CN118236355A - Hydrogel throat plaster for resolving phlegm and detoxifying, and preparation method and application thereof - Google Patents
Hydrogel throat plaster for resolving phlegm and detoxifying, and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a hydrogel throat patch for resolving phlegm and detoxifying, and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine preparations. The hydrogel throat plaster for resolving phlegm and detoxifying, the preparation method and the application thereof are adopted, the traditional Chinese medicine active ingredients are combined with the traditional Chinese medicine menstruation guiding theory, the effect of external treatment of internal diseases is achieved, the application field of combining traditional Chinese medicines with novel dressing is explored, and special consumption demands of consumers are expanded.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a hydrogel throat plaster for resolving phlegm and detoxifying, and a preparation method and application thereof.
Background
Sputum is a metabolite secreted by the respiratory system of the human body, and small amounts of sputum are generally not harmful to the body. However, if sputum secretion is increased due to occurrence of various respiratory tract infections, even if the sputum contains a large amount of microorganisms, the sputum is harmful to the body. In-vivo sputum should be promoted to be discharged out of the body in time through cough and even drug use, otherwise, the sputum can aggravate infection after long-time storage in a respiratory system, and serious lung diseases can be caused.
The traditional Chinese medicine considers that phlegm is caused by dysfunction of lung, and body fluid in the body cannot be normally transported and transformed, so that the phlegm is coagulated. The throat plaster can lead the medicine components to directly reach the focus without being absorbed by the digestive system, and is more direct and effective than the oral effect. Therefore, the development of a throat plaster for resolving phlegm and detoxication is very important, but the special cough-relieving and phlegm-resolving throat plaster sold in the market is not very much, and the existing plaster (such as Xuanfei plaster, tolote plaster and the like) has various defects of greasy skin, difficult cleaning, short action time, inaccurate curative effect and the like.
Therefore, there is a need to develop a hydrogel throat patch for resolving phlegm and removing toxin to solve the above problems.
Disclosure of Invention
In order to solve the technical problems, the invention aims to provide the hydrogel throat plaster for resolving phlegm and detoxifying, and the preparation method and the application thereof, and aims to treat cough with excessive phlegm and qi movement occlusion in an external treatment mode of internal diseases, reduce toxic and side effects of oral administration and injection of medicaments, and has the advantages of mild effect, no irritation to skin, easy acceptance by patients and remarkable curative effect.
In order to achieve the aim, the invention provides a hydrogel throat patch for resolving phlegm and detoxifying, which consists of a hydrogel drug-containing matrix layer and non-woven fabrics;
The hydrogel drug-containing matrix layer is prepared by mixing and crosslinking sodium alginate, polyacrylamide, a catalyst and active ingredients of traditional Chinese medicines; the active ingredients of the traditional Chinese medicine are prepared by mixing monarch drugs, ministerial drugs and extracts of adjuvant drugs; the catalyst component comprises ammonium persulfate and N' N methylene bisacrylamide.
Preferably, the catalyst component is prepared by extracting the following raw materials in parts by weight: 0.01 part of ammonium persulfate and 0.01 part of N' N methylene bisacrylamide;
preferably, the monarch drug component is prepared by extracting the following raw materials in parts by weight: 3 parts of Indian iphigenia bulb, 1 part of moleplant seed and 1-2 parts of euphorbia pekinensis;
the ministerial drug components are prepared by extracting the following raw materials in parts by weight: musk 0.3 parts, realgar 1 part and cinnabar 1 part;
The adjuvant and guiding medicine components are prepared by extracting the following raw materials in parts by weight: and 3 parts of Chinese gall.
Preferably, in the traditional Chinese medicine active ingredients, the weight ratio of monarch drug, ministerial drug and adjuvant drug is 1:1:1.
Preferably, the hydrogel medicine-containing matrix layer comprises 0.05 to 0.1 part of sodium alginate, 1 to 2 parts of acrylamide, 0.01 to 0.03 part of catalyst and 0.01 to 0.1 part of traditional Chinese medicine active ingredient in parts by weight.
The invention also provides a preparation method of the hydrogel throat plaster for resolving phlegm and detoxifying, which comprises the following steps:
S1, selecting monarch drugs, ministerial drugs and adjuvant drugs, and preparing materials;
S2, extracting the effective components of the required traditional Chinese medicine raw materials to obtain the traditional Chinese medicine active components, wherein the means are any one of a percolation method, an immersion method, a reflux method, a decoction method and an ultrasonic extraction method;
S3, preparing 1wt% sodium alginate solution, adding acrylamide in a corresponding proportion, and carrying out crosslinking reaction on the acrylamide, the catalyst and the traditional Chinese medicine active ingredients obtained in the step S2 on the surface of the non-woven fabric for 3-5 minutes to obtain the hydrogel throat plaster.
