CN114042022A - Anti-dropping composition, anti-dropping washing and protecting product and preparation method - Google Patents

Anti-dropping composition, anti-dropping washing and protecting product and preparation method Download PDF

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CN114042022A
CN114042022A CN202111356865.8A CN202111356865A CN114042022A CN 114042022 A CN114042022 A CN 114042022A CN 202111356865 A CN202111356865 A CN 202111356865A CN 114042022 A CN114042022 A CN 114042022A
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extract
composition
hair
hair loss
dropping
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刘刚儒
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Chuzhou Zhiwu Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755Gymnosperms [Coniferophyta]
    • A61K8/9767Pinaceae [Pine family], e.g. pine or cedar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/12Preparations containing hair conditioners
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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  • Animal Behavior & Ethology (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses an anti-hair-loss composition, an anti-hair-loss washing and protecting product and a preparation method thereof, and relates to the field of cosmetics. The method comprises the following raw materials: phyllanthus EMBLICA (Phyllanthus EMBLICA) fruit extract, Camellia sinensis (CAMELLIA SINENSIS) leaf extract, Stachylurus HIMALAICUS (Stachylurus) extract, Larix gmelinii (Larix EUROPAEA) wood extract, and Malus domestica (Limonia ACIDISSIMA) extract. According to the application, different anti-hair loss mechanisms are provided by the plant extracts, and meanwhile, the synergistic interaction is realized, the activity of hair follicle cells is activated, cells are promoted to secrete growth factors, the toxicity to the cells is low, and the excellent anti-hair loss and hair growth effects are achieved.

Description

Anti-dropping composition, anti-dropping washing and protecting product and preparation method
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-hair-loss composition, an anti-hair-loss washing and protecting product and a preparation method thereof.
Background
The hair is used as an important component of a human body, can protect the head and regulate the body temperature, and has an important modification effect on an appearance instrument of the human body. However, with the increasing severity of environmental pollution, suspended particle pollutants are present in the air more and more, and ultraviolet radiation is stronger and stronger, and the factors can damage hair to a certain extent, block pores, influence hair follicle cells and cause alopecia. Meanwhile, male seborrheic alopecia caused by male sex hormone is also a common alopecia inducing cause, so that sebum is excessively secreted to press hair roots, and alopecia is caused.
The existing anti-hair loss and hair-nourishing cosmetics contain more traditional Chinese medicine components, have multiple efficacies, weak pertinence, heavy smell, slow effect taking and insignificant anti-hair loss effect, and cannot effectively solve the problem of consumers.
Disclosure of Invention
The invention provides an anti-hair loss composition, an anti-hair loss washing and protecting product and a preparation method thereof, which are used for repairing hair follicle cells, improving hair follicle environment and improving anti-hair loss effect.
In order to solve the technical problems, the invention provides an anti-dropping composition, which comprises the following raw materials: phyllanthus EMBLICA (Phyllanthus EMBLICA) fruit extract, Camellia sinensis (CAMELLIA SINENSIS) leaf extract, Stachylurus HIMALAICUS (Stachylurus) extract, Larix gmelinii (Larix EUROPAEA) wood extract, and Malus domestica (Limonia ACIDISSIMA) extract.
By adopting the scheme, different anti-hair loss mechanisms are provided by the plant extracts, and meanwhile, the components are mutually synergistic to activate hair follicle cells, so that the toxicity to the hair follicle cells is low, the hair follicle cells are promoted to secrete growth factors, and the anti-hair loss and hair growth effects are excellent.
Preferably, the weight ratio of the emblic extract (PHYLLANTHUS EMBLICA) fruit extract, the tea (CAMELLIA SINENSIS) leaf extract, the Stachylurus HIMALAICUS extract, the Larix gmelini (Larix EUROPAEA) wood extract and the Malus domestica (Limonia acidisimia) extract is 4: 2: 1: 1: 2.
in order to solve the above technical problems, the present invention also provides a use of the anti-hair loss composition in a hair washing product or a hair care product.
In order to solve the technical problems, the invention also provides an anti-falling washing and protecting product which comprises the anti-falling composition with the mass fraction of 11.25-18.75 wt% and the balance of base materials.
By adopting the scheme, the addition amount of the anti-hair loss composition in the washing and protecting product is controlled within the range of 11.25-18.75 wt%, so that the toxicity to hair follicle cells can be reduced, the activity of the hair follicle cells can be stimulated, and the anti-hair loss effect can be provided.
