CN118112225A - Blood sample detection method and blood sample detection device - Google Patents
Blood sample detection method and blood sample detection device Download PDFInfo
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- CN118112225A CN118112225A CN202211516080.7A CN202211516080A CN118112225A CN 118112225 A CN118112225 A CN 118112225A CN 202211516080 A CN202211516080 A CN 202211516080A CN 118112225 A CN118112225 A CN 118112225A
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- 210000004369 blood Anatomy 0.000 title claims abstract description 339
- 239000008280 blood Substances 0.000 title claims abstract description 339
- 238000001514 detection method Methods 0.000 title claims abstract description 292
- 210000004027 cell Anatomy 0.000 claims abstract description 181
- 210000000265 leukocyte Anatomy 0.000 claims abstract description 98
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 68
- 238000000034 method Methods 0.000 claims abstract description 55
- 238000012360 testing method Methods 0.000 claims description 67
- 238000004140 cleaning Methods 0.000 claims description 40
- 238000003018 immunoassay Methods 0.000 claims description 16
- 238000010790 dilution Methods 0.000 claims description 8
- 239000012895 dilution Substances 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 5
- 239000000523 sample Substances 0.000 claims 67
- 239000000758 substrate Substances 0.000 claims 3
- 238000010998 test method Methods 0.000 claims 1
- 238000005070 sampling Methods 0.000 description 27
- 239000007788 liquid Substances 0.000 description 21
- 239000003085 diluting agent Substances 0.000 description 20
- 238000000926 separation method Methods 0.000 description 16
- 238000006073 displacement reaction Methods 0.000 description 14
- 238000009826 distribution Methods 0.000 description 14
- 238000010586 diagram Methods 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000009534 blood test Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000004590 computer program Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 206010011409 Cross infection Diseases 0.000 description 2
- 102000012214 Immunoproteins Human genes 0.000 description 2
- 108010036650 Immunoproteins Proteins 0.000 description 2
- 206010029803 Nosocomial infection Diseases 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 238000009666 routine test Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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Abstract
The application relates to the technical field of blood sample detection, and discloses a blood sample detection method and blood sample detection equipment. The method comprises the following steps: collecting a blood sample through a sample sucking component; distributing a part of blood samples in the sample suction assembly to a WBC detection pond to detect leukocyte parameters; distributing at least one part of the blood sample of the rest blood sample in the sample sucking assembly to a DIFF detection cell to detect each type of leukocyte parameter; and collecting the diluted blood sample in the DIFF detection pool through the sample sucking component, and distributing the diluted blood sample to the RBC detection pool to detect the red blood cell parameters. Through the mode, the time for separating blood from different detection pools by the sample sucking component can be reduced, and the overall detection efficiency is improved.
Description
Technical Field
The application relates to the technical field of blood sample detection, in particular to a blood sample detection method and blood sample detection equipment.
Background
Current blood sample testing devices typically have a plurality of test cells, each for making a respective measurement of a dispensed blood sample to obtain a respective measurement parameter. For example, the detection cell may include a WBC detection cell, a DIFF detection cell, a RBC detection cell, and the like.
The inventor of the present application has found in long-term research and development that, due to the positional relationship between the detecting cells and the distribution logic of blood, the sample sucking assembly in the related art needs to complete blood distribution to and from different detecting cells, resulting in long blood distribution time and slow detection speed.
Disclosure of Invention
In order to solve the problem of low blood detection efficiency, the application provides a blood sample detection method and a blood sample detection device, which can improve the blood measurement efficiency.
In one aspect, the present application provides a method for detecting a blood sample, including: collecting a blood sample through a sample sucking component; distributing a part of blood sample in the sample suction assembly to a WBC detection pond to detect a first leukocyte parameter; distributing at least a part of the blood sample of the rest blood sample in the sample sucking assembly to a DIFF detection cell to detect a second leukocyte parameter; the blood sample in the DIFF detection cell is collected by the sample suction assembly and the blood sample collected from the DIFF detection cell is distributed to the RBC detection cell for detection of the red blood cell parameter.
In one embodiment, the RBC detection cell is a distance from the DIFF detection cell that is less than the distance from the RBC detection cell to the WBC detection cell.
In one embodiment, prior to dispensing a portion of the blood sample within the sample assembly to the WBC test cell, the method includes: distributing a part of blood samples in the sample sucking assembly to an immune detection pool, and detecting immune protein parameters; or, after dispensing a portion of the blood sample within the sample assembly to the WBC test cell, includes: and distributing a part of blood samples of the rest blood samples in the sample sucking assembly to the immune detection pool to detect immune protein parameters, wherein the blood sample amount distributed to the immune detection pool by the rest of the sample sucking assembly is larger than a threshold value, and the threshold value is used for ensuring that the blood samples distributed to the immune detection pool cannot cause inaccurate detection results due to dilution effect.
In one embodiment, the immunoassay well is at least one of a portion of the blood sample in the sample assembly to the immunoassay well or a portion of the blood sample in the remainder of the blood sample in the sample assembly to the immunoassay well, comprising: determining a target immunodetection pool from the at least one immunodetection pool; a portion of the blood sample within the sample-absorbing assembly is dispensed to the target immunodetection cell.
In one embodiment, dispensing a portion of the blood sample within the sample assembly to the target immunodetection well comprises: controlling the sample sucking assembly to move to a target immune detection pool; controlling the sample sucking assembly to move downwards and distributing a preset volume of blood sample in a part of blood samples to a target immune detection pool; and controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly in the upward moving process.
In one embodiment, dispensing at least a portion of the remaining portion of the blood sample within the sample intake assembly to the DIFF test cell includes: controlling the sample sucking assembly to move to the DIFF detection pool; controlling the sample sucking assembly to move downwards and distributing at least one part of blood sample of the rest blood sample in the sample sucking assembly to the DIFF detection pool; and controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly in the upward moving process.
