CN114250144A - Liquid path system for gene sequencing - Google Patents
Liquid path system for gene sequencing Download PDFInfo
- Publication number
- CN114250144A CN114250144A CN202111552460.1A CN202111552460A CN114250144A CN 114250144 A CN114250144 A CN 114250144A CN 202111552460 A CN202111552460 A CN 202111552460A CN 114250144 A CN114250144 A CN 114250144A
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- channel
- conduit
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- injection pump
- reaction
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- 239000007788 liquid Substances 0.000 title claims abstract description 32
- 238000012163 sequencing technique Methods 0.000 title claims abstract description 25
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 22
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 92
- 238000002347 injection Methods 0.000 claims abstract description 51
- 239000007924 injection Substances 0.000 claims abstract description 51
- 239000002699 waste material Substances 0.000 claims abstract description 25
- 238000007789 sealing Methods 0.000 claims abstract description 3
- 239000012530 fluid Substances 0.000 claims description 13
- 238000004891 communication Methods 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 239000000284 extract Substances 0.000 description 4
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 238000007599 discharging Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Abstract
The invention relates to a liquid path system for gene sequencing, which comprises a rotary valve, an electromagnetic valve, a reaction device, an injection pump and a waste liquid collecting device, wherein the rotary valve is provided with a plurality of reagent input channels communicated with a kit and a reagent output channel; the electromagnetic valve is a three-way electromagnetic valve provided with a first channel, a second channel and a third channel; a fourth channel and a fifth channel are arranged on the reaction device; the injection pump is provided with a first injection pump channel and a second injection pump channel; the first channel is communicated with the reagent output channel through a second conduit, and the second channel is communicated with the fourth channel through a third conduit; the third channel is communicated with a first channel of the injection pump through a fourth conduit, the fifth channel and the second channel of the injection pump are correspondingly connected with a fifth conduit and a sixth conduit, and the fifth conduit and the sixth conduit are both communicated with the waste liquid collecting device in a non-sealing mode. The invention is more stable, and the picture can not fluctuate during photographing and is clearer.
Description
Technical Field
The invention relates to the technical field of biology, in particular to a liquid path system for gene sequencing.
Background
A novel gene detection technology in gene sequencing can analyze and determine the complete sequence of genes from blood or saliva, predict whether a certain disease exists or not, and realize early prevention and treatment. In gene sequencing, a camera is required to shoot a picture after reaction after the reaction is finished, a reaction device is in a negative pressure state in the existing gene sequencing, the pressure intensity of the interior of the reaction device is different from that of the external normal pressure state, micro fluctuation can be generated in the interior of the reaction device, the photographing effect is influenced, and the phenomena of blurring, unclear boundary and the like can be generated, so that the sequencing result is influenced.
Disclosure of Invention
Aiming at the existing defects, the invention provides a liquid path system for gene sequencing.
The technical scheme adopted by the invention for solving the technical problems is as follows: a liquid path system for gene sequencing comprises a rotary valve, an electromagnetic valve, a reaction device, an injection pump and a waste liquid collecting device, wherein the rotary valve is provided with a plurality of reagent input channels and a reagent output channel, and the reagent input channels are communicated with a reagent box through a first conduit; the electromagnetic valve is a three-way electromagnetic valve provided with a first channel, a second channel and a third channel; a fourth channel and a fifth channel are arranged on the reaction device; the injection pump is provided with a first injection pump channel and a second injection pump channel which is dynamically communicated with the first injection pump channel; the first channel is communicated with the reagent output channel through a second conduit, and the second channel is communicated with the fourth channel through a third conduit; the third channel is communicated with a first channel of the injection pump through a fourth conduit, the fifth channel and the second channel of the injection pump are correspondingly connected with a fifth conduit and a sixth conduit which are used for guiding liquid into the waste liquid collecting device, and the fifth conduit and the sixth conduit are both in non-sealing communication with the waste liquid collecting device.
Preferably, the number of the reagent boxes is the same as that of the reagent input channels, and the reagent boxes correspond to the reagent input channels one by one.
Preferably, each reagent input channel is provided with a channel identification code, and each reagent kit is provided with a reagent kit identification code corresponding to the channel identification code on the reagent input channel communicated with the reagent kit.
Preferably, a plurality of said cartridges are arranged in a matrix configuration.
Preferably, the volume of the fourth conduit is not less than the sum of the volumes of the added reagents required for sequencing.
Preferably, the reaction device comprises a reaction chamber and a reaction chip arranged in the reaction chamber, and the fourth channel and the fifth channel are arranged on the reaction chamber.
Preferably, the reaction apparatus is provided with a plurality of reaction chambers for reaction, each of which is provided with a fourth channel and a fifth channel.
Preferably, a pressure sensor is disposed between the reagent output channel and the first channel.
