CN114028443A - 一种对抗幽门螺旋杆菌的组合物及一体化解决方案 - Google Patents
一种对抗幽门螺旋杆菌的组合物及一体化解决方案 Download PDFInfo
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Abstract
本发明属于药物制剂技术领域,更具体的涉及一种对抗幽门螺旋杆菌的组合物及一体化解决方案。一种对抗幽门螺旋杆菌的组合物,制备原料包括乳香提取物、蜂胶提取物、青蒿提取物、罗伊氏乳杆菌、皱波角叉菜提取物、乳香提取物、厚朴树皮提取物、蒲公英提取物、香茅草提取物、洋甘菊提取物、西兰花粉、银耳多糖、西兰花种子水提物、丁香粉、汉麻籽油、南瓜籽油中的至少一种。经本发明提供的对抗幽门螺旋杆菌组合物及一体化解决方案通过对口腔、咽部、食道和胃部的一体化治疗,达到全方位祛除细菌的效果,较单独胃部治疗的方式具有更好的根除效果。
Description
技术领域
本发明属于药物制剂技术领域,更具体的涉及一种对抗幽门螺旋杆菌的组合物及一体化解决方案。
背景技术
幽门螺旋杆菌,是一种螺旋状、对生长条件的要求十分苛刻的细菌。如大家熟知的,幽门螺旋杆菌的不良预后是胃癌,虽然常见的发病部位是胃部,但是口腔、咽部、食道、胃部均是幽门螺旋杆菌可能存在的部位。
现阶段医院对于幽门螺旋杆菌的治疗方式多通过抗生素进行治疗,但是抗生素再治疗过程中可能出现细菌的耐药性,增加患者对抗生素的依赖或者大量服用药物治疗效果不佳,增加患者的负担;另外,抗生素治疗还会导致神经精神系统出现损伤,出现抑郁、精神异常;或者出现肝功能异常、肾功能异常等副作用,对患者产生更大程度的伤害。
面对现阶段抗生素使用存在的弊端和幽门螺旋杆菌日渐增多的情况,研发一种全方位、一体化解决幽门螺旋杆菌困扰的方案成为现阶段亟待解决的重要难题。
发明内容
为了解决上述技术问题,本发明的第一方面提供了一种对抗幽门螺旋杆菌的组合物,制备原料包括乳香提取物、蜂胶提取物、青蒿提取物、罗伊氏乳杆菌、皱波角叉菜提取物、乳香提取物、厚朴树皮提取物、蒲公英提取物、香茅草提取物、洋甘菊提取物、西兰花粉、银耳多糖、西兰花种子水提物、丁香粉、汉麻籽油、南瓜籽油中的至少一种。
本发明的第二方面提供了一种对抗幽门螺旋杆菌的组合物的应用,用于口部、咽部、食道、胃肠部幽门螺旋杆菌的治疗。
本发明的第三方面提供了一种对抗幽门螺旋杆菌的组合物的使用方式,包括牙膏、口腔喷剂、药丸、片剂和粉剂;所述的牙膏包括成人牙膏和儿童牙膏。
作为一种优选的技术方案,所述的成人牙膏的制备原料按重量份计,包括:1-8份乳香提取物、1-8份蜂胶提取物、1-8份青蒿提取物、1-5份罗伊氏乳杆菌;优选的,制备原料按重量份计还包括:50-65份山梨糖醇、1-5份水、10-20份水合硅石、1-5份聚乙二醇-8、15-20份甘油、1-5份月桂酰肌氨酸钠、1-3份纤维素胶、1-3份黄原胶、0.001-0.003份食用香精、0.1-1份薄荷脑、2-5份乙酰磺胺酸钾、0.5-2份苯甲酸钠、1-5份云母。
