CN114062036A - Blood sample distribution method, blood detection device, and computer-readable storage medium - Google Patents
Blood sample distribution method, blood detection device, and computer-readable storage medium Download PDFInfo
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- CN114062036A CN114062036A CN202010761455.0A CN202010761455A CN114062036A CN 114062036 A CN114062036 A CN 114062036A CN 202010761455 A CN202010761455 A CN 202010761455A CN 114062036 A CN114062036 A CN 114062036A
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- 210000004369 blood Anatomy 0.000 title claims abstract description 293
- 239000008280 blood Substances 0.000 title claims abstract description 293
- 238000001514 detection method Methods 0.000 title claims abstract description 214
- 238000000034 method Methods 0.000 title claims abstract description 60
- 238000005070 sampling Methods 0.000 claims abstract description 223
- 238000003018 immunoassay Methods 0.000 claims abstract description 62
- 238000000926 separation method Methods 0.000 claims abstract description 48
- 238000012360 testing method Methods 0.000 claims description 46
- 238000004140 cleaning Methods 0.000 claims description 31
- 239000007788 liquid Substances 0.000 claims description 29
- 238000002156 mixing Methods 0.000 claims description 20
- 230000036039 immunity Effects 0.000 claims description 4
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- 210000004027 cell Anatomy 0.000 description 59
- 210000003743 erythrocyte Anatomy 0.000 description 22
- 239000003085 diluting agent Substances 0.000 description 19
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- 238000006073 displacement reaction Methods 0.000 description 9
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- 238000012864 cross contamination Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 238000009534 blood test Methods 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
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- 230000005540 biological transmission Effects 0.000 description 2
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- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
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- 238000011109 contamination Methods 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1445—Overpressure, pressurisation at sampling point
- G01N2001/1463—Injector; Air-lift
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Abstract
The application relates to the technical field of medical treatment, and discloses a blood sample distribution method, a blood detection device and a computer readable storage medium. The blood sample distribution method comprises the following steps: controlling a sampling needle to suck a blood sample to be detected; controlling the sampling to perform blood separation operation aiming at the WBC detection pool; and controlling the sampling to perform blood separation operation aiming at the rest detection pools, wherein the rest detection pools at least comprise an immunoassay detection pool. Through the mode, the accuracy of blood sample detection can be improved.
Description
Technical Field
The present application relates to the field of medical technology, and in particular, to a blood sample distribution method, a blood testing device, and a computer-readable storage medium.
Background
In order to increase the speed of the current blood detection device, blood is firstly separated from an immunoassay pool and then the blood is moved to a blood routine detection pool, so that when a user selects or does not select an immunoassay channel or the number of the selected immunoassay channels is variable, the volume of a blood sample to be sucked is uncertain, and the position of the blood sample to be separated to the blood routine is also uncertain.
The method has the disadvantages that on one hand, the quantity of the blood sample detection items is uncertain, so that the volume of the blood sample sucked by the sampling needle is also uncertain, and therefore, the volume of the blood sample which is divided into the conventional blood detection pool each time has larger deviation, and the accuracy of the blood sample detection is influenced; on the other hand, the number of the immunoassay cells used for detection also affects the time for the blood sample to stay in the sampling needle, the more the number of the immunoassay cells used for detection is, the longer the time for the blood sample to stay in the sampling needle is, and when the blood sample is separated into the conventional blood detection cells, the number of blood cells contained in the blood sample is less, which affects the accuracy of the blood sample detection.
Disclosure of Invention
The technical problem that this application mainly solved is to provide blood sample distribution method, blood detection device and computer readable storage medium, can improve the accuracy that blood sample detected.
One technical solution adopted in the present application is to provide a blood sample distribution method, including: controlling a sampling needle to suck a blood sample to be detected; controlling the sampling to perform blood separation operation aiming at the WBC detection pool; and controlling the sampling to perform blood separation operation aiming at the rest detection pools, wherein the rest detection pools at least comprise an immunoassay detection pool.
Wherein, control sampling is to remaining detection pond branch blood operation, includes: performing blood separation operation on at least one immunoassay pool according to a preset sequence; carrying out blood separation operation on the DIFF detection pool; and carrying out blood separation operation on the RBC detection pool.
Wherein, the method also comprises: and during the blood sample distribution process of the at least one immunoassay testing pool, the liquid in the WBC testing pool is mixed evenly.
Wherein, in the process of blood sample distribution to at least one immunoassay pond, the liquid in the WBC detection pond is mixed uniformly, and the operation comprises the following steps: during the blood sample distribution process of each immunoassay cell, the liquid in the WBC detection cell is mixed uniformly.
Wherein, divide the blood operation to at least one immunodetection pond according to preset order, include: controlling the sampling needle and the swab component to move to the target immunodetection pool; controlling the sampling needle to perform blood throwing operation in the swab component; controlling the sampling needle to move downwards, and distributing a blood sample to be detected with a preset volume to a target immunoassay pool; and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the process of moving upwards.