In one embodiment, collecting a blood sample in a DIFF test cell by a sample uptake assembly includes: controlling the sample sucking assembly to move to the DIFF detection pool; controlling the sample sucking assembly to throw blood, and cleaning the inner wall of the sample sucking assembly; controlling the sample sucking component to move downwards into the DIFF detection pool and sucking part of diluted blood sample from the DIFF detection pool; and controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly in the upward moving process.
In one embodiment, dispensing a blood sample collected from a DIFF test cell to a RBC test cell includes: controlling the sample sucking assembly to move to the RBC detection pool; controlling the sample sucking assembly to move downwards, and distributing part of diluted blood sample in the sample sucking assembly to the RBC detection pool; and controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly in the upward moving process.
Another aspect of an embodiment of the present application provides a blood sample testing device including: a sample-absorbing assembly for collecting a blood sample and dispensing the blood sample; the driving assembly is connected with the sample sucking assembly and used for driving the sample sucking assembly to move; the detection pool is used for detecting the blood sample collected by the sample suction assembly and at least comprises an immune detection pool, a WBC detection pool, a DIFF detection pool and a RBC detection pool; a control assembly connected to the sample absorbing assembly, the drive assembly and the detection cell, respectively, for controlling the sample absorbing assembly, the drive assembly and the detection cell to implement the method according to any one of claims 1-8.
Wherein, the distance between the RBC detection pool and the DIFF detection pool is smaller than the distance between the RBC detection pool and the WBC detection pool; or WBC detection cell, DIFF detection cell, RBC detection cell are arranged in sequence.
The beneficial effects of the application are as follows: compared with the prior art, the sample absorbing component does not need to be additionally moved to the WBC detection tank to absorb the blood sample, so that the time for the sample absorbing component to divide blood of different detection tanks is reduced, and the overall blood detection efficiency is improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present application, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Wherein:
FIG. 1 is a schematic view of an embodiment of a blood test apparatus according to the present application;
FIG. 2 is a flow chart of a first embodiment of a blood sample testing method according to the present application;
FIG. 3 is a schematic diagram of the RBC, DIFF, and WBC test cell position distributions provided by the present application;
FIG. 4 is a schematic diagram of another location distribution of RBC, DIFF, and WBC test cells provided by the present application;
FIG. 5 is a flow chart of a second embodiment of a blood sample distribution method according to the present application;
FIG. 6 is a flow chart of a third embodiment of a blood sample distribution method according to the present application;
FIG. 7 is a schematic view of an application scenario of the blood sample distribution method provided by the present application;
FIG. 8 is a flow chart of a fourth embodiment of a blood sample distribution method provided by the present application;
FIG. 9 is a flow chart of an embodiment of step 805 provided in the present application;
FIG. 10 is a flow chart of an embodiment of step 807 provided in the present application;
FIG. 11 is a flow chart of an embodiment of step 808 provided in the present application;
FIG. 12 is a schematic view of another embodiment of a blood sample testing device provided by the present application;
Fig. 13 is a schematic structural diagram of an embodiment of a computer readable storage medium according to the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. It is to be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the application. It should be further noted that, for convenience of description, only some, but not all of the structures related to the present application are shown in the drawings. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the application. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of skill in the art will explicitly and implicitly appreciate that the embodiments described herein may be combined with other embodiments.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a blood test apparatus according to the present application. The blood testing device 10 includes a sample-aspirating assembly 11, a blood routine testing chamber 12, a washing assembly 13, a drive assembly 14, and a control assembly 15.
The blood routine test cell 12 includes at least a WBC (white blood cell) test cell, a RBC (red blood cell) test cell, and a DIFF (differential) test cell.
Wherein the sample suction assembly 11 is used for collecting a blood sample and dispensing the blood sample. The sample sucking assembly 11 comprises a sampling needle, a small-displacement syringe for sucking blood samples, a swab assembly for cleaning the sampling needle, a large-displacement syringe for cleaning diluent, a negative pressure assembly for sucking waste liquid in the cleaning sampling needle and the swab assembly, and a reversing valve and a pipeline connector for connecting the components.
The control assembly 15 controls the small-displacement syringe in the sample-sucking assembly 11 to suck the blood sample into the sampling needle, and then controls the driving assembly 14 to move the sampling needle to a designated test cell, and then the control assembly 15 controls the small-displacement syringe in the sample-sucking assembly 11 to precisely separate blood into the designated test cell, such as the blood routine test cell 12. After the control component 15 controls the sampling needle to separate blood, the control component 15 further controls the swab component to treat and clean the waste liquid of the sampling needle. It will be understood that all descriptions herein of movement and cleaning of the sample assembly refer primarily to movement and cleaning of the sampling needle in the sample assembly 11.
The control component 15 is further configured to control the cleaning component 13 to clean the detection tank after the blood sample signal is collected, and add the base fluid to keep the detection tank in a ready state, clean a pipeline connected with the detection tank, and then the cleaning component 13 returns to an initial state, so that the next blood sample is not affected.
The control component 15 is further configured to control the corresponding detection component to perform detection, cleaning, resetting, and other operations.
In some embodiments, the workflow of the blood testing device is: the control component 15 controls the sampling needle in the sample sucking component 11 to suck a preset volume of blood sample to be detected, then controls the driving component 14 to move the sampling needle to a specified detection pool according to a preset sequence, continuously controls the small-displacement syringe in the sample sucking component 11 to perform blood separation operation on the blood conventional detection pool 12, and then controls the blood conventional detection pool to detect the blood sample to obtain a corresponding detection result.