Preferably, the electromagnetic valve, the injection pump and the rotary valve are all electrically connected with a control unit.
Preferably, the first conduit, the second conduit, the third conduit, the fourth conduit, the fifth conduit and the sixth conduit are hoses.
The invention has the beneficial effects that: the reaction device is not provided with a closed device at the tail end, is in a normal pressure state and is more stable, and the fluctuation is avoided during photographing, so that the picture is clearer and more standard, and the test result is more accurate.
Drawings
FIG. 1 is a schematic structural diagram of an embodiment of the present invention;
part names and serial numbers in the figure: 1-rotary valve 10-reagent input channel 11-reagent output channel 100-channel identification code 110-first conduit 2-electromagnetic valve 20-first channel 21-second channel 22-third channel 200-second conduit 210-third conduit 220-fourth conduit 3-reaction device 30-fourth channel 31-fifth channel 310-fifth conduit 4-injection pump 40-injection pump first channel 41-injection pump second channel 410-sixth conduit 5-waste liquid collection device 6-kit 60-kit identification code 61-base 7 pressure sensor.
Detailed Description
To more clearly illustrate the objects, technical solutions and advantages of the embodiments of the present invention, the present invention will be further described with reference to the following embodiments, which are clearly and completely described, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without inventive step, are within the scope of the present invention. Furthermore, directional terms used in the present invention, such as "upper", "lower", "front", "rear", "left", "right", "inner", "outer", etc., refer to directions only as shown in the attached drawings, and are used for better, clearer illustration and understanding of the present invention, but do not indicate or imply orientations which the present invention must have, and thus, should not be construed as limiting the present invention
In the embodiment of the present invention, as shown in fig. 1, a fluid path system for gene sequencing comprises a rotary valve 1, an electromagnetic valve 2, a reaction device 3, an injection pump 4, and a waste fluid collecting device 5, wherein the rotary valve 2 is provided with a plurality of reagent input channels 10 and a reagent output channel 11, the reagent input channels 10 are communicated with reagent kits 6 through a first conduit 110, that is, the reagent kits 6 are set to be different numbers according to requirements, which can be more or less than the number of the reagent input channels, or the same number as the number of the reagent input channels, the waste fluid collecting device uses waste fluid bottles, when the two numbers are the same, the reagent kits 6 correspond to the reagent input channels 10 one by one, so as to identify the added reagents and avoid false addition, at this time, each reagent input channel 10 is provided with a channel identification code 100, each reagent kit 6 is provided with a kit identification code 60 corresponding to the channel identification code 100 on the reagent input channel 10 communicated with the reagent input channel, if the reagent input channels 10 are distinguished by using the channel identification codes 100 of A, B, c, etc., the reagent kits 6 are correspondingly distinguished by setting the reagent kit identification codes 60a, b, c, etc., and the reagent input channels 10 corresponding to a and a are communicated with the reagent kits 6, so that the rotary valve 1 can be conveniently adjusted and identified. In order to place the reagent boxes 6 conveniently, a plurality of reagent boxes 6 are arranged on a base 61 in a row-column structure, the reagent boxes 6 are test tubes or other conventional containers, corresponding counter bores or through holes are arranged on the base 61, for example, the reagent boxes are test tubes, and the base is a test tube rack; the electromagnetic valve 2 is a three-way electromagnetic valve provided with a first channel 20, a second channel 21 and a third channel 22, and the conduction among different channels can be realized by controlling the electromagnetic valve 2; the reaction device 3 is provided with a fourth channel 30 and a fifth channel 31, the reaction device 3 can be implemented by any existing reaction device, and the fourth channel 30 and the fifth channel 31 respectively correspond to an input channel of a reagent before reaction and an output channel of waste liquid after reaction of the reaction device 3; the injection pump 4 is provided with a first injection pump channel 40 and a second injection pump channel 41 which is dynamically communicated with the first injection pump channel 40, the two channels are communicated by arranging corresponding valves, for example, an electromagnetic valve is adopted, the first injection pump channel 40 is used for pumping a reagent, and the second injection pump channel 41 is used for discharging the residual reagent; the first channel 20 is communicated with the reagent output channel 11 through a second conduit 200, and the second channel 21 is communicated with the fourth channel 30 through a third conduit 210; the third channel 22 is communicated with the first channel 40 of the injection pump through the fourth conduit 220, the fifth channel 31 and the second channel 41 of the injection pump are correspondingly connected with a fifth conduit 310 and a sixth conduit 410 for guiding liquid into the waste liquid collecting device 5, the fifth conduit 310 and the sixth conduit 410 are respectively communicated with the waste liquid collecting device 5 in an unsealed way, the first conduit 110, the second conduit 200, the third conduit 210, the fourth conduit 220, the fifth conduit 310 and the sixth conduit 410 are all hoses which are