Wherein, divide blood operation to DIFF detection pool, include: controlling the sampling needle and the swab component to move to the DIFF detection pool; controlling the sampling needle to perform blood throwing operation in the swab component; controlling the sampling needle to move downwards, and distributing a blood sample to be detected with a preset volume to a DIFF detection pool; and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the process of moving upwards.
Wherein, before the blood separation operation of the RBC detection pool, the method comprises the following steps: controlling movement of the sampling needle and swab assembly to the WBC detection cell; controlling the sampling needle to throw blood in the swab component and cleaning the inner wall of the sampling needle; controlling the sampling needle to move downwards into the WBC detection pool, and sucking part of liquid from the WBC detection pool; and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the process of moving upwards.
Wherein, the blood separation operation is carried out on the RBC detection pool, and comprises the following steps: controlling the sampling needle and the swab assembly to move to the RBC detection pool; controlling the sampling needle to perform blood throwing operation in the swab component; controlling the sampling needle to move downwards, and distributing part of liquid in the sampling needle to an RBC detection pool; and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the process of moving upwards.
Another technical solution adopted by the present application is to provide a blood test device, which includes a processor and a memory connected to the processor; the memory is used for storing program data and the processor is used for executing the program data so as to realize the method provided by the technical scheme.
Another technical solution adopted by the present application is to provide a computer-readable storage medium for storing program data, which when executed by a processor, is used for implementing the method provided in the above technical solution.
The beneficial effect of this application is: in contrast to the prior art, a method of distributing a blood sample of the present application comprises: controlling a sampling needle to suck a blood sample to be detected; controlling the sampling to perform blood separation operation aiming at the WBC detection pool; and controlling the sampling to perform blood separation operation aiming at the rest detection pools, wherein the rest detection pools at least comprise an immunoassay detection pool. In this way, for prior art, on the one hand owing to preferentially divide the blood operation to WBC detection pond, the volume of waiting to detect the blood sample of distribution to WBC detection pond has been confirmed, and reduce the stay time of waiting to detect the blood sample in the sampling needle of distribution to WBC detection pond, improve the blood cell settlement problem that waits to detect in the blood sample in the sampling needle, can guarantee to distribute to the number of waiting to detect the blood cell in the blood sample of WBC detection pond, improve the accuracy that the blood sample detected, on the other hand can realize going on jointly of a plurality of detection projects, promote detection efficiency.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts. Wherein:
FIG. 1 is a schematic structural diagram of an embodiment of a blood testing device provided herein;
FIG. 2 is a schematic flow chart diagram of a first embodiment of a blood sample distribution method provided herein;
FIG. 3 is a schematic flow chart of an application scenario of the blood sample distribution method provided herein;
FIG. 4 is a schematic flow chart diagram of a second embodiment of a blood sample distribution method provided herein;
FIG. 5 is a detailed flow chart of step 408 of FIG. 4 provided herein;
FIG. 6 is a detailed flow chart of step 409 in FIG. 4 provided herein;
FIG. 7 is a detailed flow chart of step 410 of FIG. 4 provided herein;
FIG. 8 is a schematic view of a sampling needle provided herein after aspiration;
FIG. 9 is a schematic view of another embodiment of the sampling needle provided herein after aspiration;
FIG. 10 is a schematic structural view of another embodiment of a blood testing device provided herein;
FIG. 11 is a schematic structural diagram of an embodiment of a computer-readable storage medium provided in the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the specific embodiments described herein are merely illustrative of the application and are not limiting of the application. It should be further noted that, for the convenience of description, only some of the structures related to the present application are shown in the drawings, not all of the structures. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a blood testing device provided in the present application. The blood test device 10 comprises a sample sucking component 11, a blood routine test pool 12, an immunity test pool 13, a cleaning component 14 and a transmission component 15.
The blood routine detecting pool 12 at least includes a White Blood Cell (WBC) detecting pool, a Red Blood Cell (RBC) detecting pool, and a differential flow (DIFF) detecting pool.
The immunoassay pool 14 includes at least one immunoassay pool, and as shown in fig. 1, the immunoassay pool 14 includes n immunoassay pools, where n > 2. Each immunoassay pool is used for the detection of a different immune function.
Wherein the sample aspirating assembly 11 is used for collecting and dispensing blood samples. The sample sucking assembly 11 comprises a sampling needle, a small-displacement syringe for sucking a blood sample, a swab assembly for cleaning the sampling needle, a large-displacement syringe for providing diluent for cleaning, a negative pressure assembly for pumping waste liquid in the sampling needle and the swab assembly, and a reversing valve and a pipeline joint for connecting the sampling needle, the small-displacement syringe for sucking the blood sample, the swab assembly for cleaning the sampling needle and the swab assembly.
The sampling needle is moved to a designated detection pool through the transmission assembly 15, and then blood is accurately separated to the designated detection pool, such as the blood routine detection pool 12 and the immunity detection pool 13, through the small-displacement syringe in the sample suction assembly 11.
Wherein, wash subassembly 14 is used for the washing to the measuring cell after blood sample signal acquisition is accomplished, and adds the base solution to make the measuring cell keep ready state, wash the pipeline of being connected with the measuring cell, then wash subassembly 16 and revert to initial condition, do not influence going on of next blood sample.