The invention provides an application of a hydrogel throat patch for resolving phlegm and detoxifying, which is applied to Tiantu acupoint, feng acupoint and Feishu acupoint of throat for once daily replacement.
Preferably, the added traditional Chinese medicine active ingredients comprise the ingredients of the ancient prescription of the traditional Chinese medicine, namely the purple gold ingot.
Preferably, the active ingredients of the traditional Chinese medicine can be added with ginger, peppermint juice, calamus, turpentine and peach root ingredients for matching use.
Therefore, the hydrogel throat plaster for resolving phlegm and detoxifying has the following beneficial effects:
The invention is a Chinese medicine odd prescription, has unique preparation method, fine medicine and reasonable compatibility, and the radix zanthoxyli tablet has the efficacies of clearing away heat and toxic material, and relieving swelling and pain, and is mainly used for treating heatstroke, abdominal distention and pain, nausea and vomiting, diarrhea and infantile phlegm syncope; it is indicated for furuncle, mumps, erysipelas and laryngeal wind. Different versions of the medicine are recorded in the pharmacopoeia of the people's republic of China, and the medicine can be purchased in general pharmacies. The composition comprises Indian iphigenia bulb, musk, euphorbia pekinensis, stephania root cream, chinese gall, realgar and cinnabar, and has the effects of resolving phlegm, inducing resuscitation, removing toxic substances, reducing swelling and relieving pain. The range of the adaptation syndrome is relatively wide, and the pathogenesis of the formula is the feeling of the pathogenic factors of foul and aversion to turbid phlegm, the blockage of gastrointestinal qi movement and abnormal ascending and descending, so that the formula is used as both an abdominal distention, a stuffiness and pain, and an vomiting and diarrhea. The purple gold spindle is a common recipe for treating abdominal distention, fullness and pain, vomiting and diarrhea caused by summer-heat feeling of the body due to foul and turbid phlegm. Modern is often used to treat acute gastroenteritis, food poisoning, diarrhea and the like caused by pathogenic factors such as foul and aversion to turbid phlegm. It can also be used for treating acute suppurative infectious diseases of skin and soft tissue by external application.
The throat plaster reduces the toxic and side effects of oral medicines by a method of externally treating internal diseases such as Tiantu acupoint, feng acupoint and Feishu acupoint of the throat, has no pain, is easy to be accepted by patients and has obvious curative effect. The throat plaster is mainly prepared from common medicines, has simple preparation method, does not need special equipment, is easy to operate and is convenient to popularize.
The technical scheme of the invention is further described in detail through examples.
Detailed Description
The technical scheme of the invention is further described below by examples.
Unless defined otherwise, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs.
Example 1
A hydrogel throat patch for eliminating phlegm and removing toxic substances comprises hydrogel medicated matrix and non-woven fabric.
Composition of hydrogel drug-containing matrix
1. The hydrogel medicine-containing matrix layer is prepared by mixing and crosslinking sodium alginate, acrylamide, a catalyst and active ingredients of traditional Chinese medicines, and comprises the following components:
Sodium alginate, acrylamide and a catalyst, which are formed by crosslinking the following raw materials in parts by weight: sodium alginate: acrylamide: ammonium persulfate: n' N-methylenebisacrylamide=1: 10:0.2:0.1, active ingredients of the traditional Chinese medicine, which are prepared from the following raw materials in parts by weight:
the monarch drug is prepared from the following raw materials in parts by weight: 3 parts of Indian iphigenia bulb, 1 part of spikenard seed and 1-2 parts of euphorbia pekinensis
The ministerial drug is prepared from the following raw materials in parts by weight: musk 0.3 part, realgar 1 part and cinnabar 1 part, which consists of the following raw materials in parts by weight: chinese gall 3 parts
3. The traditional Chinese medicine comprises the following active ingredients in percentage by weight: 5.
(II) preparation method
1) The materials are prepared according to the mass ratio.
2) The required traditional Chinese medicine raw materials are extracted for effective components by means including but not limited to percolation method, dipping method, reflux method, decoction method, ultrasonic extraction method and the like.
