AU2020272939A1 - Killer cell lectin-like receptor subfamily G member 1 (KLRG1) depleting antibodies - Google Patents

Killer cell lectin-like receptor subfamily G member 1 (KLRG1) depleting antibodies Download PDF

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Publication number
AU2020272939A1
AU2020272939A1 AU2020272939A AU2020272939A AU2020272939A1 AU 2020272939 A1 AU2020272939 A1 AU 2020272939A1 AU 2020272939 A AU2020272939 A AU 2020272939A AU 2020272939 A AU2020272939 A AU 2020272939A AU 2020272939 A1 AU2020272939 A1 AU 2020272939A1
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AU
Australia
Prior art keywords
seq
fragment
antibody
cells
klrg1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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AU2020272939A
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English (en)
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AU2020272939A8 (en
Inventor
Stefano Vincenzo Gulla
Evan Kenneth Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abcuro Inc
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Abcuro Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abcuro Inc filed Critical Abcuro Inc
Publication of AU2020272939A1 publication Critical patent/AU2020272939A1/en
Publication of AU2020272939A8 publication Critical patent/AU2020272939A8/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2020272939A 2019-04-09 2020-04-09 Killer cell lectin-like receptor subfamily G member 1 (KLRG1) depleting antibodies Pending AU2020272939A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962831713P 2019-04-09 2019-04-09
US62/831,713 2019-04-09
PCT/US2020/027498 WO2020210512A1 (en) 2019-04-09 2020-04-09 Killer cell lectin-like receptor subfamily g member 1 (klrg1) depleting antibodies

Publications (2)

Publication Number Publication Date
AU2020272939A1 true AU2020272939A1 (en) 2021-11-11
AU2020272939A8 AU2020272939A8 (en) 2021-12-02

Family

ID=72748720

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020272939A Pending AU2020272939A1 (en) 2019-04-09 2020-04-09 Killer cell lectin-like receptor subfamily G member 1 (KLRG1) depleting antibodies

Country Status (13)

Country Link
US (3) US11180561B2 (https=)
EP (1) EP3952999A4 (https=)
JP (1) JP7560476B2 (https=)
KR (1) KR20210150506A (https=)
CN (1) CN114040800B (https=)
AU (1) AU2020272939A1 (https=)
BR (1) BR112021019128A2 (https=)
CA (1) CA3136625A1 (https=)
IL (1) IL287044A (https=)
MX (1) MX2021012171A (https=)
SG (1) SG11202110610VA (https=)
WO (1) WO2020210512A1 (https=)
ZA (1) ZA202107414B (https=)

Families Citing this family (8)

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WO2020060781A1 (en) 2018-09-17 2020-03-26 Abcuro, Inc. Anti-klrg1 antibodies
WO2022056289A1 (en) * 2020-09-11 2022-03-17 National Jewish Health Methods and compositions for treating respiratory diseases or conditions related to innate lymphoid cells
AU2022246164A1 (en) * 2021-03-26 2023-09-28 The Brigham And Women’S Hospital, Inc. Anti-klrg1 antibodies
WO2022204529A1 (en) * 2021-03-26 2022-09-29 Abcuro, Inc. Anti-klrg1 antibodies
MX2024001277A (es) * 2021-07-26 2024-02-15 Abcuro Inc Anticuerpos agotadores del miembro 1 de la subfamilia g del receptor tipo lectina de celulas asesinas (klrg1).
WO2024072872A2 (en) * 2022-09-27 2024-04-04 The Brigham And Women's Hospital, Inc. Klrg1 signalling therapy for infectious disease
WO2025147544A1 (en) 2024-01-02 2025-07-10 Abcuro, Inc. Methods of treating inclusion body myositis (ibm)
WO2026072990A1 (en) 2024-09-27 2026-04-02 Abcuro, Inc. Methods of treating t-cell large granular lymphocytic leukemia

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Also Published As

Publication number Publication date
WO2020210512A1 (en) 2020-10-15
US20220089747A1 (en) 2022-03-24
EP3952999A4 (en) 2023-01-25
US20250101114A1 (en) 2025-03-27
BR112021019128A2 (pt) 2022-01-04
CN114040800A (zh) 2022-02-11
JP7560476B2 (ja) 2024-10-02
JP2022528721A (ja) 2022-06-15
MX2021012171A (es) 2021-12-10
KR20210150506A (ko) 2021-12-10
WO2020210512A9 (en) 2020-11-19
IL287044A (en) 2021-12-01
AU2020272939A8 (en) 2021-12-02
EP3952999A1 (en) 2022-02-16
US11180561B2 (en) 2021-11-23
US20200325233A1 (en) 2020-10-15
CN114040800B (zh) 2024-09-20
CA3136625A1 (en) 2020-10-15
SG11202110610VA (en) 2021-10-28
ZA202107414B (en) 2023-02-22
US12139541B2 (en) 2024-11-12

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Free format text: IN VOL 35 , NO 45 , PAGE(S) 8789 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME ABCURO, INC., APPLICATION NO. 2020272939, UNDER INID (54) CORRECT THE TITLE TO READ KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY G MEMBER 1 (KLRG1) DEPLETING ANTIBODIES