In some embodiments, a number of immunoassay wells (not shown) may also be included in the blood testing device 10.
Referring to fig. 2, fig. 2 is a schematic flow chart of a first embodiment of a blood sample distribution method according to the present application. The method comprises the following steps:
Step 201: blood samples are collected by the sample-sucking assembly.
In some embodiments, the blood testing device includes a sample-aspirating assembly for aspirating a blood sample to be tested. The sample sucking component comprises a sampling needle and a syringe A. Wherein, syringe A passes through the pipeline with the sampling needle and connects. When the blood sample to be detected is sucked, the sampling needle is controlled to move downwards into the blood sample container at the sampling position and enter the blood sample, the injector A works, and the sampling needle is controlled to suck the blood sample to be detected.
It will be appreciated that the volume of each draw of blood sample is determined on a per-pass basis.
In some embodiments, the volume of blood sample drawn at a time may be set to a fixed volume that may meet the blood sample requirements of all test items in the blood test apparatus.
Step 202: a portion of the blood sample within the sample assembly is dispensed to a WBC test cell and a first leukocyte parameter is measured.
After the blood sample is collected through the sample suction assembly, a part of the blood sample, which is close to the needle head, of the sampling needle of the sample suction assembly is distributed to the WBC detection pond, and the first leukocyte parameter is detected. Wherein the volume of the blood sample assigned to the WBC detection cell is a preset volume that can meet the detection requirements of the WBC detection cell.
Wherein the first leukocyte parameter refers to the number of leukocytes.
In some embodiments, step 202 may be controlling the sampling needle to move over the WBC detection cell and then inject a sample of blood to be detected into the WBC detection cell corresponding to the WBC detection project demand volume.
In some embodiments, the sampling needle is controlled to expel a first volume of blood sample to be tested and to clean the outer wall of the sampling needle during movement of the sampling needle to the WBC test cell.
After the sampling needle moves to the WBC detection cell, the sampling needle is controlled to inject a second volume of blood sample to be detected into the WBC detection cell. It should be noted that the second volume of blood sample to be tested can meet the WBC test project demand.
Step 203: at least a portion of the remaining portion of the blood sample within the sample intake assembly is dispensed to a DIFF test cell for testing a second leukocyte parameter.
After the sample sucking assembly is used for separating blood into the WBC detection pond, the part of the blood sample, which is close to the needle head, of the rest blood sample in the sampling needle of the sample sucking assembly is distributed to the DIFF detection pond, and the second leukocyte parameters are detected. Wherein the volume of the blood sample assigned to the DIFF detection cell is a preset volume that is capable of meeting the detection requirements of the DIFF detection cell.
The second leukocyte parameter refers to a parameter of different types of leukocytes such as a parameter in which neutrophils, eosinophils, lymphocytes and monocytes can be detected, such as a percentage and absolute value of each type of leukocytes. And simultaneously, calculating the corresponding parameters of the basophils by combining the detection results of the WBC detection cell.
Step 204: the blood sample in the DIFF detection cell is collected by the sample suction assembly and the blood sample collected from the DIFF detection cell is distributed to the RBC detection cell for detection of the red blood cell parameter.
In some embodiments, it is generally necessary to dilute the blood sample in the corresponding test cell, such as by adding a diluent or an anticoagulant, and then mixing the diluted blood sample with the blood sample in the test cell.
In one application scenario, described in connection with fig. 3, the RBC detection cell is a smaller distance from the DIFF detection cell than the RBC detection cell.
As shown in fig. 3, WBC, DIFF, and RBC test cells are distributed in the direction of the arrows. And distributing a part of blood samples in the sample sucking assembly, which are close to the sample sucking assembly collecting port, to the WBC detection pond to detect white blood cell parameters, distributing at least a part of blood samples in the sample sucking assembly, which are close to the sample sucking assembly collecting port, to the DIFF detection pond to detect white blood cell parameters of various types, collecting diluted blood samples in the DIFF detection pond through the sample sucking assembly, distributing the diluted blood samples to the RBC detection pond, and detecting red blood cell parameters. By the method, after at least a part of the blood sample of the rest blood sample in the sample sucking component is distributed to the DIFF detection tank, the sample sucking component is not required to be controlled to move to the WBC detection tank as in the related technology, the blood sample is collected from the WBC detection tank and then is moved to the RBC detection tank to be distributed, the corresponding blood sample can be directly collected in the DIFF detection tank and then is moved to the RBC detection tank to be distributed with the blood sample, the sample sucking component is not required to be additionally moved to the WBC detection tank to suck the blood sample, the time of the sample sucking component for separating blood from different detection tanks is reduced, and the overall detection efficiency is improved.
In an application scenario, described in connection with fig. 4, WBC detection cells, DIFF detection cells, RBC detection cells are arranged in sequence. As shown in fig. 4, DIFF, WBC and RBC test cells are distributed in the direction of the arrow. And distributing a part of blood samples in the sample sucking assembly, which are close to the sample sucking assembly collecting port, to the WBC detection pond to detect white blood cell parameters, distributing at least a part of blood samples in the sample sucking assembly, which are close to the sample sucking assembly collecting port, to the DIFF detection pond to detect white blood cell parameters of various types, collecting diluted blood samples in the DIFF detection pond through the sample sucking assembly, distributing the diluted blood samples to the RBC detection pond, and detecting red blood cell parameters. Through the above mode, the WBC detection pond does not need to wait for the sample sucking component to suck the blood sample from the WBC detection pond, so that the white blood cell count can be directly carried out, and the overall blood detection efficiency is improved.