Preferably, the addition amount of the anti-dropping composition is 11.25 wt%.
Preferably, the composition comprises 11.25 wt% -18.75 wt% of the anti-dropping composition, 0.3 wt% -0.6 wt% of pyridoxine hydrochloride and the balance of base materials.
The preferable scheme comprises the following raw material components:
polyol: 3 to 8 weight percent;
oil: 5-12 wt%;
pyridoxine hydrochloride salt: 0.3 wt% -0.6 wt%;
oligopeptide-2: 1 wt% -3 wt%;
surfactant (b): 1 wt% -3 wt%;
the anti-dropping composition comprises: 11.25 wt% -18.75 wt%;
water: and (4) the balance.
Preferably, the oil comprises glycerin and PEG-40 hydrogenated castor oil, the surfactant is arginine/lysine polypeptide, and the polyol is propylene glycol.
Preferably, the base stock comprises the following raw material components:
propylene glycol: 5 wt;
glycerol: 5 wt;
PEG-40 hydrogenated castor oil: 2 wt;
pyridoxine hydrochloride salt: 0.5 wt;
oligopeptide-2: 1.5 wt;
arginine/lysine polypeptide: 1.5 wt;
the anti-dropping composition comprises: 11.25 wt%;
water: 73.25 wt%.
In order to solve the technical problems, the fourth object of the invention is to provide a preparation method of an anti-drop washing and protecting product, which comprises the following steps: adding water, glycerol, PEG-40 hydrogenated castor oil, arginine/lysine polypeptide and the anti-dropping composition into a container, and uniformly stirring; sequentially adding propylene glycol, pyridoxine hydrochloride and oligopeptide-2 into a container, and uniformly stirring; filtering and discharging to obtain the anti-drop washing protective product.
Compared with the prior art, the embodiment of the invention has the following beneficial effects:
according to the application, different anti-hair loss mechanisms are provided by the plant extracts, and meanwhile, the components are mutually synergistic to activate hair follicle cells, so that the toxicity to the hair follicle cells is low, the hair follicle cells are promoted to secrete growth factors, and the anti-hair loss and hair growth effects are excellent.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The present application provides an anti-hair loss composition comprising an extract of fruit of emblic leafflower (Phyllanthus EMBLICA), an extract of leaf of tea (CAMELLIA SINENSIS), an extract of Stachyrus HIMALAICUS, an extract of Larix gmelinii (Larix gmeiroaea) wood and an extract of Malus domestica.
In one embodiment, the weight ratio of the extract of emblic leafflower (PHYLLANTHUS EMBLICA) fruit, the extract of tea (CAMELLIA SINENSIS) leaf, the extract of Stachylurus HIMALAICUS, the extract of Larix EUROPAEA (Larix EUROPAEA) wood and the extract of Malus domestica (Limonia ACIDISIA) is 4: 2: 1: 1: 2.
the application also provides an anti-falling washing and protecting product, which comprises the anti-falling composition with the mass fraction of 11.25 wt% -18.75 wt% and the balance of base materials, wherein the addition amount of the anti-falling composition is preferably 11.25 wt%.
In one embodiment, the anti-desquamation care product comprises 11.25 wt% to 18.75 wt% of the anti-desquamation composition, 0.3 wt% to 0.6 wt% pyridoxine hydrochloride, and the balance a base.
In one embodiment, the anti-rinse off care product comprises a polyol: 3 to 8 weight percent; oil: 5-12 wt%; pyridoxine hydrochloride salt: 0.3 wt% -0.6 wt%; oligopeptide-2: 1 wt% -3 wt%; surfactant (b): 1 wt% -3 wt%; the anti-dropping composition comprises: 11.25 wt% -18.75 wt%; water: and (4) the balance.
In one embodiment, the oil may be glycerin and/or PEG-40 hydrogenated castor oil.
In one embodiment, the surfactant may be an arginine/lysine polypeptide.
In one embodiment, the polyol may be propylene glycol.
In one embodiment, the preparation method of the anti-falling washing and protecting product comprises the following steps: adding water, glycerol, PEG-40 hydrogenated castor oil, arginine/lysine polypeptide and the anti-dropping composition into a container, and uniformly stirring; sequentially adding propylene glycol, pyridoxine hydrochloride and oligopeptide-2 into a container, and uniformly stirring; filtering and discharging to obtain the anti-drop washing protective product.
