyzer entirety.
The workflow of the utility model embodiment is as follows：
Power control switch is opened, checks whether detection analysis instrument is normal.
Storehouse instruction is operated and sent out on human-computer interaction touch screen, and control system, which receives, to be instructed and send working signal extremely
Driving motor, driving motor driving sliding block simultaneously drive detection storehouse to move forward, and photoelectricity catch triggers the second optoelectronic switch, driving electricity
Machine is stopped, and detection door is opened, and is manually put into reagent strip to be detected in detection storehouse by injection port；
Operated on human-computer interaction touch screen and send detection instruction, driving motor drive sliding block on guide rail at the uniform velocity backward
Mobile, detection door is automatically closed, and when photoelectricity catch triggers the first optoelectronic switch, expression detection storehouse is moved to origin position, drives
Dynamic motor is stopped, and barcode scanner is scanned reagent strip, and scanning information is sent to human-computer interaction touch-control screen display
Show；
Driving motor driving detection storehouse uniform speed slow moves forward, and excitation light source emits exciting light, and exciting light passes through cylinder
Mirror converges on reagent strip to be detected, and the fluorescent material in reagent strip is excited to send out fluorescence emission, and transmitting light passes through first
Convex lens convergence is directional light, and directional light pools detection hot spot by the second convex lens, and detection hot spot passes through the mistake of colour filter
Filter, the fluorescence signal of collected specified wavelength, then electric signal is converted to by photocell and is sent to control system, by control
After the software operation of system by detection data include on human-computer interaction touch screen, obtain analysis result；
When photoelectricity catch triggers the second optoelectronic switch, driving motor is stopped, and detection door is opened, and reagent is taken out
Item prepares detection and analysis next time.
Print command can be inputted by human-computer interaction touch screen, analysis result is printed by mini-printer, can also be led to
Data transmission module is crossed to export analysis result.
A kind of fluorescence immunoassay detection analysis instrument provided by the utility model excites optical channel and receiving light path channel to realize
Excitation, conduction, collection and the opto-electronic conversion of fluorescence signal, improve the detection sensitivity of analyzer, using sealing detection storehouse, drop
Low interference of the ambient noise to detection light；The setting of handle, facilitates user to carry, and meets more scene use demands；Man-machine friendship
The user-friendly instrument of mutual part, realizes the friendly of human-computer interaction；Data transmission interface, for facilitating data transmission and depositing
Storage.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Within the spirit and principle of utility model, any modification, equivalent replacement, improvement and so on should be included in the utility model
Protection domain within.
Claims (10)
1. a kind of fluorescence immunoassay detection analysis instrument, which is characterized in that including Instrument shell, the Instrument shell is equipped with fortune control machine
Structure, the Yun Kong mechanisms include placing the detection storehouse of reagent strip, and reagent strip, the fortune control machine are transported by the detection storehouse
Be equipped with the optical de-tection means to detection reagent fluorescence signal on the upside of structure, the optical de-tection means include it is mating to
Conduct the excitation light path channel of exciting light and to conduct the receiving light path channel of fluorescence emission, the Yun Kong mechanisms with it is described
Optical de-tection means are connect with control system, and the Instrument shell upper surface is equipped with the man-machine friendship being connect with the control system
Mutual part.
2. fluorescence immunoassay detection analysis instrument as described in claim 1, which is characterized in that the Yun Kong mechanisms include being fixed on institute
The driving motor and guide rail stated the bottom plate on Instrument shell and be installed on the bottom plate, the guide rail are equipped with to fixation
The sliding block in the detection storehouse, the driving motor drive the sliding block to move by synchronous belt.
3. fluorescence immunoassay detection analysis instrument as claimed in claim 2, which is characterized in that the guide rail both ends, which are respectively equipped with, to be used
To monitor the first optoelectronic switch and the second optoelectronic switch of the detection storehouse shift position, the detection storehouse is equipped with described the
The photoelectricity catch that one optoelectronic switch and second optoelectronic switch are adapted to.