In this embodiment, by first distributing a part of the blood sample of the WBC detection cell to detect the number of white blood cells, then distributing a part of the blood sample of the DIFF detection cell, collecting the diluted blood sample in the DIFF detection cell, distributing the diluted blood sample to the RBC detection cell, and detecting the red blood cell parameters, the blood sample detected in the RBC detection cell is derived from the DIFF detection cell.
Referring to fig. 5, fig. 5 is a schematic flow chart of a second embodiment of a blood sample distribution method according to the present application. The method comprises the following steps:
Step 51: blood samples are collected by the sample-sucking assembly.
Step 52: and distributing a part of blood samples in the sample sucking assembly to an immune detection cell, and detecting immune protein parameters.
In some embodiments, the number of immunodetection wells may be multiple, each immunodetection well detecting a corresponding immunofunction or immunoprotein parameter.
The blood sample near the needle head of the sampling needle is preferentially distributed to an immune detection pool for immune detection, and according to the current detection technology, the immune detection needs longer reaction time, so the reaction time of the immune detection determines the time of routine blood and immune combined detection, and if the blood is finally separated to the immune detection pool, the integral detection time is prolonged, and the speed of routine blood and immune protein combined detection is reduced. Meanwhile, the concentration change of the blood sample near the needle head part of the sampling needle is small, so that the accuracy and the reliability of the immunodetection can be improved.
Step 53: a portion of the blood sample within the sample assembly is dispensed to a WBC test cell and a first leukocyte parameter is measured.
Step 54: at least a portion of the remaining portion of the blood sample within the sample intake assembly is dispensed to a DIFF test cell for testing a second leukocyte parameter.
Step 55: the blood sample in the DIFF detection cell is collected by the sample suction assembly and the blood sample collected from the DIFF detection cell is distributed to the RBC detection cell for detection of the red blood cell parameter.
In this embodiment, the blood sample in the needle portion of the sample sucking assembly is preferentially distributed to the immunodetection pool for immunodetection, so that the detection time period can be shortened, and further, the possibility that the blood sample in the front section near the needle of the sample sucking assembly is affected by the diluent in the sample sucking assembly is smaller, the concentration of the immunodetection substance is high, the blood volume for detection can be reduced, and thus, the blood sampling volume of a patient is reduced, and the pain of the patient is alleviated.
And the sample sucking component does not need to be additionally moved to the WBC detection tank to suck the blood sample, so that the time for the sample sucking component to separate blood from different detection tanks is reduced, and the overall detection efficiency is improved.
Referring to fig. 6, fig. 6 is a schematic flow chart of a third embodiment of a blood sample distribution method according to the present application. The method comprises the following steps:
Step 61: blood samples are collected by the sample-sucking assembly.
Step 62: a portion of the blood sample within the sample assembly is dispensed to a WBC test cell and a first leukocyte parameter is measured.
Step 63: at least a portion of the blood sample from the remainder of the blood sample within the sample intake assembly is dispensed to an immunoassay well for detection of an immunoprotein parameter.
Wherein the remaining portion of the sample absorbing assembly is assigned to the immunoassay well with a blood sample volume greater than a threshold value that is used to ensure that the blood sample being assigned to the immunoassay well does not experience inaccurate test results due to dilution effects.
Considering that the liquid is filled in the interior of the sample sucking assembly after the sample sucking assembly is cleaned before sampling, when a blood sample is sucked, the liquid in the sample sucking assembly can move along a pipeline to the interior of the device, liquid residues are left on the inner wall of the sample sucking assembly in the liquid moving process, the blood sample can be mixed with the residual liquid on the inner wall when entering the sample sucking assembly, the more the blood entering the sample sucking assembly is diluted, and the diffusion phenomenon can occur at the junction of the blood sample and the liquid. If the immunoassay blood separation sequence is put at the end, the concentration of the substance to be detected in the blood sample is reduced due to dilution of the blood sample, and thus inaccurate detection occurs. And because the different test modes are selected, the more the blood samples are sampled, the more the blood samples which firstly enter the sampling mechanism are diluted, the inconsistent values obtained by testing the same blood samples in the different test modes can be caused. And because it is diluted, more blood sample is needed for more accurate detection, which results in increased blood consumption, increased blood volume drawn by the patient and increased pain for the patient.
Based on this, when the blood separation sequence of the immunodetection cell is behind the WBC detection cell, the blood separation sequence of the immunodetection cell cannot be arranged at the end, and at the same time, it is required to ensure that the amount of the blood sample distributed to the immunodetection cell by the rest of the sample suction assembly is greater than a threshold value, and the threshold value is used for ensuring that the blood sample distributed to the immunodetection cell cannot occur due to inaccurate detection results caused by dilution effect, so as to ensure the accuracy of immunodetection.
Step 64: at least a portion of the remaining portion of the blood sample within the sample intake assembly is dispensed to a DIFF test cell for testing a second leukocyte parameter.
After at least a portion of the remaining blood sample in the sample absorbing assembly is distributed to the DIFF detection cell, the blood sample in the DIFF detection cell is diluted, step 65 is performed after the dilution, and then the second leukocyte parameter of the diluted blood sample remaining in the DIFF detection cell is detected.
Step 65: and collecting the diluted blood sample in the DIFF detection pool through the sample sucking component, and distributing the diluted blood sample to the RBC detection pool to detect the red blood cell parameters.
In this embodiment, on the one hand, the blood separation operation is preferentially performed on the WBC detection cell, so that the residence time of the blood sample to be detected, which is distributed to the WBC detection cell, in the sample suction component is reduced, thereby improving the sedimentation problem of blood cells in the blood sample to be detected in the sample suction component, ensuring the number of blood cells in the blood sample to be detected, which is distributed to the WBC detection cell, and improving the accuracy of blood sample detection, and immediately after the blood separation operation is performed on the immune detection cell, the influence of dilution effect on the blood sample to be detected is reduced as much as possible, thereby reducing the blood consumption for detection and ensuring the accuracy of immune detection, on the other hand, the diluted blood sample in the DIFF detection cell is collected and distributed to the RBC detection cell, so that the blood sample detected in the RBC detection cell is derived from the DIFF detection cell.
