CN114252421B - Handheld fluorescence detector - Google Patents
Handheld fluorescence detector Download PDFInfo
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- CN114252421B CN114252421B CN202111570674.1A CN202111570674A CN114252421B CN 114252421 B CN114252421 B CN 114252421B CN 202111570674 A CN202111570674 A CN 202111570674A CN 114252421 B CN114252421 B CN 114252421B
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- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 32
- 238000012545 processing Methods 0.000 claims abstract description 29
- 230000003287 optical effect Effects 0.000 claims abstract description 27
- 238000001514 detection method Methods 0.000 claims abstract description 11
- 230000005540 biological transmission Effects 0.000 claims description 7
- 238000012360 testing method Methods 0.000 claims description 6
- 239000003814 drug Substances 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 238000010586 diagram Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 230000004075 alteration Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000012921 fluorescence analysis Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The invention discloses a handheld fluorescence detector which comprises a shell, a card inserting mechanism, a touch screen, a power module, a control module, a light source, an optical module, a photoelectric sensor and a processing module, wherein the power module, the control module, the light source, the optical module, the photoelectric sensor and the processing module are arranged in the shell, the card inserting mechanism is connected with the shell in a sliding mode, the touch screen is fixed outside the shell, the power module supplies power for the control module, the light source, the photoelectric sensor and the processing module, the control module is respectively connected with the card inserting mechanism, the light source, the processing module and the touch screen, and the light source, the optical module, the photoelectric sensor and the processing module are sequentially connected. The invention has reasonable structure, is convenient to carry, can conveniently detect in real time on site, and can rapidly output results, and the results are displayed through the touch screen; the card inserting mechanism can simultaneously put in a plurality of detection cards, and the control module controls the multi-face clamp to automatically rotate so as to detect a plurality of reagent cards, and the detection efficiency is improved.
Description
Technical Field
The invention relates to the field of handheld fluorescence detectors, in particular to a handheld fluorescence detector.
Background
The detection of drugs, drug-taking personnel hair and the like is an essential important component in the work of drug inhibition, and currently, drug cases are difficult to severely punish and punish the criminals involved in the drugs, deterrent and fight the drug crimes due to difficult evidence obtaining, meanwhile, the difficulty of preventing the drug crimes and reducing drug-taking groups is increased, and the spread of the drug crimes is difficult to be effectively restrained. Therefore, detection techniques and equipment that can rapidly, in real-time, accurately obtain evidence of drugs are highly desirable for controlling the increase of drug-absorbing populations, preventing and fighting drug crimes.
The fluorescence analysis method is widely applied due to the characteristics of high sensitivity, high accuracy, strong selectivity, high detection speed, capability of being used for real-time online measurement and the like. The fluorescent signal has simple measuring light path and low instrument development cost. Most of the existing fluorescence detectors are inconvenient to carry, and only have a single reagent card slot, so that the efficiency is low.
Disclosure of Invention
The invention aims to provide a handheld fluorescence detector aiming at the defects in the prior art.
In order to achieve the above purpose, the invention provides a handheld fluorescence detector, which comprises a shell, a card inserting mechanism, a touch screen, a power module, a control module, a light source, an optical module, a photoelectric sensor and a processing module, wherein the power module, the control module, the light source, the photoelectric sensor and the processing module are arranged in the shell, the card inserting mechanism is in sliding connection with the shell, the touch screen is fixed outside the shell, the power module provides power for the control module, the light source, the photoelectric sensor and the processing module, the control module is respectively connected with the card inserting mechanism, the light source, the processing module and the touch screen, the light source, the optical module, the photoelectric sensor and the processing module are sequentially connected, the card inserting mechanism comprises a bracket in sliding connection with the shell, a circular rail fixedly connected with the bracket, a multi-face clamp which rotates in the circular rail, and a first motor which is in transmission connection with the multi-face clamp and is connected with the control module, the power module provides power for the first motor, when the card inserting mechanism is pushed into the shell to be in place, the multi-face clamp is arranged on the shell below the shell, the optical module is arranged on the shell corresponding to the position of a test line on the card.
Further, the multiaspect fixture face number is trilateral at least, multiaspect fixture inboard is through mount fixedly connected with pivot, the pivot downside is connected with through gear drive with the fixed first motor of circular rail, multiaspect fixture upper and lower both ends apex angle position is equipped with the slider with circular rail sliding connection, all be equipped with on each face of multiaspect fixture with reagent card complex spout, the spout lower extreme is equipped with the riding block, riding block middle part and pushing away the fluting of card mechanism complex.
