CN114025630A - 微波加热单元和方法 - Google Patents
微波加热单元和方法 Download PDFInfo
- Publication number
- CN114025630A CN114025630A CN202080041390.0A CN202080041390A CN114025630A CN 114025630 A CN114025630 A CN 114025630A CN 202080041390 A CN202080041390 A CN 202080041390A CN 114025630 A CN114025630 A CN 114025630A
- Authority
- CN
- China
- Prior art keywords
- sample
- microwave
- aerosol
- unit
- microwave radiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000010438 heat treatment Methods 0.000 title claims abstract description 74
- 238000000034 method Methods 0.000 title claims abstract description 21
- 230000005855 radiation Effects 0.000 claims abstract description 78
- 239000000463 material Substances 0.000 claims abstract description 31
- 239000000443 aerosol Substances 0.000 claims abstract description 17
- 238000002663 nebulization Methods 0.000 claims abstract description 8
- 238000012383 pulmonary drug delivery Methods 0.000 claims abstract description 7
- 238000010521 absorption reaction Methods 0.000 claims abstract description 6
- -1 polypropylene Polymers 0.000 claims description 45
- 241000208125 Nicotiana Species 0.000 claims description 15
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 15
- 241000196324 Embryophyta Species 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 12
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 229960002715 nicotine Drugs 0.000 claims description 10
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 10
- 239000013543 active substance Substances 0.000 claims description 9
- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 claims description 8
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 8
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 claims description 8
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 claims description 8
- 229950011318 cannabidiol Drugs 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 8
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 239000000758 substrate Substances 0.000 claims description 8
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims description 6
- 229940088679 drug related substance Drugs 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 230000010355 oscillation Effects 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 230000000391 smoking effect Effects 0.000 claims description 6
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 claims description 5
- 239000003989 dielectric material Substances 0.000 claims description 5
- 240000004308 marijuana Species 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 230000005540 biological transmission Effects 0.000 claims description 4
- 229930003827 cannabinoid Natural products 0.000 claims description 4
- 239000003557 cannabinoid Substances 0.000 claims description 4
- 229960004242 dronabinol Drugs 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 239000010453 quartz Substances 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- XXGMIHXASFDFSM-UHFFFAOYSA-N Delta9-tetrahydrocannabinol Natural products CCCCCc1cc2OC(C)(C)C3CCC(=CC3c2c(O)c1O)C XXGMIHXASFDFSM-UHFFFAOYSA-N 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 239000006096 absorbing agent Substances 0.000 claims description 2
- 230000004308 accommodation Effects 0.000 claims description 2
- 239000002041 carbon nanotube Substances 0.000 claims description 2
- 229910021393 carbon nanotube Inorganic materials 0.000 claims description 2
- 238000012377 drug delivery Methods 0.000 claims description 2
- 229940126534 drug product Drugs 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 229910021389 graphene Inorganic materials 0.000 claims description 2
- 229910002804 graphite Inorganic materials 0.000 claims description 2
- 239000010439 graphite Substances 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 229920003023 plastic Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920000734 polysilsesquioxane polymer Polymers 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 239000004065 semiconductor Substances 0.000 claims description 2
- 239000011343 solid material Substances 0.000 claims description 2
- 229920002994 synthetic fiber Polymers 0.000 claims description 2
- 239000000523 sample Substances 0.000 description 67
- 241000795633 Olea <sea slug> Species 0.000 description 60
- 239000003814 drug Substances 0.000 description 25
- 229940079593 drug Drugs 0.000 description 25
- 150000001875 compounds Chemical class 0.000 description 22
- 239000000796 flavoring agent Substances 0.000 description 9
- 235000019634 flavors Nutrition 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 235000014749 Mentha crispa Nutrition 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- ZLYNXDIDWUWASO-UHFFFAOYSA-N 6,6,9-trimethyl-3-pentyl-8,10-dihydro-7h-benzo[c]chromene-1,9,10-triol Chemical compound CC1(C)OC2=CC(CCCCC)=CC(O)=C2C2=C1CCC(C)(O)C2O ZLYNXDIDWUWASO-UHFFFAOYSA-N 0.000 description 4
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 4
- 240000003538 Chamaemelum nobile Species 0.000 description 4
- 244000166124 Eucalyptus globulus Species 0.000 description 4
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 4
- 244000165082 Lavanda vera Species 0.000 description 4
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 4
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 4
- 235000006679 Mentha X verticillata Nutrition 0.000 description 4
- 244000078639 Mentha spicata Species 0.000 description 4
- 235000002899 Mentha suaveolens Nutrition 0.000 description 4
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 4
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 4
- 229930182555 Penicillin Natural products 0.000 description 4
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 4
- 235000008184 Piper nigrum Nutrition 0.000 description 4
- 244000203593 Piper nigrum Species 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- 244000299461 Theobroma cacao Species 0.000 description 4
- 244000042324 Trifolium repens Species 0.000 description 4
- 235000013540 Trifolium repens var repens Nutrition 0.000 description 4
- 235000013614 black pepper Nutrition 0.000 description 4
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 4
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 4
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical class CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 4
- 229940049954 penicillin Drugs 0.000 description 4
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 4
- 229960002646 scopolamine Drugs 0.000 description 4
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 4
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 3
- 108010087806 Carnosine Proteins 0.000 description 3
- 229930186147 Cephalosporin Natural products 0.000 description 3
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 240000006927 Foeniculum vulgare Species 0.000 description 3
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 3
- 240000004670 Glycyrrhiza echinata Species 0.000 description 3
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 3
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 3
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 3
- 241000721662 Juniperus Species 0.000 description 3
- 235000004357 Mentha x piperita Nutrition 0.000 description 3
- XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 description 3
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 3
- 235000011925 Passiflora alata Nutrition 0.000 description 3
- 235000000370 Passiflora edulis Nutrition 0.000 description 3
- 235000011922 Passiflora incarnata Nutrition 0.000 description 3
- 240000002690 Passiflora mixta Species 0.000 description 3
- 235000013750 Passiflora mixta Nutrition 0.000 description 3
- 235000013731 Passiflora van volxemii Nutrition 0.000 description 3
- 235000011751 Pogostemon cablin Nutrition 0.000 description 3
- 240000002505 Pogostemon cablin Species 0.000 description 3
- 240000002657 Thymus vulgaris Species 0.000 description 3
- 235000007303 Thymus vulgaris Nutrition 0.000 description 3
- 240000000143 Turnera diffusa Species 0.000 description 3
- 229940044199 carnosine Drugs 0.000 description 3
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 3
- 229940124587 cephalosporin Drugs 0.000 description 3
- 150000001780 cephalosporins Chemical class 0.000 description 3
- 235000017803 cinnamon Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 3
- 229960004193 dextropropoxyphene Drugs 0.000 description 3
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 description 3
- 230000005684 electric field Effects 0.000 description 3
- 239000001102 lavandula vera Substances 0.000 description 3
- 235000018219 lavender Nutrition 0.000 description 3
- 229940010454 licorice Drugs 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical class COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 229960004503 metoclopramide Drugs 0.000 description 3
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 description 3
- 229960000482 pethidine Drugs 0.000 description 3
- 239000001585 thymus vulgaris Substances 0.000 description 3
- 229960002324 trifluoperazine Drugs 0.000 description 3
- ZEWQUBUPAILYHI-UHFFFAOYSA-N trifluoperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 ZEWQUBUPAILYHI-UHFFFAOYSA-N 0.000 description 3
- 235000004952 turnera diffusa Nutrition 0.000 description 3
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- GJJFMKBJSRMPLA-HIFRSBDPSA-N (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 description 2
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Chemical class 0.000 description 2
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 description 2
- ZROLHBHDLIHEMS-HUUCEWRRSA-N (6ar,10ar)-6,6,9-trimethyl-3-propyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCC)=CC(O)=C3[C@@H]21 ZROLHBHDLIHEMS-HUUCEWRRSA-N 0.000 description 2
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 2
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Chemical class CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 2
- WSPOMRSOLSGNFJ-AUWJEWJLSA-N (Z)-chlorprothixene Chemical compound C1=C(Cl)C=C2C(=C/CCN(C)C)\C3=CC=CC=C3SC2=C1 WSPOMRSOLSGNFJ-AUWJEWJLSA-N 0.000 description 2
- GWEHVDNNLFDJLR-UHFFFAOYSA-N 1,3-diphenylurea Chemical compound C=1C=CC=CC=1NC(=O)NC1=CC=CC=C1 GWEHVDNNLFDJLR-UHFFFAOYSA-N 0.000 description 2
- KWTSXDURSIMDCE-UHFFFAOYSA-N 1-phenylpropan-2-amine Chemical group CC(N)CC1=CC=CC=C1 KWTSXDURSIMDCE-UHFFFAOYSA-N 0.000 description 2
- SPCKHVPPRJWQRZ-UHFFFAOYSA-N 2-benzhydryloxy-n,n-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 SPCKHVPPRJWQRZ-UHFFFAOYSA-N 0.000 description 2
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 description 2
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 description 2
- 240000000073 Achillea millefolium Species 0.000 description 2
- 235000007754 Achillea millefolium Nutrition 0.000 description 2
- 244000205574 Acorus calamus Species 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 2
- 240000002234 Allium sativum Species 0.000 description 2
- KPYSYYIEGFHWSV-UHFFFAOYSA-N Baclofen Chemical compound OC(=O)CC(CN)C1=CC=C(Cl)C=C1 KPYSYYIEGFHWSV-UHFFFAOYSA-N 0.000 description 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N Benzylformate Chemical compound O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 2
- 235000016068 Berberis vulgaris Nutrition 0.000 description 2
- 240000000724 Berberis vulgaris Species 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 240000007154 Coffea arabica Species 0.000 description 2
- 241001648652 Croton ovalifolius Species 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 241000208296 Datura Species 0.000 description 2
- ZROLHBHDLIHEMS-UHFFFAOYSA-N Delta9 tetrahydrocannabivarin Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCC)=CC(O)=C3C21 ZROLHBHDLIHEMS-UHFFFAOYSA-N 0.000 description 2
- 206010012335 Dependence Diseases 0.000 description 2
- 244000133098 Echinacea angustifolia Species 0.000 description 2
- 241000218671 Ephedra Species 0.000 description 2
- 208000010228 Erectile Dysfunction Diseases 0.000 description 2
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 2
- 241001558017 Gynura Species 0.000 description 2
- BXNJHAXVSOCGBA-UHFFFAOYSA-N Harmine Chemical compound N1=CC=C2C3=CC=C(OC)C=C3NC2=C1C BXNJHAXVSOCGBA-UHFFFAOYSA-N 0.000 description 2
- 241001504226 Hoodia Species 0.000 description 2
- 235000021506 Ipomoea Nutrition 0.000 description 2
- 241000207783 Ipomoea Species 0.000 description 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 2
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 description 2
- 235000013757 Juglans Nutrition 0.000 description 2
- 241000758789 Juglans Species 0.000 description 2
- 235000019501 Lemon oil Nutrition 0.000 description 2
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 2
- 240000007472 Leucaena leucocephala Species 0.000 description 2
- ZPXSCAKFGYXMGA-UHFFFAOYSA-N Mazindol Chemical compound N12CCN=C2C2=CC=CC=C2C1(O)C1=CC=C(Cl)C=C1 ZPXSCAKFGYXMGA-UHFFFAOYSA-N 0.000 description 2
- 244000062730 Melissa officinalis Species 0.000 description 2
- 244000024873 Mentha crispa Species 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 2
- 208000019695 Migraine disease Diseases 0.000 description 2
- WUKZPHOXUVCQOR-UHFFFAOYSA-N N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C1=CC(Cl)=CC2=C1OCC(=O)N2C WUKZPHOXUVCQOR-UHFFFAOYSA-N 0.000 description 2
- MITFXPHMIHQXPI-UHFFFAOYSA-N Oraflex Chemical compound N=1C2=CC(C(C(O)=O)C)=CC=C2OC=1C1=CC=C(Cl)C=C1 MITFXPHMIHQXPI-UHFFFAOYSA-N 0.000 description 2
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 description 2