作为一种优选的技术方案,所述的儿童牙膏的制备原料按重量份计,包括:1-8份皱波角叉菜提取物、1-8份花椰菜提取物、1-8份乳香提取物、1-5份罗伊氏乳杆菌、0.001-0.005份氟化钠;优选的,制备原料按重量份计,还包括:50-65份山梨糖醇、1-5份水、10-20份水合硅石、1-5份聚乙二醇-8、15-20份甘油、1-5份月桂酰肌氨酸钠、1-6份黄原胶、0.001-0.005份食用香精、5-10份木糖醇、2-5份乙酰磺胺酸钾、5-10份半乳糖、1-3份苯甲酸钠。
作为一种优选的技术方案,所述的口腔喷剂的制备原料按重量份计,包括:2-10份厚朴树皮提取物、2-10份蒲公英提取物、2-10份香茅草提取物、2-10份洋甘菊提取物、1-5份罗伊氏乳杆菌;优选的,制备原料按重量份计,还包括:70-80份去离子水、5-8份山梨糖醇、1-3份乙醇、1-3份PEG-40氢化蓖麻油、5-8份木糖醇、0.5-2份薄荷素油、0.01-0.03份香精、0.01-0.05份薄荷醇、1-5份羟苯甲酯、0-0.1份糖精钠、0.05-2份醋酸氯已定。
作为一种优选的技术方案,所述的药丸的制备原料按重量份计,包括:10-30份南瓜籽油、10-30份汉麻籽油、2-10份罗伊氏乳杆菌、2-10份丁香粉、2-10份西兰花粉;优选的,制备原料按重量份计,还包括:5-10份明胶、80-120份纯化水、15-30份甘油、20-40份山梨糖醇、0.1-0.5份食用香精、2-10份三氯蔗糖、0.1-0.5份柠檬黄、0.1-1份亮蓝。
作为一种优选的技术方案,所述的片剂的制备原料按重量份计,包括:1-5份西兰花粉、5-20份罗伊氏乳杆菌、3-6份乳糖。
作为一种优选的技术方案,所述的粉剂的制备原料按重量百分份计,包括:5-20份罗伊氏乳杆菌、2-10份银耳多糖、1-5份西兰花种子水提物;优选的,制备原料按重量份计,还包括:10-30份低聚果糖、10-20份浓缩香蕉粉、5-10份木糖醇、0.1-0.5份食用香精、2-5份混合乳酸菌粉、2-5份混合蔬菜粉、1-5份甘草提取粉、2-8份三氯蔗糖、1-6份蛋黄粉、1-5份甜菊糖苷。
本发明的第四方面提供了一种对抗幽门螺旋杆菌的一体化解决方案,包括所述的对抗幽门螺旋杆菌的组合物的使用方式。
有益效果:经本发明提供的对抗幽门螺旋杆菌组合物及一体化解决方案具有以下优点:
1.经本发明提供的对抗幽门螺旋杆菌组合物及一体化解决方案避免了传统方法中抗生素的使用,避免了对患者的二次伤害;
2.经本发明提供的对抗幽门螺旋杆菌组合物及一体化解决方案通过对口腔、咽部、食道和胃部的一体化治疗,达到全方位祛除细菌的效果,较单独胃部治疗的方式具有更好的根除效果;
3.经本发明提供的对抗幽门螺旋杆菌组合物及一体化解决方通过罗伊氏乳杆菌和植物提取物之间相互协同作用,可以实现快速捕获细菌,高效清除的效果,对人体无任何毒害作用,制备原料均为安全、无刺激性成分,可以在儿童和成人中使用,涵盖年龄范围广,应用价值高,适合大量生产和使用。
具体实施方式
参选以下本发明的优选实施方案的详述以及包括的实施例可更容易地理解本发明的内容。除非另有限定,本文使用的所有技术以及科学术语具有与本发明所属领域普通技术人员通常理解的相同的含义。当存在矛盾时,以本说明书中的定义为准。
如本文所用术语“由…制备”与“包含”同义。本文中所用的术语“包含”、“包括”、“具有”、“含有”或其任何其它变形,意在覆盖非排它性的包括。例如,包含所列要素的组合物、步骤、方案、制品或装置不必仅限于那些要素,而是可以包括未明确列出的其它要素或此种组合物、步骤、方案、制品或装置所固有的要素。