In some embodiments, the workflow of the blood testing device is: controlling a sampling needle in the sample sucking component 11 to suck a blood sample to be detected with a preset volume, and then carrying out blood separation operation on the conventional blood detection pool 12 and the immunoassay detection pool 13 according to a preset sequence, wherein the conventional blood detection pool and the immunoassay detection pool detect the blood sample to obtain a corresponding detection result.
In some embodiments, the blood conventional test cell 12 in the blood testing device 10 may not include a DIFF test cell.
Referring to fig. 2, fig. 2 is a schematic flow chart of a first embodiment of a blood sample distribution method provided in the present application. The method comprises the following steps:
step 21: controlling the sampling needle to suck a blood sample to be detected.
In some embodiments, the blood testing device includes a sample aspirating assembly for aspirating a blood sample to be tested. The sample sucking component comprises a sampling needle and a syringe A. Wherein, the syringe A is connected with the sampling needle through a pipeline. When a blood sample to be detected is sucked, the sampling needle is controlled to move downwards to enter the blood sample container and enter the blood sample, and the syringe A works to control the sampling needle to suck the blood sample to be detected.
It will be appreciated that the volume of each blood sample drawn is determined according to the requirements of each.
In some embodiments, the volume of blood sample drawn at a time may be set to a fixed volume that satisfies the blood sample requirements of all test items in the blood testing device.
Step 22: the control sampling is performed for blood separation operation of the WBC detection pool.
In some embodiments, step 22 may be to control the movement of the sampling needle over the WBC detection cell and then to inject a second volume of the blood sample to be tested into the WBC detection cell.
In some embodiments, the sampling needle is controlled to expel the first volume of blood sample to be tested and clean the outer wall of the sampling needle during movement of the sampling needle to the WBC detection cell. And after the sampling needle moves to the WBC detection pool, controlling the sampling needle to inject a second volume of blood sample to be detected into the WBC detection pool.
Step 23: and controlling the sampling to perform blood separation operation aiming at the rest detection pools, wherein the rest detection pools at least comprise an immunoassay detection pool.
In some embodiments, the remaining detection pools are determined according to the requirement of the current detection. If the detection requirement is WBC detection, multiple item immunity detection and RBC detection. After the blood separation operation is carried out on the WBC detection pool, the blood separation operation is carried out on a plurality of immunodetection pools corresponding to the plurality of immunodetections, and after the blood separation operation is carried out on the plurality of immunodetection pools, the blood separation operation is carried out on the RBC detection pool.
In some embodiments, the WBC detection cells are blended during a control sampling to bleed the remaining detection cells.
In an application scenario, reference is made to fig. 3:
firstly, cleaning a sampling needle, and controlling the sampling needle to suck a sample so as to suck a blood sample to be detected with a preset volume. Then the sampling needle is controlled to move to the WBC detection pool, the blood throwing operation is carried out so as to control the sampling needle to throw away the blood sample to be detected with the first volume, then the blood separating operation is carried out on the WBC detection pool, and the blood sample to be detected with the second volume is distributed. The method comprises the steps of controlling a sampling needle to move to a first immunoassay pool, carrying out blood throwing operation to control the sampling needle to throw away a blood sample to be detected with a first volume, then carrying out blood dividing operation on the first immunoassay pool, distributing the blood sample to be detected with a third volume, and carrying out uniform mixing operation after the blood dividing operation is finished so that the blood sample to be detected with the third volume is uniformly distributed in the first immunoassay pool. At this time, the first immunoassay cell may perform subsequent blood sample sampling, channel detection and data collection, and channel cleaning. After the first immunodetection pool is used for distributing and mixing blood, the sampling needle is controlled to move to the nth immunodetection pool, the blood throwing operation is carried out, the sampling needle is controlled to throw away the blood sample to be detected with the first volume, the blood distributing operation is carried out on the nth immunodetection pool, the blood sample to be detected with the fourth volume is distributed, and the mixing operation is carried out after the blood distributing operation is finished, so that the blood sample to be detected with the fourth volume is uniformly distributed in the nth immunodetection pool. At this time, the nth immunodetection cell can perform subsequent works such as blood sample sampling, channel detection and data acquisition, channel cleaning and the like. After the nth immunodetection pool is used for blood distribution and uniform mixing, the sampling needle is controlled to move to the DIFF detection pool, blood throwing operation is carried out, the sampling needle is controlled to throw away the blood sample to be detected with the first volume, blood distribution operation is carried out on the DIFF detection pool, the blood sample to be detected with the fifth volume is distributed, and uniform mixing operation is carried out after blood distribution is completed, so that the blood sample to be detected with the fifth volume is uniformly distributed in the DIFF detection pool. At the moment, the DIFF detection pool can perform work such as subsequent blood sample sampling, channel detection and data acquisition, channel cleaning and the like. After the DIFF detection pool is used for separating blood and mixing uniformly, the sampling needle is controlled to move to the WBC detection pool, the inner wall and the outer wall of the sampling needle are cleaned in the moving process, and after the cleaning is finished, the sampling needle is controlled to suck liquid with a preset volume from the WBC detection pool. And then controlling the sampling needle to move to the RBC detection pool, and distributing the liquid with the preset volume to the RBC detection pool. After the sampling needle sucks liquid with a preset volume from the WBC detection pool, the reagent is added into the WBC detection pool and is uniformly mixed, and then the WBC can carry out channel detection, channel cleaning and other work. After the sampling needle is controlled to distribute liquid with a preset volume to the RBC detection pool, the liquid in the RBC detection pool is uniformly mixed, and then channel detection is carried out to carry out channel cleaning and other work after the detection is finished.