- 240000001090 Papaver somniferum Species 0.000 description 2
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 2
- BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical class NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 2
- BKRGVLQUQGGVSM-KBXCAEBGSA-N Revanil Chemical compound C1=CC(C=2[C@H](N(C)C[C@H](C=2)NC(=O)N(CC)CC)C2)=C3C2=CNC3=C1 BKRGVLQUQGGVSM-KBXCAEBGSA-N 0.000 description 2
- 235000016954 Ribes hudsonianum Nutrition 0.000 description 2
- 240000001890 Ribes hudsonianum Species 0.000 description 2
- 235000001466 Ribes nigrum Nutrition 0.000 description 2
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 description 2
- 235000010841 Silybum marianum Nutrition 0.000 description 2
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 2
- 244000223014 Syzygium aromaticum Species 0.000 description 2
- 241000245665 Taraxacum Species 0.000 description 2
- 235000009470 Theobroma cacao Nutrition 0.000 description 2
- ZZHLYYDVIOPZBE-UHFFFAOYSA-N Trimeprazine Chemical compound C1=CC=C2N(CC(CN(C)C)C)C3=CC=CC=C3SC2=C1 ZZHLYYDVIOPZBE-UHFFFAOYSA-N 0.000 description 2
- WNTYBHLDCKXEOT-UHFFFAOYSA-N acetophenazine Chemical compound C12=CC(C(=O)C)=CC=C2SC2=CC=CC=C2N1CCCN1CCN(CCO)CC1 WNTYBHLDCKXEOT-UHFFFAOYSA-N 0.000 description 2
- 229960000276 acetophenazine Drugs 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229960001570 ademetionine Drugs 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 201000007930 alcohol dependence Diseases 0.000 description 2
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 description 2
- 229960002576 amiloride Drugs 0.000 description 2
- NTJOBXMMWNYJFB-UHFFFAOYSA-N amisulpride Chemical compound CCN1CCCC1CNC(=O)C1=CC(S(=O)(=O)CC)=C(N)C=C1OC NTJOBXMMWNYJFB-UHFFFAOYSA-N 0.000 description 2
- 229960000836 amitriptyline Drugs 0.000 description 2
- KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 description 2
- 229940025084 amphetamine Drugs 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000003474 anti-emetic effect Effects 0.000 description 2
- 239000001961 anticonvulsive agent Substances 0.000 description 2
- 239000000935 antidepressant agent Substances 0.000 description 2
- 229940005513 antidepressants Drugs 0.000 description 2
- 239000002111 antiemetic agent Substances 0.000 description 2
- 239000000739 antihistaminic agent Substances 0.000 description 2
- 239000002249 anxiolytic agent Substances 0.000 description 2
- 230000000949 anxiolytic effect Effects 0.000 description 2
- 229950005951 azasetron Drugs 0.000 description 2
- 229960000794 baclofen Drugs 0.000 description 2
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical group CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 description 2
- CNBGNNVCVSKAQZ-UHFFFAOYSA-N benzydamine Chemical compound C12=CC=CC=C2C(OCCCN(C)C)=NN1CC1=CC=CC=C1 CNBGNNVCVSKAQZ-UHFFFAOYSA-N 0.000 description 2
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 description 2
- 229960001736 buprenorphine Drugs 0.000 description 2
- 229960001948 caffeine Drugs 0.000 description 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 2
- 229960003669 carbenicillin Drugs 0.000 description 2
- FPPNZSSZRUTDAP-UWFZAAFLSA-N carbenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)C(C(O)=O)C1=CC=CC=C1 FPPNZSSZRUTDAP-UWFZAAFLSA-N 0.000 description 2
- 229950002698 cathinone Drugs 0.000 description 2
- 229940106164 cephalexin Drugs 0.000 description 2
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 description 2
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 2
- 229960001076 chlorpromazine Drugs 0.000 description 2
- 229960001552 chlorprothixene Drugs 0.000 description 2
- 235000019219 chocolate Nutrition 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- 229960004126 codeine Drugs 0.000 description 2
- 235000016213 coffee Nutrition 0.000 description 2
- 235000013353 coffee beverage Nutrition 0.000 description 2
- JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 description 2
- 229960001140 cyproheptadine Drugs 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229960000520 diphenhydramine Drugs 0.000 description 2
- 229960005426 doxepin Drugs 0.000 description 2
- ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 description 2
- 235000014134 echinacea Nutrition 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- CBOQJANXLMLOSS-UHFFFAOYSA-N ethyl vanillin Chemical group CCOC1=CC(C=O)=CC=C1O CBOQJANXLMLOSS-UHFFFAOYSA-N 0.000 description 2
- 229960002464 fluoxetine Drugs 0.000 description 2
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 description 2
- 235000004611 garlic Nutrition 0.000 description 2
- 229960003878 haloperidol Drugs 0.000 description 2
- CATSNJVOTSVZJV-UHFFFAOYSA-N heptan-2-one Chemical compound CCCCCC(C)=O CATSNJVOTSVZJV-UHFFFAOYSA-N 0.000 description 2
- 235000017277 hoodia Nutrition 0.000 description 2
- 235000001050 hortel pimenta Nutrition 0.000 description 2
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 150000002468 indanes Chemical class 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- MLFHJEHSLIIPHL-UHFFFAOYSA-N isoamyl acetate Chemical compound CC(C)CCOC(C)=O MLFHJEHSLIIPHL-UHFFFAOYSA-N 0.000 description 2
- RGFNRWTWDWVHDD-UHFFFAOYSA-N isobutyl butyrate Chemical compound CCCC(=O)OCC(C)C RGFNRWTWDWVHDD-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000010501 lemon oil Chemical class 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 229930007744 linalool Chemical class 0.000 description 2
- 229960003587 lisuride Drugs 0.000 description 2
- UTEFBSAVJNEPTR-RGEXLXHISA-N loprazolam Chemical compound C1CN(C)CCN1\C=C/1C(=O)N2C3=CC=C([N+]([O-])=O)C=C3C(C=3C(=CC=CC=3)Cl)=NCC2=N\1 UTEFBSAVJNEPTR-RGEXLXHISA-N 0.000 description 2
- 229960003019 loprazolam Drugs 0.000 description 2
- 229960004391 lorazepam Drugs 0.000 description 2
- 229960000299 mazindol Drugs 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 206010027599 migraine Diseases 0.000 description 2
- 229960000600 milnacipran Drugs 0.000 description 2
- 229960005181 morphine Drugs 0.000 description 2
- ZJQHPWUVQPJPQT-UHFFFAOYSA-N muscimol Chemical compound NCC1=CC(=O)NO1 ZJQHPWUVQPJPQT-UHFFFAOYSA-N 0.000 description 2
- 239000003158 myorelaxant agent Substances 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- 229940005483 opioid analgesics Drugs 0.000 description 2
- 229960002085 oxycodone Drugs 0.000 description 2
- 229960002296 paroxetine Drugs 0.000 description 2
- DHHVAGZRUROJKS-UHFFFAOYSA-N phentermine Chemical compound CC(C)(N)CC1=CC=CC=C1 DHHVAGZRUROJKS-UHFFFAOYSA-N 0.000 description 2
- 229960004572 pizotifen Drugs 0.000 description 2
- FIADGNVRKBPQEU-UHFFFAOYSA-N pizotifen Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2CCC2=C1C=CS2 FIADGNVRKBPQEU-UHFFFAOYSA-N 0.000 description 2
- 229960003089 pramipexole Drugs 0.000 description 2
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 description 2
- WIKYUJGCLQQFNW-UHFFFAOYSA-N prochlorperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 WIKYUJGCLQQFNW-UHFFFAOYSA-N 0.000 description 2
- 229960003111 prochlorperazine Drugs 0.000 description 2
- 229960003910 promethazine Drugs 0.000 description 2
- 229960003712 propranolol Drugs 0.000 description 2
- 150000003216 pyrazines Chemical class 0.000 description 2
- 235000002020 sage Nutrition 0.000 description 2
- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 description 2
- 229960003946 selegiline Drugs 0.000 description 2
- 229960002073 sertraline Drugs 0.000 description 2
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 2
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 description 2
- 229960004425 sibutramine Drugs 0.000 description 2
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- APJYDQYYACXCRM-UHFFFAOYSA-N tryptamine Chemical compound C1=CC=C2C(CCN)=CNC2=C1 APJYDQYYACXCRM-UHFFFAOYSA-N 0.000 description 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- DBGIVFWFUFKIQN-VIFPVBQESA-N (+)-Fenfluramine Chemical compound CCN[C@@H](C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-VIFPVBQESA-N 0.000 description 1
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- WTOYNNBCKUYIKC-JMSVASOKSA-N (+)-nootkatone Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CC(=O)C=C21 WTOYNNBCKUYIKC-JMSVASOKSA-N 0.000 description 1
- DBGIVFWFUFKIQN-UHFFFAOYSA-N (+-)-Fenfluramine Chemical compound CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-UHFFFAOYSA-N 0.000 description 1
- UIKROCXWUNQSPJ-VIFPVBQESA-N (-)-cotinine Chemical compound C1CC(=O)N(C)[C@@H]1C1=CC=CN=C1 UIKROCXWUNQSPJ-VIFPVBQESA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- WYDUSKDSKCASEF-LJQANCHMSA-N (1s)-1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol Chemical compound C([C@](O)(C1CCCCC1)C=1C=CC=CC=1)CN1CCCC1 WYDUSKDSKCASEF-LJQANCHMSA-N 0.000 description 1
- YWPHCCPCQOJSGZ-LLVKDONJSA-N (2r)-2-[(2-ethoxyphenoxy)methyl]morpholine Chemical compound CCOC1=CC=CC=C1OC[C@@H]1OCCNC1 YWPHCCPCQOJSGZ-LLVKDONJSA-N 0.000 description 1
- RJMIEHBSYVWVIN-LLVKDONJSA-N (2r)-2-[4-(3-oxo-1h-isoindol-2-yl)phenyl]propanoic acid Chemical compound C1=CC([C@H](C(O)=O)C)=CC=C1N1C(=O)C2=CC=CC=C2C1 RJMIEHBSYVWVIN-LLVKDONJSA-N 0.000 description 1
- ADIHZDIWDRJIOQ-JFGNBEQYSA-N (2s,5r,6r)-6-[[2-(3-chlorobut-2-enylsulfanyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound S1C(C)(C)[C@H](C(O)=O)N2C(=O)[C@@H](NC(=O)CSCC=C(Cl)C)[C@H]21 ADIHZDIWDRJIOQ-JFGNBEQYSA-N 0.000 description 1
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 description 1
- 229940098795 (3z)- 3-hexenyl acetate Drugs 0.000 description 1
- 239000001730 (5R)-5-butyloxolan-2-one Substances 0.000 description 1
- GBBSUAFBMRNDJC-MRXNPFEDSA-N (5R)-zopiclone Chemical compound C1CN(C)CCN1C(=O)O[C@@H]1C2=NC=CN=C2C(=O)N1C1=CC=C(Cl)C=N1 GBBSUAFBMRNDJC-MRXNPFEDSA-N 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 description 1
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 description 1
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 description 1
- BGRJTUBHPOOWDU-NSHDSACASA-N (S)-(-)-sulpiride Chemical compound CCN1CCC[C@H]1CNC(=O)C1=CC(S(N)(=O)=O)=CC=C1OC BGRJTUBHPOOWDU-NSHDSACASA-N 0.000 description 1
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 description 1
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 description 1
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 description 1
- VEPOHXYIFQMVHW-XOZOLZJESA-N 2,3-dihydroxybutanedioic acid (2S,3S)-3,4-dimethyl-2-phenylmorpholine Chemical compound OC(C(O)C(O)=O)C(O)=O.C[C@H]1[C@@H](OCCN1C)c1ccccc1 VEPOHXYIFQMVHW-XOZOLZJESA-N 0.000 description 1
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
- YSGASDXSLKIKOD-UHFFFAOYSA-N 2-amino-N-(1,2-diphenylpropan-2-yl)acetamide Chemical compound C=1C=CC=CC=1C(C)(NC(=O)CN)CC1=CC=CC=C1 YSGASDXSLKIKOD-UHFFFAOYSA-N 0.000 description 1
- YTRMTPPVNRALON-UHFFFAOYSA-N 2-phenyl-4-quinolinecarboxylic acid Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=CC=C1 YTRMTPPVNRALON-UHFFFAOYSA-N 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 1
- BGTBFNDXYDYBEY-FNORWQNLSA-N 4-(2,6,6-Trimethylcyclohex-1-enyl)but-2-en-4-one Chemical compound C\C=C\C(=O)C1=C(C)CCCC1(C)C BGTBFNDXYDYBEY-FNORWQNLSA-N 0.000 description 1
- WNWVKZTYMQWFHE-UHFFFAOYSA-N 4-ethylmorpholine Chemical compound [CH2]CN1CCOCC1 WNWVKZTYMQWFHE-UHFFFAOYSA-N 0.000 description 1
- XKFPYPQQHFEXRZ-UHFFFAOYSA-N 5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide Chemical compound O1C(C)=CC(C(=O)NNCC=2C=CC=CC=2)=N1 XKFPYPQQHFEXRZ-UHFFFAOYSA-N 0.000 description 1
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 1
- AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical compound O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 description 1
- XVASOOUVMJAZNJ-UHFFFAOYSA-N 6beta-octanoylamino-penicillanic acid Natural products S1C(C)(C)C(C(O)=O)N2C(=O)C(NC(=O)CCCCCCC)C21 XVASOOUVMJAZNJ-UHFFFAOYSA-N 0.000 description 1
- JICJBGPOMZQUBB-UHFFFAOYSA-N 7-[(3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid Chemical compound O=S1(=O)N(C)C2=CC=CC=C2C(NCCCCCCC(O)=O)C2=CC=C(Cl)C=C21 JICJBGPOMZQUBB-UHFFFAOYSA-N 0.000 description 1
- 244000161999 Acacia greggii Species 0.000 description 1
- 235000006480 Acorus calamus Nutrition 0.000 description 1
- 240000006054 Agastache cana Species 0.000 description 1
- WKEMJKQOLOHJLZ-UHFFFAOYSA-N Almogran Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1CS(=O)(=O)N1CCCC1 WKEMJKQOLOHJLZ-UHFFFAOYSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 244000208874 Althaea officinalis Species 0.000 description 1
- 235000006576 Althaea officinalis Nutrition 0.000 description 1
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 description 1
- 244000061520 Angelica archangelica Species 0.000 description 1
- 240000005528 Arctium lappa Species 0.000 description 1
- 235000003130 Arctium lappa Nutrition 0.000 description 1
- 235000008078 Arctium minus Nutrition 0.000 description 1
- 244000080767 Areca catechu Species 0.000 description 1
- 235000006226 Areca catechu Nutrition 0.000 description 1
- 235000003097 Artemisia absinthium Nutrition 0.000 description 1
- 240000001851 Artemisia dracunculus Species 0.000 description 1
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 241001494508 Arundo donax Species 0.000 description 1
- 241001106067 Atropa Species 0.000 description 1
- 241001456002 Ballota nigra Species 0.000 description 1
- MNIPYSSQXLZQLJ-UHFFFAOYSA-N Biofenac Chemical compound OC(=O)COC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl MNIPYSSQXLZQLJ-UHFFFAOYSA-N 0.000 description 1
- KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical compound C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 description 1