This application provides multiple anticreep mechanism through different plant extracts, and each component synergy promotes fibrin's growth, activates the activity of hair follicle cell, and the stimulation hair follicle cell secretes growth factor simultaneously to promote to grow, it is lower to hair follicle cytotoxicity, play excellent anticreep effect. The following description is given with reference to specific examples to illustrate the practical effects of the present disclosure.
Example one
An anti-drop washing and protecting product specifically comprises the following raw materials: 3 wt% propylene glycol, 3 wt% glycerol, 2 wt% PEG-40 hydrogenated castor oil, 0.3 wt% pyridoxine hydrochloride, 1 wt% oligopeptide-2, 1 wt% arginine/lysine polypeptide, 11.25 wt% anti-shedding composition and 78.45 wt% water, the anti-shedding composition comprising, by mass, 4: 2: 1: 1: 2 (Phyllanthus EMBLICA) fruit extract, tea (CAMELLIA SINENSIS) leaf extract, Stachyurus HIMALAICUS (Stachyurus HIMALAICUS) extract, Larix gmelinii (Larix EUROPAEA) wood extract, and Malus domestica (Limonia acidisimia) extract.
Example two
An anti-drop washing and protecting product specifically comprises the following raw materials: 8 wt% of propylene glycol, 7 wt% of glycerol, 5 wt% of PEG-40 hydrogenated castor oil, 0.6 wt% of pyridoxine hydrochloride, 3 wt% of oligopeptide-2, 3 wt% of arginine/lysine polypeptide, 11.25 wt% of an anti-shedding composition and 62.15 wt% of water, wherein the anti-shedding composition comprises 4: 2: 1: 1: 2 (Phyllanthus EMBLICA) fruit extract, tea (CAMELLIA SINENSIS) leaf extract, Stachyurus HIMALAICUS (Stachyurus HIMALAICUS) extract, Larix gmelinii (Larix EUROPAEA) wood extract, and Malus domestica (Limonia acidisimia) extract.
EXAMPLE III
An anti-drop washing and protecting product specifically comprises the following raw materials: 5 wt% propylene glycol, 5 wt% glycerol, 2 wt% PEG-40 hydrogenated castor oil, 0.5 wt% pyridoxine hydrochloride, 1.5 wt% oligopeptide-2, 1.5 wt% arginine/lysine polypeptide, 11.25 wt% anti-shedding composition and 73.25 wt% water, the anti-shedding composition comprising, by mass, 4: 2: 1: 1: 2 (Phyllanthus EMBLICA) fruit extract, tea (CAMELLIA SINENSIS) leaf extract, Stachyurus HIMALAICUS (Stachyurus HIMALAICUS) extract, Larix gmelinii (Larix EUROPAEA) wood extract, and Malus domestica (Limonia acidisimia) extract.
Example four
An anti-peeling and washing-off protective product, each step and the reagents used in each step were the same as in example 3 except that the anti-peeling composition was added in an amount of 13.125 wt% and water was added in an amount of 71.375 wt%.
EXAMPLE five
An anti-peeling and washing-off protective product, each step and the reagent used in each step were the same as in example 3 except that the anti-peeling composition was added in an amount of 15 wt% and water was added in an amount of 69.5 wt%.
EXAMPLE six
An anti-run-off cleansing care product was obtained in the same manner as in example 3 except that the anti-run-off composition was added in an amount of 16.875 wt% and water was added in an amount of 67.625 wt%.
EXAMPLE seven
An anti-peeling and washing-off protective product, each step and the reagent used in each step were the same as in example 3 except that the anti-peeling composition was added in an amount of 18.75 wt% and water was added in an amount of 65.75 wt%.
Example eight
An anti-run-off cleansing care product, each step and the reagent used in each step were the same as in example 3, except that the anti-run-off composition comprised, by mass, 2: 3: 2: 1: 3 (Phyllanthus EMBLICA) fruit extract, tea (CAMELLIA SINENSIS) leaf extract, Stachyurus HIMALAICUS (Stachyurus HIMALAICUS) extract, Larix gmelinii (Larix EUROPAEA) wood extract, and Malus domestica (Limonia acumisiana) extract.