Adding acrylamide with the weight ratio of ten times into sodium alginate solution with the weight ratio of 1wt%, and carrying out crosslinking reaction on the acrylamide with the catalyst and the extract obtained in the previous step on the surface of the non-woven fabric for 3-5 minutes.
(III) method of use
The hydrogel throat patch is applied to Tiantu acupoint, feng acupoint and Feishu acupoint of throat three times a day.
Because of the difference of disease condition, age, drug absorption capacity, etc., the treatment course is different, and the treatment can be stopped after the symptoms disappear.
And (3) storage: is placed in a cool and dry place.
(IV) drug efficacy
The functions are as follows: resolving phlegm, inducing resuscitation, removing toxic substances, relieving swelling and pain.
The main indications are: can be used for treating acute gastroenteritis, food poisoning, and dysentery caused by turbid phlegm. It can also be used for treating acute suppurative infectious diseases of skin and soft tissue by external application.
By treatment of patients with different symptoms at different ages:
500 cases of cough due to lung heat: 433 cases are healed, 47 cases are obvious, 17 cases are effective, and 3 cases are ineffective.
300 Cases of acute gastroenteritis: 276 cases are healed and 24 cases are obvious.
Skin wound infection 300 cases: 280 cases of effectiveness and 20 cases of effectiveness.
The hydrogel throat plaster for resolving phlegm and detoxifying has obvious curative effects on abdominal distension and fullness, foul and aversion to turbid phlegm, and the total effective rate is nearly 100%. The external treatment of internal diseases has obvious curative effect, simultaneously reduces other side effects or pains caused by oral administration or injection and the like, generally, 1-3 patches for light patients and 3-5 patches for heavy patients can heal, and the disease is not easy to relapse. Clinical practice proves that the prescription has remarkable effect on a modern multiple disease model.
Example 2
A hydrogel throat patch for eliminating phlegm and removing toxic substances comprises hydrogel medicated matrix and non-woven fabric.
Composition of (one) hydrogel matrix
1. The hydrogel medicine-containing matrix layer is prepared by mixing and crosslinking sodium alginate, acrylamide, a catalyst and active ingredients of traditional Chinese medicines, and comprises the following components:
Sodium alginate, acrylamide and a catalyst, which are formed by crosslinking the following raw materials in parts by weight: 1 part of sodium alginate, 4 parts of acrylamide, 1 part of ammonium persulfate and 11.2 parts of hydrogen peroxide.
The active ingredients of the traditional Chinese medicine are prepared from the following raw materials in parts by weight:
the monarch drug is prepared from the following raw materials in parts by weight: 1 portion of white mulberry root-bark and 1-2 portions of cortex lycii radicis
The ministerial drug is prepared from the following raw materials in parts by weight: 1 part of rhizoma anemarrhenae, 1 part of dried orange peel and 1 part of platycodon grandiflorum.
The adjuvant drug is prepared from the following raw materials by weight portion of 1 portion of liquorice, 1 portion of green tangerine peel, 1 portion of baical skullcap root and 1 portion of stem rice.
The menstruation inducing medicine is prepared from the following raw materials in parts by weight: 1 part of platycodon grandiflorum, 2 parts of cimicifuga foetida, 3 parts of fistular onion stalk and 3 parts of magnolia flower
3. The weight ratio of the medicinal powder to the hydrogel medicine-containing matrix=1:20.
(II) preparation method
1) The materials are prepared according to the mass ratio.
2) The required traditional Chinese medicine raw materials are extracted for effective components by means including but not limited to percolation method, dipping method, reflux method, decoction method, ultrasonic extraction method and the like.
Adding acrylamide with the weight ratio of ten times into sodium alginate solution with the weight ratio of 1wt%, and carrying out crosslinking reaction on the acrylamide with the catalyst and the extract obtained in the previous step on the surface of the non-woven fabric for 3-5 minutes. Ammonium persulfate in the catalyst: hydrogen peroxide = 1:11.2.
(III) method of use
The hydrogel throat patch is applied to Tiantu acupoint, feng acupoint and Feishu acupoint of throat twice a day.
Because of the difference of disease condition, age, drug absorption capacity, etc., the treatment course is different, and the treatment can be stopped after the symptoms disappear.
And (3) storage: is placed in a cool and dry place.
(IV) drug efficacy
The functions are as follows: resolving phlegm, inducing resuscitation, removing toxic substances, relieving swelling and pain.
The main indications are: can be used for treating acute gastroenteritis, food poisoning, and dysentery caused by turbid phlegm. It can also be used for treating acute suppurative infectious diseases of skin and soft tissue by external application.