- 235000011996 Calamus deerratus Nutrition 0.000 description 1
- 241000209507 Camellia Species 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- REOZWEGFPHTFEI-JKSUJKDBSA-N Cannabidivarin Chemical compound OC1=CC(CCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 REOZWEGFPHTFEI-JKSUJKDBSA-N 0.000 description 1
- VBGLYOIFKLUMQG-UHFFFAOYSA-N Cannabinol Chemical compound C1=C(C)C=C2C3=C(O)C=C(CCCCC)C=C3OC(C)(C)C2=C1 VBGLYOIFKLUMQG-UHFFFAOYSA-N 0.000 description 1
- 235000008697 Cannabis sativa Nutrition 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- 241000726768 Carpinus Species 0.000 description 1
- 235000005747 Carum carvi Nutrition 0.000 description 1
- 240000000467 Carum carvi Species 0.000 description 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
- GNWUOVJNSFPWDD-XMZRARIVSA-M Cefoxitin sodium Chemical compound [Na+].N([C@]1(OC)C(N2C(=C(COC(N)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)CC1=CC=CS1 GNWUOVJNSFPWDD-XMZRARIVSA-M 0.000 description 1
- 235000003301 Ceiba pentandra Nutrition 0.000 description 1
- 244000146553 Ceiba pentandra Species 0.000 description 1
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N Cephalosporin C Natural products S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 description 1
- LXWBXEWUSAABOA-UHFFFAOYSA-N Cephamycin-C Natural products S1CC(COC(N)=O)=C(C(O)=O)N2C(=O)C(OC)(NC(=O)CCCC(N)C(O)=O)C21 LXWBXEWUSAABOA-UHFFFAOYSA-N 0.000 description 1
- 241001480010 Cestrum Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 235000001258 Cinchona calisaya Nutrition 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 241000221760 Claviceps Species 0.000 description 1
- GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 description 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
- 235000021508 Coleus Nutrition 0.000 description 1
- 244000061182 Coleus blumei Species 0.000 description 1
- 240000004270 Colocasia esculenta var. antiquorum Species 0.000 description 1
- 240000009226 Corylus americana Species 0.000 description 1
- 235000001543 Corylus americana Nutrition 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- UIKROCXWUNQSPJ-UHFFFAOYSA-N Cotinine Natural products C1CC(=O)N(C)C1C1=CC=CN=C1 UIKROCXWUNQSPJ-UHFFFAOYSA-N 0.000 description 1
- 235000003392 Curcuma domestica Nutrition 0.000 description 1
- 244000008991 Curcuma longa Species 0.000 description 1
- HCYAFALTSJYZDH-UHFFFAOYSA-N Desimpramine Chemical compound C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 HCYAFALTSJYZDH-UHFFFAOYSA-N 0.000 description 1
- 244000157437 Desmanthus brachylobus Species 0.000 description 1
- 235000004924 Desmanthus brachylobus Nutrition 0.000 description 1
- 235000002723 Dioscorea alata Nutrition 0.000 description 1
- 235000007056 Dioscorea composita Nutrition 0.000 description 1
- 235000009723 Dioscorea convolvulacea Nutrition 0.000 description 1
- 235000005362 Dioscorea floribunda Nutrition 0.000 description 1
- 235000004868 Dioscorea macrostachya Nutrition 0.000 description 1
- 235000005361 Dioscorea nummularia Nutrition 0.000 description 1
- 235000005360 Dioscorea spiculiflora Nutrition 0.000 description 1
- 241001469188 Duboisia Species 0.000 description 1
- 241000230129 Eisenia <Phaeophyceae> Species 0.000 description 1
- 241000125117 Elsinoe Species 0.000 description 1
- 241000508725 Elymus repens Species 0.000 description 1
- 241000195955 Equisetum hyemale Species 0.000 description 1
- ICMAFTSLXCXHRK-UHFFFAOYSA-N Ethyl pentanoate Chemical compound CCCCC(=O)OCC ICMAFTSLXCXHRK-UHFFFAOYSA-N 0.000 description 1
- 235000004692 Eucalyptus globulus Nutrition 0.000 description 1
- 235000016622 Filipendula ulmaria Nutrition 0.000 description 1
- 244000061544 Filipendula vulgaris Species 0.000 description 1
- PLDUPXSUYLZYBN-UHFFFAOYSA-N Fluphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 PLDUPXSUYLZYBN-UHFFFAOYSA-N 0.000 description 1
- 240000001238 Gaultheria procumbens Species 0.000 description 1
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 1
- 241000208152 Geranium Species 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- RERZNCLIYCABFS-UHFFFAOYSA-N Harmaline hydrochloride Natural products C1CN=C(C)C2=C1C1=CC=C(OC)C=C1N2 RERZNCLIYCABFS-UHFFFAOYSA-N 0.000 description 1
- 241001251432 Heimia salicifolia Species 0.000 description 1
- 241000756137 Hemerocallis Species 0.000 description 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
- 235000010650 Hyssopus officinalis Nutrition 0.000 description 1
- 241000209035 Ilex Species 0.000 description 1
- 235000003325 Ilex Nutrition 0.000 description 1
- 235000003368 Ilex paraguariensis Nutrition 0.000 description 1
- 244000188472 Ilex paraguariensis Species 0.000 description 1
- 235000003366 Ilex purpurea Nutrition 0.000 description 1
- 241001100935 Ilex purpurea Species 0.000 description 1
- 244000017020 Ipomoea batatas Species 0.000 description 1
- 235000002678 Ipomoea batatas Nutrition 0.000 description 1
- 235000006350 Ipomoea batatas var. batatas Nutrition 0.000 description 1
- 240000002836 Ipomoea tricolor Species 0.000 description 1
- MIFYHUACUWQUKT-UHFFFAOYSA-N Isopenicillin N Natural products OC(=O)C1C(C)(C)SC2C(NC(=O)CCCC(N)C(O)=O)C(=O)N21 MIFYHUACUWQUKT-UHFFFAOYSA-N 0.000 description 1
- 240000005067 Jasminum grandiflorum Species 0.000 description 1
- 235000004412 Jasminum grandiflorum Nutrition 0.000 description 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical class C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 240000000161 Lagerstroemia indica Species 0.000 description 1
- 235000000283 Lagerstroemia parviflora Nutrition 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 235000010701 Lavanda vera Nutrition 0.000 description 1
- 240000007890 Leonurus cardiaca Species 0.000 description 1
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 description 1
- 240000003553 Leptospermum scoparium Species 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 235000001577 Lindera glauca Nutrition 0.000 description 1
- 244000245109 Lindera glauca Species 0.000 description 1
- 108010007859 Lisinopril Proteins 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 description 1
- 240000000982 Malva neglecta Species 0.000 description 1
- 235000000060 Malva neglecta Nutrition 0.000 description 1
- YKVWPZJHENXDAJ-VOTSOKGWSA-N Megastigmatrienone Chemical compound CC1=CC(=O)CC(C)(C)C1\C=C\C=C YKVWPZJHENXDAJ-VOTSOKGWSA-N 0.000 description 1
- 235000010654 Melissa officinalis Nutrition 0.000 description 1
- 235000014435 Mentha Nutrition 0.000 description 1
- 241001072983 Mentha Species 0.000 description 1
- 241001479543 Mentha x piperita Species 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 description 1
- UEQUQVLFIPOEMF-UHFFFAOYSA-N Mianserin Chemical compound C1C2=CC=CC=C2N2CCN(C)CC2C2=CC=CC=C21 UEQUQVLFIPOEMF-UHFFFAOYSA-N 0.000 description 1
- 241000680659 Mitragyna speciosa Species 0.000 description 1
- KLPWJLBORRMFGK-UHFFFAOYSA-N Molindone Chemical compound O=C1C=2C(CC)=C(C)NC=2CCC1CN1CCOCC1 KLPWJLBORRMFGK-UHFFFAOYSA-N 0.000 description 1
- 235000009421 Myristica fragrans Nutrition 0.000 description 1
- 244000270834 Myristica fragrans Species 0.000 description 1
- IDBPHNDTYPBSNI-UHFFFAOYSA-N N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide Chemical compound C1CN(CCN2C(N(CC)N=N2)=O)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 IDBPHNDTYPBSNI-UHFFFAOYSA-N 0.000 description 1
- JUUFBMODXQKSTD-UHFFFAOYSA-N N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester Chemical compound N1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1 JUUFBMODXQKSTD-UHFFFAOYSA-N 0.000 description 1
- IBUAVAYGESTICD-UHFFFAOYSA-N Na salt-Heptylpenicillin Natural products CCCCCCCC(=O)CC1C2SC(C)(C)C(N2C1=O)C(=O)O IBUAVAYGESTICD-UHFFFAOYSA-N 0.000 description 1
- RGPDEAGGEXEMMM-UHFFFAOYSA-N Nefopam Chemical compound C12=CC=CC=C2CN(C)CCOC1C1=CC=CC=C1 RGPDEAGGEXEMMM-UHFFFAOYSA-N 0.000 description 1
- PHVGLTMQBUFIQQ-UHFFFAOYSA-N Nortryptiline Chemical compound C1CC2=CC=CC=C2C(=CCCNC)C2=CC=CC=C21 PHVGLTMQBUFIQQ-UHFFFAOYSA-N 0.000 description 1
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 description 1
- 101800000989 Oxytocin Proteins 0.000 description 1
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241001236144 Panaeolus Species 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 241000282376 Panthera tigris Species 0.000 description 1
- 235000011096 Papaver Nutrition 0.000 description 1
- 235000007846 Papaver rhoeas Nutrition 0.000 description 1
- 240000004674 Papaver rhoeas Species 0.000 description 1
- 235000008753 Papaver somniferum Nutrition 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 241001668545 Pascopyrum Species 0.000 description 1
- 235000005126 Peganum harmala Nutrition 0.000 description 1
- 240000005523 Peganum harmala Species 0.000 description 1
- QRLCJUNAKLMRGP-UHFFFAOYSA-N Penicillin F Natural products S1C(C)(C)C(C(O)=O)N2C(=O)C(NC(=O)CC=CCC)C21 QRLCJUNAKLMRGP-UHFFFAOYSA-N 0.000 description 1
- QRLCJUNAKLMRGP-ZTWGYATJSA-N Penicillin F Chemical compound S1C(C)(C)[C@H](C(O)=O)N2C(=O)[C@@H](NC(=O)C/C=C/CC)[C@H]21 QRLCJUNAKLMRGP-ZTWGYATJSA-N 0.000 description 1
- XVASOOUVMJAZNJ-MBNYWOFBSA-N Penicillin K Chemical compound S1C(C)(C)[C@H](C(O)=O)N2C(=O)[C@@H](NC(=O)CCCCCCC)[C@H]21 XVASOOUVMJAZNJ-MBNYWOFBSA-N 0.000 description 1
- 229930195708 Penicillin V Natural products 0.000 description 1
- TZRXHJWUDPFEEY-UHFFFAOYSA-N Pentaerythritol Tetranitrate Chemical compound [O-][N+](=O)OCC(CO[N+]([O-])=O)(CO[N+]([O-])=O)CO[N+]([O-])=O TZRXHJWUDPFEEY-UHFFFAOYSA-N 0.000 description 1
- RGCVKNLCSQQDEP-UHFFFAOYSA-N Perphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 RGCVKNLCSQQDEP-UHFFFAOYSA-N 0.000 description 1
- 241000745991 Phalaris Species 0.000 description 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 description 1
- RMUCZJUITONUFY-UHFFFAOYSA-N Phenelzine Chemical compound NNCCC1=CC=CC=C1 RMUCZJUITONUFY-UHFFFAOYSA-N 0.000 description 1
- 241000722337 Pholiota Species 0.000 description 1
- 235000012550 Pimpinella anisum Nutrition 0.000 description 1
- 240000004760 Pimpinella anisum Species 0.000 description 1
- 244000274050 Platycodon grandiflorum Species 0.000 description 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 description 1
- 244000234609 Portulaca oleracea Species 0.000 description 1
- 235000001855 Portulaca oleracea Nutrition 0.000 description 1
- ZGUGWUXLJSTTMA-UHFFFAOYSA-N Promazinum Chemical compound C1=CC=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZGUGWUXLJSTTMA-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- RBQOQRRFDPXAGN-UHFFFAOYSA-N Propentofylline Chemical compound CN1C(=O)N(CCCCC(C)=O)C(=O)C2=C1N=CN2CCC RBQOQRRFDPXAGN-UHFFFAOYSA-N 0.000 description 1
- AZFUASHXSOTBNU-UHFFFAOYSA-N Propyl 2-methylpropanoate Chemical compound CCCOC(=O)C(C)C AZFUASHXSOTBNU-UHFFFAOYSA-N 0.000 description 1
- 241001237914 Psilocybe Species 0.000 description 1
- 241001453830 Pteridium Species 0.000 description 1
- ZTVQQQVZCWLTDF-UHFFFAOYSA-N Remifentanil Chemical compound C1CN(CCC(=O)OC)CCC1(C(=O)OC)N(C(=O)CC)C1=CC=CC=C1 ZTVQQQVZCWLTDF-UHFFFAOYSA-N 0.000 description 1
- 241000931938 Rhaphiolepis umbellata Species 0.000 description 1
- 241001107098 Rubiaceae Species 0.000 description 1
- 235000009122 Rubus idaeus Nutrition 0.000 description 1
- 244000235659 Rubus idaeus Species 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 235000017276 Salvia Nutrition 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- MKTFCDSHCGDUDE-UHFFFAOYSA-N Salvinorin D Natural products O1C(=O)C2CCC3(C)C(C(=O)OC)=CC(O)C(OC(C)=O)C3C2(C)CC1C=1C=COC=1 MKTFCDSHCGDUDE-UHFFFAOYSA-N 0.000 description 1
- IGQMBQQLKAUYLJ-UHFFFAOYSA-N Salvinorin E Natural products O1C(=O)C2CCC3(C)C(C(=O)OC)=CC(OC(C)=O)C(O)C3C2(C)CC1C=1C=COC=1 IGQMBQQLKAUYLJ-UHFFFAOYSA-N 0.000 description 1
- GFUASHMLKMINGK-UHFFFAOYSA-N Salvinorin F Natural products O1C(=O)C2CCC3(C)C(C(=O)OC)=CCC(O)C3C2(C)CC1C=1C=COC=1 GFUASHMLKMINGK-UHFFFAOYSA-N 0.000 description 1
- KLIYEWBCXJFOSK-UHFFFAOYSA-N Salvinorin G Natural products O1C(=O)C2CCC3(C)C(C(=O)OC)=CC(=O)C(OC(C)=O)C3C2(C)CC1C=1C=COC=1 KLIYEWBCXJFOSK-UHFFFAOYSA-N 0.000 description 1
- 240000000513 Santalum album Species 0.000 description 1
- 235000008632 Santalum album Nutrition 0.000 description 1
- 241000233910 Serenoa Species 0.000 description 1
- 240000006661 Serenoa repens Species 0.000 description 1
- 235000005318 Serenoa repens Nutrition 0.000 description 1
- 241000287219 Serinus canaria Species 0.000 description 1
- 235000005775 Setaria Nutrition 0.000 description 1
- 241000232088 Setaria <nematode> Species 0.000 description 1
- 241000320380 Silybum Species 0.000 description 1
- 244000272459 Silybum marianum Species 0.000 description 1
- 241000219315 Spinacia Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000132004 Symphyotrichum cordifolium Species 0.000 description 1
- 240000002299 Symphytum officinale Species 0.000 description 1
- 235000005865 Symphytum officinale Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- JOAHPSVPXZTVEP-YXJHDRRASA-N Terguride Chemical compound C1=CC([C@H]2C[C@@H](CN(C)[C@@H]2C2)NC(=O)N(CC)CC)=C3C2=CNC3=C1 JOAHPSVPXZTVEP-YXJHDRRASA-N 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- 241000219161 Theobroma Species 0.000 description 1
- RMMPZDDLWLALLJ-UHFFFAOYSA-N Thermophillin Chemical compound COC1=CC(=O)C(OC)=CC1=O RMMPZDDLWLALLJ-UHFFFAOYSA-N 0.000 description 1
- KLBQZWRITKRQQV-UHFFFAOYSA-N Thioridazine Chemical compound C12=CC(SC)=CC=C2SC2=CC=CC=C2N1CCC1CCCCN1C KLBQZWRITKRQQV-UHFFFAOYSA-N 0.000 description 1
- GFBKORZTTCHDGY-UWVJOHFNSA-N Thiothixene Chemical compound C12=CC(S(=O)(=O)N(C)C)=CC=C2SC2=CC=CC=C2\C1=C\CCN1CCN(C)CC1 GFBKORZTTCHDGY-UWVJOHFNSA-N 0.000 description 1