In an application scenario, the following description refers to fig. 7:
Firstly, the sample sucking component is cleaned, and the sample sucking component is controlled to suck samples so as to suck a preset volume of blood samples to be detected. Then the sample sucking component is controlled to move to the first immune detection pond to throw blood, so that the sample sucking component is controlled to throw away the first volume of blood sample to be detected, then the blood separating operation is carried out on the first immune detection pond, the second volume of blood sample to be detected is distributed, and after the blood separating operation is finished, the mixing operation is carried out, so that the second volume of blood sample to be detected is uniformly distributed in the first immune detection pond. The first immunodetection cell can perform subsequent blood sample preparation, channel detection, data acquisition, channel cleaning and other works.
After the first immune detection cell is used for separating blood, the sample sucking component is controlled to move to the second immune detection cell for blood throwing operation, so that the sample sucking component is controlled to throw away the first volume of blood sample to be detected, then the second immune detection cell is subjected to blood separating operation, the third volume of blood sample to be detected is distributed, and after the blood separation is finished, the mixing operation is performed, so that the third volume of blood sample to be detected is uniformly distributed in the second immune detection cell. The second immune detection cell can perform subsequent blood sample preparation, channel detection, data acquisition, channel cleaning and other works.
After the second immune detection cell is used for separating blood, the sample sucking assembly is controlled to move to the nth immune detection cell for blood throwing operation, so that the sample sucking assembly is controlled to throw away the first volume of blood sample to be detected, the nth immune detection cell is used for separating blood, the fourth volume of blood sample to be detected is distributed, and after the blood separation is finished, the mixing operation is carried out, so that the fourth volume of blood sample to be detected is uniformly distributed in the nth immune detection cell. At this time, the nth immunodetection cell can perform subsequent blood sample preparation, channel detection, data acquisition, channel cleaning and other works.
After the nth immune detection cell is used for separating blood, the sample sucking component is controlled to move to the WBC detection cell for blood throwing operation, so that the sample sucking component is controlled to throw away the first volume of blood sample to be detected, then the WBC detection cell is subjected to blood separating operation, the fifth volume of blood sample to be detected is distributed, and after the blood separation is finished, the mixing operation is performed, so that the fifth volume of blood sample to be detected is uniformly distributed in the WBC detection cell. The WBC detection cell can perform subsequent blood sample preparation, channel detection, data acquisition, channel cleaning and other works.
After the WBC detection pond finishes blood separation, the sample sucking component is controlled to move to the DIFF detection pond to perform blood throwing operation so as to control the sample sucking component to throw away the first volume of blood sample to be detected, and perform blood separation operation to the DIFF detection pond, and a sixth volume of blood sample to be detected is distributed, and after the blood separation is finished, the mixing operation is performed so that the sixth volume of blood sample to be detected is uniformly distributed in the DIFF detection pond.
When the blood sample in the DIFF detection tank is uniformly mixed with the corresponding reagent for dilution, the rest blood samples in the sample absorbing assembly can be completely subjected to blood throwing operation, meanwhile, the inner wall and the outer wall of the sample absorbing assembly can be cleaned, and after the cleaning is finished, the sample absorbing assembly is controlled to absorb the liquid with the preset volume from the DIFF detection tank. And then controlling the sample sucking assembly to move to the RBC detection tank, and distributing the liquid with the preset volume to the RBC detection tank. After the sample sucking component sucks the liquid with preset volume from the DIFF detection pool, adding the reagent into the DIFF detection pool for uniform mixing, and then the DIFF detection pool can perform the working of channel detection, data acquisition, channel cleaning and the like. After the sample sucking component is controlled to distribute the liquid with the preset volume to the RBC detection tank, the liquid in the RBC detection tank is uniformly mixed, then the channel detection is carried out, and the channel cleaning and other works are carried out after the detection is completed.
In other embodiments, the WBC detection cell can be bled by the sample-absorbing assembly, the immune detection cell can be bled by the sample-absorbing assembly, the DIFF detection cell can be bled by the sample-absorbing assembly, after the blood sample in the DIFF detection cell is uniformly mixed with the corresponding reagent and diluted, the RBC detection cell can be bled by the sample-absorbing assembly by absorbing the preset volume of liquid from the DIFF detection cell. The specific blood separation method is the same as or similar to that of the other embodiments, and will not be described here.
Referring to fig. 8, fig. 8 is a flowchart of a fourth embodiment of a blood sample distribution method according to the present application. The method comprises the following steps:
Step 801: the sample suction assembly and the swab assembly are controlled to move to the blood sample container.
In some embodiments, the sample absorbing assembly is disposed within the swab assembly. The swab assembly includes a first outlet and a second outlet. The first outlet is connected with the negative pressure component and is used for pumping out liquid in the swab component through the first outlet under the action of the negative pressure component. The second outlet is connected with a large-displacement syringe for providing diluent for cleaning, when the sample sucking assembly needs cleaning, the large-displacement syringe injects the diluent into the swab assembly through the second outlet, and after cleaning, the negative pressure assembly extracts the diluent through the first outlet.
Step 802: and controlling the sample sucking assembly to move downwards and sucking the blood sample to be detected in the set volume.
The sample sucking assembly is controlled to move downwards, and a set volume of blood sample to be detected is sucked from the blood sample container.
Step 803: and controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly by using the swab assembly in the moving process.
