CN114246991A - 一种医用管道的亲水涂层 - Google Patents
一种医用管道的亲水涂层 Download PDFInfo
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- CN114246991A CN114246991A CN202111372910.9A CN202111372910A CN114246991A CN 114246991 A CN114246991 A CN 114246991A CN 202111372910 A CN202111372910 A CN 202111372910A CN 114246991 A CN114246991 A CN 114246991A
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- 239000011248 coating agent Substances 0.000 title claims abstract description 21
- 238000000576 coating method Methods 0.000 title claims abstract description 21
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 28
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 17
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 17
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 17
- 239000004814 polyurethane Substances 0.000 claims abstract description 14
- 229920002635 polyurethane Polymers 0.000 claims abstract description 14
- 239000012790 adhesive layer Substances 0.000 claims abstract description 10
- 239000010410 layer Substances 0.000 claims abstract description 10
- 229920001228 polyisocyanate Polymers 0.000 claims abstract description 10
- 239000005056 polyisocyanate Substances 0.000 claims abstract description 10
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229920001661 Chitosan Polymers 0.000 claims abstract description 4
- 239000004593 Epoxy Substances 0.000 claims abstract description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 4
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims abstract description 4
- -1 aziridine compound Chemical class 0.000 claims abstract description 4
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 4
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 4
- 229920002689 polyvinyl acetate Polymers 0.000 claims abstract description 4
- 239000011118 polyvinyl acetate Substances 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 125000005442 diisocyanate group Chemical group 0.000 claims description 3
- 239000000178 monomer Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims 2
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract description 4
- 229910021529 ammonia Inorganic materials 0.000 abstract description 2
- 229920000728 polyester Polymers 0.000 abstract description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Materials For Medical Uses (AREA)
- Paints Or Removers (AREA)
Abstract
本发明公开了一种医用管道的亲水涂层，包括粘接层和亲水层：粘接层为交联剂，亲水层为亲水聚氨酯；两者质量比为1:10；其中交联剂采用多异氰酸酯、氮丙啶化合物、环氧基交联剂、硅氧烷交联剂或多碳二亚胺交联剂；亲水聚氨酯采用聚乙烯基吡咯烷酮、聚乙烯基吡咯烷酮共聚丙烯酞胺、聚乙烯基吡咯烷酮共聚醋酸乙烯酯、聚醋酸乙烯酯、聚环氧乙烷、羧甲基壳聚糖或羟乙基纤维素。本发明提供的一种医用管道的亲水涂层，通过交联剂与亲水聚酯氨进行混合配比，提高亲水涂层在导管表面的稳定性，提高医用导管在使用时的亲水性能。
Description
技术领域
本发明涉及一种医用管道的亲水涂层。
背景技术
医用导管作为常见的介入手术用材料被广泛应用，为了能够在人体内提供管道流通，保护手术中患者的人体机能，通常都需要利用医用管道进行介入手术，在管道置入患者体内时，如果管道表面不够润滑，就会对人体器官造成损伤，而管道在人体内不能与体内的其他组织产生反应，会影响到医疗效果，因此其表面的润滑性能就只能通过改性或者涂层来达到。
传统的涂层材料成本高昂，必须要导管浸润在材料内才能进行表面附着，依靠材料本身的亲水性能来保证使用，这样的涂层表面极不稳定。
