CN114127090A - 在大脑中具有增强的特异性的病毒组合物 - Google Patents

在大脑中具有增强的特异性的病毒组合物 Download PDF

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CN114127090A
CN114127090A CN202080043549.2A CN202080043549A CN114127090A CN 114127090 A CN114127090 A CN 114127090A CN 202080043549 A CN202080043549 A CN 202080043549A CN 114127090 A CN114127090 A CN 114127090A
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aav capsid
aav
amino acid
syndrome
disease
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维维安娜·格拉迪纳鲁
S·R·库马尔
本杰明·德威曼
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California Institute of Technology
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    • C12N2750/00011—Details
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    • C12N2750/14171—Demonstrated in vivo effect

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CN202080043549.2A 2019-04-11 2020-04-10 在大脑中具有增强的特异性的病毒组合物 Pending CN114127090A (zh)

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US201962832826P 2019-04-11 2019-04-11
US62/832,826 2019-04-11
PCT/US2020/027708 WO2020210655A1 (en) 2019-04-11 2020-04-10 Virus compositions with enhanced specificity in the brain

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EP (1) EP3953371A4 (https=)
JP (2) JP2022526018A (https=)
KR (1) KR20220007056A (https=)
CN (1) CN114127090A (https=)
AU (1) AU2020271108A1 (https=)
CA (1) CA3136658A1 (https=)
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Cited By (2)

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CN116693633A (zh) * 2023-02-21 2023-09-05 广州派真生物技术有限公司 腺相关病毒突变体及其应用
CN116983437A (zh) * 2023-07-26 2023-11-03 武汉大学中南医院 一种αOlig2的无损影像标记方法和产物及其用途

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WO2020014471A1 (en) 2018-07-11 2020-01-16 The Brigham And Women's Hospital, Inc. Methods and compositions for delivery of agents across the blood-brain barrier
CN113966399A (zh) 2018-09-26 2022-01-21 加州理工学院 用于靶向基因疗法的腺相关病毒组合物
CN113166208B (zh) 2018-10-02 2024-11-22 沃雅戈治疗公司 重新定向aav衣壳的嗜性
EP4061947A4 (en) 2019-11-22 2024-04-24 California Institute of Technology METHODS FOR ROBUST CONTROL OF GENE EXPRESSION
CN115279400B (zh) 2020-01-10 2026-04-28 布里格姆妇女医院 用于跨血脑屏障递送免疫治疗剂以治疗脑癌的方法和组合物
TWI900553B (zh) 2020-05-13 2025-10-11 美商航海家醫療公司 Aav蛋白殼之趨性重定向
EP4263575A4 (en) * 2020-12-16 2025-05-07 Children's Medical Research Institute Adeno-associated virus capsids and vectors
CN116917491A (zh) * 2020-12-18 2023-10-20 Ac免疫有限公司 抗体递送
US20250281643A1 (en) * 2021-04-13 2025-09-11 Capsida, Inc. Selected aav compositions having preferred brain enrichment
JP2024513949A (ja) * 2021-04-13 2024-03-27 カプシダ， インコーポレイテッド 脳内発現レベルが高いａａｖ組成物
WO2022221421A2 (en) * 2021-04-13 2022-10-20 Capsida, Inc. Aav compositions with high brain expression for treating mucopolysaccharidosis ii
AU2022266615A1 (en) * 2021-04-27 2023-11-09 The General Hospital Corporation Aav capsids and uses thereof
EP4334332A4 (en) * 2021-05-04 2025-11-12 California Inst Of Techn VAA RECOMMENDANTS FOR ADMINISTRATION TO THE CENTRAL NERVOUS SYSTEM AND CEREBRAL VASCULATURE
US20240325568A1 (en) * 2021-07-20 2024-10-03 The Broad Institute, Inc. Engineered targeting compositions for endothelial cells of the central nervous system vasculature and methods of use thereof
KR20240095539A (ko) 2021-10-08 2024-06-25 디노 테라퓨틱스, 인코포레이티드 캡시드 변이체 및 이의 사용 방법
EP4426716A1 (en) 2021-11-02 2024-09-11 Voyager Therapeutics, Inc. Aav capsid variants and uses thereof
WO2023091934A1 (en) * 2021-11-16 2023-05-25 California Institute Of Technology Adeno-associated virus compositions having preferred heart and skeletal muscle enrichment
US20250297280A2 (en) * 2022-02-01 2025-09-25 The Broad Institute, Inc. Adeno-associated viral vectors and uses thereof
WO2023150632A2 (en) * 2022-02-02 2023-08-10 The Broad Institute, Inc. Targeting moieties promoting transduction of central nervous system cells and tissues and methods of use
EP4532515A1 (en) * 2022-06-02 2025-04-09 Voyager Therapeutics, Inc. Aav capsid variants and uses thereof
KR20240014846A (ko) * 2022-07-26 2024-02-02 숙명여자대학교산학협력단 Aav2-anks1a 재조합 바이러스를 포함하는 알츠하이머 질병 치료용 조성물
WO2024086747A1 (en) 2022-10-19 2024-04-25 Affinia Therapeutics Inc. Recombinant aavs with improved tropism and specificity
WO2024191778A1 (en) 2023-03-10 2024-09-19 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
AU2024332181A1 (en) 2023-08-31 2026-02-12 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
WO2025082176A1 (zh) * 2023-10-19 2025-04-24 北京脑科学与类脑研究所 一种脑血管内皮细胞嵌合型启动子和重组表达载体及应用
WO2025155923A1 (en) * 2024-01-17 2025-07-24 The Broad Institute, Inc. Aav capsid modifications that enable improved cns-wide gene delivery through interactions with the transferrin receptor
TW202545971A (zh) 2024-02-08 2025-12-01 美商戴諾治療公司 殼體多肽及其使用方法
WO2025250454A1 (en) 2024-05-28 2025-12-04 University Of Rochester Adeno-associated viruses evolved to specifically target human glial progenitor cells in vivo
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Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN116693633A (zh) * 2023-02-21 2023-09-05 广州派真生物技术有限公司 腺相关病毒突变体及其应用
CN116693633B (zh) * 2023-02-21 2023-12-22 广州派真生物技术有限公司 腺相关病毒突变体及其应用
CN116983437A (zh) * 2023-07-26 2023-11-03 武汉大学中南医院 一种αOlig2的无损影像标记方法和产物及其用途

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JP2022526018A (ja) 2022-05-20
SG11202111249YA (en) 2021-11-29
AU2020271108A1 (en) 2021-11-11
JP2025106514A (ja) 2025-07-15
EP3953371A4 (en) 2023-04-12
WO2020210655A1 (en) 2020-10-15
US20220220502A1 (en) 2022-07-14
KR20220007056A (ko) 2022-01-18
CA3136658A1 (en) 2020-10-15
EP3953371A1 (en) 2022-02-16

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Application publication date: 20220301