- 241000223259 Trichoderma Species 0.000 description 1
- HWHLPVGTWGOCJO-UHFFFAOYSA-N Trihexyphenidyl Chemical group C1CCCCC1C(C=1C=CC=CC=1)(O)CCN1CCCCC1 HWHLPVGTWGOCJO-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 241000994267 Turbina Species 0.000 description 1
- 235000013832 Valeriana officinalis Nutrition 0.000 description 1
- 244000126014 Valeriana officinalis Species 0.000 description 1
- 235000009499 Vanilla fragrans Nutrition 0.000 description 1
- 244000263375 Vanilla tahitensis Species 0.000 description 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 1
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 description 1
- 240000007438 Viola pedata Species 0.000 description 1
- BLGXFZZNTVWLAY-CCZXDCJGSA-N Yohimbine Natural products C1=CC=C2C(CCN3C[C@@H]4CC[C@@H](O)[C@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-CCZXDCJGSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000007244 Zea mays Nutrition 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- PJAGGJPKGNYFJH-QGZVFWFLSA-N [(6ar)-11-acetyloxy-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10-yl] acetate Chemical compound C([C@H]1N(C)CC2)C3=CC=C(OC(C)=O)C(OC(C)=O)=C3C3=C1C2=CC=C3 PJAGGJPKGNYFJH-QGZVFWFLSA-N 0.000 description 1
- 229960004420 aceclofenac Drugs 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- XBMIVRRWGCYBTQ-UHFFFAOYSA-N acetylmethadol Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(OC(C)=O)CC)C1=CC=CC=C1 XBMIVRRWGCYBTQ-UHFFFAOYSA-N 0.000 description 1
- 229950005506 acetylmethadol Drugs 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229950008644 adicillin Drugs 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229960001391 alfentanil Drugs 0.000 description 1
- 229960003790 alimemazine Drugs 0.000 description 1
- 229950008560 almecillin Drugs 0.000 description 1
- 229960004663 alminoprofen Drugs 0.000 description 1
- FPHLBGOJWPEVME-UHFFFAOYSA-N alminoprofen Chemical compound OC(=O)C(C)C1=CC=C(NCC(C)=C)C=C1 FPHLBGOJWPEVME-UHFFFAOYSA-N 0.000 description 1
- 229960002133 almotriptan Drugs 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
- 229960003805 amantadine Drugs 0.000 description 1
- 229940024554 amdinocillin Drugs 0.000 description 1
- 229950008930 amfenac Drugs 0.000 description 1
- SOYCMDCMZDHQFP-UHFFFAOYSA-N amfenac Chemical compound NC1=C(CC(O)=O)C=CC=C1C(=O)C1=CC=CC=C1 SOYCMDCMZDHQFP-UHFFFAOYSA-N 0.000 description 1
- ORFPWVRKFLOQHK-UHFFFAOYSA-N amicarbazone Chemical compound CC(C)C1=NN(C(=O)NC(C)(C)C)C(=O)N1N ORFPWVRKFLOQHK-UHFFFAOYSA-N 0.000 description 1
- 229960003036 amisulpride Drugs 0.000 description 1
- 229960002519 amoxapine Drugs 0.000 description 1
- QWGDMFLQWFTERH-UHFFFAOYSA-N amoxapine Chemical compound C12=CC(Cl)=CC=C2OC2=CC=CC=C2N=C1N1CCNCC1 QWGDMFLQWFTERH-UHFFFAOYSA-N 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- ZVSGUZQJNXHNIL-UHFFFAOYSA-N amphenidone Chemical compound NC1=CC=CC(N2C(C=CC=C2)=O)=C1 ZVSGUZQJNXHNIL-UHFFFAOYSA-N 0.000 description 1
- 229950008169 amphenidone Drugs 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- LKYQLAWMNBFNJT-UHFFFAOYSA-N anileridine Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC1=CC=C(N)C=C1 LKYQLAWMNBFNJT-UHFFFAOYSA-N 0.000 description 1
- 229960002512 anileridine Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000000648 anti-parkinson Effects 0.000 description 1
- 229940035678 anti-parkinson drug Drugs 0.000 description 1
- 230000000561 anti-psychotic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940125681 anticonvulsant agent Drugs 0.000 description 1
- 229940125683 antiemetic agent Drugs 0.000 description 1
- 229960003965 antiepileptics Drugs 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000939 antiparkinson agent Substances 0.000 description 1
- 239000000164 antipsychotic agent Substances 0.000 description 1
- 229940005530 anxiolytics Drugs 0.000 description 1
- 229960004046 apomorphine Drugs 0.000 description 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 description 1
- 229960001372 aprepitant Drugs 0.000 description 1
- ATALOFNDEOCMKK-OITMNORJSA-N aprepitant Chemical compound O([C@@H]([C@@H]1C=2C=CC(F)=CC=2)O[C@H](C)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)CCN1CC1=NNC(=O)N1 ATALOFNDEOCMKK-OITMNORJSA-N 0.000 description 1
- 239000001138 artemisia absinthium Substances 0.000 description 1
- 229960002274 atenolol Drugs 0.000 description 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical class O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
- WOIIIUDZSOLAIW-NSHDSACASA-N azapropazone Chemical compound C1=C(C)C=C2N3C(=O)[C@H](CC=C)C(=O)N3C(N(C)C)=NC2=C1 WOIIIUDZSOLAIW-NSHDSACASA-N 0.000 description 1
- 229960001671 azapropazone Drugs 0.000 description 1
- 229960000383 azatadine Drugs 0.000 description 1
- SEBMTIQKRHYNIT-UHFFFAOYSA-N azatadine Chemical compound C1CN(C)CCC1=C1C2=NC=CC=C2CCC2=CC=CC=C21 SEBMTIQKRHYNIT-UHFFFAOYSA-N 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 229960005430 benoxaprofen Drugs 0.000 description 1
- BNQDCRGUHNALGH-UHFFFAOYSA-N benserazide Chemical compound OCC(N)C(=O)NNCC1=CC=C(O)C(O)=C1O BNQDCRGUHNALGH-UHFFFAOYSA-N 0.000 description 1
- 229960000911 benserazide Drugs 0.000 description 1
- GIJXKZJWITVLHI-PMOLBWCYSA-N benzatropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(C=1C=CC=CC=1)C1=CC=CC=C1 GIJXKZJWITVLHI-PMOLBWCYSA-N 0.000 description 1
- 229960001081 benzatropine Drugs 0.000 description 1
- UMIVXZPTRXBADB-UHFFFAOYSA-N benzocyclobutene Chemical class C1=CC=C2CCC2=C1 UMIVXZPTRXBADB-UHFFFAOYSA-N 0.000 description 1
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N benzocyclopentane Natural products C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 150000001557 benzodiazepines Chemical class 0.000 description 1
- 229960000333 benzydamine Drugs 0.000 description 1
- RDJGWRFTDZZXSM-RNWLQCGYSA-N benzylmorphine Chemical compound O([C@@H]1[C@]23CCN([C@H](C4)[C@@H]3C=C[C@@H]1O)C)C1=C2C4=CC=C1OCC1=CC=CC=C1 RDJGWRFTDZZXSM-RNWLQCGYSA-N 0.000 description 1
- WHRVRSCEWKLAHX-LQDWTQKMSA-N benzylpenicillin procaine Chemical compound [H+].CCN(CC)CCOC(=O)C1=CC=C(N)C=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 WHRVRSCEWKLAHX-LQDWTQKMSA-N 0.000 description 1
- BLGXFZZNTVWLAY-UHFFFAOYSA-N beta-Yohimbin Natural products C1=CC=C2C(CCN3CC4CCC(O)C(C4CC33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-UHFFFAOYSA-N 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229960003003 biperiden Drugs 0.000 description 1
- YSXKPIUOCJLQIE-UHFFFAOYSA-N biperiden Chemical compound C1C(C=C2)CC2C1C(C=1C=CC=CC=1)(O)CCN1CCCCC1 YSXKPIUOCJLQIE-UHFFFAOYSA-N 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 239000008376 breath freshener Substances 0.000 description 1
- ZBPLOVFIXSTCRZ-UHFFFAOYSA-N bromfenac Chemical compound NC1=C(CC(O)=O)C=CC=C1C(=O)C1=CC=C(Br)C=C1 ZBPLOVFIXSTCRZ-UHFFFAOYSA-N 0.000 description 1
- 229960003655 bromfenac Drugs 0.000 description 1
- 229960002802 bromocriptine Drugs 0.000 description 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 description 1
- 229960000725 brompheniramine Drugs 0.000 description 1
- ZDIGNSYAACHWNL-UHFFFAOYSA-N brompheniramine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Br)C=C1 ZDIGNSYAACHWNL-UHFFFAOYSA-N 0.000 description 1
- MOYGZHXDRJNJEP-UHFFFAOYSA-N buclizine Chemical compound C1=CC(C(C)(C)C)=CC=C1CN1CCN(C(C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)CC1 MOYGZHXDRJNJEP-UHFFFAOYSA-N 0.000 description 1
- 229960001705 buclizine Drugs 0.000 description 1
- MXJWRABVEGLYDG-UHFFFAOYSA-N bufexamac Chemical compound CCCCOC1=CC=C(CC(=O)NO)C=C1 MXJWRABVEGLYDG-UHFFFAOYSA-N 0.000 description 1
- 229960000962 bufexamac Drugs 0.000 description 1
- QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 description 1
- 229960002495 buspirone Drugs 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 description 1
- 229960001113 butorphanol Drugs 0.000 description 1
- 229960004596 cabergoline Drugs 0.000 description 1
- KGWAITXYALRFDQ-DKWTVANSSA-L calcium;(2s)-2-(carbamoylamino)butanedioate Chemical compound [Ca+2].NC(=O)N[C@H](C([O-])=O)CC([O-])=O KGWAITXYALRFDQ-DKWTVANSSA-L 0.000 description 1
- QXACEHWTBCFNSA-SFQUDFHCSA-N cannabigerol Chemical compound CCCCCC1=CC(O)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1 QXACEHWTBCFNSA-SFQUDFHCSA-N 0.000 description 1
- 229940065144 cannabinoids Drugs 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 229960004205 carbidopa Drugs 0.000 description 1
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 description 1
- NQIZDFMZAXUZCZ-UHFFFAOYSA-N carbifene Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(OCC)C(=O)N(C)CCN(C)CCC1=CC=CC=C1 NQIZDFMZAXUZCZ-UHFFFAOYSA-N 0.000 description 1
- 229950003365 carbifene Drugs 0.000 description 1
- 229960003184 carprofen Drugs 0.000 description 1
- IVUMCTKHWDRRMH-UHFFFAOYSA-N carprofen Chemical compound C1=CC(Cl)=C[C]2C3=CC=C(C(C(O)=O)C)C=C3N=C21 IVUMCTKHWDRRMH-UHFFFAOYSA-N 0.000 description 1
- RXDMAYSSBPYBFW-PKFCDNJMSA-N carpropamide Chemical compound N([C@@H](C)C=1C=CC(Cl)=CC=1)C(=O)[C@@]1(CC)[C@H](C)C1(Cl)Cl RXDMAYSSBPYBFW-PKFCDNJMSA-N 0.000 description 1
- 235000004608 catclaw acacia Nutrition 0.000 description 1
- PUAQLLVFLMYYJJ-ZETCQYMHSA-N cathinone Chemical compound C[C@H](N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-ZETCQYMHSA-N 0.000 description 1
- 150000008367 cathinones Chemical group 0.000 description 1
- 229960001139 cefazolin Drugs 0.000 description 1
- MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 description 1
- SNBUBQHDYVFSQF-HIFRSBDPSA-N cefmetazole Chemical compound S([C@@H]1[C@@](C(N1C=1C(O)=O)=O)(NC(=O)CSCC#N)OC)CC=1CSC1=NN=NN1C SNBUBQHDYVFSQF-HIFRSBDPSA-N 0.000 description 1
- 229960003585 cefmetazole Drugs 0.000 description 1
- 229960002682 cefoxitin Drugs 0.000 description 1
- 229960002588 cefradine Drugs 0.000 description 1
- 229960005229 ceftiofur Drugs 0.000 description 1
- ZBHXIWJRIFEVQY-IHMPYVIRSA-N ceftiofur Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC(=O)C1=CC=CO1 ZBHXIWJRIFEVQY-IHMPYVIRSA-N 0.000 description 1
- HOKIDJSKDBPKTQ-GLXFQSAKSA-M cephalosporin C(1-) Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H]([NH3+])C([O-])=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-M 0.000 description 1
- UCKZMPLVLCKKMO-LHLIQPBNSA-N cephamycin Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](C)[C@]21OC UCKZMPLVLCKKMO-LHLIQPBNSA-N 0.000 description 1
- LXWBXEWUSAABOA-VXSYNFHWSA-N cephamycin C Chemical compound S1CC(COC(N)=O)=C(C(O)=O)N2C(=O)[C@@](OC)(NC(=O)CCC[C@@H](N)C(O)=O)[C@H]21 LXWBXEWUSAABOA-VXSYNFHWSA-N 0.000 description 1
- BVOBPJWSXSKGOO-UHFFFAOYSA-N cephamycin-B Natural products OC(=O)C=1N(C(C2(OC)NC(=O)CCCC(N)C(O)=O)=O)C2SCC=1COC(=O)C(OC)=CC1=CC=C(O)C=C1 BVOBPJWSXSKGOO-UHFFFAOYSA-N 0.000 description 1
- RDLPVSKMFDYCOR-UEKVPHQBSA-N cephradine Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CCC=CC1 RDLPVSKMFDYCOR-UEKVPHQBSA-N 0.000 description 1
- BWWVAEOLVKTZFQ-ISVUSNJMSA-N chembl530 Chemical compound N(/[C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)=C\N1CCCCCC1 BWWVAEOLVKTZFQ-ISVUSNJMSA-N 0.000 description 1
- ONAOIDNSINNZOA-UHFFFAOYSA-N chloral betaine Chemical compound OC(O)C(Cl)(Cl)Cl.C[N+](C)(C)CC([O-])=O ONAOIDNSINNZOA-UHFFFAOYSA-N 0.000 description 1
- 229940118803 chloral betaine Drugs 0.000 description 1
- 229960004782 chlordiazepoxide Drugs 0.000 description 1
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 description 1
- 229920005556 chlorobutyl Polymers 0.000 description 1
- 229960003291 chlorphenamine Drugs 0.000 description 1
- SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
- 229960002468 cinchophen Drugs 0.000 description 1
- DERZBLKQOCDDDZ-JLHYYAGUSA-N cinnarizine Chemical compound C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C\C=C\C1=CC=CC=C1 DERZBLKQOCDDDZ-JLHYYAGUSA-N 0.000 description 1
- 229960000876 cinnarizine Drugs 0.000 description 1
- NPFVOOAXDOBMCE-PLNGDYQASA-N cis-3-Hexenyl acetate Natural products CC\C=C/CCOC(C)=O NPFVOOAXDOBMCE-PLNGDYQASA-N 0.000 description 1
- RRGOKSYVAZDNKR-ARJAWSKDSA-M cis-3-hexenylacetate Chemical compound CC\C=C/CCCC([O-])=O RRGOKSYVAZDNKR-ARJAWSKDSA-M 0.000 description 1
- 229960001653 citalopram Drugs 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Chemical class 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 229960002881 clemastine Drugs 0.000 description 1
- YNNUSGIPVFPVBX-NHCUHLMSSA-N clemastine Chemical compound CN1CCC[C@@H]1CCO[C@@](C)(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 YNNUSGIPVFPVBX-NHCUHLMSSA-N 0.000 description 1
- 229950001647 clometacin Drugs 0.000 description 1
- DGMZLCLHHVYDIS-UHFFFAOYSA-N clometacin Chemical compound CC=1N(CC(O)=O)C2=CC(OC)=CC=C2C=1C(=O)C1=CC=C(Cl)C=C1 DGMZLCLHHVYDIS-UHFFFAOYSA-N 0.000 description 1
- 229960004606 clomipramine Drugs 0.000 description 1
- 229960002896 clonidine Drugs 0.000 description 1
- 229960001184 clopenthixol Drugs 0.000 description 1
- 229950002663 clovoxamine Drugs 0.000 description 1
- XXPVSQRPGBUFKM-SAPNQHFASA-N clovoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(Cl)C=C1 XXPVSQRPGBUFKM-SAPNQHFASA-N 0.000 description 1
- 229960003326 cloxacillin Drugs 0.000 description 1
- LQOLIRLGBULYKD-JKIFEVAISA-N cloxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl LQOLIRLGBULYKD-JKIFEVAISA-N 0.000 description 1
- 229960004170 clozapine Drugs 0.000 description 1
- QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 description 1
- 229960003920 cocaine Drugs 0.000 description 1
- 235000018597 common camellia Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000010636 coriander oil Substances 0.000 description 1