连接词“由…组成”排除任何未指出的要素、步骤或组分。如果用于权利要求中,此短语将使权利要求为封闭式,使其不包含除那些描述的材料以外的材料,但与其相关的常规杂质除外。当短语“由…组成”出现在权利要求主体的子句中而不是紧接在主题之后时,其仅限定在该子句中描述的要素;其它要素并不被排除在作为整体的所述权利要求之外。
单数形式包括复数讨论对象,除非上下文中另外清楚地指明。“任选的”或者“任意一种”是指其后描述的事项或事件可以发生或不发生,而且该描述包括事件发生的情形和事件不发生的情形。
此外,本发明要素或组分前的不定冠词“一种”和“一个”对要素或组分的数量要求(即出现次数)无限制性。因此“一个”或“一种”应被解读为包括一个或至少一个,并且单数形式的要素或组分也包括复数形式,除非所述数量明显旨指单数形式。
为了解决上述问题,本发明的第一方面提供了一种对抗幽门螺旋杆菌的组合物,制备原料包括乳香提取物、蜂胶提取物、青蒿提取物、罗伊氏乳杆菌、皱波角叉菜提取物、乳香提取物、厚朴树皮提取物、蒲公英提取物、香茅草提取物、洋甘菊提取物、西兰花粉、银耳多糖、西兰花种子水提物、丁香粉、汉麻籽油、南瓜籽油中的至少一种。
本发明的第二方面提供了一种对抗幽门螺旋杆菌的组合物的应用,用于口部、咽部、食道、胃肠部幽门螺旋杆菌的治疗。
面对生活压力的提升和人们作息不规律等问题的加重,口腔溃疡、口臭、气色不佳、缺铁血贫、慢性粉刺、排便异常等问题成为困扰人们生活的重要问题,而这些问题的出现,大部分归根于幽门螺旋杆菌对人类的威胁,为了进一步全方位对抗幽门螺旋杆菌对人类的危害,申请人经过大量创造性探究发现,采用口部、咽部、食道、胃肠部联合用药的方式,从可能存在细菌的口腔、咽部、食道、胃肠部进行对应性清除和治疗,通过植物提取物、相应的菌种和特定的天然高分子网状结构,在口腔、咽部、食道、胃肠部位形成保护层,抵御幽门螺旋杆菌的生长和繁殖,对幽门螺旋杆菌起到彻底全方位清除。
本发明的第三方面提供了一种对抗幽门螺旋杆菌的组合物的使用方式,包括牙膏、口腔喷剂、药丸、片剂和粉剂;所述的牙膏包括成人牙膏和儿童牙膏。
在一些优选的实施方式中,所述的成人牙膏的制备原料按重量份计,包括:1-8份乳香提取物、1-8份蜂胶提取物、1-8份青蒿提取物、1-5份罗伊氏乳杆菌、50-65份山梨糖醇、1-5份水、10-20份水合硅石、1-5份聚乙二醇-8、15-20份甘油、1-5份月桂酰肌氨酸钠、1-3份纤维素胶、1-3份黄原胶、0.001-0.003份食用香精、0.1-1份薄荷脑、2-5份乙酰磺胺酸钾、0.5-2份苯甲酸钠、1-5份云母。
在一些优选的实施方式中,所述的成人牙膏的制备方案包括以下步骤:
将制备原料按要求的重量份称量混合,搅拌,均质,即得。
在一些优选的实施方式中,所述的罗伊氏乳杆菌、乳香提取物、蜂胶提取物和青蒿提取物的重量比为1:(1-5):(1-3):(0.5-5)。