Further, the push-clamping mechanism comprises a screw rod rotatably connected with the shell, a guide rod fixedly connected with the shell, a push rod in threaded connection with the screw rod, and a second motor in transmission connection with the screw rod, wherein the second motor is fixedly connected with the shell and is electrically connected with the control module, and a convex strip in sliding connection with the guide rod is arranged at the lower end of the push rod.
Further, the optical module comprises a diaphragm, a first planoconvex lens, a dichroic mirror, a second planoconvex lens, an optical filter and a third planoconvex lens, the photoelectric sensor is arranged above the third planoconvex lens, the light source is arranged on the left side of the first planoconvex lens, the diaphragm and the first planoconvex lens are vertically arranged, the dichroic mirror is inclined by 45 degrees, the second planoconvex lens, the optical filter and the third planoconvex lens are horizontally arranged, light emitted by the light source passes through the diaphragm, passes through the first planoconvex lens to the dichroic mirror, passes through the second planoconvex lens after being reflected by the dichroic mirror, forms a long-strip light spot on the reagent card, and fluorescence excited by the reagent card passes through the second planoconvex lens, the dichroic mirror, the optical filter and the third planoconvex lens to reach the photoelectric sensor.
Further, a handle is arranged on the outer side of the shell, and a power switch is arranged on the lower side of the touch screen.
Further, a card pushing empty groove matched with the card inserting mechanism is formed in the shell, and a spring plate is arranged in the card pushing empty groove and used for homing the reagent card.
The beneficial effects are that: the invention has reasonable structure, the main functional elements of the fluorescence detector are smaller elements and are integrated in the shell, so that the fluorescence detector is convenient to carry, can be detected in real time on site, can rapidly output results, and can be displayed through the touch screen; the card inserting mechanism can simultaneously put a plurality of detection cards, and the control module controls the multi-surface clamp to automatically rotate so as to detect the plurality of reagent cards, thereby improving the detection efficiency.
Drawings
FIG. 1 is a schematic diagram of a handheld fluorescence detector in accordance with an embodiment of the invention;
FIG. 2 is a schematic diagram of a card insertion mechanism according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a card pushing mechanism according to an embodiment of the present invention;
FIG. 4 is a schematic illustration of the structure of a push card slot and spring plate according to an embodiment of the present invention;
FIG. 5 is a schematic view of an optical module according to an embodiment of the present invention;
fig. 6 is a block diagram of an embodiment of the present invention.
In the figure: 1. a housing; 2. a card inserting mechanism; 3. a touch screen; 4. a power module; 5. a control module; 6. a light source; 7. an optical module; 8. a photoelectric sensor; 9. a processing module; 10. a bracket; 11. a circular rail; 12. a multi-face fixture; 13. a first motor; 14. a fixing frame; 15. a rotating shaft; 16. a slide block; 17. a chute; 18. a support block; 19. slotting; 20. a screw; 21. a guide rod; 22. a push rod; 23. a second motor; 24. a convex strip; 25. a diaphragm; 26. a first plano-convex lens; 27. a dichroic mirror; 28. a second plano-convex lens; 29. a light filter; 30. a third plano-convex lens; 31. a handle; 32. a power switch; 33. pushing the empty slot; 34. and (3) a spring plate.
Detailed Description
The invention will be further illustrated by the following drawings and specific examples, which are carried out on the basis of the technical solutions of the invention, it being understood that these examples are only intended to illustrate the invention and are not intended to limit the scope of the invention.