- 229940089639 cornsilk Drugs 0.000 description 1
- 229950006073 cotinine Drugs 0.000 description 1
- 150000001907 coumarones Chemical class 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 229960003564 cyclizine Drugs 0.000 description 1
- UVKZSORBKUEBAZ-UHFFFAOYSA-N cyclizine Chemical compound C1CN(C)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 UVKZSORBKUEBAZ-UHFFFAOYSA-N 0.000 description 1
- 229960003572 cyclobenzaprine Drugs 0.000 description 1
- JURKNVYFZMSNLP-UHFFFAOYSA-N cyclobenzaprine Chemical compound C1=CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 JURKNVYFZMSNLP-UHFFFAOYSA-N 0.000 description 1
- 229930007927 cymene Natural products 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229960003914 desipramine Drugs 0.000 description 1
- 229960004597 dexfenfluramine Drugs 0.000 description 1
- HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 description 1
- 229960004253 dexmedetomidine Drugs 0.000 description 1
- INUNXTSAACVKJS-OAQYLSRUSA-N dextromoramide Chemical compound C([C@@H](C)C(C(=O)N1CCCC1)(C=1C=CC=CC=1)C=1C=CC=CC=1)N1CCOCC1 INUNXTSAACVKJS-OAQYLSRUSA-N 0.000 description 1
- 229960003701 dextromoramide Drugs 0.000 description 1
- 229960002069 diamorphine Drugs 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 229960001585 dicloxacillin Drugs 0.000 description 1
- YFAGHNZHGGCZAX-JKIFEVAISA-N dicloxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(Cl)C=CC=C1Cl YFAGHNZHGGCZAX-JKIFEVAISA-N 0.000 description 1
- RHWBUPDTXIHKGT-UHFFFAOYSA-N dideacetylsalvinorin C Natural products O1C(=O)C2CCC3(C)C(C(=O)OC)=CC(O)C(O)C3C2(C)CC1C=1C=COC=1 RHWBUPDTXIHKGT-UHFFFAOYSA-N 0.000 description 1
- PBUNVLRHZGSROC-VTIMJTGVSA-N dihydro-alpha-ergocryptine Chemical compound C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1 PBUNVLRHZGSROC-VTIMJTGVSA-N 0.000 description 1
- 229960000920 dihydrocodeine Drugs 0.000 description 1
- RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 description 1
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 description 1
- 229960002032 dihydroergocryptine Drugs 0.000 description 1
- 229960004704 dihydroergotamine Drugs 0.000 description 1
- HESHRHUZIWVEAJ-JGRZULCMSA-N dihydroergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2[C@@H](C3=CC=CC4=NC=C([C]34)C2)C1)C)C1=CC=CC=C1 HESHRHUZIWVEAJ-JGRZULCMSA-N 0.000 description 1
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 description 1
- 229960004166 diltiazem Drugs 0.000 description 1
- 235000004879 dioscorea Nutrition 0.000 description 1
- 229960004192 diphenoxylate Drugs 0.000 description 1
- HYPPXZBJBPSRLK-UHFFFAOYSA-N diphenoxylate Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 HYPPXZBJBPSRLK-UHFFFAOYSA-N 0.000 description 1
- 229960002563 disulfiram Drugs 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- WTOYNNBCKUYIKC-UHFFFAOYSA-N dl-nootkatone Natural products C1CC(C(C)=C)CC2(C)C(C)CC(=O)C=C21 WTOYNNBCKUYIKC-UHFFFAOYSA-N 0.000 description 1
- 229960003218 dolasetron mesylate Drugs 0.000 description 1
- 229960005178 doxylamine Drugs 0.000 description 1
- HCFDWZZGGLSKEP-UHFFFAOYSA-N doxylamine Chemical compound C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 HCFDWZZGGLSKEP-UHFFFAOYSA-N 0.000 description 1
- RMEDXOLNCUSCGS-UHFFFAOYSA-N droperidol Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CC=C(N2C(NC3=CC=CC=C32)=O)CC1 RMEDXOLNCUSCGS-UHFFFAOYSA-N 0.000 description 1
- 229960000394 droperidol Drugs 0.000 description 1
- 229960002866 duloxetine Drugs 0.000 description 1
- 229960002472 eletriptan Drugs 0.000 description 1
- PWVXXGRKLHYWKM-LJQANCHMSA-N eletriptan Chemical compound CN1CCC[C@@H]1CC(C1=C2)=CNC1=CC=C2CCS(=O)(=O)C1=CC=CC=C1 PWVXXGRKLHYWKM-LJQANCHMSA-N 0.000 description 1
- JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 description 1
- 229960003337 entacapone Drugs 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- RHGUXDUPXYFCTE-ZWNOBZJWSA-N ergoline Chemical class C1=CC([C@@H]2[C@H](NCCC2)C2)=C3C2=CNC3=C1 RHGUXDUPXYFCTE-ZWNOBZJWSA-N 0.000 description 1
- 229960004943 ergotamine Drugs 0.000 description 1
- OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 description 1
- XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 235000019439 ethyl acetate Nutrition 0.000 description 1
- 229940073505 ethyl vanillin Drugs 0.000 description 1
- 229960005293 etodolac Drugs 0.000 description 1
- XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 229960001582 fenfluramine Drugs 0.000 description 1
- 229960002428 fentanyl Drugs 0.000 description 1
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 description 1
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 description 1
- 229960003592 fexofenadine Drugs 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 229960002690 fluphenazine Drugs 0.000 description 1
- 229960003667 flupirtine Drugs 0.000 description 1
- 229960003528 flurazepam Drugs 0.000 description 1
- SAADBVWGJQAEFS-UHFFFAOYSA-N flurazepam Chemical compound N=1CC(=O)N(CCN(CC)CC)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1F SAADBVWGJQAEFS-UHFFFAOYSA-N 0.000 description 1
- 229960004038 fluvoxamine Drugs 0.000 description 1
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 229940068517 fruit extracts Drugs 0.000 description 1
- 239000008369 fruit flavor Substances 0.000 description 1
- 229960002870 gabapentin Drugs 0.000 description 1
- 229960003980 galantamine Drugs 0.000 description 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 description 1
- IPBFYZQJXZJBFQ-UHFFFAOYSA-N gamma-octalactone Chemical compound CCCCC1CCC(=O)O1 IPBFYZQJXZJBFQ-UHFFFAOYSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 239000010648 geranium oil Chemical class 0.000 description 1
- 235000019717 geranium oil Nutrition 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 239000010649 ginger oil Chemical class 0.000 description 1
- 229960003727 granisetron Drugs 0.000 description 1
- MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- VJHLDRVYTQNASM-UHFFFAOYSA-N harmine Natural products CC1=CN=CC=2NC3=CC(=CC=C3C=21)OC VJHLDRVYTQNASM-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 description 1
- 229960001410 hydromorphone Drugs 0.000 description 1
- ZQDWXGKKHFNSQK-UHFFFAOYSA-N hydroxyzine Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZQDWXGKKHFNSQK-UHFFFAOYSA-N 0.000 description 1
- 229960000930 hydroxyzine Drugs 0.000 description 1
- IWBJJCOKGLUQIZ-HQKKAZOISA-N hyperforin Chemical compound OC1=C(CC=C(C)C)C(=O)[C@@]2(CC=C(C)C)C[C@H](CC=C(C)C)[C@](CCC=C(C)C)(C)[C@]1(C(=O)C(C)C)C2=O IWBJJCOKGLUQIZ-HQKKAZOISA-N 0.000 description 1
- QOVWXXKVLJOKNW-UHFFFAOYSA-N hyperforin Natural products CC(C)C(=O)C12CC(CC=C(C)C)(CC(CC=C(C)C)C1CCC=C(C)C)C(=C(CC=C(C)C)C2=O)O QOVWXXKVLJOKNW-UHFFFAOYSA-N 0.000 description 1
- 229960004801 imipramine Drugs 0.000 description 1
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 description 1
- AMGQUBHHOARCQH-UHFFFAOYSA-N indium;oxotin Chemical compound [In].[Sn]=O AMGQUBHHOARCQH-UHFFFAOYSA-N 0.000 description 1
- 150000002475 indoles Chemical class 0.000 description 1
- 229960004187 indoprofen Drugs 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940117955 isoamyl acetate Drugs 0.000 description 1
- JSLCOZYBKYHZNL-UHFFFAOYSA-N isobutyric acid butyl ester Natural products CCCCOC(=O)C(C)C JSLCOZYBKYHZNL-UHFFFAOYSA-N 0.000 description 1
- 229960002672 isocarboxazid Drugs 0.000 description 1
- XVQUOJBERHHONY-UHFFFAOYSA-N isometheptene Chemical compound CNC(C)CCC=C(C)C XVQUOJBERHHONY-UHFFFAOYSA-N 0.000 description 1
- 229960003046 isometheptene Drugs 0.000 description 1
- 229960003350 isoniazid Drugs 0.000 description 1
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 description 1
- FABUFPQFXZVHFB-CFWQTKTJSA-N ixabepilone Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@H](C)C(=O)C(C)(C)[C@H](O)CC(=O)N1)O)C)=C\C1=CSC(C)=N1 FABUFPQFXZVHFB-CFWQTKTJSA-N 0.000 description 1
- 229960002014 ixabepilone Drugs 0.000 description 1
- 229960005417 ketanserin Drugs 0.000 description 1
- FPCCSQOGAWCVBH-UHFFFAOYSA-N ketanserin Chemical compound C1=CC(F)=CC=C1C(=O)C1CCN(CCN2C(C3=CC=CC=C3NC2=O)=O)CC1 FPCCSQOGAWCVBH-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 229950005862 lazabemide Drugs 0.000 description 1
- AHCPKWJUALHOPH-UHFFFAOYSA-N lesopitron Chemical compound C1=C(Cl)C=NN1CCCCN1CCN(C=2N=CC=CN=2)CC1 AHCPKWJUALHOPH-UHFFFAOYSA-N 0.000 description 1
- 229950001590 lesopitron Drugs 0.000 description 1
- 229960004502 levodopa Drugs 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 229960002394 lisinopril Drugs 0.000 description 1
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 description 1
- IMYHGORQCPYVBZ-UHFFFAOYSA-N lofentanyl Chemical group C1CN(CCC=2C=CC=CC=2)CC(C)C1(C(=O)OC)N(C(=O)CC)C1=CC=CC=C1 IMYHGORQCPYVBZ-UHFFFAOYSA-N 0.000 description 1
- 229960002813 lofepramine Drugs 0.000 description 1
- SAPNXPWPAUFAJU-UHFFFAOYSA-N lofepramine Chemical compound C12=CC=CC=C2CCC2=CC=CC=C2N1CCCN(C)CC(=O)C1=CC=C(Cl)C=C1 SAPNXPWPAUFAJU-UHFFFAOYSA-N 0.000 description 1
- 229960003088 loratadine Drugs 0.000 description 1
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 description 1
- 229960000423 loxapine Drugs 0.000 description 1
- YQZBAXDVDZTKEQ-UHFFFAOYSA-N loxapine succinate Chemical compound [H+].[H+].[O-]C(=O)CCC([O-])=O.C1CN(C)CCN1C1=NC2=CC=CC=C2OC2=CC=C(Cl)C=C12 YQZBAXDVDZTKEQ-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 229940043353 maltol Drugs 0.000 description 1
- 229960004090 maprotiline Drugs 0.000 description 1
- QSLMDECMDJKHMQ-GSXCWMCISA-N maprotiline Chemical compound C12=CC=CC=C2[C@@]2(CCCNC)C3=CC=CC=C3[C@@H]1CC2 QSLMDECMDJKHMQ-GSXCWMCISA-N 0.000 description 1
- 235000001035 marshmallow Nutrition 0.000 description 1
- 229940013798 meclofenamate Drugs 0.000 description 1
- SBDNJUWAMKYJOX-UHFFFAOYSA-M meclofenamic acid(1-) Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C([O-])=O)=C1Cl SBDNJUWAMKYJOX-UHFFFAOYSA-M 0.000 description 1
- HRLIOXLXPOHXTA-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CN=C[N]1 HRLIOXLXPOHXTA-UHFFFAOYSA-N 0.000 description 1
- 229960002140 medetomidine Drugs 0.000 description 1
- 229960004640 memantine Drugs 0.000 description 1
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 description 1
- 239000001771 mentha piperita Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- JLICHNCFTLFZJN-HNNXBMFYSA-N meptazinol Chemical compound C=1C=CC(O)=CC=1[C@@]1(CC)CCCCN(C)C1 JLICHNCFTLFZJN-HNNXBMFYSA-N 0.000 description 1
- 229960000365 meptazinol Drugs 0.000 description 1
- 229960000300 mesoridazine Drugs 0.000 description 1
- SLVMESMUVMCQIY-UHFFFAOYSA-N mesoridazine Chemical compound CN1CCCCC1CCN1C2=CC(S(C)=O)=CC=C2SC2=CC=CC=C21 SLVMESMUVMCQIY-UHFFFAOYSA-N 0.000 description 1
- 229960001797 methadone Drugs 0.000 description 1
- MKTFCDSHCGDUDE-XMTZKCFKSA-N methyl (2s,4ar,6ar,9s,10r,10ar,10br)-10-acetyloxy-2-(furan-3-yl)-9-hydroxy-6a,10b-dimethyl-4-oxo-1,2,4a,5,6,9,10,10a-octahydrobenzo[f]isochromene-7-carboxylate Chemical compound C=1([C@@H]2C[C@]3(C)[C@H]4[C@@H](OC(C)=O)[C@@H](O)C=C([C@@]4(CC[C@H]3C(=O)O2)C)C(=O)OC)C=COC=1 MKTFCDSHCGDUDE-XMTZKCFKSA-N 0.000 description 1
- IGQMBQQLKAUYLJ-XMTZKCFKSA-N methyl (2s,4ar,6ar,9s,10r,10ar,10br)-9-acetyloxy-2-(furan-3-yl)-10-hydroxy-6a,10b-dimethyl-4-oxo-1,2,4a,5,6,9,10,10a-octahydrobenzo[f]isochromene-7-carboxylate Chemical compound C=1([C@@H]2C[C@]3(C)[C@H]4[C@@H](O)[C@@H](OC(C)=O)C=C([C@@]4(CC[C@H]3C(=O)O2)C)C(=O)OC)C=COC=1 IGQMBQQLKAUYLJ-XMTZKCFKSA-N 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- RRIRDPSOCUCGBV-UHFFFAOYSA-N methylenedioxyphenethylamine Chemical class NCCC1=CC=C2OCOC2=C1 RRIRDPSOCUCGBV-UHFFFAOYSA-N 0.000 description 1
- 229960001344 methylphenidate Drugs 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- BQDBKDMTIJBJLA-UHFFFAOYSA-N metopimazine Chemical compound C12=CC(S(=O)(=O)C)=CC=C2SC2=CC=CC=C2N1CCCN1CCC(C(N)=O)CC1 BQDBKDMTIJBJLA-UHFFFAOYSA-N 0.000 description 1
- 229960000767 metopimazine Drugs 0.000 description 1
- 229960002237 metoprolol Drugs 0.000 description 1
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
- 229960003955 mianserin Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229960003793 midazolam Drugs 0.000 description 1
- DDLIGBOFAVUZHB-UHFFFAOYSA-N midazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F DDLIGBOFAVUZHB-UHFFFAOYSA-N 0.000 description 1
- 235000014569 mints Nutrition 0.000 description 1
- 229960001785 mirtazapine Drugs 0.000 description 1
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 description 1
- YHXISWVBGDMDLQ-UHFFFAOYSA-N moclobemide Chemical compound C1=CC(Cl)=CC=C1C(=O)NCCN1CCOCC1 YHXISWVBGDMDLQ-UHFFFAOYSA-N 0.000 description 1
- 229960004644 moclobemide Drugs 0.000 description 1
- 229950007856 mofetil Drugs 0.000 description 1
- 229960004938 molindone Drugs 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- JZXRLKWWVNUZRB-UHFFFAOYSA-N n-(2-aminoethyl)-5-chloropyridine-2-carboxamide Chemical compound NCCNC(=O)C1=CC=C(Cl)C=N1 JZXRLKWWVNUZRB-UHFFFAOYSA-N 0.000 description 1
- BZRZRAJFBZQJRU-UHFFFAOYSA-N n-bromo-n-carbamoyl-3-methylbutanamide Chemical compound CC(C)CC(=O)N(Br)C(N)=O BZRZRAJFBZQJRU-UHFFFAOYSA-N 0.000 description 1
- AOTWIFLKURJQGE-UHFFFAOYSA-N n-cyclopropylaniline Chemical class C1CC1NC1=CC=CC=C1 AOTWIFLKURJQGE-UHFFFAOYSA-N 0.000 description 1
- 229960004255 nadolol Drugs 0.000 description 1
- VWPOSFSPZNDTMJ-UCWKZMIHSA-N nadolol Chemical compound C1[C@@H](O)[C@@H](O)CC2=C1C=CC=C2OCC(O)CNC(C)(C)C VWPOSFSPZNDTMJ-UCWKZMIHSA-N 0.000 description 1
- GPXLMGHLHQJAGZ-JTDSTZFVSA-N nafcillin Chemical compound C1=CC=CC2=C(C(=O)N[C@@H]3C(N4[C@H](C(C)(C)S[C@@H]43)C(O)=O)=O)C(OCC)=CC=C21 GPXLMGHLHQJAGZ-JTDSTZFVSA-N 0.000 description 1