Comparative example 1
An anti-run wash-off care product, each step and the reagents used in each step were the same as in example 3 except that the anti-run-off composition was replaced with water.
Comparative example No. two
An anti-peeling and washing-off protective product, each step and the reagents used in each step were the same as in example 3 except that the anti-peeling composition was added in an amount of 9.375 wt% and water was added in an amount of 75.125 wt%.
Comparative example No. three
An anti-peeling and washing-off protective product, each step and the reagents used in each step were the same as in example 3 except that the anti-peeling composition was added in an amount of 20.625 wt% and water was added in an amount of 63.875 wt%.
Comparative example No. four
An anti-peeling and washing-off protective product, each step and the reagents used in each step were the same as in example 3 except that the anti-peeling composition was added in an amount of 22.5 wt% and water was added in an amount of 62 wt%.
Comparative example five
An anti-run-off cleansing care product, each step and the reagent used in each step were the same as in example 3, except that the anti-run-off composition comprised, by mass, 2: 1: 1: 2, extract of leaf of tea (CAMELLIA SINENSIS), extract of Stachyurus HIMALAICUS (Stachyurus HIMALAICUS), extract of larch (Larix EUROPAEA) wood, and extract of Malus domestica (Limonia acissima).
Comparative example six
An anti-run-off cleansing care product, each step and the reagent used in each step were the same as in example 3, except that the anti-run-off composition comprised a mixture of 4: 1: 1: 2 (Phyllanthus EMBLICA) fruit extract, Stachyurus HIMALAICUS (Stachyurus HIMALAICUS) extract, Larix gmelinii (Larix EUROPAEA) wood extract, and Malus domestica (Limonia acumisia) extract.
Comparative example seven
An anti-run-off cleansing care product, each step and the reagent used in each step were the same as in example 3, except that the anti-run-off composition comprised a mixture of 4: 2: 1: 2 (Phyllanthus EMBLICA) fruit extract, tea (CAMELLIA SINENSIS) leaf extract, larch (LARIX EUROPAEA) wood extract, and apple (LIMONIA acissima) extract.
Comparative example eight
An anti-run-off cleansing care product, each step and the reagent used in each step were the same as in example 3, except that the anti-run-off composition comprised a mixture of 4: 2: 1: 2 (Phyllanthus EMBLICA) fruit extract, tea (CAMELLIA SINENSIS) leaf extract, Stachyrus HIMALAICUS (Stachyurus HIMALAICUS) extract, and Malus domestica (Limonia acidisimia) extract.
Comparative example No. nine
An anti-run-off cleansing care product, each step and the reagent used in each step were the same as in example 3, except that the anti-run-off composition comprised a mixture of 4: 2: 1: 1 extract of fruit of emblic leafflower (Phyllanthus EMBLICA), extract of leaf of tea (CAMELLIA SINENSIS), extract of Stachyrus HIMALAICUS, and extract of larch (LARIX EUROPAEA) wood.
Comparative example ten
An anti-desludging care product was prepared in the same manner as in example 3 except that pyridoxine hydrochloride was replaced with water.
The preparation method of the above anti-peeling wash-off protection products of examples 1 to 8 and comparative examples 1 to 10 comprises the following steps:
1) accurately weighing required raw materials according to production batches;
2) adding water, glycerol, PEG-40 hydrogenated castor oil, arginine/lysine polypeptide and the anti-dropping composition into an emulsifying pot at normal temperature, starting stirring, and stirring at 25rpm for 10 min;
3) sequentially adding propylene glycol, pyridoxine hydrochloride and oligopeptide-2 into an emulsifying pot, mixing, stirring at 25rpm for 15-20min, and observing complete and uniform dissolution of the material body;
4) after stirring and dissolving uniformly, stopping stirring, standing, performing appearance, pH value detection and other tests on the material body, and filtering and discharging the material body by using clean 200-mesh filter cloth to obtain an anti-drop washing protective product;
5) filling, packaging finished products, and inspecting and warehousing.
Comparative example eleven
An anti-drop washing and protecting product comprises 11.25 wt% of an anti-drop composition and 88.75 wt% of water, wherein the anti-drop composition comprises 4: 2: 1: 1: 2 (Phyllanthus EMBLICA) fruit extract, tea (CAMELLIA SINENSIS) leaf extract, Stachyurus HIMALAICUS (Stachyurus HIMALAICUS) extract, Larix gmelinii (Larix EUROPAEA) wood extract, and Malus domestica (Limonia acidisimia) extract.