As shown in fig. 1 to 6, the embodiment of the invention provides a handheld fluorescence detector, which comprises a shell 1, a card inserting mechanism 2, a touch screen 3, and a power module 4, a control module 5, a light source 6, an optical module 7, a photoelectric sensor 8 and a processing module 9 which are arranged in the shell 1, wherein the card inserting mechanism 2 is in sliding connection with the shell 1, the touch screen 3 is fixed outside the shell 1, a handle 31 is arranged outside the shell 1, a power switch 32 is arranged on the lower side of the touch screen 3, the power switch 32 is connected between the power module 4 and the control module 5 so as to control the fluorescence detector to be opened and closed, the control module 5 is respectively connected with the card inserting mechanism 2, the light source 6, the processing module 9 and the touch screen 3, the power module 4 provides power for the control module 5, the light source 6, the photoelectric sensor 8 and the processing module 9 in the fluorescence detector, and the light source 6, the optical module 7, the photoelectric sensor 8 and the processing module 9 are sequentially connected. The card inserting mechanism 2 can insert the reagent card after being pulled out, when the card inserting mechanism 2 is pushed to the inside of the shell 1 to be in place, the shell 1 below the card inserting mechanism 2 is provided with a card pushing mechanism connected with the control module 5, the shell 1 corresponding to the position of a test line on the reagent card is provided with an optical module 7, the optical module 7 is connected with a photoelectric sensor 8, the photoelectric sensor 8 transmits signals to a processing module 9, the processing module 9 transmits processing results to the control module 5 after processing, and finally the processing results are displayed on the touch screen 3.
The card inserting mechanism 2 comprises a support 10, a circular rail 11, a multi-surface clamp 12, a first motor 13, a power module 4 and a limiting block, wherein the circular rail 11 is fixedly connected with the support 1, the multi-surface clamp 12 rotates in the circular rail 11, the first motor 13 is in transmission connection with the multi-surface clamp 12 and is connected with the control module 5, the power module 4 supplies power for the first motor 13, the support 10 is provided with the limiting block, the card inserting mechanism 2 cannot be thoroughly pulled out of the shell 1, wiring of the first motor 13 is not affected, the number of surfaces of the multi-surface clamp 12 is at least three, the multi-surface clamp is three-surface clamp in the embodiment, the number of surfaces can be four or more according to actual requirements, the number of surfaces is increased, unless the size of a reagent card is reduced, the size of a fluorescence detector is increased, the inner side of the multi-surface clamp 12 is fixedly connected with a rotating shaft 15 through a fixing frame 14, the lower side of the rotating shaft 15 is in transmission connection with the first motor 13 fixed with the circular rail 11, the upper end and lower end of the multi-surface clamp 12 is provided with a sliding block 16 in sliding connection with the circular rail 11, each surface of the multi-surface clamp 12 is provided with a sliding groove 17 matched with the reagent card, the sliding groove 17, the lower end of the sliding groove 17 is provided with a supporting block 18, the middle part of the sliding groove 18 is matched with the pushing card supporting block 19. The fixing frames 14 on the inner side of the multi-face fixture 12 are uniformly arranged, and as in the embodiment, each angle of the triangle of the multi-face fixture 12 extends out of the fixing frames 14 to be connected with the rotating shaft 15, a first limit switch is further arranged on the shell 1 at the lower end of the multi-face fixture 12, when one face of the multi-face fixture 12 is aligned with the optical module 7, the first limit switch just senses one of the fixing frames 14, the control module 5 controls the multi-face fixture 12 to change the face, the first motor 13 is started, and the multi-face fixture is rotated until the first limit switch senses the fixing frames 14, and stops until a face changing instruction is given again.
The push-clamping mechanism comprises a screw rod 20 rotatably connected with the shell 1, a guide rod 21 fixedly connected with the shell 1, a push rod 22 in threaded connection with the screw rod 20, and a second motor 23 in transmission connection with the screw rod 20, wherein the second motor 23 is fixedly connected with the shell 1 and is electrically connected with the control module 5, the power module 4 provides power for the second motor 23, a raised strip 24 in sliding connection with the guide rod 21 is arranged at the lower end of the push rod 22, two limit switches and a third limit switch are respectively arranged on the shell 1 at the left side of the guide rod 21, the raised strip 24 enables the second limit switch to generate a signal when the push rod 22 reaches the uppermost side, and the raised strip 24 enables the third limit switch to generate a signal when the push rod 22 reaches the lowermost side. The inside of the shell 1 is provided with a card pushing empty groove 33 matched with the card inserting mechanism 2, the card pushing empty groove 33 is specifically arranged on the upper side of the card inserting mechanism 2, a spring plate 34 for returning the reagent card is arranged in the card pushing empty groove 33, and the spring plate 34 can press the reagent card back to the original position when the push rod 22 descends after the reagent card is pushed up. When the detection is carried out, scanning detection is needed, so that the reagent card needs to move back and forth, when the card needs to be pushed, the control module 5 controls the second motor 23 to start, the screw rod 20 is driven to rotate, the push rod 22 moves upwards to push the reagent card, the second motor 23 reverses the push rod 22 to move downwards, and the spring plate 34 presses the reagent card back to the original position.