- 229960000515 nafcillin Drugs 0.000 description 1
- NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 description 1
- 229960000805 nalbuphine Drugs 0.000 description 1
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 description 1
- 229960004127 naloxone Drugs 0.000 description 1
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 description 1
- 229960003086 naltrexone Drugs 0.000 description 1
- UFWIBTONFRDIAS-UHFFFAOYSA-N naphthalene-acid Natural products C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 1
- 150000002790 naphthalenes Chemical class 0.000 description 1
- 229960005254 naratriptan Drugs 0.000 description 1
- AMKVXSZCKVJAGH-UHFFFAOYSA-N naratriptan Chemical compound C12=CC(CCS(=O)(=O)NC)=CC=C2NC=C1C1CCN(C)CC1 AMKVXSZCKVJAGH-UHFFFAOYSA-N 0.000 description 1
- 229960001800 nefazodone Drugs 0.000 description 1
- VRBKIVRKKCLPHA-UHFFFAOYSA-N nefazodone Chemical compound O=C1N(CCOC=2C=CC=CC=2)C(CC)=NN1CCCN(CC1)CCN1C1=CC=CC(Cl)=C1 VRBKIVRKKCLPHA-UHFFFAOYSA-N 0.000 description 1
- 229960000751 nefopam Drugs 0.000 description 1
- ITJNARMNRKSWTA-UHFFFAOYSA-N nisoxetine Chemical compound C=1C=CC=CC=1C(CCNC)OC1=CC=CC=C1OC ITJNARMNRKSWTA-UHFFFAOYSA-N 0.000 description 1
- 229950004211 nisoxetine Drugs 0.000 description 1
- 229960001073 nomifensine Drugs 0.000 description 1
- XXPANQJNYNUNES-UHFFFAOYSA-N nomifensine Chemical compound C12=CC=CC(N)=C2CN(C)CC1C1=CC=CC=C1 XXPANQJNYNUNES-UHFFFAOYSA-N 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 239000002664 nootropic agent Substances 0.000 description 1
- 229960001158 nortriptyline Drugs 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 229960005017 olanzapine Drugs 0.000 description 1
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 description 1
- 229960005343 ondansetron Drugs 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 1
- 229960001723 oxytocin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 1
- 229960002131 palonosetron Drugs 0.000 description 1
- CPZBLNMUGSZIPR-NVXWUHKLSA-N palonosetron Chemical compound C1N(CC2)CCC2[C@@H]1N1C(=O)C(C=CC=C2CCC3)=C2[C@H]3C1 CPZBLNMUGSZIPR-NVXWUHKLSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 235000019371 penicillin G benzathine Nutrition 0.000 description 1
- MIFYHUACUWQUKT-GPUHXXMPSA-N penicillin N Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2[C@H](NC(=O)CCC[C@@H](N)C(O)=O)C(=O)N21 MIFYHUACUWQUKT-GPUHXXMPSA-N 0.000 description 1
- QULKGELYPOJSLP-WCABBAIRSA-N penicillin O Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2[C@H](NC(=O)CSCC=C)C(=O)N21 QULKGELYPOJSLP-WCABBAIRSA-N 0.000 description 1
- 229940056360 penicillin g Drugs 0.000 description 1
- 229940056367 penicillin v Drugs 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N pentanal Chemical compound CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 description 1
- VOKSWYLNZZRQPF-GDIGMMSISA-N pentazocine Chemical compound C1C2=CC=C(O)C=C2[C@@]2(C)[C@@H](C)[C@@H]1N(CC=C(C)C)CC2 VOKSWYLNZZRQPF-GDIGMMSISA-N 0.000 description 1
- 229960005301 pentazocine Drugs 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 229960004851 pergolide Drugs 0.000 description 1
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 description 1
- 229960000762 perphenazine Drugs 0.000 description 1
- ZQHYKVKNPWDQSL-KNXBSLHKSA-N phenazocine Chemical compound C([C@@]1(C)C2=CC(O)=CC=C2C[C@@H]2[C@@H]1C)CN2CCC1=CC=CC=C1 ZQHYKVKNPWDQSL-KNXBSLHKSA-N 0.000 description 1
- 229960000897 phenazocine Drugs 0.000 description 1
- 229960000964 phenelzine Drugs 0.000 description 1
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
- 229960003562 phentermine Drugs 0.000 description 1
- 229960001999 phentolamine Drugs 0.000 description 1
- MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical compound C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 description 1
- 229940067157 phenylhydrazine Drugs 0.000 description 1
- IOLQWLOHKZENDW-UHFFFAOYSA-N phenylisobutylamine Chemical class CCC(N)CC1=CC=CC=C1 IOLQWLOHKZENDW-UHFFFAOYSA-N 0.000 description 1
- IOUNQDKNJZEDEP-UHFFFAOYSA-N phosalone Chemical compound C1=C(Cl)C=C2OC(=O)N(CSP(=S)(OCC)OCC)C2=C1 IOUNQDKNJZEDEP-UHFFFAOYSA-N 0.000 description 1
- YVUQSNJEYSNKRX-UHFFFAOYSA-N pimozide Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)CCCN1CCC(N2C(NC3=CC=CC=C32)=O)CC1 YVUQSNJEYSNKRX-UHFFFAOYSA-N 0.000 description 1
- 229960003634 pimozide Drugs 0.000 description 1
- OSJJYEUEJRVVOD-UHFFFAOYSA-N pipamazine Chemical compound C1CC(C(=O)N)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 OSJJYEUEJRVVOD-UHFFFAOYSA-N 0.000 description 1
- 229950008580 pipamazine Drugs 0.000 description 1
- 150000004885 piperazines Chemical class 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 229960000851 pirprofen Drugs 0.000 description 1
- PIDSZXPFGCURGN-UHFFFAOYSA-N pirprofen Chemical compound ClC1=CC(C(C(O)=O)C)=CC=C1N1CC=CC1 PIDSZXPFGCURGN-UHFFFAOYSA-N 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 229960005253 procyclidine Drugs 0.000 description 1
- 229960003598 promazine Drugs 0.000 description 1
- 229960003192 propacetamol Drugs 0.000 description 1
- QTGAJCQTLIRCFL-UHFFFAOYSA-N propacetamol Chemical compound CCN(CC)CC(=O)OC1=CC=C(NC(C)=O)C=C1 QTGAJCQTLIRCFL-UHFFFAOYSA-N 0.000 description 1
- 229960002934 propentofylline Drugs 0.000 description 1
- 229960002601 protriptyline Drugs 0.000 description 1
- BWPIARFWQZKAIA-UHFFFAOYSA-N protriptyline Chemical compound C1=CC2=CC=CC=C2C(CCCNC)C2=CC=CC=C21 BWPIARFWQZKAIA-UHFFFAOYSA-N 0.000 description 1
- 229960004431 quetiapine Drugs 0.000 description 1
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 description 1
- 229960000948 quinine Drugs 0.000 description 1
- RUOKEQAAGRXIBM-GFCCVEGCSA-N rasagiline Chemical compound C1=CC=C2[C@H](NCC#C)CCC2=C1 RUOKEQAAGRXIBM-GFCCVEGCSA-N 0.000 description 1
- 229960000245 rasagiline Drugs 0.000 description 1
- 229960003770 reboxetine Drugs 0.000 description 1
- CBQGYUDMJHNJBX-RTBURBONSA-N reboxetine Chemical compound CCOC1=CC=CC=C1O[C@H](C=1C=CC=CC=1)[C@@H]1OCCNC1 CBQGYUDMJHNJBX-RTBURBONSA-N 0.000 description 1
- 229950000659 remacemide Drugs 0.000 description 1
- 229960003394 remifentanil Drugs 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229960001534 risperidone Drugs 0.000 description 1
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 description 1
- 229950009626 ritanserin Drugs 0.000 description 1
- JUQLTPCYUFPYKE-UHFFFAOYSA-N ritanserin Chemical compound CC=1N=C2SC=CN2C(=O)C=1CCN(CC1)CCC1=C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 JUQLTPCYUFPYKE-UHFFFAOYSA-N 0.000 description 1
- 229960000425 rizatriptan Drugs 0.000 description 1
- ULFRLSNUDGIQQP-UHFFFAOYSA-N rizatriptan Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1CN1C=NC=N1 ULFRLSNUDGIQQP-UHFFFAOYSA-N 0.000 description 1
- 235000019719 rose oil Nutrition 0.000 description 1
- 239000010666 rose oil Substances 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- YPCKIDCZBFZYON-UHFFFAOYSA-N salvinorin I Natural products COC(=O)C1=CC(O)C(O)C2C3(C)CC(OC(O)C3CCC12C)c4cocc4 YPCKIDCZBFZYON-UHFFFAOYSA-N 0.000 description 1
- 239000010018 saw palmetto extract Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N sertindole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C2CCN(CCN3C(NCC3)=O)CC2)=C1 GZKLJWGUPQBVJQ-UHFFFAOYSA-N 0.000 description 1
- 229960000652 sertindole Drugs 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- 229960003310 sildenafil Drugs 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- PQDRXUSSKFWCFA-CFNZNRNTSA-N solanone Chemical compound CC(=O)CC[C@@H](C(C)C)\C=C\C(C)=C PQDRXUSSKFWCFA-CFNZNRNTSA-N 0.000 description 1
- PQDRXUSSKFWCFA-UHFFFAOYSA-N solanone Natural products CC(=O)CCC(C(C)C)C=CC(C)=C PQDRXUSSKFWCFA-UHFFFAOYSA-N 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- DKGZKTPJOSAWFA-UHFFFAOYSA-N spiperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC2(C(NCN2C=2C=CC=CC=2)=O)CC1 DKGZKTPJOSAWFA-UHFFFAOYSA-N 0.000 description 1
- 229950001675 spiperone Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 description 1
- 229960004739 sufentanil Drugs 0.000 description 1
- 229960004940 sulpiride Drugs 0.000 description 1
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 description 1
- 229960003708 sumatriptan Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960004558 terguride Drugs 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- AUZONCFQVSMFAP-UHFFFAOYSA-N tetraethylthiuram disulfide Natural products CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 description 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
- 229960002784 thioridazine Drugs 0.000 description 1
- 229960001918 tiagabine Drugs 0.000 description 1
- PBJUNZJWGZTSKL-MRXNPFEDSA-N tiagabine Chemical compound C1=CSC(C(=CCCN2C[C@@H](CCC2)C(O)=O)C2=C(C=CS2)C)=C1C PBJUNZJWGZTSKL-MRXNPFEDSA-N 0.000 description 1
- 229960005138 tianeptine Drugs 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 229960005013 tiotixene Drugs 0.000 description 1
- 229960000488 tizanidine Drugs 0.000 description 1
- XFYDIVBRZNQMJC-UHFFFAOYSA-N tizanidine Chemical compound ClC=1C=CC2=NSN=C2C=1NC1=NCCN1 XFYDIVBRZNQMJC-UHFFFAOYSA-N 0.000 description 1
- MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 description 1
- 229960004603 tolcapone Drugs 0.000 description 1
- YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 description 1
- 229960002905 tolfenamic acid Drugs 0.000 description 1
- 229960004380 tramadol Drugs 0.000 description 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
- NPFVOOAXDOBMCE-UHFFFAOYSA-N trans-3-hexenyl acetate Natural products CCC=CCCOC(C)=O NPFVOOAXDOBMCE-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229960003991 trazodone Drugs 0.000 description 1
- PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 description 1
- 229960002341 trifluperidol Drugs 0.000 description 1
- GPMXUUPHFNMNDH-UHFFFAOYSA-N trifluperidol Chemical compound C1CC(O)(C=2C=C(C=CC=2)C(F)(F)F)CCN1CCCC(=O)C1=CC=C(F)C=C1 GPMXUUPHFNMNDH-UHFFFAOYSA-N 0.000 description 1
- 229960003904 triflupromazine Drugs 0.000 description 1
- XSCGXQMFQXDFCW-UHFFFAOYSA-N triflupromazine Chemical compound C1=C(C(F)(F)F)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 XSCGXQMFQXDFCW-UHFFFAOYSA-N 0.000 description 1
- 229960001032 trihexyphenidyl Drugs 0.000 description 1
- 229960004161 trimethobenzamide Drugs 0.000 description 1
- FEZBIKUBAYAZIU-UHFFFAOYSA-N trimethobenzamide Chemical compound COC1=C(OC)C(OC)=CC(C(=O)NCC=2C=CC(OCCN(C)C)=CC=2)=C1 FEZBIKUBAYAZIU-UHFFFAOYSA-N 0.000 description 1
- 229960003688 tropisetron Drugs 0.000 description 1
- ZNRGQMMCGHDTEI-ITGUQSILSA-N tropisetron Chemical compound C1=CC=C2C(C(=O)O[C@H]3C[C@H]4CC[C@@H](C3)N4C)=CNC2=C1 ZNRGQMMCGHDTEI-ITGUQSILSA-N 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- QTFFGPOXNNGTGZ-RCSCTSIBSA-N u3c8e5bwkr Chemical compound O.CS(O)(=O)=O.C1=CC=C2C(C(OC3C[C@@H]4CC5C[C@@H](N4CC5=O)C3)=O)=CNC2=C1 QTFFGPOXNNGTGZ-RCSCTSIBSA-N 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 229960002381 vardenafil Drugs 0.000 description 1
- 229960004688 venlafaxine Drugs 0.000 description 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229960005318 vigabatrin Drugs 0.000 description 1
- PJDFLNIOAUIZSL-UHFFFAOYSA-N vigabatrin Chemical compound C=CC(N)CCC(O)=O PJDFLNIOAUIZSL-UHFFFAOYSA-N 0.000 description 1
- 229960001255 viloxazine Drugs 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 229960000317 yohimbine Drugs 0.000 description 1
- BLGXFZZNTVWLAY-SCYLSFHTSA-N yohimbine Chemical compound C1=CC=C2C(CCN3C[C@@H]4CC[C@H](O)[C@@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 0.000 description 1
- AADVZSXPNRLYLV-UHFFFAOYSA-N yohimbine carboxylic acid Natural products C1=CC=C2C(CCN3CC4CCC(C(C4CC33)C(O)=O)O)=C3NC2=C1 AADVZSXPNRLYLV-UHFFFAOYSA-N 0.000 description 1
- 239000001231 zea mays silk Substances 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
- 229960001360 zolmitriptan Drugs 0.000 description 1
- ULSDMUVEXKOYBU-ZDUSSCGKSA-N zolmitriptan Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1C[C@H]1COC(=O)N1 ULSDMUVEXKOYBU-ZDUSSCGKSA-N 0.000 description 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
- 229960001475 zolpidem Drugs 0.000 description 1
- 229960000820 zopiclone Drugs 0.000 description 1
- HDOZVRUNCMBHFH-UHFFFAOYSA-N zotepine Chemical compound CN(C)CCOC1=CC2=CC=CC=C2SC2=CC=C(Cl)C=C12 HDOZVRUNCMBHFH-UHFFFAOYSA-N 0.000 description 1
- 229960004496 zotepine Drugs 0.000 description 1
- WFPIAZLQTJBIFN-DVZOWYKESA-N zuclopenthixol Chemical compound C1CN(CCO)CCN1CC\C=C\1C2=CC(Cl)=CC=C2SC2=CC=CC=C2/1 WFPIAZLQTJBIFN-DVZOWYKESA-N 0.000 description 1
Images
Classifications
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/64—Heating using microwaves
- H05B6/80—Apparatus for specific applications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
- A24F40/42—Cartridges or containers for inhalable precursors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
- A24F40/46—Shape or structure of electric heating means
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/50—Control or monitoring
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/50—Control or monitoring
- A24F40/51—Arrangement of sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/64—Heating using microwaves
- H05B6/6447—Method of operation or details of the microwave heating apparatus related to the use of detectors or sensors
- H05B6/645—Method of operation or details of the microwave heating apparatus related to the use of detectors or sensors using temperature sensors
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/64—Heating using microwaves
- H05B6/66—Circuits