It will be appreciated that when the sample sucking component sucks a set volume of blood sample to be detected, the outer wall of the sample sucking component contacts with the blood sample to be detected, a portion of the blood sample to be detected will adhere, and the portion of the blood sample to be detected contacts with air and is contaminated. The outer wall of the sample-absorbing assembly is cleaned by injecting diluent into the swab assembly using a large-displacement syringe.
Step 804: the target immunodetection pool is determined from the at least one immunodetection pool.
In some embodiments, the immune items to be detected are acquired, the corresponding immune detection pools are acquired according to the immune items, and then the blood separation operation is performed on the immune detection pools corresponding to the immune items according to the preset sequence of the immune items. The immunization program to be detected is A, B, C. The immune item A corresponds to the immune detection pool A, the immune item B corresponds to the immune detection pool B, and the immune item C corresponds to the immune detection pool C. The priority of the immune projects is obtained, the immune projects with high priority are ordered according to the priority, and blood separation operation is carried out first. The target immune detection pool can be determined according to the priority.
Step 805: a portion of the blood sample within the sample-absorbing assembly is dispensed to the target immunodetection cell.
In some embodiments, a portion of the blood sample within the sample assembly comprises a first volume of blood sample, and the fluid in the first target immunoassay well is required to be drained when the first volume of blood sample within the sample assembly is dispensed to the first target immunoassay well.
It can be appreciated that the sample absorbing assembly collects the blood sample to be tested in the blood sample container, and easily absorbs the scraps when the sample absorbing assembly moves downwards to puncture the sealing layer of the blood sample container and moves upwards to move out of the blood sample container.
In some embodiments, a first volume of blood sample within the sample intake assembly is dispensed into the swab assembly, and the negative pressure assembly is controlled to draw the first volume of blood sample to be tested.
With further reference to fig. 9, the specific steps of step 805 may be:
step 8051: and controlling the sample sucking component and the swab component to move to the target immune detection pool.
Step 8052: the sample sucking assembly is controlled to throw blood in the swab assembly.
It can be understood that the sample sucking component is controlled to throw blood in the swab component, and the negative pressure component is utilized to suck the part of blood sample to be detected, so that cross infection among channels is avoided.
Step 8053: and controlling the sample sucking assembly to move downwards, and distributing a preset volume of blood sample in a part of blood samples to the target immune detection cell.
In some embodiments, the sample-absorbing assembly is controlled to move down into the interior of the target immunoassay well and dispense a predetermined volume of the blood sample to be tested to the target immunoassay well.
Step 8054: and controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly by using the swab assembly in the upward moving process.
In some embodiments, the sample absorbing assembly is controlled to move upwards, and in the upwards moving process, the large-displacement injector is controlled to inject the diluent into the swab assembly so as to clean the outer wall of the sample absorbing assembly, and the diluent after the cleaning is pumped away by utilizing the negative pressure assembly.
In some embodiments, after completion of the execution of step 8054, the sample-absorbing assembly and the swab assembly are controlled to move to the next target immunodetection cell, and steps 8052-8054 described above are performed; until all the immune detection cells needed to be used complete blood separation operation.
Step 806: a portion of the blood sample to be tested in the sample-aspirating assembly is dispensed to the WBC test cell.
Wherein, the sample volume of the blood to be detected injected into the corresponding volume of the WBC detection cell can satisfy WBC detection.
In some embodiments, the specific steps of step 806 may be: the sample sucking assembly and the swab assembly are controlled to move to the WBC detection pool, and the sample sucking assembly is controlled to throw blood in the swab assembly. The sample assembly is then controlled to move downward and at least a portion of the remaining blood sample within the sample assembly is dispensed to the WBC test cell.
And after the distribution is finished, controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly by using the swab assembly in the upward moving process.
In some embodiments, the sample absorbing assembly is controlled to move upwards, and in the upwards moving process, the large-displacement injector is controlled to inject the diluent into the swab assembly so as to clean the outer wall of the sample absorbing assembly, and the diluent after the cleaning is pumped away by utilizing the negative pressure assembly.
Step 807: at least a portion of the remaining portion of the blood sample within the sample assembly is dispensed to a DIFF test cell for testing each type of leukocyte parameter.
In some embodiments, referring to fig. 10, the specific steps of step 807 may be:
Step 8071: the sample sucking component and the swab component are controlled to move to the DIFF detection cell.
Step 8072: the sample sucking assembly is controlled to throw blood in the swab assembly.
It can be understood that the sample sucking component is controlled to throw blood in the swab component, and the negative pressure component is utilized to suck the part of blood sample to be detected, so that cross infection among channels is avoided.
Step 8073: the sample assembly is controlled to move down and at least a portion of the remaining portion of the blood sample within the sample assembly is dispensed to the DIFF test cell.
In some embodiments, the sample suction assembly is controlled to move down into the interior of the DIFF test cell and dispense a predetermined volume of blood sample to be tested to the DIFF test cell.
Step 8074: and controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly by using the swab assembly in the upward moving process.
In some embodiments, the sample absorbing assembly is controlled to move upwards, and in the upwards moving process, the large-displacement injector is controlled to inject the diluent into the swab assembly so as to clean the outer wall of the sample absorbing assembly, and the diluent after the cleaning is pumped away by utilizing the negative pressure assembly.
Step 808: and collecting the diluted blood sample in the DIFF detection pool through the sample sucking component, and distributing the diluted blood sample to the RBC detection pool to detect the red blood cell parameters.
In some embodiments, referring to fig. 11, step 808 includes the steps of:
step 8081: the sample sucking component and the swab component are controlled to move to the DIFF detection cell.
And after the sample sucking component finishes the blood separating operation on the DIFF detection pool, uniformly mixing the blood samples in the DIFF detection pool, and controlling the sample sucking component and the swab component to be kept above the DIFF detection pool.