It can be understood that when the sampling needle performs blood separation in the immunoassay detection cell and/or the DIFF detection cell, the air bubble blending operation is performed on the WBC detection cell at the same time to avoid blood cell sedimentation in the blood sample to be detected in the WBC detection cell.
In some embodiments, the blood testing apparatus is not provided with the DIFF test cell, so that when blood is separated, blood separation of the DIFF test cell is not needed.
In the embodiment, compared with the prior art, the blood sample to be detected is sucked by controlling the sampling needle; controlling the sampling to perform blood separation operation aiming at the WBC detection pool; and controlling the sampling to perform blood separation operation aiming at the rest detection pools, wherein the rest detection pools at least comprise an immunoassay detection pool. On the one hand, the blood separation operation is preferentially carried out on the WBC detection pool, the volume of the blood sample to be detected distributed to the WBC detection pool is determined, the retention time of the blood sample to be detected distributed to the WBC detection pool in the sampling needle is shortened, the problem of blood cell sedimentation in the blood sample to be detected in the sampling needle is solved, the number of blood cells in the blood sample to be detected distributed to the WBC detection pool can be guaranteed, the accuracy of blood sample detection is improved, on the other hand, the common operation of a plurality of detection projects can be realized, and the detection efficiency is improved.
Referring to fig. 4, fig. 4 is a schematic flow chart of a second embodiment of a blood sample distribution method provided by the present application. The method comprises the following steps:
step 401: controlling movement of the sampling needle and swab assembly to the blood sample container.
In some embodiments, the sampling needle is disposed within the swab assembly. The swab assembly includes a first exit aperture and a second exit aperture. The first outlet hole is connected with the negative pressure assembly and is used for pumping out liquid in the swab assembly through the first outlet hole under the action of the negative pressure assembly. The second is bored and is connected with the abluent big discharge syringe of dilution that provides, and when the sampling needle needs to wash, the big discharge syringe is gone into the swab subassembly through the second and is bored a hole with the dilution to wash the completion back, the dilution is taken out through first hole to the negative pressure subassembly.
Step 402: and controlling the sampling needle to move downwards, and sucking a set volume of blood sample to be detected.
Step 403: the sampling needle is controlled to move upwards, and the outer wall of the sampling needle is cleaned by the swab component during the movement.
It can be understood that when the sampling needle sucks a set volume of blood sample to be detected, the outer wall of the sampling needle is in contact with the blood sample to be detected, a part of the blood sample to be detected is attached, and the part of the blood sample to be detected is in contact with air and is polluted. The outer wall of the sampling needle is cleaned by injecting diluent into the swab assembly using a high-volume syringe.
Step 404: and controlling the sampling needle to move to the WBC detection pool.
Step 405: a first volume of blood sample to be tested is dispensed to the WBC test cell.
Step 406: the liquid in the WBC detection cell is drained.
It can be understood that the sampling needle gathers and waits to detect the blood sample in the blood sample container, the sealing layer that punctures the blood sample container under with move up easily adsorb the piece when moving out the blood sample container, through wait to detect the blood sample at first washing sampling needle outer wall and the first volume of distribution in WBC detection pond, can discharge most piece together with the liquid in WBC detection pond here, avoid the influence of piece to blood detection device, can reduce blood detection device's fault rate, and promote blood detection device's detection accuracy.
In some embodiments, steps 405 and 406 may be dispensing a first volume of blood sample to be tested in a swab assembly, and controlling the negative pressure assembly to draw the first volume of blood sample to be tested.
Step 407: a second volume of blood sample to be tested is dispensed to the WBC test cell.
It will be appreciated that the second volume of blood sample to be tested can be used as a blood sample for subsequent testing.
In some embodiments, after the second volume of blood sample to be tested is dispensed into the WBC test cell, the remaining components may be controlled to inject a base reagent into the WBC test cell to mix the second volume of blood sample to be tested.
Step 408: and carrying out blood separation operation on at least one immunoassay pool according to a preset sequence.
In some embodiments, an immunization item to be detected is obtained, a corresponding immunization detection pool is obtained according to the immunization item, and then blood separation operation is performed on the immunization detection pool corresponding to the immunization item according to a preset sequence of the immunization item. The immunization program needed to be detected is A, B, C. The immune item A corresponds to an immune detection pool A, the immune item B corresponds to an immune detection pool B, and the immune item C corresponds to an immune detection pool C. And acquiring the priority of the immunization items, sequencing according to the priority, and carrying out blood separation operation on the immunization items with high priority.
