CN114053368A - Compound composition for treating swollen sore throat as well as preparation method and application thereof - Google Patents
Compound composition for treating swollen sore throat as well as preparation method and application thereof Download PDFInfo
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- CN114053368A CN114053368A CN202111648700.8A CN202111648700A CN114053368A CN 114053368 A CN114053368 A CN 114053368A CN 202111648700 A CN202111648700 A CN 202111648700A CN 114053368 A CN114053368 A CN 114053368A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a compound composition for treating swollen sore throat, a preparation method and application thereof. The compound composition for treating sore throat is prepared by taking bitter shaddock seed, anoectochilus roxburghii, purslane, liquorice, luffa stem juice and water as components, preparing decoction or granules, and limiting the dosage of each component. The preparation method is simple and convenient, has wide medicine sources, utilizes the respective effects of the raw material components, and is matched with each other to effectively condition the swollen sore throat patients, and clinical application verifies that the health-care food therapy can achieve the purpose of health-care food therapy, has obvious effect and good safety, does not have toxic or side effect, and is suitable for swollen sore throat symptoms.
Description
The application is a divisional application with application date of 31.12.2019, application number of 201911419210.3 and invention name of 'a compound composition for treating sore throat and preparation method thereof'.
Technical Field
The invention relates to the technical field of biological medicines, in particular to a compound composition for treating swollen sore throat and a preparation method and application thereof.
Background
Swollen and sore throat is one of the most common disease symptoms of people, and causes many reasons, such as cold, tonsillitis, improper diet, excessive use of throat and the like.
Swelling and pain in the throat can cause an acute disease, manifested as red swelling and pain in the throat, acute congestion, swelling and suppuration of tonsil, and dysphagia, aversion to cold and high fever in severe cases. The throat is the mouth of lung and stomach, and the pain of throat is caused by wind-fire and excessive phlegm obstructing the throat, deficiency-cold of lung and stomach or excessive heat of lung and stomach, and the disease condition is rapidly changed. The obstruction of qi and blood circulation can cause pain and the pain is not smooth. At present, a plurality of medicines for treating the swelling and pain in throat comprise western medicines and traditional Chinese medicines, the general treatment mainly comprises the western medicines, however, the western medicines treat the symptoms and the root causes, the antibacterial medicines are selected for treatment under the common condition, the swelling and pain in throat is caused to occur repeatedly, and the treatment effect is not ideal. Some traditional Chinese medicine treatments have slow response and time consumption, and the symptoms can not be quickly relieved, thereby influencing the use of patients. Therefore, the development of a safe and effective medicine is urgently needed to help patients get rid of pain and achieve the effect of rapidly treating both principal and secondary aspects of disease.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a compound composition for treating sore throat, which has good curative effect, high efficiency and no side effect, and a preparation method and application thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a compound composition for treating swollen sore throat is prepared from the following components in parts by weight:
further, the compound composition for treating sore throat is prepared from the following components in parts by weight:
preferably, the compound composition for treating sore throat comprises decoction or granules.
The preparation method of the compound composition for treating the sore throat comprises the following steps:
1) cutting the luffa stem, and collecting luffa stem juice flowing out of the luffa stem;
2) soaking bitter pomelo seed, herba Anoectochili Roxburghii, herba Portulacae, and Glycyrrhrizae radix in water for 20-30min, boiling, keeping boiling for 3-5min, steaming with slow fire for 35-45min, and steaming with strong fire for 4-6 min;
3) adding the luffa stem juice collected in the step 1), boiling and keeping boiling for 3-5min, and then steaming with slow fire for 15-20min to obtain decoction, namely the compound composition for treating sore throat.
In the step 2), the temperature of water for soaking is 25-30 ℃.
Further, the preparation method also comprises the step 4), the decoction is concentrated into concentrated paste, and then the concentrated paste is sprayed, granulated and dried to obtain the compound composition granules for treating the sore throat.
Preferably, the concentration step is to concentrate the decoction at 45-50 deg.C to relative density of 1.05-1.30g/cm3The concentrated paste of (1).