- H05B6/664—Aspects related to the power supply of the microwave heating apparatus
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/64—Heating using microwaves
- H05B6/66—Circuits
- H05B6/68—Circuits for monitoring or control
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/20—Devices using solid inhalable precursors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
- A61M15/0036—Piercing means hollow piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/368—General characteristics of the apparatus related to heating or cooling by electromagnetic radiation, e.g. IR waves
- A61M2205/3686—General characteristics of the apparatus related to heating or cooling by electromagnetic radiation, e.g. IR waves microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
- A61M2205/7545—General characteristics of the apparatus with filters for solid matter, e.g. microaggregates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
Landscapes
- Health & Medical Sciences (AREA)
- Electromagnetism (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Constitution Of High-Frequency Heating (AREA)
Abstract
本发明涉及一种微波加热方法和单元(1),其用于由于由形成气溶胶的样品(2)的材料(102)吸收微波而加热所述样品(2),且特别是用于由此在加热所述样品(2)时由所述样品(2)或从所述样品(2)中释放至少一种气溶胶,其特别是在吸入、雾化和/或抽吸产品或装置(T)中或作为吸入、雾化和/或抽吸产品或装置(T),特别是用于医学和/或肺部药物递送应用。所述微波加热单元(1)包括(i)样品容纳和暴露单元(10),其被配置为在容纳和暴露空间(15)中接收和容纳样品(2)并将所述样品(2)暴露于所述容纳和暴露空间(15)内的微波辐射场(25),(ii)微波辐射产生和/或释放单元(20),其被配置为将所述微波辐射场(25)释放到所述容纳和暴露空间(15),以及(iii)阻抗匹配单元(30),其被配置为实现所述容纳和暴露空间(15)与所述微波辐射场(25)之间的阻抗匹配。
Description
技术领域
本发明涉及微波加热单元和方法,其特别地被配置用于由于形成气溶胶的样品的材料吸收微波而加热所述样品,并且特别地用于由此在加热所述样品时由所述样品或从所述样品中释放至少一种气溶胶,和/或所述微波加热单元被配置在吸入、雾化和/或抽吸(smoking)产品或装置中或作为吸入、雾化和/或抽吸产品或装置,特别地被配置用于医学和/或肺部药物递送应用。
背景技术
存在已知的作为消费产品的装置(例如电子烟等),其被配置为由于加热而从样品释放气溶胶。然而,这些已知装置中存在样品加热不完全、不均匀和/或相当缓慢的问题。因此,不能达到所需的温度和/或温度分布以实现合适的加热过程以便满足所有消费者需求。
发明内容
本发明的目的是提供替代的微波加热单元和方法,其具有改善的加热能力并因此具有改善的气溶胶释放能力。
本发明的目的通过根据独立权利要求1的微波加热单元和根据独立权利要求12的微波加热方法来实现。优选实施方案在相应的从属权利要求中限定。
根据本发明的第一方面,提供了一种微波和/或RF(射频)加热单元,其用于由于形成气溶胶的样品的材料吸收微波和/或RF而加热所述样品,并且特别是用于由此在加热所述样品时由所述样品或从所述样品中释放至少一种气溶胶,其特别是在吸入、雾化和/或抽吸产品或装置中或作为吸入、雾化和/或抽吸产品或装置,特别是用于肺部药物递送。
根据本发明的微波和/或RF加热单元包括:
(i)样品容纳和暴露单元,所述样品容纳和暴露单元被配置为在容纳和暴露空间中接收和容纳样品并将所述样品暴露于所述容纳和暴露空间内的微波辐射场,
(ii)微波辐射和/或RF单元,所述微波辐射和/或RF单元被配置为向所述容纳和暴露空间提供所述微波和/或RF辐射场和/或底层微波和/或RF辐射信号,
以及以下中的至少一个:
(iii)阻抗匹配单元,其被配置为实现所述容纳和暴露空间与所述微波和/或RF辐射场和/或底层微波和/或RF辐射信号之间的阻抗匹配,以及
(iv)自激振荡器,所述自激振荡器被配置为产生并提供所述微波和/或RF辐射场和/或所述底层微波和/或RF辐射信号。
通过这些措施,特别是在快速性、均匀性和/或完整性方面,可以实现加热过程的相当高的可靠性。这特别是通过本发明的微波加热单元和方法强调的非接触和/或非电阻加热过程来实现。
根据本发明的微波加热单元的优选实施方案,所述样品容纳和暴露单元包括样品容纳器,所述样品容纳器借助于第一容纳部分和第二容纳部分和/或由狭缝结构分开的第一容纳部分和所述第二容纳部分在内部,特别是作为腔体限定并形成所述容纳和暴露空间。
有利地,所述阻抗匹配单元且特别是其阻抗匹配网络在其关于阻抗、频率和形成气溶胶的样品中的至少一个的匹配特性方面是可调谐的。通过这些措施,可以进一步改善微波加热过程的有效性和/或均匀性。
所述阻抗匹配单元且特别是其阻抗匹配网络可以包括以下中的至少一个:
-电极,其用于在接收到底层微波辐射信号时产生所述微波辐射场和/或几何上配合于所述形成气溶胶的样品,所述容纳和暴露空间和/或其腔体,
-输出端,其包含波导结构、传输线和/或短截线,
-1/8λ至1/4λ波导匹配元件,其中λ表示所述底层微波辐射的波长,以及
-一个或多个介电材料部分,
据此,所述阻抗匹配单元在其特性方面是特别可调谐的。
此外,附加地或可选地,所述微波辐射单元可以是或可以包括一个或多个微波辐射源和/或微波辐射信号源,特别是分别为固态微波源或和/或微波辐射信号源的形式。
此外,附加地或可选地,可以提供针对此类一个或多个微波辐射源和/或微波辐射信号源的连接配置,设置连接配置具有用于为相应源提供连接的连接器和/或波导。
所述一个或多个微波辐射(信号)源和/或固态微波(信号)源可以被配置为使得在其通电时能够产生和/或释放所述底层微波辐射场和/或所述微波辐射场信号。
因此,可以提供电源单元,其被配置为为所述底层微波辐射单元,特别是一个或多个微波辐射(信号)源提供能量,并且所述电源单元特别包括一个或多个DC电源。
所述微波辐射单元,特别是其微波辐射(信号)源可以是或可以包括晶体管放大器。
所述阻抗匹配单元并且特别是其阻抗匹配网络可以是或可以包括微波反馈端口和/或微波信号反馈端口,其连接到所述晶体管放大器的输入端以便满足底层振荡条件。
在这种情况下,如果在所述反馈端口和所述晶体管放大器的输入端之间连接额外的智能相位(additional smart phase)和/或幅度校正设备,则是特别有利的。
所述微波辐射产生和/或释放单元并且特别是其微波源可以是或可以包括晶体管放大器,并且特别地可以具有连接到低功率信号源的输出端的输入端。
在这种情况下,所述低功率信号源可以是或可以包括锁相环(PLL)、压控振荡器(VCO)和直接数字合成器(DDS)中的至少一个。
根据本发明的微波和/或RF加热单元可经配置以便实现以下中的至少一个:
-处理形成气溶胶的样品,所述形成气溶胶的样品形成为或包括液体物质、固体物质、含有医用大麻的物质、含有尼古丁的物质、植物活性(phyto-active)物质、植物源药物物质、药物活性物质和烟草物质中的至少一种,以及
-释放包含植物活性物质、植物源药物物质和药物活性成分中的至少一种的所述至少一种气溶胶。
在不同的具体实施方案中,本发明的微波加热单元可以形成在药物递送产品和/或装置、吸入产品和/或装置、抽吸产品和/或装置、移动产品和/或装置和/或便携式产品和/或装置中的至少一种中,或形成为药物递送产品和/或装置、吸入产品和/或装置、抽吸产品和/或装置、移动产品和/或装置和/或便携式产品和/或装置中的至少一种。
根据本发明的微波和/或RF加热单元的进一步可选的或额外的优选实施方案,所述底层自激振荡器是以下中的至少一个:
-连接到所述样品容纳和暴露单元或是所述样品容纳和暴露单元的一部分,
-是、包括和/或实现IQ调制器和/或IQ调制器的功能,这意味着控制相位和/或增益的能力,以及
-在所述反馈回路内包括晶体管放大器或所述晶体管放大器,阻抗匹配单元或所述阻抗匹配单元和/或阻抗匹配网络以及幅度/相位校正设备或所述幅度/相位校正设备。
所述自激振荡器的操作以及因此的振荡过程由统计和/或随机特性启动,并且特别是由整个电路的噪声启动。幅度、相位和增益特性由所述样品、所述样品容纳和暴露装置、特别是具有容纳和暴露空间的所述样品容纳器、特别是所述腔和所述阻抗匹配单元和网络(例如狭缝结构和任何电介质)的其他部件和/或几何形状和材料部分的电特性限定。
通常并且在振荡过程的启动阶段,所有频率分量根据其比率包含在噪声频谱内。然而,基于整个电路的进一步的特性,特别是基于所采用的幅度校正装置的特性,可以在由反馈过程形成的放大中获得所需的信号。
在这点上,所述相位和幅度校正设备能够改变放大器或放大器链的总相位响应以及总增益和谐振阻抗匹配,以满足期望频率下的相位和幅度条件,从而使电路成为振荡器。通过改变相位部分,振荡频率的轻微调谐是可能的。通过调整总增益幅度,第二Mayor振荡条件是可控的,并且需要在小信号条件下满足至少1的增益。其可以用于功率和效率控制。
当然,所述阻抗匹配单元和网络以及特性也是重要的:
通常,需要给定频率的高电场来介电地加热样品。当使用低频信号时,变压器和/或集总元件(如电容器和电感器/线圈)构建谐振电路,其可用于使发生器输出阻抗与电极的高阻抗行为匹配以用于样品的介电加热。由其tan(δ)性质带来的样品材料的电损耗确实提供了阻抗的实部,并且在插入电场时导致样品的加热。
在较高频率下,更适合使用传输线和波导来匹配电极和信号源。这意味着增加源输出的电压幅度。容纳结构的电极具有由其几何形状导致的轻微电容性阻抗,例如,在100fF的数量级。长度约为1/8λ至约1/5λ的传输线(例如作为阻抗匹配单元30的一部分,即30a)将其转换为较低的电容性阻抗,该较低的电容性阻抗相当于较高的电容。当将线圈或短路与此时小于1/10λ的短波导连接时,电感和电容部分彼此补偿并构建谐振电路。这种类型的阻抗匹配将样品的电损耗转换为微波信号源(例如晶体管输出级)的合适阻抗范围。
本发明还涉及微波和/或RF(射频)加热方法,所述方法用于由于形成气溶胶的样品的材料吸收微波而加热所述样品,且特别是用于由此在加热所述样品时由所述样品或从所述样品中释放至少一种气溶胶,所述至少一种气溶胶包含植物活性物质和药物活性成分中的至少一种,其中将根据前述权利要求中任一项所述的微波加热单元用于加热所述样品。
可以将不同的实体作为样品和/或其一部分来使用和/或加热,例如:
-抽吸制品,特别是含尼古丁和/或不含尼古丁的抽吸制品的形成气溶胶的基质,
-抽吸样品,特别是含尼古丁和/或不含尼古丁的抽吸样品的装载烟草的形成固体气溶胶的样品,
-含有含尼古丁和/或不含尼古丁的液体的形成气溶胶的基质,或尼古丁和/或不含尼古丁的液体的形成气溶胶的基质,
-形成气溶胶的活性药物成分,
-形成气溶胶的植物活性物质,特别是来自植物原料和/或来自植物材料,
-形成气溶胶的δ-9-四氢大麻酚(THC)和/或大麻二酚(CBD)和/或含有大麻素的植物材料,
-形成气溶胶的植物源药物物质和/或植物源药物产品,和/或
-形成气溶胶的基质,所述形成气溶胶的基质具有一组物质中的微波敏化剂和/或吸收剂中的至少一种,所述一组物质包括官能化聚倍半硅氧烷、碳纳米管、石墨、石墨烯、活性炭、活性木炭、金属粉末、半导体粉末以及其组合和混合物,
或其任何组合。
为了实现更高的微波效率,本文中称为敏化剂的材料可以是形成气溶胶的材料的一部分或可以低浓度与形成气溶胶的材料混合,以便显著增加局部介电损耗。当暴露于微波能量时,所述敏化剂产生形成气溶胶的材料的均匀加热并提高加热效率。
优选地,测量或/和估计所述形成气溶胶的样品的温度,并且可以将其值馈送到温度控制回路单元,所述温度控制回路单元被配置用于控制用于为微波产生和/或释放过程供能所提供的电力。
具有在约1MHz至约15GHz的范围内,优选地在ISM频带中,在约2.4GHz至约2.5GHz的范围内和/或具有约2.45GHz的中心频率的操作频率是特别有利的。
连续模式下的突出操作功率可以在约0.1mW至50W的范围内,并且优选地约2W。
附加地或可选地,脉冲模式下的操作功率可以在约0.1mW至约50W的范围内,并且优选地约3W。
操作功率可以在约0.1W的值和约30W的值之间斜升。
作为另一附加或可选的实施方案,可以将操作频率设置为恒定值。
操作频率也可以随时间变化,特别是在最小值和最大值之间扫频,特别是在约2.4GHz和约2.5GHz之间扫频。
根据本发明的优选实施方案,可使用形成气溶胶的样品,所述形成气溶胶的样品形成为、包含流体材料、固体材料、片剂、胶囊、药筒、压盖瓶(shell vial)、丸剂中的至少一种、容纳在其内部或和/或包装在其内部,和/或可根据底层腔体的尺寸进行匹配和/或将药物赋形剂添加到形成气溶胶的样品中。
进一步可选地或另外地,所述形成气溶胶的样品可以是或可以形成容器和/或可以具有壳体,其中所述壳体特别地可以相对于微波辐射是可透射的,可以包括塑料、合成材料、聚丙烯、玻璃、石英或可以由塑料、合成材料、聚丙烯、玻璃、石英形成,和/或具有相当的低的介电损耗因子ε″和/或相当的低损耗角正切tan(δ)。
作为本发明的另一可选的或另外的实施方案,所述的胶囊、药筒等可以由玻璃或石英形成或可以包括玻璃或石英,特别是在其端部包括ITO(氧化铟锡),因为ITO是导电的并且因此可以向胶囊的内部提供高频或微波信号。在这种布置中,所述胶囊还可以包括具有顶板的2个通孔,以便允许气体流或空气流流过其中以释放从内部产生的气溶胶。
所述形成气溶胶的样品可以包含在容器中,所述容器形成为烟嘴、形成为整体件、形成为一次性部件和/或包括过滤器和/或中空管,所述烟嘴被配置为允许吸入所形成的气溶胶,所述过滤器特别是具有低或非常低的颗粒过滤效率。
根据本发明的优选实施方案,可以使用植物基材料,所述植物基材料可以选自包括以下的组:大麻、印度大麻、莠草大麻、金合欢属(Acacia spp)、捕蝇蕈、Yage、颠茄、槟榔、木曼陀罗属、长叶鸳鸯茉莉、伊利诺合欢草(Desmanthus illinoensis)、南美卡皮木、毛花柱(Trichocereus spp.)、可可树(Theobroma cacao)、辣椒属、夜香树属(Cestrum spp.)、古柯树、彩叶草、芦竹、咖啡树、曼陀罗属、虎刺叶属(Desfontainia spp.)、死藤、草麻黄、麦角菊(Claviceps purpurea)、巴西香可可、美丽银背藤、天仙子、、伊波加木(Tabernantheiboga)、短刺兔唇花(Lagochilus inebriens)、狐狸孙子花(Justicia pectoralis)、卷圆草(Sceletium tortuosum)、卡瓦胡椒、阿拉伯茶树、美丽帽柱木(Mitragyna speciosa)、狮耳花、睡莲属、莲属、侧花槐(Sophora secundiflora)、刺蒺黎豆、药用茄参、细叶含羞草、管花薯(Ipomoea violacea)、光盖伞属(Psilocybe spp.)、花褶伞属(Panaeolus spp.)、肉豆蔻、榛子属(Turbina corymbosa)、西番莲、乌羽玉(Lophophora williamsii)、虉草属(Phalaris spp.)、烟叶软木茄(Duboisia hopwoodii)、罂粟、绿九节属、鼠尾草、四角鼠尾草(Combretum quadrangulare)、毛花柱(Trichocereus pachanoi)、柳叶霓裳花(Heimiasalicifolia)、睡眠草(Stipa robusta)、金杯藤属(Solandra spp.)、贯叶连翘、骆驼蓬、虎皮藤(Tabernaemontanaspp)、茶树、烟草、锈菌(rusticum)、维罗寇木(Virola theidora)、非洲伏枥(Voacanga africana)、莴苣(Lactuca virosa)、苦艾(Artemisia absinthium)、巴拉圭冬青(Ilex paraguariensis)、黑金檀属(Anadenanthera spp.)、育亨宾树、墨西哥梦境草、咖啡属(茜草科)、无患子科、山茶属、锦葵属、冬青科属、蝴蝶亚属(Hoodia、spp.)、洋甘菊、西番莲、茶树(Camellia sinensis)、薄荷(Mentha piperita)、留兰香、甜茶(Rubusidaeus)、蓝桉、薰衣草(Lavandula officinalis)、百里香、蜂花(Melissa officinalis)、芦荟、当归、八角、死藤水(卡皮木)、伏牛花(Barberry)、臭夏至草(Black Horehound)、蓝莲花、牛蒡、甘菊/洋甘菊(Camomille/Chamomile)、香菜、猫爪草、丁香、聚合草(Comfrey)、玉米须、冰草(Couch Grass)、达米阿那(Damiana)、达米阿那(Damiana)、蒲公英、麻黄(Ephedra)、桉树、月见草、茴香、小白菊、流苏树、大蒜、生姜、银杏、人参、秋麒麟草(Goldenrod)、白毛茛、雷公根、绿茶、瓜拉那(Guarana)、山楂、啤酒花(Hops)、马尾草、牛膝草、科拉坚果(Kola Nut)、桔梗(Kratom)、薰衣草(Lavender)、柠檬香脂(Lemon Balm)、甘草、狮子尾(野生大麻)、马卡根(Maca Root)、药蜀葵、绣线菊、水飞蓟(Milk Thistle)、益母草、西番莲、西番莲、薄荷(Peppermint)、多刺罂粟、马齿苋、覆盆子叶(Raspberry Leaf)、红罂粟、鼠尾草(Sage)、塞润榈(Saw Palmetto)、心叶黄花稔、柳叶黄薇(Mayan Sun Opener)、留兰香(Spearmint)、白菖蒲(Sweet Flag)、叙利亚芸香(骆驼蓬)、百里香(Thyme)、姜黄、缬草、野山药、艾草、蓍草、叶尔巴、马黛茶、育亨宾树、大麻(Cannabis sativa)、印度大麻和大麻(Cannabis ruderalis),其任何部分和/或其任何组合。
另外地或可选地,可以使用包含和/或能够释放样品和/或释放的气溶胶的药理学活性剂的样品,所述药理学活性剂选自A9-四氢大麻酚(THC)、大麻二酚(CBD)、大麻萜酚(CBG)、大麻环萜酚(CBC)、大麻酚(CBN)、大麻二醇(CBDL)、大麻二环(CBL)、大麻素(CBE)、次大麻二酚(CBDV)、四氢次大麻酚(THCV)、大麻三醇(CBT)及其组合和部分。
根据本发明微波加热方法中的本发明的另外的或可选的优选实施方案,可使用包含和/或能够释放一种或多种调味剂(flavorant)和/或感知剂(sensate)的样品,所述一种或多种调味剂和/或感知剂被配置成产生味道和/或香味,包括任何天然或合成调味剂,诸如烟草、烟雾、薄荷醇、薄荷(诸如胡椒薄荷和留兰香)、巧克力、甘草、柑橘和其他水果调味剂、γ辛内酯、香草醛、乙基香草醛、口气清新剂调味剂、香料调味剂诸如肉桂、水杨酸甲酯、芳樟醇、佛手柑油、天竺葵油、柠檬油和姜油、选自酸、醇、酯、醛、酮、吡嗪、其组合和等同物的调味剂化合物,选自呈用于控制递送的胶囊化形式的苯乙酸、茄酮、巨豆三烯酮、2-庚酮、苯甲醇、顺式-3-己烯基乙酸酯、戊酸、戊醛、酯、萜烯、倍半萜烯、诺卡酮、麦芽醇、大马烯酮、吡嗪、内酯、茴香脑、异戊酸、其组合和等同物,薄荷、留兰香、冬青、薄荷醇、肉桂、巧克力、香草醛、甘草、丁香、茴香、檀香、天竺葵、玫瑰油、香草、柠檬油、肉桂、留兰香、小茴香、姜、乙酸乙酯、醋酸异戊酯、异丁酸丙酯、丁酸异丁酯、丁酸乙酯、戊酸乙酯、甲酸苄酯、薴烯、伞花烃、芳樟醇、香茅醇、柠檬醛、薄荷油、橙油、芫荽油、冰片、水果提取物和等同物。在一个优选的实施方案中,咖啡、茶、可可和薄荷的精油和香精,存在于芯中的调味剂的合适量的范围为约0.001wt%至约50wt%、约1wt%至约40wt%、约10wt%至约30wt%,调味剂作为固体粉末掺入,作为液体喷雾干燥,或与淀粉或树胶型基质混合,和/或其中任何感知剂形成为或包含一种或多种成分,所述成分被配置为以便诱导感官体验,例如刺痛、温暖感、凉爽感以及等同物,并且是或包含乙酸、己二酸、柠檬酸、乳酸、马来酸、琥珀酸、酒石酸、等同物及其混合物中的至少一种,其中合适量的感知剂在约0.001wt%至约5wt%,优选约0.1wt%至约2wt%的范围内,和/或其任意组合。
可以将包含烟草、烟草提取物和烟草胶囊、烟草的任何原始或加工形式的样品以粉末、粉尘、颗粒、碎片、浆料、可流动凝胶和等同物使用,特别是所述样品具有最终烟草浓度范围为最终组合物的1wt%至99wt%和/或至多约10%、15%、20%、25%、30%、35%、40%、45%、50%、55%、60%、65%、70%、75%、80%、85%或90%烟草和/或任意组合之一。
根据本发明的微波加热方法的其他优选实施方案,可以使用样品,所述包含一种或多种保湿剂用于维持和/或保护样品材料,特别是含烟草的水凝胶胶囊中的烟草材料的水分水平,和/或作为防腐剂以除去过量的水,从而减少微生物的生长,以在更干燥的样品材料、烟草材料、烟草替代材料和/或更干燥的无烟烟草材料中提供更高的水分感觉,所述保湿剂在约0.001wt%至约5wt%、约0.1wt%至约2wt%的范围内包含甘油和丙二醇中的一种或多种,和/或其任意组合。
根据本发明的微波加热方法的其它另外的或可选的优选实施方案,可以使用包含液体的样品,所述液体选自由甘油、丙二醇及其组合组成的多元醇的组。
在下文中,将从所涉及的形成气溶胶的样品和所述样品的材料方面而言描述本发明的其它可选的或另外的优选的实施方案:
所述形成气溶胶的样品和/或所述样品的材料的成分可以包括以下类别之一的组成的药物:抗生素、抗惊厥剂、抗抑郁剂、止吐剂、抗组胺剂、抗帕金森病药、抗精神病药、抗焦虑药、勃起功能障碍药、偏头痛药、酒精中毒治疗药、成瘾治疗药、肌肉松弛剂、非甾体抗炎药、阿片类药物、其他镇痛药和兴奋剂。
当药物是抗生素时,可以选自以下化合物之一:头孢美唑;头孢唑啉;头孢氨苄;头孢西丁;头孢乙腈;头孢甘氨酸;头孢噻啶;头孢菌素类,如头孢菌素C;头孢菌素;头霉素类,如头霉素A、头霉素B和头霉素C;头孢菌素;头孢拉定;氨苄青霉素;阿莫西林;海他西林;卡非西林;卡茚西林;羧苄青霉素;戊青霉素;叠氮西林;苄青霉素;氯美西林;氯唑西林;环青霉素;甲氧西林;萘夫西林;2戊烯基青霉素;青霉素,如青霉素N、青霉素O、青霉素S、青霉素V;氯丁青霉素;双氯西林;联苯青霉素;庚基青霉素;和美氨西林。
当药物是抗惊厥剂时,其可以选自以下化合物之一:加巴喷丁、噻加宾和氨己烯酸。
当药物是抗抑郁剂时,它可以选自以下化合物之一:阿米替林、阿莫沙平、苯莫辛、布替林、氯米帕明、地昔帕明、度琉平、多塞平、丙米嗪、酮色林(kitanserin)、洛非帕明、美地沙明、米安色林、马普替林、米氮平、去甲替林、普罗替林、三甲丙米嗪、维洛沙秦、西酞普兰、可替宁、度洛西汀、氟西汀、氟伏沙明、米那普仑、尼索西汀、帕罗西汀、瑞波西汀、舍曲林、噻萘普汀、醋奋乃静(acetaphenazine)、苯奈达林、溴法罗明、西立氯胺、氯伏胺、异丙烟肼、异卡波肼、吗氯贝胺、苯肼、苯乙肼、司来吉兰、西布曲明、反苯环丙胺、腺苷蛋氨酸、阿屈非尼、安麦角、氨磺必利、安哌齐特、苯乃静、安非他酮、卡罗沙酮、吉哌隆、咪唑克生、美曲吲哚、米那普仑、苯哒吗啉、奈法唑酮、诺米芬新、利坦色林、罗克吲哚、S-腺苷蛋氨酸、托芬那辛、曲唑酮、色氨酸、文拉法辛和扎螺酮。
当药物是止吐剂时,其可以选自以下化合物之一:阿立必利、阿扎司琼(azasetron)、苯喹酰胺、溴必利、布克利嗪、氯丙嗪、桂利嗪、氯波必利、赛克利嗪、苯海拉明、氯哌尼多、多拉司琼甲磺酸盐、氟哌利多、格拉司琼、东莨菪碱(hyoscine)、劳拉西泮、甲氧氯普胺、美托哌丙嗪、昂丹司琼、奋乃静、异丙嗪、丙氯拉嗪、东莨菪碱(scopolamine)、三乙拉嗪、三氟拉嗪、三氟丙嗪、曲美苄胺、托烷司琼、多美立酮和帕洛诺司琼。
当药物是抗组胺剂时,其可以选自以下化合物之一:阿扎他定、溴苯那敏、氯苯那敏、氯马斯汀、赛庚啶、右美托咪定、苯海拉明、多西拉敏、羟嗪、西曲嗪、非索非那定、氯雷他定和异丙嗪。
当药物是抗帕金森病药时,其可以选自以下化合物中的一种:金刚烷胺、巴氯芬、比哌立登、苯扎托品、奥芬那君、丙环定、苯海索、左旋多巴、卡比多巴、司来吉兰、丙炔苯丙胺、雄匹尼(andropinirole)、阿朴吗啡、苄丝肼、溴隐亭、布地平、卡麦角林、二氢麦角隐亭碱、依利罗地、依斯的明、麦角林、普拉克索、加兰他敏、拉扎贝胺、麦角乙脲、马吲哚、美金刚、莫非吉兰、培高利特、普拉克索、丙戊茶碱、雷沙吉兰、瑞马西胺、spheramine、特麦角脲、恩他卡朋和托卡朋。
当药物是抗精神病药时,其可以选自以下化合物之一:醋奋乃静、阿立必利、安哌齐特、苯哌利多、苯喹胺、溴哌利多、布拉氨酯、布他哌嗪、丙酰奋乃静、卡匹帕明、氯丙嗪、氯普噻吨、氯卡帕明、氯马克仑、氯哌噻吨、氯螺旋嗪、氯噻平、氰美马嗪、氟哌利多、氟哌噻吨、氟奋乃静、氟司必林、氟哌啶醇、美索哒嗪、美托奋乃酯、吗茚酮、五氟利多、哌氰嗪、奋乃静、匹莫齐特、匹哌马嗪、哌西他嗪、哌泊塞嗪、丙氯拉嗪、普马嗪、瑞莫必利、舍吲哚、螺哌隆、舒必利、硫利哒嗪、替沃噻吨、三氟哌多、三氟普马嗪、三氟吡拉嗪、齐拉西酮、佐替平、珠氯噻醇、氨磺必利、布他拉莫、氯氮平、美哌隆、奥氮平、喹硫平和利培酮。
当药物是抗焦虑药时,它可以选自以下化合物之一:甲氯喹酮、美托咪定、美托咪酯、阿地唑仑(adinazolai)、利眠宁、氯苯西泮、氟西泮、劳拉西泮、氯普唑仑(loprazulam)、咪达唑仑、阿吡坦、阿舍西隆(alseroxion)、安非尼酮、阿扎环醇、溴异戊酰脲、丁螺环酮、N-氨甲酰基天冬氨酸钙(calcium N-carboamoylaspartate)、卡普托胺、卡普脲、卡氯脲(carbcloral)、卡溴脲、氯醛甜菜碱、恩西拉嗪、氟辛克生、伊沙匹隆、来索吡琼、洛沙平、甲喹酮、甲乙哌酮(methprylon)、普萘洛尔、坦度螺酮、曲唑酮、佐匹克隆和唑吡坦。
当药物是用于勃起功能障碍药时,其可以选自以下化合物之一:西力士(IC351)、西地那非、伐地那非、阿朴吗啡、二醋酸阿朴吗啡、酚妥拉明和育亨宾。
当药物是用于偏头痛的药物时,其可以选自以下化合物之一:阿莫曲普坦、阿吡必利(alperopride)、可待因、二氢麦角胺、麦角胺、依来曲普坦、罗曲坦、异美汀、利多卡因、麦角乙脲、甲氧氯普胺、那拉曲坦、氧可酮、丙氧酚、利扎曲普坦、舒马普坦、托芬那酸、佐米曲普坦、阿米替林、阿替洛尔、可乐定、塞庚啶、地尔硫卓、多塞平、氟西汀、赖诺普利、美西麦角、美托洛尔、纳多洛尔、去甲替林、帕罗西汀、苯噻啶(pizotifen)、苯噻啶(pizotyline)、普萘洛尔、普罗替林、舍曲林、噻吗洛尔和维拉帕米。
当药物是用于治疗酒精中毒的药物时,其可以选自以下化合物之一:纳洛酮、纳曲酮和双硫仑。
当药物是适于治疗成瘾的药物时,其可以是丁丙诺啡。
当药物是肌肉松弛剂时,其可以选自以下化合物之一:巴氯芬、环苯扎林、奥芬那君、奎宁和替扎尼定。
当药物是非甾体抗炎药时,它可以选自以下化合物之一:醋氯芬酸、阿明洛芬、氨芬酸、氨丙吡酮、阿米西群、苯噁洛芬、溴芬酸、丁苯羟酸、卡洛芬、胆碱、水杨酸盐、辛可芬、桂美辛、氯吡酸(clopriac)、氯美辛、双氯芬酸、依托度酸、吲哚洛芬、马泼尼酮、甲氯芬那酸盐、吡罗昔康、吡洛芬和托芬那酯(tofenamate)。
当药物是阿片类药物时,它可以选自以下化合物之一:阿芬太尼、烯丙罗定、阿法罗定、阿尼利定、苯甲基吗啡、苯腈米特、丁丙诺啡、布托啡诺、卡比芬、西拉马朵(cipramadol)、氯尼他秦、可待因、右吗拉胺、右旋丙氧吩、二乙酰吗啡、双氢可待因、地芬诺酯、地匹哌酮、芬太尼、氢吗啡酮、L-α乙酰基美沙酮、洛芬太尼、左吗啡、哌替啶、美沙酮、美普他酚、美托酮、吗啡、纳布啡、纳洛芬、氧可酮、阿片全碱、哌替啶、喷他佐辛、非那佐辛、瑞芬太尼、舒芬太尼和曲马朵。
当药物是其它镇痛药时,其可以选自以下化合物之一:阿扎丙宗、苄哌立隆(benzpiperylon)、苄达明(benzydramine)、咖啡因、氯尼辛、依索庚嗪、氟吡汀、奈福泮、奥芬那君、丙帕他莫和丙氧芬。
当药物是兴奋剂时,它可以选自以下化合物之一:安非他明、马钱子碱、咖啡因、右芬氟拉明、右苯丙胺、麻黄碱、芬氟拉明、马吲哚、哌甲酯、匹莫林、芬特明和西布曲明。
所述药物可以选自以下化合物之一:吲哚、色胺、苯并呋喃、类脂质(ibogoids)、麦角碱、苯乙胺、取代的苯乙胺、茚满衍生物、苯并环丁烯衍生物、nBOMe衍生物、NBOH衍生物、NBMD衍生物、NBF衍生物、取代的苯丙胺(α-甲基-苯乙胺):取代的苯丙胺(α-甲基-苯乙胺)、DOX家族(2,5-二甲氧基,4-取代的苯丙胺)、苯基环丙胺衍生物(技术上不是苯丙胺)、取代的亚甲二氧基-苯乙胺(MDxx)、取代苯丙胺、卡西酮、取代卡西酮、苯并呋喃、取代苯并呋喃、四氢萘、取代四氢萘、取代茚满、取代萘、取代苯基异丁基胺(α-乙基-苯乙胺)、α-取代(-烷基化)色胺、芳基环己基胺、andamantanes、二芳基乙胺、,吗啡类、阿片类、苯二氮卓类、噻吩二氮卓类、GHB、GHB类似物、甲喹酮、甲喹酮类似物、合成大麻素、骆驼蓬碱、鼠尾草素、鼠尾草素A、鼠尾草素B、鼠尾草素C、鼠尾草素D、鼠尾草素E、鼠尾草素F、鼠尾草素G、鼠尾草素H、鼠尾草素I、17α-鼠尾草素J、17β-鼠尾草素J、哌嗪、阿托品衍生物、鹅膏蕈氨酸、蝇蕈醇、赛洛西宾、氯胺酮、氯胺酮衍生物、催产素、促智药、racteams、可卡因和可卡因类似物。
这些方面可以以任意方式组合。
附图描述
将基于本发明的实施方案并通过参考附图来描述本发明的这些和进一步的细节、优点和特征。
图1至3通过示意性框图阐明了本发明的微波加热单元的优选实施方案。
图4至10C示出了本发明的微波加热单元及其细节的优选实施方案的细节。
图11至14通过横截面侧视图解释了本发明的微波加热单元及其细节的其他实施方案。
具体实施方式
在下文中,通过参考附图1至14详细呈现了本发明的实施方案和技术背景。相同或等效的元件以及相同或等效地起作用的元件用相同的附图标记表示。并不是在其每次出现时都重复对元件和部件的详细描述。
在不脱离本发明的主旨的情况下,可以任意地分离和重新组合所描绘和描述的本发明实施方案的特征和其他性质。
图1至3通过示意性框图阐明了本发明的微波加热单元1的优选实施方案。图1至3中任一幅所示的微波加热单元或装置1中的每一个均可以形成为吸入、雾化或抽吸产品和/或装置1',从而特别是用于医疗和/或肺部药物递送/吸入功能。
如图1所示的本发明的微波加热装置或单元1的实施方案由微波辐射产生和/或释放单元20形成或包括微波辐射产生和/或释放单元20,其在本发明的意义上也可以被称为微波辐射信号产生和/或释放单元。优选地,固态微波源100在这方面可以用作微波辐射源20。
