CN114106099B - 蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法 - Google Patents

蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法 Download PDF

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CN114106099B
CN114106099B CN202111432527.8A CN202111432527A CN114106099B CN 114106099 B CN114106099 B CN 114106099B CN 202111432527 A CN202111432527 A CN 202111432527A CN 114106099 B CN114106099 B CN 114106099B
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amino acid
antibody
acid sequence
isolated polypeptide
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CN114106099A (zh
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S.J.穆尔
M.T.L.阮
D.R.霍斯特特
O.瓦西列瓦
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Cytomx Therapeutics Inc
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Cytomx Therapeutics Inc
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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CN202111432527.8A 2014-01-31 2015-01-30 蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法 Active CN114106099B (zh)

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US201461934619P 2014-01-31 2014-01-31
US61/934619 2014-01-31
US201461971009P 2014-03-27 2014-03-27
US61/971009 2014-03-27
PCT/US2015/013776 WO2015116933A2 (en) 2014-01-31 2015-01-30 Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
CN202111432527.8A CN114106099B (zh) 2014-01-31 2015-01-30 蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法
CN201580016781.6A CN106459153B (zh) 2014-01-31 2015-01-30 蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法

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CN202111432527.8A Active CN114106099B (zh) 2014-01-31 2015-01-30 蛋白裂解酶和u型纤溶酶原激活物的底物和其它可裂解部分及其使用方法

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