申请人经过大量创造性实验探究发现,在本体系中,在罗伊氏乳杆菌存在的条件下,可以与乳香提取物、蜂胶提取物和青蒿提取物之间更好的发挥协同作用,尤其在罗伊氏乳杆菌、乳香提取物、蜂胶提取物和青蒿提取物的重量比为1:(1-5):(1-3):(0.5-5)时,可以进一步提升口腔部位对幽门螺旋杆菌的清除效果;申请人推测可能的原因:蜂胶提取物中含有的多酚类物质和黄酮类物质可以对牙齿起到更好的养护效果,并且可以与生物体粘膜有害分泌物进行进一步结合,排出体外;同时,在乳香提取物和青蒿提取物存在的情况下,可以提升对细菌的抵抗和防御作用,并且在使用的过程中可以在口腔内部筑起一层防火墙,进一步提升对口腔的护理作用,避免幽门螺旋杆菌的生长和滞留,保证了口腔部位对幽门螺旋杆菌的清除效果。
在一些优选的实施方式中,所述的儿童牙膏的制备原料按重量份计,包括:1-8份皱波角叉菜提取物、1-8份花椰菜提取物、1-8份乳香提取物、1-5份罗伊氏乳杆菌、0.001-0.005份氟化钠、50-65份山梨糖醇、1-5份水、10-20份水合硅石、1-5份聚乙二醇-8、15-20份甘油、1-5份月桂酰肌氨酸钠、1-6份黄原胶、0.001-0.005份食用香精、5-10份木糖醇、2-5份乙酰磺胺酸钾、5-10份半乳糖、1-3份苯甲酸钠。
在一些优选的实施方式中,所述的儿童牙膏的制备方案包括以下步骤:
将制备原料按要求的重量份称量混合,搅拌,均质,即得。
在一些优选的实施方式中,所述的口腔喷剂的制备原料按重量份计,包括:2-10份厚朴树皮提取物、2-10份蒲公英提取物、2-10份香茅草提取物、2-10份洋甘菊提取物、1-5份罗伊氏乳杆菌、70-80份去离子水、5-8份山梨糖醇、1-3份乙醇、1-3份PEG-40氢化蓖麻油、5-8份木糖醇、0.5-2份薄荷素油、0.01-0.03份香精、0.01-0.05份薄荷醇、1-5份羟苯甲酯、0-0.1份糖精钠、0.05-2份醋酸氯已定。
在一些优选的实施方式中,所述的口腔喷剂的制备方案包括以下步骤:
将制备原料按要求的重量份称量混合,搅拌,均质,即得。
在一些优选的实施方式中,所述的罗伊氏乳杆菌和蒲公英提取物的重量比为1:(1-6)。
在一些优选的实施方式中,所述的罗伊氏乳杆菌和蒲公英提取物的重量比为1:2。
在实验过程中申请人发现,通过口腔喷剂的使用可以进一步提升细菌灭活率,减弱因油门螺旋杆菌出现的口臭等现象,尤其在罗伊氏乳杆菌和蒲公英提取物的重量比为1:2时,可以表现出最佳的细菌崩解效果,出现这种现象的原因申请人推测可能是:罗伊氏乳杆菌和蒲公英提取物中存在的活性基团可以实现与细菌细胞壁和细胞膜表面结合,通过罗伊氏乳杆菌表面带有的正电荷可以取代细菌表里面钙、镁等离子,引起细菌外膜破裂,而此时通过细菌外膜的罗伊氏乳杆菌和蒲公英提取物中带有的正电荷可以和细菌内膜上的负电荷的磷脂通过静电引力结合,导致细菌细胞膜出现空洞,引起细菌崩解,达到最好的细菌灭活效果;细菌的清除和灭活缓解了因细菌导致的口臭现象的出现。
在一些优选的实施方式中,所述的药丸的制备原料按重量份计,包括:10-30份南瓜籽油、10-30份汉麻籽油、2-10份罗伊氏乳杆菌、2-10份丁香粉、2-10份西兰花粉、5-10份明胶、80-120份纯化水、15-30份甘油、20-40份山梨糖醇、0.1-0.5份食用香精、2-10份三氯蔗糖、0.1-0.5份柠檬黄、0.1-1份亮蓝。
在一些优选的实施方式中,所述的药丸的制备方案包括以下步骤:
将制备原料按要求的重量份称量混合,搅拌,均质,成型,即得。
在一些优选的实施方式中,所述的罗伊氏乳杆菌和汉麻籽油的重量比为1:(1-15)。
在一些优选的实施方式中,所述的罗伊氏乳杆菌和汉麻籽油的重量比为1:(3-10)。
在实验过程中申请人发现,选择重量比为1:(3-10)的罗伊氏乳杆菌和汉麻籽油制备得到的药丸对幽门螺旋杆菌的对抗效果较好,申请人推测可能的原因是因为汉麻籽油中,其中不饱和脂肪酸占比83.6-90.4%,在不饱和脂肪酸中多不饱和脂肪酸占比达71.6-79.1%,由于不饱和脂肪酸的存在可以在使用过程中起到瓦解细胞膜结构的作用,通过对细菌细胞膜结构的瓦解使其内容物渗漏,此时,体系中存在的罗伊氏乳杆菌可以特异性捕获内容物,形成共聚物沉淀,从粘膜壁脱落,从消化道排除体外,达到药到病除的功效。
在一些优选的实施方式中,所述的片剂的制备原料按重量份计,包括:1-5份西兰花粉、5-20份罗伊氏乳杆菌、3-6份乳糖。
在一些优选的实施方式中,所述的片剂包括成人片剂和儿童片剂。
在一些优选的实施方式中,所述的成人片剂的制备原料按重量份计,包括:50-80份山梨糖醇、10-20份D-甘露糖醇、10-20份浓缩苹果粉、3-6份乳糖、5-20份罗伊氏乳杆菌、0.1-0.5份食用香精、2-10份维生素C、1-5份蛋白核小球藻、1-5份西兰花粉、1-5份银耳多糖、1-5份浓缩蓝莓粉、1-5份浓缩葡萄粉、1-5份浓缩结球甘蓝粉、1-5份硬脂酸镁、1-5份甜菊糖苷。
在一些优选的实施方式中,所述的儿童片剂的制备原料按重量百分份计,包括:40-60份山梨糖醇、10-20份浓缩草莓粉、5-15份D-甘露糖醇、8-15份异麦芽酮糖醇、5-20份罗伊氏乳杆菌、1-5份维生素C、1-5份银耳多糖、1-5份西兰花粉、1-5份山楂粉、1-5份浓缩蔓越莓粉、1-5份浓缩南瓜粉、1-5份浓缩胡萝卜粉、2-4份硬脂酸镁、0.01-0.1份食用香精、1-5份甜菊糖苷。
在一些优选的实施方式中,所述的片剂的制备方案包括以下步骤:
将制备原料按要求的重量份称量混合,搅拌,压片,即得。
在一些优选的实施方式中,所述的粉剂的制备原料按重量百分份计,包括:5-20份罗伊氏乳杆菌、2-10份银耳多糖、1-5份西兰花种子水提物、10-30份低聚果糖、10-20份浓缩香蕉粉、5-10份木糖醇、0.1-0.5份食用香精、2-5份混合乳酸菌粉、2-5份混合蔬菜粉、1-5份甘草提取粉、2-8份三氯蔗糖、1-6份蛋黄粉、1-5份甜菊糖苷。
在一些优选的实施方式中,所述的混合乳酸菌粉包括植物乳杆菌粉、动物双歧杆菌粉、乳酸乳球菌乳酸亚种粉、嗜酸乳杆菌粉、嗜热链球菌粉、短双歧杆菌粉、干酪乳杆菌粉、鼠李糖乳杆菌粉、长双歧杆菌粉、两歧双歧杆菌粉、发酵乳杆菌粉、副干酪乳杆菌粉。
在一些优选的实施方式中,所述的混合蔬菜粉包括糊精、浓缩花椰菜粉、浓缩黄瓜粉、浓缩南瓜粉、浓缩水芹粉、浓缩结球甘蓝粉、浓缩羽衣甘蓝粉、浓缩欧芹粉、浓缩红甜椒粉、浓缩绿甜椒粉、浓缩西兰花粉、浓缩红甜菜粉。
在一些优选的实施方式中,所述的粉剂的制备方案包括以下步骤:
将制备原料按要求的重量份称量混合,搅拌,即得。
本发明的第四方面提供了一种对抗幽门螺旋杆菌的一体化解决方案,包括所述的对抗幽门螺旋杆菌的组合物的使用方式。
