CN114040800B - 杀伤细胞凝集素样受体亚家族g成员1(klrg1)耗竭抗体 - Google Patents

杀伤细胞凝集素样受体亚家族g成员1(klrg1)耗竭抗体 Download PDF

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CN114040800B
CN114040800B CN202080036935.9A CN202080036935A CN114040800B CN 114040800 B CN114040800 B CN 114040800B CN 202080036935 A CN202080036935 A CN 202080036935A CN 114040800 B CN114040800 B CN 114040800B
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seq
antibody
ser
fragment
klrg1
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CN114040800A (zh
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斯蒂芬诺·文森索·古洛
肯尼斯·埃文·汤普森
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Apoco Ltd
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Apoco Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202080036935.9A 2019-04-09 2020-04-09 杀伤细胞凝集素样受体亚家族g成员1(klrg1)耗竭抗体 Active CN114040800B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962831713P 2019-04-09 2019-04-09
US62/831713 2019-04-09
PCT/US2020/027498 WO2020210512A1 (en) 2019-04-09 2020-04-09 Killer cell lectin-like receptor subfamily g member 1 (klrg1) depleting antibodies

Publications (2)

Publication Number Publication Date
CN114040800A CN114040800A (zh) 2022-02-11
CN114040800B true CN114040800B (zh) 2024-09-20

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Country Status (13)

Country Link
US (3) US11180561B2 (https=)
EP (1) EP3952999A4 (https=)
JP (1) JP7560476B2 (https=)
KR (1) KR20210150506A (https=)
CN (1) CN114040800B (https=)
AU (1) AU2020272939A1 (https=)
BR (1) BR112021019128A2 (https=)
CA (1) CA3136625A1 (https=)
IL (1) IL287044A (https=)
MX (1) MX2021012171A (https=)
SG (1) SG11202110610VA (https=)
WO (1) WO2020210512A1 (https=)
ZA (1) ZA202107414B (https=)

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WO2020060781A1 (en) 2018-09-17 2020-03-26 Abcuro, Inc. Anti-klrg1 antibodies
WO2022056289A1 (en) * 2020-09-11 2022-03-17 National Jewish Health Methods and compositions for treating respiratory diseases or conditions related to innate lymphoid cells
AU2022246164A1 (en) * 2021-03-26 2023-09-28 The Brigham And Women’S Hospital, Inc. Anti-klrg1 antibodies
WO2022204529A1 (en) * 2021-03-26 2022-09-29 Abcuro, Inc. Anti-klrg1 antibodies
MX2024001277A (es) * 2021-07-26 2024-02-15 Abcuro Inc Anticuerpos agotadores del miembro 1 de la subfamilia g del receptor tipo lectina de celulas asesinas (klrg1).
WO2024072872A2 (en) * 2022-09-27 2024-04-04 The Brigham And Women's Hospital, Inc. Klrg1 signalling therapy for infectious disease
WO2025147544A1 (en) 2024-01-02 2025-07-10 Abcuro, Inc. Methods of treating inclusion body myositis (ibm)
WO2026072990A1 (en) 2024-09-27 2026-04-02 Abcuro, Inc. Methods of treating t-cell large granular lymphocytic leukemia

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Publication number Publication date
WO2020210512A1 (en) 2020-10-15
US20220089747A1 (en) 2022-03-24
EP3952999A4 (en) 2023-01-25
US20250101114A1 (en) 2025-03-27
BR112021019128A2 (pt) 2022-01-04
CN114040800A (zh) 2022-02-11
JP7560476B2 (ja) 2024-10-02
JP2022528721A (ja) 2022-06-15
MX2021012171A (es) 2021-12-10
KR20210150506A (ko) 2021-12-10
WO2020210512A9 (en) 2020-11-19
AU2020272939A1 (en) 2021-11-11
IL287044A (en) 2021-12-01
AU2020272939A8 (en) 2021-12-02
EP3952999A1 (en) 2022-02-16
US11180561B2 (en) 2021-11-23
US20200325233A1 (en) 2020-10-15
CA3136625A1 (en) 2020-10-15
SG11202110610VA (en) 2021-10-28
ZA202107414B (en) 2023-02-22
US12139541B2 (en) 2024-11-12

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