Step 8082: and controlling the sample sucking assembly to throw blood in the swab assembly, and cleaning the inner wall of the sample sucking assembly.
It can be understood that after the sample sucking component divides blood into the DIFF detection pool, the residual blood sample to be detected in the sample sucking component does not need to be used, and then the diluent is injected into the sample sucking component by using the large-displacement syringe, so that the residual blood sample to be detected in the sample sucking component is completely pushed out to the swab component, the inner wall of the sample sucking component is cleaned by using the diluent, and then the residual blood sample to be detected and the diluent are pumped away by using the negative pressure component and recycled to the waste liquid barrel.
Step 8083: the control sample-sucking assembly moves down into the DIFF test cell and sucks a portion of the diluted blood sample from the DIFF test cell.
It will be appreciated that the DIFF test cell now includes a mixed fluid mixed with a predetermined volume of blood sample to be tested.
Step 8084: and controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly by using the swab assembly in the upward moving process.
In some embodiments, the sample absorbing assembly is controlled to move upwards, and in the upwards moving process, the large-displacement injector is controlled to inject the diluent into the swab assembly so as to clean the outer wall of the sample absorbing assembly, and the diluent after the cleaning is pumped away by utilizing the negative pressure assembly.
Step 8085: and controlling the sample sucking component and the swab component to move to the RBC detection pool.
In some embodiments, the sample pipetting assembly controls movement of the sample pipetting assembly and the swab assembly to the RBC test cell after pipetting a portion of the liquid from the DIFF test cell.
Step 8086: the sample sucking assembly is controlled to throw blood in the swab assembly.
In some embodiments, the blood-throwing operation at this time is to throw away a portion of the volume of liquid from the portion of liquid drawn from the DIFF test cell, avoiding cross-contamination between channels.
Step 8087: and controlling the sample sucking assembly to move downwards, and distributing part of diluted blood sample in the sample sucking assembly to the RBC detection pool.
It will be appreciated that some of the liquid that is drawn from the DIFF detection cell is present in the sample assembly at this point, and the sample assembly is controlled to move down and dispense some of the liquid in the sample assembly to the RBC detection cell.
Step 8088: and controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly by using the swab assembly in the upward moving process.
In some embodiments, the sample absorbing assembly is controlled to move upwards, and in the upwards moving process, the large-displacement injector is controlled to inject the diluent into the swab assembly so as to clean the outer wall of the sample absorbing assembly, and the diluent after the cleaning is pumped away by utilizing the negative pressure assembly.
After the execution of step 8088 is completed, the sample-sucking component is cleaned, and the sample-sucking component is controlled to move to the initial position for the next time of sucking the blood sample.
In some embodiments, the order of steps 805 and 806 may be reversed, i.e., a portion of the blood sample to be tested in the sample-absorbing assembly is dispensed to the WBC test cell and a portion of the blood sample in the sample-absorbing assembly is dispensed to the target immune test cell. The specific operation method is the same as the above method, and will not be described here again.
Referring to fig. 12, fig. 12 is a schematic structural diagram of another embodiment of a blood sample testing device according to the present application. The blood sample testing device 20 includes: a sample absorbing assembly 21, a driving assembly 22, a detection cell 23 and a control assembly 24.
Wherein the sample sucking assembly 21 is used for collecting a blood sample and distributing the blood sample; the driving component 22 is connected with the sample sucking component 21 and is used for driving the sample sucking component 21 to move;
The detection cell 23 includes at least an immunoassay cell 231, a WBC detection cell 232, a DIFF detection cell 233, and a RBC detection cell 234.
The control assembly 24 is respectively connected with the sample sucking assembly 21, the driving assembly 22 and the detection pool 23, and is used for controlling the sample sucking assembly 21, the driving assembly 22 and the detection pool 23 to implement the method according to any embodiment.
In some embodiments, the RBC detection cell 234 is a smaller distance from DIFF detection cell 233 than the RBC detection cell 234 is from WBC detection cell 232.
In some embodiments, WBC detection cell 232, DIFF detection cell 233, RBC detection cell 234 are arranged in sequence.
Compared with the prior art, the sample sucking component does not need to be additionally moved to the WBC detection tank to suck the blood sample, so that the control logic of the whole system is optimized, and the running stability of the device is improved.
Referring to fig. 13, fig. 13 is a schematic structural diagram of an embodiment of a computer readable storage medium according to the present application. The computer-readable storage medium 120 is for storing a computer program 121, which computer program 121, when being executed by a processor, is for carrying out the following method steps:
Collecting a blood sample through a sample sucking component; distributing a part of blood samples in the sample suction assembly to a WBC detection pond to detect leukocyte parameters; distributing at least one part of the blood sample of the rest blood sample in the sample sucking assembly to a DIFF detection cell to detect each type of leukocyte parameter; and collecting the diluted blood sample in the DIFF detection pool through the sample sucking component, and distributing the diluted blood sample to the RBC detection pool to detect the red blood cell parameters.
It will be appreciated that the computer program 121, when executed by a processor, may also implement the method described in any of the embodiments above.
In the several embodiments provided in the present application, it should be understood that the disclosed method and apparatus may be implemented in other manners. For example, the above-described device embodiments are merely illustrative, e.g., the division of the modules or units is merely a logical functional division, and there may be additional divisions when actually implemented, e.g., multiple units or components may be combined or integrated into another system, or some features may be omitted, or not performed.
The units described as separate units may or may not be physically separate, and units shown as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the embodiment.
In addition, each functional unit in each embodiment of the present application may be integrated in one processing unit, each unit may exist alone physically, or two or more units may be integrated in one unit. The integrated units may be implemented in hardware or in software functional units.