By treatment of patients with different symptoms at different ages:
500 cases of cough due to lung heat: 458 cases are cured, 22 cases are obvious, 17 cases are effective, and 3 cases are ineffective.
300 Cases of acute gastroenteritis: 289 cases were healed and 11 cases were obvious.
Skin wound infection 300 cases: 290 cases are effective and 10 cases are obvious.
The hydrogel throat plaster for resolving phlegm and detoxifying has obvious curative effects on abdominal distension and fullness, foul and aversion to turbid phlegm, and the total effective rate is nearly 100%. The external treatment of internal diseases has obvious curative effect, simultaneously reduces other side effects or pains caused by oral administration or injection and the like, generally, 1-3 patches for light patients and 3-5 patches for heavy patients can heal, and the disease is not easy to relapse. Clinical practice proves that the prescription has remarkable effect on a modern multiple disease model.
Example 3
A hydrogel throat patch for eliminating phlegm and removing toxic substances comprises hydrogel medicated matrix and non-woven fabric.
Composition of hydrogel drug-containing matrix layer
The hydrogel drug-containing matrix layer is prepared by mixing and crosslinking sodium alginate, acrylamide, a catalyst and active ingredients of traditional Chinese medicines, and comprises the following components: sodium alginate, acrylamide and a catalyst, which are formed by crosslinking the following raw materials in parts by weight: 1 part of sodium alginate, 4 parts of acrylamide, 1 part of ammonium persulfate and 11.2 parts of hydrogen peroxide.
2. The active ingredients of the traditional Chinese medicine are prepared from the following raw materials in parts by weight:
the monarch drug is prepared from the following raw materials in parts by weight: 1 portion of white mulberry root-bark and 1-2 portions of cortex lycii radicis
The ministerial drug is prepared from the following raw materials in parts by weight: 1 part of rhizoma anemarrhenae, 1 part of dried orange peel and 1 part of platycodon grandiflorum.
The adjuvant drug is prepared from the following raw materials by weight portion of 1 portion of liquorice, 1 portion of green tangerine peel, 1 portion of baical skullcap root and 1 portion of stem rice.
The menstruation inducing medicine is prepared from the following raw materials in parts by weight: 1 part of platycodon grandiflorum, 2 parts of cimicifuga foetida, 3 parts of fistular onion stalk and 3 parts of magnolia flower
3. The weight ratio of the medicinal powder to the hydrogel medicine-containing matrix=1:20.
(II) preparation method
1) The materials are prepared according to the mass ratio.
2) The required traditional Chinese medicine raw materials are extracted for effective components by means including but not limited to percolation method, dipping method, reflux method, decoction method, ultrasonic extraction method and the like.
Adding acrylamide with the weight ratio of ten times into sodium alginate solution with the weight ratio of 1wt%, and carrying out crosslinking reaction on the acrylamide with the catalyst and the extract obtained in the previous step on the surface of the non-woven fabric for 3-5 minutes. Wherein ammonium persulfate in the catalyst: hydrogen peroxide = 1:11.2.
(III) method of use
The hydrogel throat patch is applied to SHENQUE acupoint once daily.
Because of the difference of disease condition, age, drug absorption capacity, etc., the treatment course is different, and the treatment can be stopped after the symptoms disappear.
And (3) storage: is placed in a cool and dry place.
(III) method of use
The hydrogel throat patch is applied on Tiantu acupoint, feng acupoint and Feishu acupoint of throat, three patches a day.
Because of the difference of disease condition, age, drug absorption capacity, etc., the treatment course is different, and the treatment can be stopped after the symptoms disappear.
And (3) storage: is placed in a cool and dry place.
(IV) drug efficacy
The functions are as follows: resolving phlegm, inducing resuscitation, removing toxic substances, relieving swelling and pain.
The main indications are: can be used for treating acute gastroenteritis, food poisoning, and dysentery caused by turbid phlegm. It can also be used for treating acute suppurative infectious diseases of skin and soft tissue by external application.
By treatment of patients with different symptoms at different ages:
500 cases of cough due to lung heat: 478 cases were healed, 12 cases were significant, 7 cases were significant, and 3 cases were ineffective.
300 Cases of acute gastroenteritis: the patients recover 297 cases and take 3 obvious effects.
Skin wound infection 300 cases: 294 cases are effective and 6 cases are obvious.