The optical module 7 includes a diaphragm 25, a first plano-convex lens 26, a dichroic mirror 27, a second plano-convex lens 28, an optical filter 29, and a third plano-convex lens 30. The photosensor 8 is disposed above the third plano-convex lens 30, the light source 6 is disposed on the left side of the first plano-convex lens 26, the diaphragm 25 and the first plano-convex lens 26 are disposed vertically, the dichroic mirror 27 is disposed inclined by 45 °, and the second plano-convex lens 28, the optical filter 29 and the third plano-convex lens 30 are disposed horizontally. In this embodiment, an ultraviolet lamp is used as the light source 6, the light source 6 is connected with the control module 5 and controlled, the light emitted by the light source 6 passes through the diaphragm 25, passes through the first plano-convex lens 26 to the dichroic mirror 27, and passes through the second plano-convex lens 28 after being reflected by the dichroic mirror 27, so that a long-strip light spot is formed on the reagent card, the light spot irradiates the test area of the reagent card, the fluorescence excited on the reagent card reaches the photoelectric sensor 8 through the second plano-convex lens 28, the dichroic mirror 27, the optical filter 29 and the third plano-convex lens 30, the photoelectric sensor 8 transmits a photoelectric signal to the processing module 9, and the processing module 9 performs analysis processing.
When the device is used, the power switch 32 is pressed down to start the device, the card inserting mechanism 2 is pulled out, a plurality of reagent cards are put in, one card surface is pushed into the card inserting mechanism 2, the touch screen 3 is clicked to start detection, the control module 5 controls the first motor 13 to rotate, after the first limit switch senses the position, the first motor 13 stops, the reagent card is opposite to the optical module 7 at the moment, the control module 5 controls the light source 6 to be started, a strip light spot is formed in a test area of the reagent card, the card pushing mechanism is started, the reagent card moves back and forth, the generated photoelectric signal is transmitted to the processing module 9 for analysis processing, after the analysis processing result is transmitted to the control module 5, the surface changing instruction is excited, the surface changing is detected, and the final result is displayed on the touch screen 3.
The foregoing is merely a preferred embodiment of the present invention, and it should be noted that other parts not specifically described are within the prior art or common general knowledge to a person of ordinary skill in the art. Modifications and alterations may be made without departing from the principles of this invention, and such modifications and alterations should also be considered as being within the scope of the invention.
Claims (5)
1. The handheld fluorescence detector is characterized by comprising a shell, a card inserting mechanism, a touch screen, a power module, a control module, a light source, an optical module, a photoelectric sensor and a processing module, wherein the power module, the control module, the light source, the optical module, the photoelectric sensor and the processing module are arranged in the shell;
The pushing and clamping mechanism comprises a screw rod rotationally connected with the shell, a guide rod fixedly connected with the shell, a push rod in threaded connection with the screw rod, and a second motor in transmission connection with the screw rod, wherein the second motor is fixedly connected with the shell and is electrically connected with the control module, a convex strip in sliding connection with the guide rod is arranged at the lower end of the push rod, a first limit switch is further arranged on the shell at the lower end of the multi-face clamp, when the multi-face clamp is provided with one face and is aligned with the optical module, the first limit switch just senses one face in the fixing frame, and the control module starts the first motor to rotate until the first limit switch senses the fixing frame to stop; when the test device is used, the power switch opening equipment is pressed down, the card inserting mechanism is pulled out, a plurality of reagent cards are placed in, one card surface is pushed into the card inserting mechanism, the touch screen is clicked to start detection, the control module controls the first motor to rotate, after the first limit switch senses the position, the first motor stops, the reagent card is opposite to the optical module at the moment, the control module controls the light source to be opened, a strip light spot is formed in a test area of the reagent card, the card pushing mechanism is started, the reagent card acts back and forth, and a generated photoelectric signal is transmitted to the processing module.