Performance test
1. Anti-drop function detection
1) Detecting a sample: examples 1 to 8 and comparative examples 1 to 11;
2) detection indexes are as follows: a VEGF growth factor;
3) detecting the required materials: human dermal papilla cells (obtained by Cell subculture of boxi, guangdong), mesechial Stem Cell Medium (ScienCell), PBS (solibao), mtt (Sigma), dmso (Sigma), minoxidil (alatin), dihydrotestosterone (Sigma), Human VEGF ELISA kit (Abcam);
4) the detection method comprises the following steps:
A. inoculation: inoculating cells into 6-well plate at inoculation density of 3 × 105 cells/well, and culturingCase (37 ℃, 5% CO)2) And incubated overnight.
B. Preparing liquid: the test article working solution was prepared according to the experimental design shown in table 1.
TABLE 1 Experimental design
Figure BDA0003357804050000081
C. Administration: according to the experimental design shown in Table 1, when the cell plating rate in the 6-well plate reaches 40% -60%, the administration amount is 2mL per well, each group is provided with 3 multiple wells, and the incubator (37 ℃, 5% CO)2) Performing medium incubation for 24 h;
D. collecting cell supernatant: culturing for 24h, collecting cell culture supernatant in EP tube, detecting secretion content of growth factor (VEGF) after collection, and freezing and storing the sample in-80 deg.C refrigerator;
E. and (3) detection of VEGF content: detection analysis is carried out according to the operation instruction of the kit, GraphPad Prism Program software is used for drawing, a t-test method is adopted for statistical analysis, and the detection results are shown in Table 2.
TABLE 2 VEGF content assay results
Figure BDA0003357804050000091
Figure BDA0003357804050000101
2. Cell viability assay
The products obtained in examples 1 to 8 and comparative examples 1 to 11 were subjected to MMT method based on dermal papilla cells to detect the relative viability value (%) of cells, criterion for cytotoxicity determination: the relative viability value of the cells is more than 90%, which is the safe concentration, and the detection results are shown in Table 3.
TABLE 3 cell viability assay results
Figure BDA0003357804050000102
Figure BDA0003357804050000111
Combining the results of example 3 and comparative examples 1 and 5 to 9 in tables 2 to 3, it can be seen that the extract of emblic leafflower fruit (PHYLLANTHUS EMBLICA), the extract of tea leaf (CAMELLIA SINENSIS), the extract of praecox ribbon (stachyrus HIMALAICUS), the extract of larch (LARIX EUROPAEA) wood and the extract of apple (LIMONIA acidisissima) in the present application provide multiple anti-alopecia mechanisms, and the components synergize, and can promote the secretion of growth factors by hair follicle cells, have low toxicity to hair follicle cells, promote the activity of hair follicle cells, and provide excellent anti-alopecia and hair growth promoting functions.
Combining the test results of examples 3-7 and comparative examples 2-4 in tables 2-3, it can be seen that by controlling the addition amount of the anti-hair loss composition in the wash care product to be in the range of 11.25 wt% to 18.75 wt%, toxicity to hair follicle cells can be reduced, thereby stimulating the activity of hair follicle cells and providing anti-hair loss effect.
The results of the tests in examples 3 and comparative examples 10 to 11 in tables 2 to 3 show that the anti-hair loss composition has good compatibility with the base material components in the anti-hair loss washing and protecting product, and the anti-hair loss effect is improved by promoting the fusion of the anti-hair loss composition by using pyridoxine hydrochloride.
The above-mentioned embodiments are provided to further explain the objects, technical solutions and advantages of the present invention in detail, and it should be understood that the above-mentioned embodiments are only examples of the present invention and are not intended to limit the scope of the present invention. It should be understood that any modifications, equivalents, improvements and the like, which come within the spirit and principle of the invention, may occur to those skilled in the art and are intended to be included within the scope of the invention.

Claims (10)

1. The anti-dropping composition is characterized by comprising the following raw materials: phyllanthus EMBLICA (Phyllanthus EMBLICA) fruit extract, Camellia sinensis (CAMELLIA SINENSIS) leaf extract, Stachylurus HIMALAICUS (Stachylurus) extract, Larix gmelinii (Larix EUROPAEA) wood extract, and Malus domestica (Limonia ACIDISSIMA) extract.