Therefore, the hydrogel throat plaster for resolving phlegm and detoxifying has obvious curative effects on abdominal distension and fullness, foul and aversion to turbid phlegm, and the total effective rate is nearly 100%. The external treatment of internal diseases has obvious curative effect, simultaneously reduces other side effects or pains caused by oral administration or injection and the like, generally, 1-3 patches for light patients and 3-5 patches for heavy patients can heal, and the disease is not easy to relapse. Clinical practice proves that the prescription has remarkable effect on a modern multiple disease model.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention and not for limiting it, and although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that: the technical scheme of the invention can be modified or replaced by the same, and the modified technical scheme cannot deviate from the spirit and scope of the technical scheme of the invention.
Claims (9)
1. The hydrogel throat patch for resolving phlegm and removing toxicity is characterized by comprising a hydrogel drug-containing matrix layer and non-woven fabrics;
the hydrogel drug-containing matrix layer is prepared by mixing and crosslinking sodium alginate, polyacrylamide, a catalyst and active ingredients of traditional Chinese medicines; the active ingredients of the traditional Chinese medicine are prepared by mixing monarch drugs, ministerial drugs and extracts of adjuvant drugs; the catalyst component comprises ammonium persulfate and N' N-methylene bisacrylamide.
2. The hydrogel throat plaster for resolving phlegm and removing toxicity according to claim 1, wherein the catalyst component is prepared by extracting the following raw materials in parts by weight: ammonium persulfate 0.01 parts, N' N methylene bisacrylamide 0.01 parts.
3. The hydrogel throat plaster for resolving phlegm and removing toxicity according to claim 1, wherein the monarch drug components are extracted from the following raw materials in parts by weight: 3 parts of Indian iphigenia bulb, 1 part of moleplant seed and 1-2 parts of euphorbia pekinensis;
the ministerial drug components are prepared by extracting the following raw materials in parts by weight: musk 0.3 parts, realgar 1 part and cinnabar 1 part;
The adjuvant and guiding medicine components are prepared by extracting the following raw materials in parts by weight: and 3 parts of Chinese gall.
4. The hydrogel throat plaster for resolving phlegm and removing toxicity according to claim 3, wherein in the active ingredients of the traditional Chinese medicine, the weight ratio of monarch drug, ministerial drug and adjuvant drug is 1:1:1.
5. The hydrogel throat plaster for resolving phlegm and removing toxicity according to claim 2, wherein the hydrogel drug-containing matrix layer comprises, by weight, 0.05-0.1 part of sodium alginate, 1-2 parts of acrylamide, 0.01-0.03 part of a catalyst and 0.01-0.1 part of a traditional Chinese medicine active ingredient.
6. A method for preparing a hydrogel throat patch for resolving phlegm and removing toxicity according to any one of claims 1 to 5, comprising the steps of:
S1, selecting monarch drugs, ministerial drugs and adjuvant drugs, and preparing materials;
S2, extracting the effective components of the required traditional Chinese medicine raw materials to obtain the traditional Chinese medicine active components, wherein the means are any one of a percolation method, an immersion method, a reflux method, a decoction method and an ultrasonic extraction method;
S3, preparing 1wt% sodium alginate solution, adding acrylamide in a corresponding proportion, and carrying out crosslinking reaction on the acrylamide, the catalyst and the traditional Chinese medicine active ingredients obtained in the step S2 on the surface of the non-woven fabric for 3-5 minutes to obtain the hydrogel throat plaster.
7. Use of a hydrogel throat patch according to any one of claims 1-5 for resolving phlegm, removing toxic substances, detumescence and relieving pain, wherein the hydrogel throat patch is applied to Tiantu acupoint, feng acupoint and Feishu acupoint of throat, and is changed once daily.
8. The use of a hydrogel throat patch for resolving phlegm and removing toxic substances according to claim 6, wherein the added active ingredients of the traditional Chinese medicine comprise the ingredients of the ancient formula of zijinshi.
9. The application of the hydrogel throat plaster for resolving phlegm and removing toxicity according to claim 6, wherein the traditional Chinese medicine active ingredients can be added with ginger, peppermint juice, calamus, turpentine and peach root ingredients for matching.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410332658.6A CN118236355A (en) | 2024-03-22 | 2024-03-22 | Hydrogel throat plaster for resolving phlegm and detoxifying, and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202410332658.6A CN118236355A (en) | 2024-03-22 | 2024-03-22 | Hydrogel throat plaster for resolving phlegm and detoxifying, and preparation method and application thereof |
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