CN1141167A

CN1141167A - Endoscope aerosol and method for preparing same

Info

Publication number: CN1141167A
Application number: CN 95109308
Authority: CN
Inventors: 乔贵宾
Original assignee: Individual
Current assignee: Individual
Priority date: 1995-07-27
Filing date: 1995-07-27
Publication date: 1997-01-29

Abstract

In the medical aerosol prepn. for endoscopy in addition to anesthetic and defoaming agent, it also contains lubricant, drug with the functions of sedative, antispasmodic and inhibiting gastric secretion, solvent, cosolvent, synergistic defoaming agent and propellant, etc.. The invented aerosol prepn. is favourable for smoothly implementing endoscopy, not only is large in effective area, low in dosage, good quick-acting property, and low in side effect, but also easy to use and low in cost.

Description

Endoscope aerosol and preparation method thereof

The invention belongs to the medicinal aerosol technical field.Relate to a kind of endoscope operation medicinal aerosol and preparation method thereof

At present, in medical diagnostic techniqu, use endoscope the inspection of digestive tract, respiratory tract to be become the important tool of such medical diagnosis on disease and treatment.It has not only significantly improved the diagnosis of disease, also can use it and effectively stop blooding, extracts non-operative treatments such as polyp, taking foreign body.When using endoscopic technic and carry out medical diagnosis on disease, not only require the medical worker that consummate endoscopic technic is arranged, but also before will carrying out good art to the patient, postoperative prepares, to alleviate patient's misery.In the domestic and international prior art before the present invention, all give medicine prepare half an hour before art when China generally is expert at splanchnoscopy at present, to alleviate patient's misery, get rid of stress, reduce gastric secretion and gastric peristalsis, expeling gastric foam, only to spray 2% tetracaine usually and carry out throat's anesthesia.Also just before art, give the associating intramuscular injection to nervous, unstrung patient individually and penetrate 0.5 milligram of atropine and stable 5 milligrams.Some big unit also adopted the infusion of dispelling to dispel the gastric foam.Above-mentioned measure effect is unsatisfactory, and increases medical worker's workload, increases patient's fear.And some developed countries abroad at present for carrying out smoothly of guaranteeing to check, avoid bringing unnecessary misery to patient, then manyly apply general anaesthetic before art.Though this way can make patient's no pain, the doctor operates smoothly, and the monitoring problem of general anesthesia, funding problems, side-effect problem etc. all are the reasons that influence is promoted.

At above-mentioned problems of the prior art, the objective of the invention is to: provide that a kind of dosage is few, the effect of paying is little, easy to use, the property of medicine significantly, act on newtype drug, dosage form and preparation method thereof rapidly.

Now the technology of the present invention solution is described below:

For medicine can be played a role most effectively, the present invention has adopted aerosol-type, make the medicine of suction can microgranular liquid big, little at interval by its active area of bottleneck throat, can absorb by the abundant mucosa of blood fortune, alveolar surface, its quick-acting can be compared with injection, but do not need the such strict aseptic manipulation of injection, simultaneously dosage is few, the effect of paying is little, also have easy to use, cheap, be easy to carry, characteristics such as available at any time.In addition, when carrying out splanchnoscopy, because the existence of human body bottleneck throat and digestive tract physiological bending, the taking out of endoscope itself, insert, rotation etc. all can cause mechanical irritation and damage to patient's bottleneck throat mucosa and gastrointestinal tract, even also the bottleneck throat pathological changes can appear, esophagus and gastric perforation, endoscope's incarceration, hemorrhage, complication such as gastric mucosa is torn.Simultaneously, make the patient calm before inspection, loosen, do not feel sick, vomiting, gastric secretion is few, gastrointestinal smooth muscle is light, the foam in the elimination gastrointestinal tract etc. all is the key issue of required consideration and solution.Therefore, have anesthetis, lubricant in the medicine of the present invention, the medicine of dispel infusion and calmness, spasmolytic, inhibition gastric secretion.The present invention adopts lignocaine as topical anesthetic cream; Adopt Sodium Tvlose, nipalgin, silicon dioxide as dispelling infusion; Adopt nitric oxide (laughing gas), benactyzine as calmness, spasmolytic, inhibition stomachial secretion medicine; Adopt dimethicone, SG type to tan soft dose as solvent; Adopt dichlorodifluoromethane as propellant; The employing of glucose is in order to increase mouthfeel.Concrete medicine of the present invention consists of:

Dimethicone, tan soft dose, sodium carboxymethyl cellulose, nipalgin, silicon dioxide, glucose, lignocaine, benactyzine, nitric oxide, ethanol, dichlorodifluoromethane.

Its manufacture method is:

1, sodium carboxymethyl cellulose is made into 5% solution and places a week;

2, get 20 milliliters of these solution, add 4.0 gram dimethicones, 1.28 grams tan 200 milliliters of soft doses, 10% 0.6 milliliter of nipalgin ethanol liquid, silicon dioxide 0.2 gram, glucose 20 grams, distilled water;

3, with this liquid heating to 80 ℃, stirred 5-10 minute, make transparent and uniform solution;

4, Caledonia caine 4 grams in this solution, 20 milligrams of benactyzine;

5, getting more than 10 milliliters liquid packs in the spray bottle;

6, adopt plunging to charge into 8 milliliters of freon gas, charge into 5 milliliters of nitric oxide gas simultaneously.Promptly become aerosol of the present invention after the examination spray.

The present invention's routine clinical verification surplus 100 shows that the dosage form of this medicine and employing has good anesthesia, lubricant effect.Foam in the removing intestinal has good sedative, spasmolysis to the patient effectively.Patient's peace and quiet in the art, no violent nausea and vomiting move, get a clear view with doctor's no-float, scope, and do not have the generation of effect of paying of any poison and endoscopy complication

Aerosol of the present invention is as a kind of safe, efficient, economic, preparation before the endoscopy easily, can not only increase work efficiency, reduce medical worker's workload, alleviate the unnecessary misery of patient, reduce the generation of complication, and can also improve medical diagnosis on disease and treatment level, bring certain economic benefits and huge social benefit.

Claims

1, a kind of medical endoscope art aerosol, have anesthetis, the infusion of dispelling, it is characterized in that: the consisting of of aerosol: two first class silicone oil, tan soft dose, sodium carboxymethyl cellulose, nipalgin, silicon dioxide, glucose, lignocaine, benactyzine, nitric oxide, ethanol, dichlorodifluoromethane.

2, a kind of manufacture method of medical endoscope art aerosol according to claim 1 is characterized in that:

Preparation method is followed successively by:

(1), carboxylic first class cellulose is received is made into 5% solution and places a week;

(2), get 20 milliliters of these solution, add 4.0 gram dimethicones, 1.28 grams tan 200 milliliters of soft doses, 10% 0.6 milliliter of nipalgin ethanol liquid, silicon dioxide 0.2 gram, glucose 20 grams, distilled water;

(3), with this liquid heat to 80 ℃, stirred 5-10 minute, make transparent and uniform solution;

(4), Caledonia caine 4 grams, benactyzine 20 grams in this solution;

(5), getting more than 10 milliliters liquid packs in the spray bottle;

(6), adopt plunging to charge into 8 liters of freon gas, charge into 5 milliliters of nitric oxide gas simultaneously.