In some embodiments, the fluid in the WBC test cells is homogenized during the dispensing of the blood sample to the at least one immunoassay test cell. Specifically, during the process of blood sample distribution to each immunoassay cell, a mixing operation may be performed on the fluid in the WBC detection cells to avoid the sedimentation of blood cells in the WBC detection cells.
In some embodiments, the blending of the fluid in the WBC test cell during the dispensing of the blood sample to the at least one immunoassay test cell may be performed by blending the fluid in the WBC test cell at predetermined time intervals. Such as preset time intervals of 2 seconds, 3 seconds, 5 seconds, and 10 seconds. It will be appreciated that in practical situations, the preset time interval is set according to requirements.
In some embodiments, prior to step 408, the outer wall of the sampling needle is cleaned within the swab assembly.
In some embodiments, the specific steps of step 408 may be:
step 4081: and controlling the sampling needle and the swab component to move to the target immunoassay detection pool.
Step 4082: the sampling needle is controlled to perform a blood-throwing operation in the swab assembly.
It will be appreciated that the sampling needle is controlled to perform a blood-throwing operation in the swab assembly and the negative pressure assembly is used to draw away the portion of the blood sample to be tested, avoiding cross-contamination between channels.
Step 4083: and controlling the sampling needle to move downwards, and distributing the blood sample to be detected with the preset volume to the target immunoassay pool.
In some embodiments, the sampling needle is controlled to move downward into the target immunoassay reservoir, and a predetermined volume of the blood sample to be detected is dispensed into the target immunoassay reservoir.
Step 4084: and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the process of moving upwards.
In some embodiments, the sampling needle is controlled to move upwards, and during the upward movement, the large-displacement syringe is controlled to inject diluent into the swab assembly so as to clean the outer wall of the sampling needle, and the diluent after the cleaning is pumped away by the negative pressure assembly.
In some embodiments, after the completion of step 4084, the sampling needle and swab assembly is controlled to move to the next target immunoassay pool, and the steps 4082 and 4084 are performed; until all the required immunoassay wells are used to complete the blood separation operation.
Step 409: and carrying out blood separation operation on the DIFF detection pool.
In some embodiments, the specific steps of step 409 may be:
step 4091: and controlling the sampling needle and the swab component to move to the DIFF detection pool.
Step 4092: the sampling needle is controlled to perform a blood-throwing operation in the swab assembly.
It will be appreciated that the sampling needle is controlled to perform a blood-throwing operation in the swab assembly and the negative pressure assembly is used to draw away the portion of the blood sample to be tested, avoiding cross-contamination between channels.
Step 4093: and controlling the sampling needle to move downwards, and distributing the blood sample to be detected with the preset volume to the DIFF detection pool.
In some embodiments, the sampling needle is controlled to move down into the target immunoassay reservoir and a predetermined volume of blood sample to be tested is dispensed into the DIFF assay reservoir.
Step 4094: and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the process of moving upwards.
In some embodiments, the sampling needle is controlled to move upwards, and during the upward movement, the large-displacement syringe is controlled to inject diluent into the swab assembly so as to clean the outer wall of the sampling needle, and the diluent after the cleaning is pumped away by the negative pressure assembly.
In some embodiments, the blood testing apparatus does not have a DIFF test cell, so that the step 409 is not required to be performed when the blood is separated, and the step 410 can be directly performed.
Step 410: and carrying out blood separation operation on the RBC detection pool.
In some embodiments, step 410 is preceded by the steps of:
step A: the sampling needle and swab assembly is controlled to move to the WBC detection cell.
After the blood separation operation of the DIFF detection pool is completed, the sampling needle and the swab assembly are controlled to move to the WBC detection pool.
And B: controlling the sampling needle to perform blood throwing operation in the swab component, and cleaning the inner wall of the sampling needle.
It can be understood that after the sampling needle divides the blood to the DIFF detection pool, the blood sample need not be used to wait to detect in the surplus of sampling needle, then through utilizing the big discharge syringe to the inside injection diluent of sampling needle to make the inside surplus of sampling needle wait to detect that the blood sample is whole to be pushed out to the swab subassembly, and utilize the diluent to wash the sampling needle inner wall, then utilize negative pressure assembly to wait to detect the surplus and take away blood sample and diluent, retrieve to the waste liquid bucket.
And C: and controlling the sampling needle to move downwards into the WBC detection pool, and sucking part of liquid from the WBC detection pool.
It will be appreciated that the WBC test cell now includes a mixing fluid therein that mixes the second volume of the blood sample to be tested.
Step D: and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the process of moving upwards.
In some embodiments, the sampling needle is controlled to move upwards, and during the upward movement, the large-displacement syringe is controlled to inject diluent into the swab assembly so as to clean the outer wall of the sampling needle, and the diluent after the cleaning is pumped away by the negative pressure assembly.
In some embodiments, the specific steps of step 410 may be:
step 4101: controlling the movement of the sampling needle and swab assembly to the RBC detection cell.
In some embodiments, after the sampling needle aspirates a portion of the liquid from the WBC detection cell, the sampling needle and swab assembly is controlled to move to the RBC detection cell.