Preferably, the concentrated paste is subjected to fluidized bed spray granulation drying by using a multifunctional granulator, and the steps are as follows:
preheating equipment: placing and jacking the material bed, sealing the equipment, and starting a fan and a heater to preheat the equipment;
feeding: stopping when the temperature of the material bed reaches 55 ℃, putting down the material bed, adding maltodextrin 50-60% of the weight of the extract into the material bed, jacking the material bed, and sealing the equipment;
preheating materials: setting the air inlet temperature to be 55-65 ℃, the material temperature to be 60-65 ℃ and the fan frequency to be 10-15Hz, and starting the fan and the heater to heat the maltodextrin;
spray granulation: when the temperature of the materials reaches 60 ℃, setting the rotating speed of a peristaltic pump to be 35-45rpm, setting the pressure of a spray gun to be 0.1-0.15Mpa, spraying the concentrated paste, starting spraying, and starting granulation;
drying and discharging: and after the spray granulation is finished, drying to obtain the compound composition granules for treating the sore throat.
By adopting the technical scheme, the compound composition for treating the sore throat is prepared by taking 5-8 parts of bitter pomelo seeds, 0.8-1.5 parts of anoectochilus formosanus, 0.5-1 part of purslane, 1-2 parts of liquorice and 1-2 parts of luffa stem juice as raw materials and steaming. Clinical application verifies that the health-care food can achieve the purpose of food therapy, has obvious effect and good safety, does not have toxic or side effect, and is suitable for sore throat symptoms. All the raw materials of the invention are cheap and easily available, and the preparation method is simple and easy to implement and has low cost.
Detailed Description
A compound composition for treating swollen sore throat is prepared from the following components in parts by weight:
the preparation method of the compound composition for treating the sore throat comprises the following steps:
1) cutting the luffa stem, and collecting luffa stem juice flowing out of the luffa stem;
2) soaking bitter pomelo seed, herba Anoectochili Roxburghii, herba Portulacae, and Glycyrrhrizae radix in water of 25-30 deg.C for 20-30min, boiling, keeping boiling for 3-5min, steaming with slow fire for 35-45min, and steaming with strong fire for 4-6 min;
3) adding the luffa stem juice collected in the step 1), boiling and keeping boiling for 3-5min, and then steaming with slow fire for 15-20min to obtain decoction, namely the compound composition for treating sore throat.
Further, the preparation method further comprises step 4) of concentrating the decoction at 45-50 deg.C to relative density of 1.05-1.30g/cm3Is then usedThe spray granulation and drying of the fluidized bed are carried out by a multifunctional granulator, and the steps are as follows:
preheating equipment: placing and jacking the material bed, sealing the equipment, and starting a fan and a heater to preheat the equipment;
feeding: stopping when the temperature of the material bed reaches 55 ℃, putting down the material bed, adding maltodextrin 50-60% of the weight of the extract into the material bed, jacking the material bed, and sealing the equipment;
preheating materials: setting the air inlet temperature to be 55-65 ℃, the material temperature to be 60-65 ℃ and the fan frequency to be 10-15Hz, and starting the fan and the heater to heat the maltodextrin;
spray granulation: when the temperature of the materials reaches 60 ℃, setting the rotating speed of a peristaltic pump to be 35-45rpm, setting the pressure of a spray gun to be 0.1-0.15Mpa, spraying the concentrated paste, starting spraying, and starting granulation;
drying and discharging: and after the spray granulation is finished, drying to obtain the compound composition granules for treating the sore throat.
The present invention is further illustrated in detail with reference to the following specific examples:
example 1
A compound composition for treating swollen sore throat is prepared from the following components in parts by weight:
the preparation method comprises the following steps:
1) cutting the luffa stem, and collecting luffa stem juice flowing out of the luffa stem;
2) soaking bitter pomelo seed, herba Anoectochili Roxburghii, herba Portulacae, and Glycyrrhrizae radix in water of 25 deg.C for 30min, boiling, keeping boiling for 3min, steaming with slow fire for 45min, and steaming with strong fire for 4 min;
3) adding the luffa stem juice collected in the step 1), boiling and keeping boiling for 3min, and then steaming with slow fire for 20min to obtain a decoction, namely the compound composition for treating the sore throat.
Example 2
A compound composition for treating swollen sore throat is prepared from the following components in parts by weight:
the preparation method comprises the following steps:
1) cutting the luffa stem, and collecting luffa stem juice flowing out of the luffa stem;
2) soaking bitter pomelo seed, herba Anoectochili Roxburghii, herba Portulacae, and Glycyrrhrizae radix in water at 0 deg.C for 20min, boiling, keeping boiling for 5min, steaming with slow fire for 35min, and steaming with strong fire for 4 min;
3) adding the luffa stem juice collected in the step 1), boiling and keeping boiling for 5min, and then steaming with slow fire for 15min to obtain a decoction, namely the compound composition for treating the sore throat.