需要说明的是,本发明中牙膏、口腔喷剂、药丸、片剂和粉剂涉及到的制备原料均购于百康利医学科技(上海)有限公司、中科力荐医学科技(湖州)有限公司和湖州中科院应用技术研究与产业化中心。
下面通过实施例对本发明进行具体描述。有必要在此指出的是,以下实施例只用于对本发明的作进一步说明,不能理解为对本发明保护范围的限制,该领域的专业技术人员根据上述本发明的内容做出的一些非本质的改进和调整,仍属于本发明的保护范围。
实施例
实施例1
一种对抗幽门螺旋杆菌的组合物的应用,用于口部幽门螺旋杆菌的治疗;
一种对抗幽门螺旋杆菌的组合物的使用方式,为牙膏;
所述的牙膏包括成人牙膏和儿童牙膏。
所述的成人牙膏的制备原料按重量份计,包括:4份乳香提取物、3份蜂胶提取物、6份青蒿提取物、2份罗伊氏乳杆菌、55份山梨糖醇、4份水、15份水合硅石、3份聚乙二醇-8、18份甘油、3份月桂酰肌氨酸钠、2份纤维素胶、3份黄原胶、0.001份食用香精、0.2份薄荷脑、3份乙酰磺胺酸钾、1份苯甲酸钠、4份云母。
所述的成人牙膏的制备方案包括以下步骤:
将制备原料按要求的重量份称量混合,搅拌,均质,即得。
所述的儿童牙膏的制备原料按重量份计,包括:6份皱波角叉菜提取物、4份花椰菜提取物、4份乳香提取物、2份罗伊氏乳杆菌、0.001份氟化钠、50份山梨糖醇、3份水、15份水合硅石、3份聚乙二醇-8、17份甘油、4份月桂酰肌氨酸钠、5份黄原胶、0.001份食用香精、6份木糖醇、3份乙酰磺胺酸钾、8份半乳糖、2份苯甲酸钠。
所述的儿童牙膏的制备方案包括以下步骤:
将制备原料按要求的重量份称量混合,搅拌,均质,即得。
实施例2
一种对抗幽门螺旋杆菌的组合物的应用,用于口部幽门螺旋杆菌的治疗;
一种对抗幽门螺旋杆菌的组合物的使用方式,为口腔喷雾;
所述的口腔喷剂的制备原料按重量份计,包括:6份厚朴树皮提取物、8份蒲公英提取物、4份香茅草提取物、5份洋甘菊提取物、2份罗伊氏乳杆菌、75份去离子水、6份山梨糖醇、2份乙醇、2份PEG-40氢化蓖麻油、6份木糖醇、0.5份薄荷素油、0.01份香精、0.02份薄荷醇、3份羟苯甲酯、0.05份糖精钠、0.08份醋酸氯已定。
所述的口腔喷剂的制备方案包括以下步骤:
将制备原料按要求的重量份称量混合,搅拌,均质,即得。
实施例3
一种对抗幽门螺旋杆菌的组合物的应用,用于咽部和食道幽门螺旋杆菌的治疗;
一种对抗幽门螺旋杆菌的组合物的使用方式,为药丸;
所述的药丸的制备原料按重量份计,包括:20份南瓜籽油、18份汉麻籽油、3份罗伊氏乳杆菌、6份丁香粉、6份西兰花粉、7份明胶、100份纯化水、25份甘油、30份山梨糖醇、0.1份食用香精、5份三氯蔗糖、0.2份柠檬黄、0.1份亮蓝。
所述的药丸的制备方案包括以下步骤:
将制备原料按要求的重量份称量混合,搅拌,均质,成型,即得。
实施例4
一种对抗幽门螺旋杆菌的组合物的应用,用于胃肠幽门螺旋杆菌的治疗;
一种对抗幽门螺旋杆菌的组合物的使用方式,为片剂;
所述的片剂包括成人片剂和儿童片剂。
所述的成人片剂的制备原料按重量份计,包括:70份山梨糖醇、14份D-甘露糖醇、15份浓缩苹果粉、5份乳糖、12份罗伊氏乳杆菌、0.1份食用香精、8份维生素C、3份蛋白核小球藻、4份西兰花粉、4份银耳多糖、4份浓缩蓝莓粉、4份浓缩葡萄粉、4份浓缩结球甘蓝粉、3份硬脂酸镁、4份甜菊糖苷。