2. The handheld fluorescence detector according to claim 1, wherein the number of the surfaces of the multi-surface fixture is at least three, the inner side of the multi-surface fixture is fixedly connected with a rotating shaft through a fixing frame, the lower side of the rotating shaft is connected with a first motor fixed with a circular rail through gear transmission, the top angle positions of the upper end and the lower end of the multi-surface fixture are provided with sliding blocks which are in sliding connection with the circular rail, each surface of the multi-surface fixture is provided with a sliding groove matched with a reagent card, the lower end of each sliding groove is provided with a supporting block, and the middle part of each supporting block is provided with a groove matched with a card pushing mechanism.
3. The hand-held fluorescence detector according to claim 1, wherein the optical module comprises a diaphragm, a first plano-convex lens, a dichroic mirror, a second plano-convex lens, a filter and a third plano-convex lens, the photoelectric sensor is arranged above the third plano-convex lens, the light source is arranged on the left side of the first plano-convex lens, the diaphragm and the first plano-convex lens are vertically arranged, the dichroic mirror is inclined by 45 degrees, the second plano-convex lens, the filter and the third plano-convex lens are horizontally arranged, light emitted by the light source passes through the diaphragm, passes through the first plano-convex lens to the dichroic mirror, passes through the second plano-convex lens through the dichroic mirror to form a strip on the reagent card, and fluorescence excited by the reagent card passes through the second plano-convex lens, the dichroic mirror, the filter and the third plano-convex lens to reach the photoelectric sensor.
4. The handheld fluorescence detector of claim 1, wherein a handle is provided on the outside of the housing and a power switch is provided on the underside of the touch screen.
5. The handheld fluorescence detector of claim 1, wherein a card pushing empty slot is formed in the shell and matched with the card inserting mechanism, and a spring plate is arranged in the card pushing empty slot and used for homing the reagent card.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111570674.1A CN114252421B (en) | 2021-12-21 | 2021-12-21 | Handheld fluorescence detector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111570674.1A CN114252421B (en) | 2021-12-21 | 2021-12-21 | Handheld fluorescence detector |
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| Publication Number | Publication Date |
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| CN114252421A CN114252421A (en) | 2022-03-29 |
| CN114252421B true CN114252421B (en) | 2024-04-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202111570674.1A Active CN114252421B (en) | 2021-12-21 | 2021-12-21 | Handheld fluorescence detector |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117871846B (en) * | 2024-03-12 | 2024-06-18 | 南京长健生物科技有限公司 | Handheld fluorescence immunoassay device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN206684046U (en) * | 2017-04-27 | 2017-11-28 | 南京微测生物科技有限公司 | The quantitative quick analytic instrument of portable food safety fluorescent |
| CN206756842U (en) * | 2017-05-21 | 2017-12-15 | 苏州和迈精密仪器有限公司 | A kind of handhold portable immunochromatographiassays assays instrument |
| CN210401442U (en) * | 2019-07-10 | 2020-04-24 | 郑州科蒂亚生物技术有限公司 | Reagent card feeding device of fluorescence immunoassay appearance |
| CN112630204A (en) * | 2020-12-31 | 2021-04-09 | 奥谱天成（厦门）光电有限公司 | Hand-held fluorescence detector |
| CN112748245A (en) * | 2020-12-30 | 2021-05-04 | 浙江省智能诊疗设备制造业创新中心 | Multi-channel fluorescence immunochromatography quantitative detector and detection method thereof |
-
2021
- 2021-12-21 CN CN202111570674.1A patent/CN114252421B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN206684046U (en) * | 2017-04-27 | 2017-11-28 | 南京微测生物科技有限公司 | The quantitative quick analytic instrument of portable food safety fluorescent |
| CN206756842U (en) * | 2017-05-21 | 2017-12-15 | 苏州和迈精密仪器有限公司 | A kind of handhold portable immunochromatographiassays assays instrument |
| CN210401442U (en) * | 2019-07-10 | 2020-04-24 | 郑州科蒂亚生物技术有限公司 | Reagent card feeding device of fluorescence immunoassay appearance |
| CN112748245A (en) * | 2020-12-30 | 2021-05-04 | 浙江省智能诊疗设备制造业创新中心 | Multi-channel fluorescence immunochromatography quantitative detector and detection method thereof |
| CN112630204A (en) * | 2020-12-31 | 2021-04-09 | 奥谱天成（厦门）光电有限公司 | Hand-held fluorescence detector |
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| CN114252421A (en) | 2022-03-29 |
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