2. The anti-hair loss composition according to claim 1, wherein the weight ratio of the emblic leafflower fruit (PHYLLANTHUS EMBLICA) extract, the tea (CAMELLIA SINENSIS) leaf extract, the praecox hispanicus (STACHYURUS HIMALAICUS) extract, the larch (LARIX EUROPAEA) wood extract and the apple (LIMONIA acidisimia) extract is 4: 2: 1: 1: 2.
3. use of the anti-hair loss composition according to claim 1 or 2 in a hair washing or hair care product.
4. An anti-shedding wash-and-care product, characterized in that the anti-shedding composition as claimed in claim 1 or 2 is adopted, and comprises the anti-shedding composition with the mass fraction of 11.25-18.75 wt% and the balance of base materials.
5. The anti-hair loss wash care product of claim 4, wherein the anti-hair loss composition is added in an amount of 11.25 wt%.
6. The anti-hair loss rinse-off product of claim 4 comprising from 11.25% to 18.75% by weight of said anti-hair loss composition, from 0.3% to 0.6% by weight pyridoxine hydrochloride, and the balance a base.
7. The anti-falling wash-off protection product according to claim 4, characterized by comprising the following raw material components:
polyol: 3 to 8 weight percent;
oil: 5-12 wt%;
pyridoxine hydrochloride salt: 0.3 wt% -0.6 wt%;
oligopeptide-2: 1 wt% -3 wt%;
surfactant (b): 1 wt% -3 wt%;
the anti-dropping composition comprises: 11.25 wt% -18.75 wt%;
water: and (4) the balance.
8. The anti-desquamation care product of claim 7, wherein said oil comprises glycerin and PEG-40 hydrogenated castor oil, said surfactant is arginine/lysine polypeptide, and said polyhydric alcohol is propylene glycol.
9. The anti-falling wash-off protection product according to claim 8, wherein the base comprises the following raw material components:
propylene glycol: 5 wt;
glycerol: 5 wt;
PEG-40 hydrogenated castor oil: 2 wt;
pyridoxine hydrochloride salt: 0.5 wt;
oligopeptide-2: 1.5 wt;
arginine/lysine polypeptide: 1.5 wt;
the anti-dropping composition comprises: 11.25 wt%;
water: 73.25 wt%.
10. A process for the preparation of a leave-on rinse-off protection product according to claim 8 or 9, comprising the steps of: adding water, glycerol, PEG-40 hydrogenated castor oil, arginine/lysine polypeptide and the anti-dropping composition into a container, and uniformly stirring; sequentially adding propylene glycol, pyridoxine hydrochloride and oligopeptide-2 into a container, and uniformly stirring; filtering and discharging to obtain the anti-drop washing protective product.
CN202111356865.8A 2021-11-16 2021-11-16 Anti-dropping composition, anti-dropping washing and protecting product and preparation method Pending CN114042022A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107296769A (en) * 2017-07-28 2017-10-27 伽蓝(集团)股份有限公司 Ancient type of banner hoisted on a featherdecked mast section flower extract and its application
CN110731922A (en) * 2019-07-30 2020-01-31 浙江养生堂天然药物研究所有限公司 Enhanced hair loss prevention and hair growth promoting composition
CN111228175A (en) * 2020-02-26 2020-06-05 苏州工业园区黛宜菲化妆品有限公司 A composition derived from plant for preventing alopecia and/or promoting hair growth
CN113318043A (en) * 2021-05-21 2021-08-31 广州市涵美化妆品有限公司 Essence with effects of fixing hair and growing hair and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107296769A (en) * 2017-07-28 2017-10-27 伽蓝(集团)股份有限公司 Ancient type of banner hoisted on a featherdecked mast section flower extract and its application
CN110731922A (en) * 2019-07-30 2020-01-31 浙江养生堂天然药物研究所有限公司 Enhanced hair loss prevention and hair growth promoting composition
CN111228175A (en) * 2020-02-26 2020-06-05 苏州工业园区黛宜菲化妆品有限公司 A composition derived from plant for preventing alopecia and/or promoting hair growth
CN113318043A (en) * 2021-05-21 2021-08-31 广州市涵美化妆品有限公司 Essence with effects of fixing hair and growing hair and preparation method thereof

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