Step 4102: the sampling needle is controlled to perform a blood-throwing operation in the swab assembly.
In some embodiments, the blood discard at this point operates to discard a portion of the volume of the portion of the fluid drawn from the WBC detection cell, avoiding channel contamination.
Step 4103: and controlling the sampling needle to move downwards, and distributing part of liquid in the sampling needle to the RBC detection pool.
It will be appreciated that the sample needle at this point is the portion of fluid drawn from the WBC detection cell, the sample needle is controlled to move downward, and the portion of fluid in the sample needle is dispensed to the RBC detection cell.
Step 4104: and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component in the process of moving upwards.
In some embodiments, the sampling needle is controlled to move upwards, and during the upward movement, the large-displacement syringe is controlled to inject diluent into the swab assembly so as to clean the outer wall of the sampling needle, and the diluent after the cleaning is pumped away by the negative pressure assembly.
After completion of step 4104, the sampling needle is cleaned and controlled to move to the initial position for the next blood sample to be drawn.
In an application scenario, the following is explained with reference to fig. 8:
controlling the sampling needle and the swab component to move to the sample sucking position, and sucking the volume of the blood sample to be detected required by the counting by the high-precision small-displacement syringe according to the time sequence requirement, and distributing the blood sample to be detected into b1, b2, a1, a2, an, delta a, b3, b4, b5 and the like according to the volume as shown in fig. 8.
After the appearance of inhaling, lifting on the sampling needle, getting back to the initial position of vertical position, simultaneously, lifting the in-process on the sampling needle, big discharge syringe and valve module begin work, provide the diluent, wash the sampling needle outer wall in the swab subassembly to the negative pressure subassembly is also opened simultaneously, in time takes away the diluent of washing use in the swab subassembly, guarantees that the sampling needle outer wall is clean.
The sample needle and swab assembly is then controlled to travel to the WBC detection cell, the head blood b1 portion of the sample needle is first spit out of the WBC detection cell and is allowed to drain with the body fluid in the WBC detection cell, and the sample needle is then controlled to dispense a b2 volume of the blood sample to be tested to the WBC detection cell. The blood is firstly divided into the WBC detection pool, so that the positions of blood samples to be detected which are divided into the WBC detection pool each time in the sampling needle can be ensured to be the same no matter what number of selected detection items is, the blood division consistency can be ensured, and the repeatability and the stability of a measurement result can be improved; meanwhile, debris is easy to exist when the sampling needle is used for puncturing, most of the debris can be discharged together with the base solution of the WBC detection pool through cleaning the head part of the sampling needle and spitting head blood in the WBC detection pool, and the failure rate of the instrument can be greatly reduced.
After the WBC detection cell is finished, the control sampling needle and swab assembly is moved to the immunodetection cell x 1. When the sampling needle runs to the position vertically above the immunoassay detection pool x1, the sampling needle firstly spits a blood sample to be detected with the volume delta a in the swab component, and the blood sample is pumped away by the negative pressure component, so that the cross contamination of the detection channel is avoided. And then the sampling needle is controlled to move downwards into an immunodetection pool x1, a blood sample to be detected with the volume of a 1-delta a is distributed to an immunodetection pool x1, the blood sample to be detected is mixed with an immunoreagent through a mixing pipeline of the immunodetection pool x1, and the blood separating action of an immunodetection pool x1 channel is completed.
After the immunoassay pool x1 is completed, the sampling needle and the swab assembly are controlled to move to the immunoassay pool x 2. When the sampling needle runs to the position vertically above the immunoassay detection pool x2, the sampling needle firstly spits a blood sample to be detected with the volume delta a in the swab component, and the blood sample is pumped away by the negative pressure component, so that the cross contamination of the detection channel is avoided. And then the sampling needle is controlled to move downwards into an immunodetection pool x2, a blood sample to be detected with the volume of a 2-delta a is distributed to an immunodetection pool x2, the blood sample to be detected is mixed with an immunoreagent through a mixing pipeline of the immunodetection pool x2, and the blood separating action of an immunodetection pool x2 channel is completed.
After the immunoassay pool x2 is completed, the sampling needle and the swab assembly are controlled to move to the immunoassay pool x 3. When the sampling needle runs to the position vertically above the immunoassay detection pool x3, the sampling needle firstly spits a blood sample to be detected with the volume delta a in the swab component, and the blood sample is pumped away by the negative pressure component, so that the cross contamination of the detection channel is avoided. And then the sampling needle is controlled to move downwards into an immunodetection pool x3, a blood sample to be detected with the volume of a 3-delta a is distributed to an immunodetection pool x3, the blood sample to be detected is mixed with an immunoreagent through a mixing pipeline of the immunodetection pool x3, and the blood separating action of an immunodetection pool x3 channel is completed.
And controlling the sampling needle and the swab component to move to the immunoassay pool xn according to the steps. When the sampling needle runs to the position vertically above the immunoassay pool xn, a blood sample to be detected with the volume of delta a is firstly spitted out by the sampling needle in the swab component and is pumped away by the negative pressure component, so that the cross contamination of a detection channel is avoided. And then controlling the sampling needle to move downwards into the immunoassay pool xn, distributing the blood sample to be detected with the volume of an-delta a to the immunoassay pool xn, blending the blood sample to be detected into an immunoassay reagent through a blending pipeline of the immunoassay pool xn, and completing the blood separation action of the channel xn of the immunoassay pool. And the immune channel is divided into blood.