所述的儿童片剂的制备原料按重量百分份计,包括:50份山梨糖醇、15份浓缩草莓粉、10份D-甘露糖醇、10份异麦芽酮糖醇、12份罗伊氏乳杆菌、3份维生素C、4份银耳多糖、4份西兰花粉、4份山楂粉、4份浓缩蔓越莓粉、4份浓缩南瓜粉、4份浓缩胡萝卜粉、3份硬脂酸镁、0.02份食用香精、4份甜菊糖苷。
所述的片剂的制备方案包括以下步骤:
将制备原料按要求的重量份称量混合,搅拌,压片,即得。
实施例5
一种对抗幽门螺旋杆菌的组合物的应用,用于胃肠幽门螺旋杆菌的治疗;
一种对抗幽门螺旋杆菌的组合物的使用方式,为粉剂;
所述的粉剂的制备原料按重量百分份计,包括:16份罗伊氏乳杆菌、8份银耳多糖、3份西兰花种子水提物、24份低聚果糖、16份浓缩香蕉粉、8份木糖醇、0.1份食用香精、3份混合乳酸菌粉、4份混合蔬菜粉、4份甘草提取粉、4份三氯蔗糖、3份蛋黄粉、2份甜菊糖苷。
所述的粉剂的制备方案包括以下步骤:
将制备原料按要求的重量份称量混合,搅拌,即得。
实施例6
一种对抗幽门螺旋杆菌的组合物的应用,用于口部幽门螺旋杆菌的治疗;
其具体实施方式同实施例1,与实施例1不同的是成人牙膏中的罗伊氏乳杆菌的重量份为1份。
实施例7
一种对抗幽门螺旋杆菌的组合物的应用,用于口部幽门螺旋杆菌的治疗;
其具体实施方式同实施例1,与实施例1不同的是成人牙膏中不含罗伊氏乳杆菌。
实施例8
一种对抗幽门螺旋杆菌的组合物的应用,用于口部幽门螺旋杆菌的治疗;
其具体实施方式同实施例1,与实施例1不同的是成人牙膏中不含青蒿提取物。
性能测试:
将实施例1制备得到的成人牙膏用于幽门螺旋杆菌抑菌效果测试;
测试条件:将制备的牙膏用水进行稀释,牙膏的稀释比例为1:1.6;
作用时间:20min;
实验菌种:幽门螺旋杆菌,ATCC43504,第三代;
评判依据:WS/T 650-2019中5.1.1.5;
将测试结果记录于下表。
参照实施例1的幽门螺旋杆菌抑菌测试,对实施例6-8制备得到的成人牙膏进行抗菌性能测试,并将测试结果记录于下表。
实验 | 平均抑菌率/% |
实施例6 | 90.7 |
实施例7 | 86.2 |
实施例8 | 86.8 |
以上所述实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对本发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。
Claims (10)
1.一种对抗幽门螺旋杆菌的组合物,其特征在于,制备原料包括乳香提取物、蜂胶提取物、青蒿提取物、罗伊氏乳杆菌、皱波角叉菜提取物、乳香提取物、厚朴树皮提取物、蒲公英提取物、香茅草提取物、洋甘菊提取物、西兰花粉、银耳多糖、西兰花种子水提物、丁香粉、汉麻籽油、南瓜籽油中的至少一种。
2.一种根据权利要求1所述的对抗幽门螺旋杆菌的组合物的应用,其特征在于,用于口部、咽部、食道、胃肠部幽门螺旋杆菌的治疗。
3.一种根据权利要求1所述的对抗幽门螺旋杆菌的组合物的使用方式,其特征在于,包括牙膏、口腔喷剂、药丸、片剂和粉剂;所述的牙膏包括成人牙膏和儿童牙膏。