The integrated units of the other embodiments described above may be stored in a computer readable storage medium if implemented in the form of software functional units and sold or used as stand alone products. Based on such understanding, the technical solution of the present application may be embodied in essence or a part contributing to the prior art or all or part of the technical solution in the form of a software product stored in a storage medium, including several instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) or a processor (processor) to execute all or part of the steps of the method according to the embodiments of the present application. And the aforementioned storage medium includes: a usb disk, a removable hard disk, a Read-Only Memory (ROM), a random access Memory (RAM, random Access Memory), a magnetic disk, or an optical disk, or other various media capable of storing program codes.
The foregoing description is only of embodiments of the present application, and is not intended to limit the scope of the application, and all equivalent structures or equivalent processes using the descriptions and the drawings of the present application or directly or indirectly applied to other related technical fields are included in the scope of the present application.
Claims (10)
1. A method of testing a blood sample, the method comprising:
collecting a blood sample through a sample sucking component;
Distributing a part of blood samples in the sample sucking assembly to a WBC detection pond to detect a first leukocyte parameter;
distributing at least a part of the blood sample of the rest blood sample in the sample sucking assembly to a DIFF detection cell to detect a second leukocyte parameter;
And collecting a blood sample in the DIFF detection cell through the sample sucking component, distributing the blood sample collected from the DIFF detection cell to a RBC detection cell, and detecting red blood cell parameters.
2. The method of claim 1, wherein the step of determining the position of the substrate comprises,
The RBC detection cell is a distance from the DIFF detection cell that is less than the RBC detection cell is a distance from the WBC detection cell.
3. The method of claim 1, wherein prior to dispensing a portion of the blood sample within the sample assembly to a WBC test cell, comprising:
distributing a part of blood samples in the sample sucking assembly to an immune detection pool, and detecting immune protein parameters; or alternatively, the first and second heat exchangers may be,
After dispensing a portion of the blood sample within the sample assembly to a WBC test cell, the method includes:
And distributing a part of blood samples of the rest blood samples in the sample sucking assembly to the immune detection pool to detect the immune protein parameters, wherein the blood sample amount distributed to the immune detection pool by the rest sample sucking assembly is larger than a threshold value, and the threshold value is used for ensuring that the blood samples distributed to the immune detection pool cannot be inaccurate in detection result due to dilution effect.
4. The method of claim 3, wherein the at least one of the immunoassay wells is at least one of the dispensing a portion of the blood sample in the sample receiving assembly to the immunoassay well or dispensing a portion of the blood sample in the remainder of the blood sample in the sample receiving assembly to the immunoassay well, comprising:
determining a target immunodetection pool from at least one immunodetection pool;
And distributing a part of blood samples in the sample sucking assembly to the target immune detection cell.
5. The method of claim 4, wherein said dispensing a portion of the blood sample within the sample intake assembly to the target immunodetection cell comprises:
Controlling the sample sucking assembly to move to the target immune detection cell;
Controlling the sample sucking assembly to move downwards and distributing a preset volume of blood sample in the part of blood samples to the target immune detection pool;
And controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly in the upward moving process.
6. The method of claim 1, wherein the step of determining the position of the substrate comprises,
The dispensing at least a portion of the remaining blood sample within the sample intake assembly to a DIFF test cell, comprising:
controlling the sample sucking assembly to move to the DIFF detection cell;
Controlling the sample sucking assembly to move downwards and distributing at least part of the blood sample of the rest blood samples in the sample sucking assembly to the DIFF detection cell;
And controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly in the upward moving process.
7. The method of claim 1, wherein the step of determining the position of the substrate comprises,
The collection of the blood sample in the DIFF test cell by the sample uptake assembly comprises:
Controlling the sample sucking assembly to move to a DIFF detection pool;
Controlling the sample sucking assembly to throw blood, and cleaning the inner wall of the sample sucking assembly;
Controlling the sample sucking assembly to move downwards into the DIFF detection cell and sucking part of diluted blood sample from the DIFF detection cell;
And controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly in the upward moving process.
8. The method of claim 7, wherein the step of determining the position of the probe is performed,
The dispensing the blood sample collected from the DIFF detection cell to an RBC detection cell, comprising:
Controlling the sample sucking assembly to move to an RBC detection pool;
controlling the sample sucking assembly to move downwards and distributing partial diluted blood sample in the sample sucking assembly to the RBC detection pool;
And controlling the sample sucking assembly to move upwards, and cleaning the outer wall of the sample sucking assembly in the upward moving process.
9. A blood sample testing device, the blood sample testing device comprising:
A sample-absorbing assembly for collecting a blood sample and dispensing the blood sample;
The driving assembly is connected with the sample sucking assembly and used for driving the sample sucking assembly to move;
The detection pool is used for detecting the blood sample collected by the sample suction assembly and at least comprises an immune detection pool, a WBC detection pool, a DIFF detection pool and a RBC detection pool;
a control assembly connected to the sample suction assembly, the drive assembly and the detection cell, respectively, for controlling the sample suction assembly, the drive assembly and the detection cell to implement the method of any one of claims 1-8.
10. The blood sample testing device of claim 9, wherein the device further comprises a sensor,
The distance between the RBC detection cell and the DIFF detection cell is less than the distance between the RBC detection cell and the WBC detection cell; or (b)
The WBC detection cell, the DIFF detection cell, and the RBC detection cell are arranged in sequence.
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| CN202211516080.7A CN118112225A (en) | 2022-11-29 | 2022-11-29 | Blood sample detection method and blood sample detection device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211516080.7A CN118112225A (en) | 2022-11-29 | 2022-11-29 | Blood sample detection method and blood sample detection device |
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| CN118112225A true CN118112225A (en) | 2024-05-31 |
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