convenient to connect for use, so that under the pumping of the injector in the injection pump 4, a reagent enters the rotary valve 1 from the reagent box 6 through the first conduit 110 via the reagent input channel 10, then enters the second conduit 200 via the reagent output channel 11, then enters the electromagnetic valve 2 via the first channel 20, then enters the fourth conduit 220 and the injector of the injection pump 4 via the third channel 22, and then under the pushing of the injector of the injection pump 4, the electromagnetic valve 2 closes the first channel 20 to conduct the second channel 21, the reagent enters the third conduit 210 through the second channel 21, and then enters the reaction device 3 through the fourth channel 30, after the reagent is added into the reaction device 3, the electromagnetic valve 2 closes the third channel 22, the first injection pump channel 40, the fourth conduit 220 and the second injection pump channel 41 are conducted, the waste liquid in the injector of the injection pump 4 and the fourth conduit 220 is pushed to the sixth conduit 410 through the second injection pump channel 41 and then discharged into the waste liquid collecting device 5, each reagent is sequentially added into the reaction device 3, and after the reaction is completed, the waste liquid in the reaction device 3 enters the fifth conduit 310 through the fifth channel 31 and then discharged into the waste liquid collecting device 5. That is to say reagent passes through rotary valve 1 and switches different passageways, flow out from the three-way valve passageway through the three-way valve passageway 2 negative pressure extraction promptly, to injection pump 4 syringe in, then by injection pump 4 back injection again, through the three-way valve passageway, discharge by the three-way valve passageway, it begins the reaction to get into reaction unit 3, the reaction is finished, waste liquid discharges to the waste liquid box, terminal fifth pipe 310 and the 5 non-sealed intercommunication of waste liquid collection device at reaction unit 3, that is to say that reaction unit 3 has not been sealed, be in the ordinary pressure state, the internal and external pressure of reaction is the same, it is inside more stable, can not appear undulantly when shooing, make the photo more clear, and is standard, it is more accurate to have guaranteed that the test result. In application, the reagent input channel 10 can be set to different numbers, such as 12, 15, 24, 30, etc., for example, 24, when the reagent input channel 10, the reagent box 6, the first conduit 110 are all 24, the rotary valve 1 is connected with 24 reagent boxes 6 through the first conduit 110, there are various reagents from reagent box one to reagent box twenty four, firstly the rotary valve 1 is switched to channel one, the injection pump 4 is operated, the injector generates negative pressure, the reagent one passes through the first channel 20 of the electromagnetic valve 2 through the channel of the rotary valve 1, passes through the third channel 22 of the electromagnetic valve 2, enters the injector of the injection pump 4 through the fourth conduit 220, then the injector is pushed by the injection pump 4, the reagent in the fourth conduit 220 between the first channel 40 and the third channel 22 of the injection pump is reversely injected into the fourth channel 30 through the electromagnetic valve 2, passes through the second channel 21 and then enters the reaction device 3, carry out first reaction, after the reaction, unnecessary waste liquid is discharged to the waste liquid box by injection pump second passageway 41 in the syringe, and the waste liquid in reaction unit 3 is by discharging from fifth passageway 31 and fifth pipe 310, and fifth pipe 310 directly is in the ordinary pressure state with external UNICOM, analogizes from this, extracts the second kind, the third kind.
In a further improvement, the volume of the fourth conduit 220 is not less than the sum of the volumes of the added reagents required for sequencing, that is, if the diameter of the fourth conduit 220 is constant, the fourth conduit 220 is set to a sufficient length to store all the reagents required for sequencing in the fourth conduit 220. When adding reagent, reagent passes through rotary valve 1, it is rotatory to different passageways, injection pump 4 moves, the syringe produces the negative pressure and extracts different reagent, extract the distance through control syringe, reach the reagent of extracting the different volume, reagent passes through the three-way valve earlier and arrives in the pipeline between three-way valve and the syringe, according to the reaction requirement, can be according to first reagent, the second reagent, the order of third reagent extracts the different reagent of different volume in the pipe between three-way valve and syringe in proper order, then according to the order in proper order reverse injection to react in the reaction unit, after the reaction, follow-up shooing, just can save time and practice thrift reagent.
In a further improvement, the reaction device 3 comprises a reaction chamber and a reaction chip arranged in the reaction chamber, and the fourth channel and the fifth channel are arranged on the reaction chamber, so that the operation is convenient. The corresponding reaction device 3 is provided with a plurality of reaction chambers for reaction, each of which is provided with the fourth channel 30 and the fifth channel 31, so that the reaction can be performed in the plurality of reaction chambers, thereby improving the efficiency. Valves are provided in the fourth channel 30 and the fifth channel 31, and the valves are opened in sequence when adding the reagent, and the plurality of fourth channels 30 are communicated with the third conduit 210, the plurality of fifth channels 31 and the fifth conduit 310.