Example 3
A compound composition for treating swollen sore throat is prepared from the following components in parts by weight:
the preparation method comprises the following steps:
1) cutting the luffa stem, and collecting luffa stem juice flowing out of the luffa stem;
2) soaking bitter pomelo seed, herba Anoectochili Roxburghii, herba Portulacae, and Glycyrrhrizae radix in 28 deg.C water for 25min, boiling, keeping boiling for 4min, steaming with slow fire for 40min, and steaming with strong fire for 5 min;
3) adding the luffa stem juice collected in the step 1), boiling and keeping boiling for 4min, and then steaming for 18min with slow fire to obtain decoction, namely the compound composition for treating swollen sore throat.
Example 4
A compound composition for treating swollen sore throat is prepared from the following components in parts by weight:
the preparation method comprises the following steps:
1) cutting the luffa stem, and collecting luffa stem juice flowing out of the luffa stem;
2) soaking bitter pomelo seed, herba Anoectochili Roxburghii, herba Portulacae, and Glycyrrhrizae radix in 28 deg.C water for 25min, boiling, keeping boiling for 4min, steaming with slow fire for 40min, and steaming with strong fire for 5 min;
3) adding the luffa stem juice collected in the step 1), boiling and keeping boiling for 4min, and then steaming with slow fire for 18min to obtain a decoction;
4) concentrating the decoction at 45 deg.C to relative density of 1.05g/cm3Then adopting a multifunctional granulator to carry out fluidized bed spray granulation and drying, and comprising the following steps:
preheating equipment: placing and jacking the material bed, sealing the equipment, and starting a fan and a heater to preheat the equipment;
feeding: stopping when the temperature of the material bed reaches 55 ℃, putting down the material bed, adding maltodextrin 50-60% of the weight of the extract into the material bed, jacking the material bed, and sealing the equipment;
preheating materials: setting the air inlet temperature to be 55 ℃, the material temperature to be 60 ℃ and the fan frequency to be 10Hz, and starting the fan and the heater to heat the maltodextrin;
spray granulation: when the temperature of the materials reaches 60 ℃, setting the rotating speed of a peristaltic pump to be 35rpm, setting the pressure of a spray gun to be 0.1Mpa, spraying the concentrated paste, starting spraying, and starting granulation;
drying and discharging: and after the spray granulation is finished, drying to obtain the compound composition granules for treating the sore throat.
Example 5
A compound composition for treating swollen sore throat is prepared from the following components in parts by weight:
the preparation method comprises the following steps:
1) cutting the luffa stem, and collecting luffa stem juice flowing out of the luffa stem;
2) soaking bitter pomelo seed, herba Anoectochili Roxburghii, herba Portulacae, and Glycyrrhrizae radix in 28 deg.C water for 25min, boiling, keeping boiling for 4min, steaming with slow fire for 40min, and steaming with strong fire for 5 min;
3) adding the luffa stem juice collected in the step 1), boiling and keeping boiling for 4min, and then steaming with slow fire for 18min to obtain a decoction;
4) concentrating the decoction at 50 deg.C to relative density of 1.30g/cm3Then adopting a multifunctional granulator to carry out fluidized bed spray granulation and drying, and comprising the following steps:
preheating equipment: placing and jacking the material bed, sealing the equipment, and starting a fan and a heater to preheat the equipment;
feeding: stopping when the temperature of the material bed reaches 55 ℃, putting down the material bed, adding maltodextrin 50-60% of the weight of the extract into the material bed, jacking the material bed, and sealing the equipment;
preheating materials: setting the air inlet temperature to be 65 ℃, the material temperature to be 65 ℃ and the fan frequency to be 15Hz, and starting the fan and the heater to heat the maltodextrin;
spray granulation: when the temperature of the materials reaches 60 ℃, setting the rotating speed of a peristaltic pump to be 45rpm, setting the pressure of a spray gun to be 0.15Mpa, spraying the concentrated paste, starting spraying, and starting granulation;
drying and discharging: and after the spray granulation is finished, drying to obtain the compound composition granules for treating the sore throat.