Because this application divides blood WBC to detect the pond earlier, then divide blood immunodetection pond, so divide blood to accomplish from WBC to begin to detect and need wait for comparatively long time to the time length is relevant with the immunodetection pond quantity of selection, for avoiding the subsidence of blood cell in the WBC detection pond, guarantee that follow-up secondary draws the appearance even, when dividing blood immunodetection pond at every turn, carry out the bubble mixing operation in the WBC detection pond.
And after the blood separation of the immunoassay pool xn is finished, controlling the sampling needle and the swab component to move to the DIFF detection pool. When the sampling needle runs vertically above the DIFF detection pool, a blood sample to be detected with the volume of b3 is firstly spit off by the sampling needle in the swab component and is drawn away by the negative pressure component, so that the cross contamination of the channel is avoided. And then controlling the sampling needle to move downwards to the interior of the DIFF detection pool, and distributing the b4 volume of the blood sample to be detected to the DIFF detection pool, wherein the blood separation of the DIFF detection pool is completed.
After the DIFF detection pool is used for blood separation, the sampling needle and the swab assembly are controlled to move to the WBC detection pool. During the movement, the sampling needle is raised while diluent is added to the swab assembly via the high-volume syringe to clean the outer wall of the sampling needle. When the needle point of the sampling needle reaches the interior of the swab component, diluent is injected into the sampling needle by using a large-discharge syringe as power, and the blood sample to be detected with the volume b5 left in the sampling needle is completely pushed out and the inner wall of the sampling needle is cleaned. And the negative pressure component is utilized to recover the waste liquid into the waste liquid barrel. After the sampling needle moves to the WBC detection pool, a certain amount of uniformly mixed partial liquid in the WBC detection pool is sucked as blood sample liquid of the RBC detection pool by taking a diluent injector as power.
And controlling the sampling needle and the swab assembly to move to the RBC pool, injecting the sucked part of liquid into the sampling needle by using a large-discharge syringe as a power source, and distributing the part of liquid and the part of diluent to the RBC detection pool so as to finish blood separation and sample addition of the RBC detection pool. Finally, the sampling needle and the swab component are controlled to return to the initial position.
In some embodiments, the blood sample dispensed to the WBC test cell is determined inside the sampling needle, and the blood sample in the remaining locations can be dispensed to the remaining test cells at fixed positions. The immunoassay pool with long detection time or more urgent need can be preferentially arranged for distributing blood samples, the sequence of distributing the blood samples is flexibly arranged, and the whole detection process is accelerated.
As shown in fig. 9, the sampling needle 91 of the blood test apparatus is connected to the pipeline 92, and then the sampling needle 91 is controlled to draw a blood sample, and the corresponding volume of the blood sample is stored in the sampling needle 91 and the pipeline 92. As shown in fig. 9, the sampling needle 91 is divided into a section a, a section B, a section C, and a section D; the blood sample in the section D is used as head blood, and the blood sample in the section A is used for detection items with high priority, such as immunization items and classification items; the blood sample in section B is used for routine blood testing, such as WBC testing. The blood sample in section C and line 92 is used for the remaining test items.
Through the mode, can arrange the distribution blood sample to the test cell of the test item that test time is long or more urgent need by priority, arrange the order of distribution blood sample in a flexible way, improve the detection efficiency of whole detection procedure, and the position of the blood sample of distribution to the conventional test cell of blood is fixed in inside the sampling needle, reduce the stay time of the blood sample of waiting to detect of distribution to the conventional test cell of blood in the sampling needle inside, improve the blood cell settlement problem of waiting to detect in the sampling needle, can guarantee to distribute to the conventional test cell of blood (like WBC test cell) wait to detect the quantity of the blood cell in the blood sample, improve the accuracy that the blood sample detected.
In this embodiment, through the mode mentioned above, on the one hand owing to preferentially divide the blood operation to the WBC detection pond, the volume of waiting to detect the blood sample of allowwing to the WBC detection pond has been confirmed, and reduce the stay time of waiting to detect the blood sample of allowwing to the WBC detection pond in the sampling needle inside, improve the blood cell settlement problem of waiting to detect the blood sample in the sampling needle, can guarantee to allocate to the number of waiting to detect the blood cell in the blood sample of WBC detection pond, improve the accuracy that the blood sample detected, on the other hand can realize going on jointly of a plurality of detection projects, promote detection efficiency.
Referring to fig. 10, fig. 10 is a schematic structural diagram of another embodiment of the blood testing device provided in the present application. The blood test apparatus 100 includes a processor 101 and a memory 102 connected to the processor 101; the memory 102 is used for storing program data and the processor 101 is used for executing the program data to realize the following method steps:
controlling a sampling needle to suck a blood sample to be detected; controlling the sampling to perform blood separation operation aiming at the WBC detection pool; and controlling the sampling to perform blood separation operation aiming at the rest detection pools, wherein the rest detection pools at least comprise an immunoassay detection pool.
