CN114096238A - 一种阿可拉定的纳米胶束制剂及其制备方法和用途 - Google Patents

一种阿可拉定的纳米胶束制剂及其制备方法和用途 Download PDF

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CN114096238A
CN114096238A CN202080044930.0A CN202080044930A CN114096238A CN 114096238 A CN114096238 A CN 114096238A CN 202080044930 A CN202080044930 A CN 202080044930A CN 114096238 A CN114096238 A CN 114096238A
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preparation
micelle
solution
alcaladine
nano
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汤城
陈小明
姚华
张然然
孟坤
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Beijing Shengnuoji Pharmaceutical Technology Co Ltd
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Beijing Shengnuoji Pharmaceutical Technology Co Ltd
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    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

一种阿可拉定的纳米胶束制剂，该制剂包括阿可拉定和聚合物辅料。还提供了这种纳米胶束制剂的制备方法。制备的阿可拉定的纳米胶束制剂具有生物利用度高的优点。

Description

PCT国内申请，说明书已公开。

Claims (19)

  1. PCT国内申请，权利要求书已公开。
CN202080044930.0A 2019-07-25 2020-07-26 一种阿可拉定的纳米胶束制剂及其制备方法和用途 Pending CN114096238A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019106793090 2019-07-25
CN201910679309 2019-07-25
PCT/CN2020/104704 WO2021013262A1 (zh) 2019-07-25 2020-07-26 一种阿可拉定的纳米胶束制剂及其制备方法和用途

Publications (1)

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CN114096238A true CN114096238A (zh) 2022-02-25

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US (1) US20220249370A1 (zh)
EP (1) EP4005561A4 (zh)
JP (1) JP7386967B2 (zh)
KR (1) KR20220061943A (zh)
CN (1) CN114096238A (zh)
WO (1) WO2021013262A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112294765A (zh) * 2019-07-25 2021-02-02 北京盛诺基医药科技股份有限公司 一种阿可拉定的无定型及其制备方法和用途
CN114748447A (zh) * 2022-03-14 2022-07-15 中国科学院华南植物园 一种淫羊藿素纳米粒及其制备方法和应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115350153A (zh) * 2022-08-12 2022-11-18 青岛科技大学 一种紫檀芪纳米胶束制剂及其肝保护作用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013044734A1 (zh) * 2011-09-28 2013-04-04 中国科学院深圳先进技术研究院 骨靶向脂质体及其制备方法
CN103860542A (zh) * 2014-01-22 2014-06-18 贾晓斌 环淫羊藿苷元在制备抗肿瘤组合物中的应用
CN105476957A (zh) * 2014-12-18 2016-04-13 北京珅奥基医药科技有限公司 一种阿可拉定注射剂及其制备方法和用途
CN108904447A (zh) * 2018-08-15 2018-11-30 烟台大学 一种肝肿瘤靶向载体材料、胶束制剂及其制备方法
CN109464674A (zh) * 2019-01-04 2019-03-15 湖北医药学院 羧基化聚乙二醇单甲醚-淫羊藿苷纳米粒子、制备方法及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003012505A (ja) 2001-07-06 2003-01-15 Nano Career Kk 薬物含有高分子ミセルの凍結乾燥
CA2666587C (en) 2006-10-20 2015-12-22 Solvay Pharmaceuticals B.V. Micellar nanoparticles of chemical substances
CN110721156A (zh) * 2018-06-29 2020-01-24 鲁南制药集团股份有限公司 一种淫羊藿苷元口服胶束制剂的制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013044734A1 (zh) * 2011-09-28 2013-04-04 中国科学院深圳先进技术研究院 骨靶向脂质体及其制备方法
CN103860542A (zh) * 2014-01-22 2014-06-18 贾晓斌 环淫羊藿苷元在制备抗肿瘤组合物中的应用
CN105476957A (zh) * 2014-12-18 2016-04-13 北京珅奥基医药科技有限公司 一种阿可拉定注射剂及其制备方法和用途
CN108904447A (zh) * 2018-08-15 2018-11-30 烟台大学 一种肝肿瘤靶向载体材料、胶束制剂及其制备方法
CN109464674A (zh) * 2019-01-04 2019-03-15 湖北医药学院 羧基化聚乙二醇单甲醚-淫羊藿苷纳米粒子、制备方法及应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHAN SHIBING等: "Preparation of Icaritin-Loaded mPEG-PLA Micelles and Evaluation on Ischemic Brain Injury", 《JOURNAL OF BIOMEDICAL NANOTECHNOLOGY》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112294765A (zh) * 2019-07-25 2021-02-02 北京盛诺基医药科技股份有限公司 一种阿可拉定的无定型及其制备方法和用途
CN114748447A (zh) * 2022-03-14 2022-07-15 中国科学院华南植物园 一种淫羊藿素纳米粒及其制备方法和应用

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JP7386967B2 (ja) 2023-11-27
EP4005561A1 (en) 2022-06-01
EP4005561A4 (en) 2022-12-07
US20220249370A1 (en) 2022-08-11
KR20220061943A (ko) 2022-05-13
JP2022542585A (ja) 2022-10-05
WO2021013262A1 (zh) 2021-01-28

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