Application example
The compound composition of the invention is used for conditioning patients with sore throat, and has obvious curative effect, and typical cases are as follows:
1. in a certain forest, women and 26 years old, the main symptoms are dry cough, excessive phlegm and throat swelling and pain discomfort, and the patients are cured after taking the compound composition of the embodiment 1 twice a day and three days;
2. old male, 50 years old, the main symptom is swelling and pain of throat, the compound composition of the embodiment 1 of the invention is taken twice a day, three days are taken, and the disease is cured;
3. the major symptoms of the male, 31 years old, of Zhou Zhi are swelling and pain in throat and hoarse voice, and the patient can be cured by taking the compound composition of the embodiment 1 twice a day and three days.
Although the present invention has been described in detail with reference to the above embodiments, it is only a part of the embodiments of the present invention, not all of the embodiments, and other embodiments can be obtained without inventive step according to the embodiments, and the embodiments are within the scope of the present invention.
Claims (8)
1. The application of the compound composition in preparing the medicine for treating the swelling and pain in throat is characterized in that the compound composition is prepared from the following components in parts by weight:
2. the use of claim 1, wherein the compound composition is prepared from the following components in parts by weight:
3. the use of claim 1 or 2, wherein the compound composition is in the form of decoction or granule.
4. A preparation method of a compound composition decoction is characterized by comprising the following steps: the method comprises the following steps:
cutting the luffa stem, and collecting luffa stem juice flowing out of the luffa stem;
soaking bitter pomelo seed, herba Anoectochili Roxburghii, herba Portulacae, and Glycyrrhrizae radix in water for 20-30min, boiling, keeping boiling for 3-5min, steaming with slow fire for 35-45min, steaming with strong fire for 4-6min, adding collected luffa stem juice, boiling, keeping boiling for 3-5min, and steaming with slow fire for 15-20min to obtain decoction;
the temperature of the soaking water is 25-30 ℃;
the compound composition is the compound composition in the application of claim 1 or 2.
5. A preparation method of compound composition granules is characterized in that: the method comprises the following steps:
cutting the luffa stem, and collecting luffa stem juice flowing out of the luffa stem;
soaking bitter pomelo seed, herba Anoectochili Roxburghii, herba Portulacae, and Glycyrrhrizae radix in water for 20-30min, boiling, keeping boiling for 3-5min, steaming with slow fire for 35-45min, steaming with strong fire for 4-6min, adding collected luffa stem juice, boiling, keeping boiling for 3-5min, and steaming with slow fire for 15-20min to obtain decoction;
concentrating the decoction into a concentrated paste, and then performing spray granulation and drying on the concentrated paste to obtain granules;
the temperature of the soaking water is 25-30 ℃;
the compound composition is the compound composition in the application of claim 1 or 2.
6. The method of claim 5, wherein: the concentration is carried out by concentrating the decoction at 45-50 deg.C to relative density of 1.05-1.30g/cm3The concentrated paste of (1).
7. The method of claim 6, wherein: the concentrated paste is subjected to fluidized bed spray granulation drying by adopting a multifunctional granulator, and the steps are as follows:
preheating equipment: placing and jacking the material bed, sealing the equipment, and starting a fan and a heater to preheat the equipment;
feeding: stopping when the temperature of the material bed reaches 55 ℃, putting down the material bed, adding maltodextrin 50-60% of the weight of the extract into the material bed, jacking the material bed, and sealing the equipment;
preheating materials: setting the air inlet temperature to be 55-65 ℃, the material temperature to be 60-65 ℃ and the fan frequency to be 10-15Hz, and starting the fan and the heater to heat the maltodextrin;
spray granulation: when the temperature of the materials reaches 60 ℃, setting the rotating speed of a peristaltic pump to be 35-45rpm, setting the pressure of a spray gun to be 0.1-0.15Mpa, spraying the concentrated paste, starting spraying, and starting granulation;
drying and discharging: and after the spray granulation is finished, drying to obtain the compound composition granules for treating the sore throat.
8. Decoction or granules of the compound composition obtained by the preparation method of claim 4 or 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111648700.8A CN114053368A (en) | 2019-12-31 | 2019-12-31 | Compound composition for treating swollen sore throat as well as preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111648700.8A CN114053368A (en) | 2019-12-31 | 2019-12-31 | Compound composition for treating swollen sore throat as well as preparation method and application thereof |
| CN201911419210.3A CN110934955A (en) | 2019-12-31 | 2019-12-31 | Compound composition for treating swollen sore throat and preparation method thereof |
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