4. fluorescence immunoassay detection analysis instrument as claimed in claim 2, which is characterized in that the optical de-tection means pass through holder
It is fixed on the bottom plate, the optical de-tection means further include scanning the barcode scanner of bar code on reagent strip.
5. fluorescence immunoassay detection analysis instrument as described in claim 1, which is characterized in that the optical de-tection means include fastening
The left cover body and right cover body of adaptation, the optical de-tection means inside is equipped with the first excitation light path channel, the second excitation light path leads to
Road and receiving light path channel, the one end in first excitation light path channel and the one end in second excitation light path channel are and institute
State one end connection in receiving light path channel, the other end in first excitation light path channel, second excitation light path channel
The other end and the other end in the receiving light path channel are equipped with circuit board, and first excitation light path channel and described second swash
Angle of the luminous paths respectively between the receiving light path channel is 45 degree, first excitation light path channel, described
It is equipped with optical device mounting groove in second excitation light path channel and the receiving light path channel.
6. fluorescence immunoassay detection analysis instrument as claimed in claim 5, which is characterized in that first excitation light path channel and institute
State one end in the second excitation light path channel close to the circuit board and be equipped with excitation light source, first excitation light path channel and
It is equipped with cylindrical mirror in the middle part of second excitation light path channel.
7. fluorescence immunoassay detection analysis instrument as claimed in claim 5, which is characterized in that along fluorescence in the receiving light path channel
Direction of illumination is equipped with the first convex lens, the second convex lens, colour filter and photoelectric converter successively.
8. fluorescence immunoassay detection analysis instrument as described in claim 1, which is characterized in that the Instrument shell is equipped with handle, institute
It states handle to be integrally formed with the Instrument shell, the handle includes handle arm, and the arm surface that carries is equipped with power-assisted frictional layer.
9. fluorescence immunoassay detection analysis instrument as described in claim 1, which is characterized in that the Instrument shell is equipped with to install
The installing port of printer, the installation window to install the human-computer interaction part, is used the mounting hole to install power control switch
With the mounting hole of mount message indicator light, injection port, supply hub and data transmission interface to installation data transmission module.
10. such as claim 1-9 any one of them fluorescence immunoassay detection analysis instruments, which is characterized in that the human-computer interaction part
Entire detection analysis instrument operation is manipulated by the control system.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201820246649.5U CN207832803U (en) | 2018-02-11 | 2018-02-11 | A kind of fluorescence immunoassay detection analysis instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820246649.5U CN207832803U (en) | 2018-02-11 | 2018-02-11 | A kind of fluorescence immunoassay detection analysis instrument |
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| CN207832803U true CN207832803U (en) | 2018-09-07 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111323401A (en) * | 2020-02-25 | 2020-06-23 | 北京协和洛克生物技术有限责任公司 | Portable fluorescence detector, and detection method and system thereof |
| CN112748245A (en) * | 2020-12-30 | 2021-05-04 | 浙江省智能诊疗设备制造业创新中心 | Multi-channel fluorescence immunochromatography quantitative detector and detection method thereof |
| CN113686825A (en) * | 2021-08-16 | 2021-11-23 | 帝鸿科技(珠海)有限公司 | Hand-held fluorescence immune data acquisition instrument based on ICT |
-
2018
- 2018-02-11 CN CN201820246649.5U patent/CN207832803U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111323401A (en) * | 2020-02-25 | 2020-06-23 | 北京协和洛克生物技术有限责任公司 | Portable fluorescence detector, and detection method and system thereof |
| CN112748245A (en) * | 2020-12-30 | 2021-05-04 | 浙江省智能诊疗设备制造业创新中心 | Multi-channel fluorescence immunochromatography quantitative detector and detection method thereof |
| CN113686825A (en) * | 2021-08-16 | 2021-11-23 | 帝鸿科技(珠海)有限公司 | Hand-held fluorescence immune data acquisition instrument based on ICT |
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