In a further modification, as shown in fig. 1, a pressure sensor 7 is disposed between the reagent output channel 11 and the first channel 20, and the pressure in the second conduit 200 is monitored by the pressure sensor 7, so that the pumping force of the syringe pump 4 can be controlled according to the pressure signal.
In a further improvement, the electromagnetic valve 2, the injection pump 4 and the rotary valve 1 are electrically connected with a control unit, so that the system is controlled in a centralized manner, and the structure is compact and is easier to control.
It will be understood that modifications and variations can be made by persons skilled in the art in light of the above teachings and all such modifications and variations are intended to be included within the scope of the invention as defined in the appended claims.
Claims (10)
1. A liquid path system for gene sequencing is characterized by comprising a rotary valve, an electromagnetic valve, a reaction device, an injection pump and a waste liquid collecting device, wherein the rotary valve is provided with a plurality of reagent input channels and a reagent output channel, and the reagent input channels are communicated with a reagent box through a first conduit; the electromagnetic valve is a three-way electromagnetic valve provided with a first channel, a second channel and a third channel; a fourth channel and a fifth channel are arranged on the reaction device; the injection pump is provided with a first injection pump channel and a second injection pump channel which is dynamically communicated with the first injection pump channel; the first channel is communicated with the reagent output channel through a second conduit, and the second channel is communicated with the fourth channel through a third conduit; the third channel is communicated with a first channel of the injection pump through a fourth conduit, the fifth channel and the second channel of the injection pump are correspondingly connected with a fifth conduit and a sixth conduit which are used for guiding liquid into the waste liquid collecting device, and the fifth conduit and the sixth conduit are both in non-sealing communication with the waste liquid collecting device.
2. The fluid path system for gene sequencing of claim 1, wherein the number of the reagent cartridges and the number of the reagent input channels are the same and correspond to each other.
3. The fluid path system for gene sequencing of claim 2, wherein each of the reagent input channels is provided with a channel identification code, and each of the reagent kits is provided with a kit identification code corresponding to the channel identification code on the reagent input channel communicated therewith.
4. The fluid path system for gene sequencing of claim 2, wherein a plurality of said reagent cartridges are arranged in a matrix in a row-column configuration.
5. The fluid path system for gene sequencing of claim 1, wherein the volume of the fourth conduit is not less than the sum of the volumes of the reagents required for sequencing.
6. The fluid path system for gene sequencing of claim 1, wherein the reaction device comprises a reaction chamber, a reaction chip disposed in the reaction chamber, and the fourth channel and the fifth channel are disposed on the reaction chamber.
7. The fluid path system for gene sequencing of claim 6, wherein the reaction apparatus is provided with a plurality of reaction chambers for reaction, each of which is provided with a fourth channel and a fifth channel.
8. The fluid path system for gene sequencing of claim 1, wherein a pressure sensor is disposed between the reagent output channel and the first channel.
9. The fluid path system for gene sequencing of claim 1, wherein the solenoid valve, the syringe pump and the rotary valve are electrically connected to a control unit.
10. The fluid path system for gene sequencing of claim 1, wherein the first, second, third, fourth, fifth and sixth conduits are flexible tubes.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111552460.1A CN114250144A (en) | 2021-12-17 | 2021-12-17 | Liquid path system for gene sequencing |
| PCT/CN2022/086208 WO2023108962A1 (en) | 2021-12-17 | 2022-04-12 | Liquid path system for gene sequencing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111552460.1A CN114250144A (en) | 2021-12-17 | 2021-12-17 | Liquid path system for gene sequencing |
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| Publication Number | Publication Date |
|---|---|
| CN114250144A true CN114250144A (en) | 2022-03-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111552460.1A Pending CN114250144A (en) | 2021-12-17 | 2021-12-17 | Liquid path system for gene sequencing |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN114250144A (en) |
| WO (1) | WO2023108962A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023108962A1 (en) * | 2021-12-17 | 2023-06-22 | 深圳铭毅智造科技有限公司 | Liquid path system for gene sequencing |
| CN117568144A (en) * | 2024-01-17 | 2024-02-20 | 中国科学院长春光学精密机械与物理研究所 | Liquid path device, use method of liquid path device and gene sequencer |
| CN117568144B (en) * | 2024-01-17 | 2024-04-12 | 中国科学院长春光学精密机械与物理研究所 | Liquid path device, use method of liquid path device and gene sequencer |
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- 2021-12-17 CN CN202111552460.1A patent/CN114250144A/en active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2023108962A1 (en) | 2023-06-22 |
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