4.根据权利要求3所述的对抗幽门螺旋杆菌的组合物的使用方式,其特征在于,所述的成人牙膏的制备原料按重量份计,包括:1-8份乳香提取物、1-8份蜂胶提取物、1-8份青蒿提取物、1-5份罗伊氏乳杆菌;优选的,制备原料按重量份计还包括:50-65份山梨糖醇、1-5份水、10-20份水合硅石、1-5份聚乙二醇-8、15-20份甘油、1-5份月桂酰肌氨酸钠、1-3份纤维素胶、1-3份黄原胶、0.001-0.003份食用香精、0.1-1份薄荷脑、2-5份乙酰磺胺酸钾、0.5-2份苯甲酸钠、1-5份云母。
5.根据权利要求3所述的对抗幽门螺旋杆菌的组合物的使用方式,其特征在于,所述的儿童牙膏的制备原料按重量份计,包括:1-8份皱波角叉菜提取物、1-8份花椰菜提取物、1-8份乳香提取物、1-5份罗伊氏乳杆菌、0.001-0.005份氟化钠;优选的,制备原料按重量份计,还包括:50-65份山梨糖醇、1-5份水、10-20份水合硅石、1-5份聚乙二醇-8、15-20份甘油、1-5份月桂酰肌氨酸钠、1-6份黄原胶、0.001-0.005份食用香精、5-10份木糖醇、2-5份乙酰磺胺酸钾、5-10份半乳糖、1-3份苯甲酸钠。
6.根据权利要求3所述的对抗幽门螺旋杆菌的组合物的使用方式,其特征在于,所述的口腔喷剂的制备原料按重量份计,包括:2-10份厚朴树皮提取物、2-10份蒲公英提取物、2-10份香茅草提取物、2-10份洋甘菊提取物、1-5份罗伊氏乳杆菌;优选的,制备原料按重量份计,还包括:70-80份去离子水、5-8份山梨糖醇、1-3份乙醇、1-3份PEG-40氢化蓖麻油、5-8份木糖醇、0.5-2份薄荷素油、0.01-0.03份香精、0.01-0.05份薄荷醇、1-5份羟苯甲酯、0-0.1份糖精钠、0.05-2份醋酸氯已定。
7.根据权利要求3所述的对抗幽门螺旋杆菌的组合物的使用方式,其特征在于,所述的药丸的制备原料按重量份计,包括:10-30份南瓜籽油、10-30份汉麻籽油、2-10份罗伊氏乳杆菌、2-10份丁香粉、2-10份西兰花粉;优选的,制备原料按重量份计,还包括:5-10份明胶、80-120份纯化水、15-30份甘油、20-40份山梨糖醇、0.1-0.5份食用香精、2-10份三氯蔗糖、0.1-0.5份柠檬黄、0.1-1份亮蓝。
8.根据权利要求3所述的对抗幽门螺旋杆菌的组合物的使用方式,其特征在于,所述的片剂的制备原料按重量份计,包括:1-5份西兰花粉、5-20份罗伊氏乳杆菌、3-6份乳糖。
9.根据权利要求3所述的对抗幽门螺旋杆菌的组合物的使用方式,其特征在于,所述的粉剂的制备原料按重量百分份计,包括:5-20份罗伊氏乳杆菌、2-10份银耳多糖、1-5份西兰花种子水提物;优选的,制备原料按重量份计,还包括:10-30份低聚果糖、10-20份浓缩香蕉粉、5-10份木糖醇、0.1-0.5份食用香精、2-5份混合乳酸菌粉、2-5份混合蔬菜粉、1-5份甘草提取粉、2-8份三氯蔗糖、1-6份蛋黄粉、1-5份甜菊糖苷。
10.一种对抗幽门螺旋杆菌的一体化解决方案,其特征在于,包括权利要求3-9任一项所述的对抗幽门螺旋杆菌的组合物的使用方式。
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