It will be appreciated that the processor 101, when executing program data, may also implement the methods described in any of the embodiments above.
Referring to fig. 11, fig. 11 is a schematic structural diagram of an embodiment of a computer-readable storage medium provided in the present application. The computer-readable storage medium 110 is for storing program data 111, the program data 111, when being executed by a processor, is for implementing the method steps of:
controlling a sampling needle to suck a blood sample to be detected; controlling the sampling to perform blood separation operation aiming at the WBC detection pool; and controlling the sampling to perform blood separation operation aiming at the rest detection pools, wherein the rest detection pools at least comprise an immunoassay detection pool.
It will be appreciated that the program data 111, when executed by a processor, may also implement the methods described in any of the embodiments above.
In the several embodiments provided in the present application, it should be understood that the disclosed method and apparatus may be implemented in other manners. For example, the above-described device embodiments are merely illustrative, and for example, the division of the modules or units is only one logical division, and other divisions may be realized in practice, for example, a plurality of units or components may be combined or integrated into another system, or some features may be omitted, or not executed.
The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the embodiment.
In addition, functional units in the embodiments of the present application may be integrated into one processing unit, or each unit may exist alone physically, or two or more units may be integrated into one unit. The integrated unit can be realized in a form of hardware, and can also be realized in a form of a software functional unit.
The integrated units in the other embodiments described above may be stored in a computer-readable storage medium if they are implemented in the form of software functional units and sold or used as separate products. Based on such understanding, the technical solution of the present application may be substantially implemented or contributed by the prior art, or all or part of the technical solution may be embodied in a software product, which is stored in a storage medium and includes instructions for causing a computer device (which may be a personal computer, a server, a network device, or the like) or a processor (processor) to execute all or part of the steps of the method according to the embodiments of the present application. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk, and other various media capable of storing program codes.
The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made by the contents of the specification and the drawings of the present application or are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.
Claims (10)
1. A method of distributing a blood sample, the method comprising:
controlling a sampling needle to suck a blood sample to be detected;
controlling the sampling to perform a blood separation operation on the WBC detection pool;
controlling the sampling to perform a blood separation operation on the remaining detection pools, wherein the remaining detection pools at least comprise an immunoassay detection pool.
2. The method of claim 1,
the controlling the sampling to perform a blood separation operation for the remaining detection cells includes:
performing blood separation operation on at least one immunoassay pool according to a preset sequence;
carrying out blood separation operation on the DIFF detection pool;
and carrying out blood separation operation on the RBC detection pool.
3. The method of claim 2,
the method further comprises the following steps:
and in the process of distributing the blood sample to the at least one immunoassay testing pool, carrying out blending operation on the liquid in the WBC testing pool.
4. The method of claim 3,
in the process of distributing the blood sample to the at least one immunoassay testing cell, the blending operation of the liquid in the WBC testing cell includes:
and in the process of distributing blood samples to each immunoassay pond, carrying out primary mixing operation on the liquid in the WBC detection pond.
5. The method of claim 2,
the blood separation operation is carried out on at least one immunity detection pool according to a preset sequence, and comprises the following steps:
controlling the sampling needle and the swab component to move to a target immunodetection pool;
controlling the sampling needle to perform a blood-throwing operation in the swab assembly;
controlling the sampling needle to move downwards, and distributing the blood sample to be detected with a preset volume to the target immunoassay pool;
and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component during the upward movement.
6. The method of claim 2,
the operation of separating blood from the DIFF detection pool comprises the following steps:
controlling the sampling needle and the swab component to move to a DIFF detection pool;
controlling the sampling needle to perform a blood-throwing operation in the swab assembly;
controlling the sampling needle to move downwards, and distributing a preset volume of the blood sample to be detected to the DIFF detection pool;
and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component during the upward movement.
7. The method of claim 2,
before the blood separation operation is performed on the RBC detection pool, the method comprises the following steps:
controlling the sampling needle and swab assembly to move to a WBC detection cell;
controlling the sampling needle to throw blood in the swab component and cleaning the inner wall of the sampling needle;
controlling the sampling needle to move downwards into the WBC detection pool and sucking part of liquid from the WBC detection pool;
and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component during the upward movement.
8. The method of claim 7,
the blood separation operation of the RBC detection pool comprises the following steps:
controlling the sampling needle and swab assembly to move to an RBC detection cell;
controlling the sampling needle to perform a blood-throwing operation in the swab assembly;
controlling the sampling needle to move downwards, and distributing the part of liquid in the sampling needle to the RBC detection pool;
and controlling the sampling needle to move upwards, and cleaning the outer wall of the sampling needle by using the swab component during the upward movement.
9. A blood testing device, comprising a processor and a memory coupled to the processor; the memory is for storing program data and the processor is for executing the program data to implement the method of any one of claims 1-8.
10. A computer-readable storage medium, characterized in that the computer-readable storage medium is used for storing program data, which, when being executed by a processor, is used for carrying out the method according to any one of claims 1-8.
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