发明内容
本发明旨在提供一种医用管道的亲水涂层，利用材料配比的修改，将传统的单一涂层改为粘接层和亲水层，使得粘接层与导管外圆相连接，再连接亲水层，提高亲水涂层在导管表面的稳定性。
为解决上述问题，本发明提供的一种医用管道的亲水涂层采用了如下技术方案：
一种医用管道的亲水涂层，包括粘接层和亲水层：粘接层为交联剂，亲水层为亲水聚氨酯，；两者质量比为1:10；其中交联剂采用多异氰酸酯、氮丙啶化合物、环氧基交联剂、硅氧烷交联剂或多碳二亚胺交联剂；亲水聚氨酯采用聚乙烯基吡咯烷酮、聚乙烯基吡咯烷酮共聚丙烯酞胺、聚乙烯基吡咯烷酮共聚醋酸乙烯酯、聚醋酸乙烯酯、聚环氧乙烷、羧甲基壳聚糖或羟乙基纤维素。
进一步的，交联剂优选多异氰酸酯，多异氰酸酯为二异氰酸酯单体与二元醇和三元醇的混合物，摩尔比为1:0.1-0.4:0.25-0.3。
进一步的，亲水聚氨酯优选聚乙烯基吡咯烷酮，其质量比占总材料比重为30％。
进一步的，交联剂与亲水聚氨酯混合在45度温度下进行混合，加入的溶剂中进行搅拌，固体重量占溶剂重量的50％。
进一步的，搅拌频率为4000-6000r/min。
本发明的有益效果在于：本发明提供的一种医用管道的亲水涂层，通过交联剂与亲水聚酯氨进行混合配比，提高亲水涂层在导管表面的稳定性，提高医用导管在使用时的亲水性能。
具体实施方式
为了更清楚的了解本发明提供的技术方案，下面结合具体的实施例对本发明做进一步的说明。
本发明提供的一种医用管道的亲水涂层，一种医用管道的亲水涂层，包括粘接层和亲水层：粘接层为交联剂，亲水层为亲水聚氨酯，；两者质量比为1:10；其中交联剂采用多异氰酸酯、氮丙啶化合物、环氧基交联剂、硅氧烷交联剂或多碳二亚胺交联剂；亲水聚氨酯采用聚乙烯基吡咯烷酮、聚乙烯基吡咯烷酮共聚丙烯酞胺、聚乙烯基吡咯烷酮共聚醋酸乙烯酯、聚醋酸乙烯酯、聚环氧乙烷、羧甲基壳聚糖或羟乙基纤维素。
进一步的，交联剂优选多异氰酸酯，多异氰酸酯为二异氰酸酯单体与二元醇和三元醇的混合物，摩尔比为1:0.1-0.4:0.25-0.3。
进一步的，亲水聚氨酯优选聚乙烯基吡咯烷酮，其质量比占总材料比重为30％。
进一步的，交联剂与亲水聚氨酯混合在45度温度下进行混合，加入的溶剂中进行搅拌，固体重量占溶剂重量的50％。
进一步的，搅拌频率为4000-6000r/min。
最后需要说明的是，以上实施例仅用以说明本发明的技术方案而非限制性技术方案，本领域的普通技术人员应当理解，那些对本发明的技术方案进行修改或者等同替换，而不脱离本技术方案的宗旨和范围，均应涵盖在本发明的权利要求范围当中。
Claims (5)
1.一种医用管道的亲水涂层，其特征在于，包括粘接层和亲水层，粘接层为交联剂，亲水层为亲水聚氨酯，；两者质量比为1:10；其中交联剂采用多异氰酸酯、氮丙啶化合物、环氧基交联剂、硅氧烷交联剂或多碳二亚胺交联剂；亲水聚氨酯采用聚乙烯基吡咯烷酮、聚乙烯基吡咯烷酮共聚丙烯酞胺、聚乙烯基吡咯烷酮共聚醋酸乙烯酯、聚醋酸乙烯酯、聚环氧乙烷、羧甲基壳聚糖或羟乙基纤维素。
2.根据权利要求1所述的一种医用管道的亲水涂层，其特征在于，交联剂优选多异氰酸酯，多异氰酸酯为二异氰酸酯单体与二元醇和三元醇的混合物，摩尔比为1:0.1-0.4:0.25-0.3。
3.根据权利要求1所述的一种医用管道的亲水涂层，其特征在于，亲水聚氨酯优选聚乙烯基吡咯烷酮，其质量比占总材料比重为30％。
4.根据权利要求1所述的一种医用管道的亲水涂层，其特征在于，交联剂与亲水聚氨酯混合在45度温度下进行混合，加入的溶剂中进行搅拌，固体重量占溶剂重量的50％。
5.根据权利要求4所述的一种医用管道的亲水涂层，其特征在于，搅拌频率为4000-6000r/min。
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998058990A1 (en) * | 1997-06-20 | 1998-12-30 | Coloplast A/S | A hydrophilic coating and a method for the preparation thereof |
| CN1442458A (zh) * | 2003-04-03 | 2003-09-17 | 复旦大学 | 一种用于医疗器械的亲水润滑涂层及其涂覆方法 |
| CN101812265A (zh) * | 2009-02-24 | 2010-08-25 | 赛诺医疗科学技术有限公司 | 一种应用于医疗器械表面的亲水涂层溶液及其制备方法 |
| CN101934101A (zh) * | 2010-08-24 | 2011-01-05 | 北京迪玛克医药科技有限公司 | 一种用于医疗器械表面的亲水涂层及其制备方法 |
| CN107899092A (zh) * | 2017-11-23 | 2018-04-13 | 湘潭大学 | 一种医用介入金属导丝表面亲水润滑涂层及其制备方法 |
| CN109045367A (zh) * | 2018-07-13 | 2018-12-21 | 北京化工大学 | 一种医用导管导丝表面的亲水涂层的制备方法及其产品 |
-
2021
- 2021-11-19 CN CN202111372910.9A patent/CN114246991A/zh active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998058990A1 (en) * | 1997-06-20 | 1998-12-30 | Coloplast A/S | A hydrophilic coating and a method for the preparation thereof |
| CN1442458A (zh) * | 2003-04-03 | 2003-09-17 | 复旦大学 | 一种用于医疗器械的亲水润滑涂层及其涂覆方法 |
| CN101812265A (zh) * | 2009-02-24 | 2010-08-25 | 赛诺医疗科学技术有限公司 | 一种应用于医疗器械表面的亲水涂层溶液及其制备方法 |
| CN101934101A (zh) * | 2010-08-24 | 2011-01-05 | 北京迪玛克医药科技有限公司 | 一种用于医疗器械表面的亲水涂层及其制备方法 |
| CN107899092A (zh) * | 2017-11-23 | 2018-04-13 | 湘潭大学 | 一种医用介入金属导丝表面亲水润滑涂层及其制备方法 |
| CN109045367A (zh) * | 2018-07-13 | 2018-12-21 | 北京化工大学 | 一种医用导管导丝表面的亲水涂层的制备方法及其产品 |
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