可以将由此产生和/或提供的微波辐射场提供给含有植物/药物的化合物/材料102,所述含有植物/药物的化合物/材料102作为待包含在容纳和暴露空间15(例如腔体16)中的样品,该容纳和暴露空间15例如基于第一和第二容纳部件或容纳部分11、12由样品容纳和暴露装置10形成。
这优选地通过阻抗匹配单元30或与阻抗匹配单元30协作来完成,阻抗匹配单元30被配置用于匹配所提供的微波辐射场与限定容纳和暴露空间15及其腔体16的样品容纳器13之间的阻抗。
在这方面,阻抗匹配可以通过至少一个电气或电子手段、几何手段和/或材料手段来实现。电气或电子手段是指辐射的性质及其潜在生成和/或供应过程。几何手段是指某些物理物品的定位、几何形状和/或取向。材料手段是指某些材料物品的定位、几何形状和/或取向,例如通过使用介电材料。
在这方面,可以涉及阻抗匹配网络101,从而实现阻抗匹配单元30,所述网络101实现电气/电子几何和/或材料方面之一。
在图2所示的实施方案中,除了图1所示的实施方案之外,微波辐射产生和/或释放单元20可以由小功率或低功率信号源104和晶体管放大器103的连续布置形成,该小功率或低功率信号源104包括微波辐射源或微波辐射信号源21,例如同样作为固态微波(信号)源100。
在图3所示的实施方案中,除了图2所示的实施方案之外,微波辐射产生和/或释放单元20还包括连接在阻抗匹配单元30与其网络101之间的反馈回路106,该反馈回路106向幅度/相位校正设备105提供输入,幅度/相位校正设备105的输出被馈送到晶体管放大器103的输入端口。因此,在图3所示的实施方案中,小/低功率信号源104由反馈回路106和幅度/相位校正设备105代替。
图4至10C示出了本发明的微波加热单元1及其细节的优选实施方案的细节,每个微波加热单元1均形成为吸入、雾化和/或抽吸产品和/或装置1',从而特别是用于医疗和/或肺部药物递送/吸入功能。
根据这些实施方案的本发明的样品容纳和暴露装置10以及阻抗匹配单元30由第一和第二容纳部件或容纳部分11和12形成,从而限定样品容纳器13,用于通过腔体16限定容纳和暴露空间15。
阻抗匹配单元30及其阻抗匹配网络的基本方面可以基于狭缝或狭缝结构14的几何和材料方面以及在这方面使用的电介质17来形成。
样品容纳和暴露装置10可以被壳体18包围,壳体18也可用作护罩。
图8B通过沿图8A中所示的平面B-B的横截面图阐明了底层微波辐射场25的E场配置的细节,即与样品容纳和暴露装置10、阻抗匹配单元30及其狭缝结构14和介电材料17的布置有关,并且还与可以同时分别用作第一电极53和第二电极54的第一容纳部件/部分和第二容纳部件/部分有关。
如图8A所示,在一个优选实施方案中,阻抗匹配单元30可以包括馈电点31的馈电部分,微波辐射可以通过该馈电部分被引入到容纳和暴露空间15和腔体16中。在这方面,阻抗匹配单元30的套药筒部件的第一部分30a和第二部分30b可以具有约1/8λ至约1/5λ且小于1/10λ的长度或尺寸,其中λ表示底层微波辐射的波长。
图11至图14通过横截面侧视图解释了本发明的微波加热单元1及其细节的其他实施方案,每个微波加热单元1形成为吸入、雾化和/或抽吸产品和/或装置1',从而特别是用于医疗和/或肺部药物递送/吸入功能。
在这些实施方案的每种情况下,可以使用电源单元40,其包括DC电源40,例如电池,其能够用其微波辐射源21及其控制单元或控制电子器件50为底层微波辐射产生和/或释放单元20提供能量,基于此或经由此,第一和第二供电线路51、52第一电极53和第二电极54经受相应的电场,以在样品容纳器13的样品容纳和暴露装置10中形成的容纳和暴露空间15的腔体16内产生所需的微波辐射场25。
借助于微波辐射场25,以快速、可靠和均匀的方式加热样品2及其样品材料102(在含有植物/药物的化合物或材料的意义上),从而释放待输送的气溶胶,所述气溶胶采用进入在装置1'的主体或壳体118中形成的气流通道110的气流111输送。
样品2和样品材料102可以以不同的形式设计。
例如,在图12和图14所示的实施方案中,使用由或多或少稳定的壁形成的胶囊3,在使用时,必须通过容纳并形成在装置1'的气流通道110中的针112或任何其他穿透装置穿透该壁。
如图14所示,主体118或其壳体118的至少一部分可以形成为烟嘴119,烟嘴119任选地配备有用于与气流通道110中的气流111相互作用的过滤器部件115。
附图标记列表
1 微波加热装置/单元
1’ 吸入、雾化和/或抽吸产品和/或装置
2 样品
10 样品容纳和暴露装置
11 第一容纳部件/容纳部分
12 第二容纳部件/容纳部分
13 样品容纳器
14 狭缝、狭缝结构
15 容纳和暴露空间
16 腔体
17 介电材料部分
18 壳体、护罩
20 微波辐射产生和/或释放单元、微波辐射信号产生和/或释放单元
21 微波辐射源、固态微波源、微波辐射信号源、固态微波信号源
22 波导
23 连接器
25 微波辐射场
26 微波辐射场信号
30 阻抗匹配单元
30a 阻抗匹配单元30的第一部分
30b 阻抗匹配单元30的第二部分
31 微波辐射场25的馈电点
40 电源单元
41 DC电源、电池
50 控制单元、电子器件
51 第一供电线路
52 第二供电线路
53 第一电极
54 第二电极
100 固态微波源、固态微波信号源
101 阻抗匹配网络
102 样品材料、含植物/药物的化合物/材料
103 晶体管放大器
104 小/低功率信号源
105 幅度/相位校正设备
106 反馈回路/分支/线路
109 (自激)振荡器
110 气流通道
111 气流
112 针、穿透装置
115 过滤器
118 主体、壳体
119 烟嘴
x 空间方向
y 空间方向
z 空间方向
Claims (16)
1.一种微波加热单元(1),其用于凭借形成气溶胶的样品(2)的材料(102)吸收微波而加热所述样品(2),且特别是用于由此在加热所述样品(2)时由所述样品(2)或从所述样品(2)中释放至少一种气溶胶,其特别是在吸入、雾化和/或抽吸产品或装置(1')中或作为吸入、雾化和/或抽吸产品或装置(1')和/或用于肺部药物递送,其中所述微波加热单元(1)包括:
(i)样品容纳和暴露单元(10),其被配置为在容纳和暴露空间(15)中接收和容纳样品(2),并将所述样品(2)暴露于所述容纳和暴露空间(15)内的微波辐射场(25),
(ii)微波辐射单元(20),其被配置为向所述容纳和暴露空间(15)提供所述微波辐射场(25)和/或底层微波辐射信号(26),以及
以下中的至少一个:
(iii)阻抗匹配单元(30),其被配置为实现所述容纳和暴露空间(15)与所述信号(26)和/或所述微波辐射场(25)之间的阻抗匹配,以及
(iv)自激振荡器(109),其被配置为产生并提供所述微波辐射场(25)和/或所述底层微波辐射信号(26)。
2.根据权利要求1所述的微波加热单元(1),其中,所述样品容纳和暴露单元(10)包括样品容纳器(13),所述样品容纳器(13)借助于第一容纳部分(11)和第二容纳部分(12)和/或由狭缝结构(40)分开的第一容纳部分和第二容纳部分在内部,特别是作为腔体(16)限定并形成所述容纳和暴露空间(15)。
3.根据前述权利要求中任一项所述的微波加热单元(1),其中,所述阻抗匹配单元(30)且特别是其阻抗匹配网络(101)在其关于阻抗、频率和所述形成气溶胶的样品(2)中的至少一个的匹配特性方面是可调谐的。
4.根据前述权利要求中任一项所述的微波加热单元(1),其中,所述阻抗匹配单元(30)且特别是其阻抗匹配网络(101)包括以下中的至少一个:
-电极(53、54),用于在接收到底层微波辐射信号(26)时产生所述微波辐射场(25),其在几何上与所述形成气溶胶的样品(2),所述容纳和暴露空间(15)和/或其腔体(16)相匹配,
-输出端,其包含波导结构、传输线和/或短截线,
-1/8λ至1/4λ波导匹配元件,以及
-一个或多个介电材料部分(17),
据此,所述阻抗匹配单元(30)在其特性方面是特别可调谐的。
5.根据前述权利要求中任一项所述的微波加热单元(1),其中,
-所述微波辐射单元(20)是或包括一个或多个微波辐射或辐射信号源(21),特别是固态微波或辐射信号源的形式,和/或具有连接器(23)和/或波导(22)的连接配置,用于提供与一个或多个微波辐射源(21)的连接,以及
-所述一个或多个微波辐射或辐射信号源(21)和固态微波或辐射信号源被配置为在其通电时产生和/或释放所述底层微波辐射场(25)或所述底层信号(26)。
6.根据权利要求5所述的微波加热单元(1),包括电源单元(40),所述电源单元(40)被配置为为所述底层微波辐射单元(20),特别是所述一个或多个微波辐射或辐射信号源(21)提供能量,并且所述电源单元(40)特别包括一个或多个DC电源(41)。
7.根据前述权利要求中任一项所述的微波加热单元(1),其中,
-所述微波辐射单元(20),特别是其微波辐射或辐射信号源(21),是或包括晶体管放大器(103),和/或
-所述阻抗匹配单元(30)并且特别是其阻抗匹配网络(101)包括微波反馈端口和/或微波信号反馈端口,所述微波反馈端口和/或微波信号反馈端口连接到所述晶体管放大器(103)的输入端以便满足底层振荡条件。
8.根据权利要求7所述的微波加热单元(1),其中,在所述反馈端口和所述晶体管放大器(103)的输入端之间连接额外的智能相位和/或幅度校正设备(105)。
9.根据前述权利要求中任一项所述的微波加热单元(1),其中,
-所述微波辐射单元(20),特别是其微波辐射源(21)和/或微波辐射信号源(21)是或包括晶体管放大器(103),并特别地
-具有连接到低功率信号源(104)的输出端的输入端,和/或
-所述低功率信号源(104)是或包括锁相环(PLL)、压控振荡器(VCO)和直接数字合成器(DDS)中的至少一个。
10.根据前述权利要求中任一项所述的微波加热单元(1),其被配置以便实现以下中的至少一个:
-处理形成气溶胶的样品(2),所述形成气溶胶的样品(2)形成为或包括液体物质、固体物质、含有医用大麻的物质、含有尼古丁的物质、植物活性物质、植物源药物物质、药物活性物质和烟草物质中的至少一种,
-释放包含植物活性物质、植物源药物物质和药物活性成分中的至少一种的所述至少一种气溶胶。
11.根据前述权利要求中任一项所述的微波加热单元(1),其形成在药物递送产品和/或装置、吸入产品或装置(1')、抽吸产品或装置(1')、移动产品或装置(1')和/或便携式产品或装置(1')中的至少一种中,或形成为药物递送产品和/或装置、吸入产品或装置(1')、抽吸产品或装置(1')、移动产品或装置(1')和/或便携式产品或装置(1')中的至少一种。
12.根据前述权利要求中任一项所述的微波加热单元(1),其中,所述自激振荡器(109)是以下中的至少一个:
-连接到所述样品容纳和暴露单元(10)或者是所述样品容纳和暴露单元(10)的一部分,
-是、包括和/或实现IQ调制器和/或IQ调制器的功能,其特别意味着控制相位和/或增益的能力,以及
-在反馈回路(106)内包括晶体管放大器(103)、阻抗匹配单元(30)和/或阻抗匹配网络(101)以及幅度/相位校正设备(105)。
13.一种微波和/或RF加热方法,其用于凭借形成气溶胶的样品(2)的材料(102)的吸收微波而加热所述样品(2),且特别是用于由此在加热所述样品(2)时由所述样品(2)或从所述样品(2)中释放至少一种气溶胶,包括植物活性物质和药物活性成分中的至少一种的所述至少一种气溶胶作为所述样品(2)或作为其一部分使用和/或加热,
-其中,根据前述权利要求中任一项所述的微波加热单元(1)用于加热所述样品(2),并且
-其中,特别是以下中的至少一个:
-抽吸制品,特别是含尼古丁和/或不含尼古丁的抽吸制品的形成气溶胶的基质(102),
-抽吸样品,特别是含尼古丁和/或不含尼古丁的抽吸样品的装载烟草的形成固体气溶胶的样品,
-含有含尼古丁和/或不含尼古丁的液体的形成气溶胶的基质,或尼古丁和/或不含尼古丁的液体的形成气溶胶的基质,
-形成气溶胶的活性药物成分,
-形成气溶胶的植物活性物质,特别是来自植物原料和/或来自植物材料,
-形成气溶胶的δ-9-四氢大麻酚(THC)和/或大麻二酚(CBD)和/或含有大麻素的植物材料,
-形成气溶胶的植物源药物物质和/或植物源药物产品,
-形成气溶胶的基质(102),其具有一组物质中的微波敏化剂和/或吸收剂中的至少一种,所述一组物质包括官能化聚倍半硅氧烷、碳纳米管、石墨、石墨烯、活性炭、活性木炭、金属粉末、半导体粉末以及其组合和混合物。
14.根据权利要求13所述的微波加热方法,其中,测量或/和估计所述形成气溶胶的样品(2)的温度,并且将其值馈送到温度控制回路单元,所述温度控制回路单元控制用于为微波产生和/或释放过程供能所提供的电力。
15.根据权利要求13和14中任一项所述的微波加热方法,其中:
-操作频率在约1MHz至约15GHz的范围内,优选地在ISM频带中和/或在约2.4GHz至约2.5GHz的范围内和/或具有约2.45GHz的中心频率,
-连续模式下的操作功率在约0.1mW至50W的范围内,优选约2W,
-脉冲模式下的操作功率在约0.1mW至约50W的范围内,优选约3W,
-操作功率在约0.1W的值和约30W的值之间斜升,和/或
-将操作频率设置为恒定值,
-操作频率随时间变化,特别是在最小值和最大值之间扫频,特别是在约2.4GHz和约2.5GHz之间扫频。
16.根据权利要求13至15中任一项所述的微波加热方法,其中,使用形成气溶胶的样品(2),所述形成气溶胶的样品(2)为以下中的至少一种:
-形成为、包含流体材料、固体材料、片剂、胶囊、药筒、压盖瓶、丸剂中的至少一种、容纳在其内部和/或包装在其内部,和/或可以根据底层腔体(16)的尺寸进行匹配,和/或将药物赋形剂添加到所述形成气溶胶的样品(2),
-是或形成容器和/或具有壳体,其中所述壳体特别地对于微波辐射是可透射的,包括塑料、合成材料、聚丙烯、玻璃、石英或由塑料、合成材料、聚丙烯、玻璃、石英形成,和/或具有相当低的介电损耗因子(ε”)和/或相当低的损耗角正切(tan(δ)),并且
-包含在容器中,所述容器形成为烟嘴(119)、整体件、一次性部件和/或包括过滤器(115)和/或中空管,所述烟嘴(119)被配置为允许吸入所形成的气溶胶,所述过滤器(115)特别是具有低或非常低的颗粒过滤效率。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19178687.0 | 2019-06-06 | ||
EP19178687.0A EP3747289B8 (en) | 2019-06-06 | 2019-06-06 | Microwave heating unit and method |
PCT/EP2020/064699 WO2020244996A1 (en) | 2019-06-06 | 2020-05-27 | Microwave heating unit and method |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114025630A true CN114025630A (zh) | 2022-02-08 |
Family
ID=66776185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202080041390.0A Pending CN114025630A (zh) | 2019-06-06 | 2020-05-27 | 微波加热单元和方法 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220330396A1 (zh) |
EP (2) | EP3747289B8 (zh) |
JP (1) | JP2022535369A (zh) |
KR (1) | KR20220018489A (zh) |
CN (1) | CN114025630A (zh) |
CA (1) | CA3142259A1 (zh) |
ES (1) | ES2911635T3 (zh) |
PL (1) | PL3747289T3 (zh) |
PT (1) | PT3747289T (zh) |
WO (1) | WO2020244996A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114304753A (zh) * | 2022-02-24 | 2022-04-12 | 湖北中烟工业有限责任公司 | 一种多极点射频加热烟具 |
CN114982831A (zh) * | 2022-03-25 | 2022-09-02 | 江南大学 | 一种风味强化预制辣椒油及其微波加工方法和应用 |
WO2023178565A1 (zh) * | 2022-03-23 | 2023-09-28 | 深圳麦时科技有限公司 | 气溶胶产生装置及其制造方法 |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220035408A (ko) | 2019-07-19 | 2022-03-22 | 필립모리스 프로덕츠 에스.에이. | 유전체 가열을 사용하는 에어로졸 발생 시스템 및 방법 |
WO2021073867A1 (en) | 2019-10-18 | 2021-04-22 | Philip Morris Products S.A. | Shisha system with a heating unit comprising two electrodes |
KR102373590B1 (ko) * | 2020-09-22 | 2022-03-14 | (주)아이엠지티 | 음이온성 고분자를 이용한 신규한 나노 입자, 이의 제조 방법 및 조성물 |
EP4265061A1 (en) * | 2020-12-18 | 2023-10-25 | Philip Morris Products S.A. | Filled resonant cavity for optimized dielectric heating |
WO2022170468A1 (zh) * | 2021-02-09 | 2022-08-18 | 深圳麦克韦尔科技有限公司 | 电子雾化装置及其微波控制方法 |
WO2022170467A1 (zh) * | 2021-02-09 | 2022-08-18 | 深圳麦克韦尔科技有限公司 | 气溶胶产生系统及其气溶胶生成制品 |
KR20230154444A (ko) * | 2021-03-02 | 2023-11-08 | 필립모리스 프로덕츠 에스.에이. | 최적화된 치수를 갖는 유전체 가열식 에어로졸 발생 시스템 |
EP4301168A1 (en) * | 2021-03-02 | 2024-01-10 | Philip Morris Products S.A. | Dielectrically heated aerosol-generating system with segmented heater |
CN113093614B (zh) * | 2021-04-02 | 2022-07-15 | 北京航天雷特机电工程有限公司 | 一种微波发生电路及微波发生装置 |
JP2023542771A (ja) * | 2021-08-25 | 2023-10-12 | 深▲せん▼麦克韋爾科技有限公司 | エアロゾル発生モジュール及びエアロゾル発生システム |
CN113712265A (zh) * | 2021-10-08 | 2021-11-30 | 海南摩尔兄弟科技有限公司 | 气溶胶生成品、电子雾化器和雾化系统 |
EP4193857A4 (en) * | 2021-10-20 | 2023-09-13 | Shenzhen Smoore Technology Limited | AEROSOL GENERATING DEVICE AND CONTROL METHOD FOR THE AEROSOL GENERATING DEVICE |
JP7481495B2 (ja) | 2021-10-20 | 2024-05-10 | 深▲せん▼麦克韋爾科技有限公司 | エアロゾル発生装置 |
CN114652012A (zh) * | 2022-03-23 | 2022-06-24 | 深圳麦时科技有限公司 | 一种微波式碳加热的点火方法、点火器具及加热系统 |
WO2024049259A1 (ko) * | 2022-08-31 | 2024-03-07 | 주식회사 케이티앤지 | 히터 조립체 및 이를 포함하는 에어로졸 생성 장치 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1545823A (zh) * | 2001-08-23 | 2004-11-10 | 俄勒冈州,由高等教育州委员会代表俄勒 | 变频自动电容射频(rf)介电加热系统 |
CN101116542A (zh) * | 2007-09-07 | 2008-02-06 | 中国科学院理化技术研究所 | 具有纳米尺度超精细空间加热雾化功能的电子烟 |
US20110139773A1 (en) * | 2009-12-16 | 2011-06-16 | Magnus Fagrell | Non-Modal Interplate Microwave Heating System and Method of Heating |
CN103315404A (zh) * | 2013-07-17 | 2013-09-25 | 中国烟草总公司郑州烟草研究院 | 基于微波加热的非燃烧型烟草抽吸装置 |
CN104055223A (zh) * | 2014-05-26 | 2014-09-24 | 深圳市麦克韦尔科技有限公司 | 电子烟 |
CN104432509A (zh) * | 2014-11-25 | 2015-03-25 | 云南中烟工业有限责任公司 | 利用微波进行分组加热的烟斗式低温卷烟抽吸装置 |
CA2939649A1 (en) * | 2014-06-20 | 2015-12-23 | Philip Morris Products S.A. | Nicotine powder delivery system with airflow management means |
US20170127722A1 (en) * | 2015-11-06 | 2017-05-11 | R.J. Reynolds Tobacco Company | Aerosol delivery device including a wirelessly-heated atomizer and related method |
CN108552613A (zh) * | 2018-07-16 | 2018-09-21 | 云南中烟工业有限责任公司 | 一种微波谐振致雾化的电子烟 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA06000112A (es) * | 2003-06-27 | 2006-04-27 | Johnson & Son Inc S C | Sistemas y ensambles distribuidores incluyendo una unidad de almacenamiento de calor. |
WO2007007123A1 (en) * | 2005-07-14 | 2007-01-18 | Stanelco Rf Technologies Limited | Radio frequency power apparatus |
JP6778639B2 (ja) * | 2017-03-08 | 2020-11-04 | 東京エレクトロン株式会社 | 高周波発生器及びプラズマ処理装置 |
US10790118B2 (en) * | 2017-03-16 | 2020-09-29 | Mks Instruments, Inc. | Microwave applicator with solid-state generator power source |
US10219544B2 (en) * | 2017-03-24 | 2019-03-05 | Rai Strategic Holdings, Inc. | Aerosol delivery device and a related method |
US10917948B2 (en) * | 2017-11-07 | 2021-02-09 | Nxp Usa, Inc. | Apparatus and methods for defrosting operations in an RF heating system |
CN108777893A (zh) * | 2018-06-26 | 2018-11-09 | 东莞市国研电热材料有限公司 | 一种电子烟用微波加热装置 |
-
2019
- 2019-06-06 PT PT191786870T patent/PT3747289T/pt unknown
- 2019-06-06 PL PL19178687T patent/PL3747289T3/pl unknown
- 2019-06-06 EP EP19178687.0A patent/EP3747289B8/en active Active
- 2019-06-06 ES ES19178687T patent/ES2911635T3/es active Active
-
2020
- 2020-05-27 CN CN202080041390.0A patent/CN114025630A/zh active Pending
- 2020-05-27 JP JP2021570884A patent/JP2022535369A/ja active Pending
- 2020-05-27 US US17/616,309 patent/US20220330396A1/en active Pending
- 2020-05-27 KR KR1020217039820A patent/KR20220018489A/ko not_active Application Discontinuation
- 2020-05-27 EP EP20727333.5A patent/EP3979865A1/en active Pending
- 2020-05-27 CA CA3142259A patent/CA3142259A1/en active Pending
- 2020-05-27 WO PCT/EP2020/064699 patent/WO2020244996A1/en unknown
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1545823A (zh) * | 2001-08-23 | 2004-11-10 | 俄勒冈州,由高等教育州委员会代表俄勒 | 变频自动电容射频(rf)介电加热系统 |
CN101116542A (zh) * | 2007-09-07 | 2008-02-06 | 中国科学院理化技术研究所 | 具有纳米尺度超精细空间加热雾化功能的电子烟 |
US20110139773A1 (en) * | 2009-12-16 | 2011-06-16 | Magnus Fagrell | Non-Modal Interplate Microwave Heating System and Method of Heating |
CN103315404A (zh) * | 2013-07-17 | 2013-09-25 | 中国烟草总公司郑州烟草研究院 | 基于微波加热的非燃烧型烟草抽吸装置 |
CN104055223A (zh) * | 2014-05-26 | 2014-09-24 | 深圳市麦克韦尔科技有限公司 | 电子烟 |
CA2939649A1 (en) * | 2014-06-20 | 2015-12-23 | Philip Morris Products S.A. | Nicotine powder delivery system with airflow management means |
CN104432509A (zh) * | 2014-11-25 | 2015-03-25 | 云南中烟工业有限责任公司 | 利用微波进行分组加热的烟斗式低温卷烟抽吸装置 |
US20170127722A1 (en) * | 2015-11-06 | 2017-05-11 | R.J. Reynolds Tobacco Company | Aerosol delivery device including a wirelessly-heated atomizer and related method |
CN108552613A (zh) * | 2018-07-16 | 2018-09-21 | 云南中烟工业有限责任公司 | 一种微波谐振致雾化的电子烟 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114304753A (zh) * | 2022-02-24 | 2022-04-12 | 湖北中烟工业有限责任公司 | 一种多极点射频加热烟具 |
WO2023178565A1 (zh) * | 2022-03-23 | 2023-09-28 | 深圳麦时科技有限公司 | 气溶胶产生装置及其制造方法 |
CN114982831A (zh) * | 2022-03-25 | 2022-09-02 | 江南大学 | 一种风味强化预制辣椒油及其微波加工方法和应用 |
CN114982831B (zh) * | 2022-03-25 | 2023-08-25 | 江南大学 | 一种风味强化预制辣椒油及其微波加工方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
US20220330396A1 (en) | 2022-10-13 |
EP3747289B1 (en) | 2022-01-26 |
EP3747289A1 (en) | 2020-12-09 |
EP3979865A1 (en) | 2022-04-13 |
WO2020244996A1 (en) | 2020-12-10 |
PL3747289T3 (pl) | 2022-06-20 |
ES2911635T3 (es) | 2022-05-20 |
KR20220018489A (ko) | 2022-02-15 |
PT3747289T (pt) | 2022-04-21 |
JP2022535369A (ja) | 2022-08-08 |
CA3142259A1 (en) | 2020-12-10 |
EP3747289B8 (en) | 2022-02-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN114025630A (zh) | 微波加热单元和方法 | |
EP3102266B1 (en) | Pulmonary delivery devices | |
KR20200076703A (ko) | 에어로졸 전달 장치용의 에어로졸 전구체를 제형화하는 방법 | |
JP6218803B2 (ja) | 導電性基材を組み込んだ喫煙物品 | |
RU2766733C2 (ru) | Устройство для пульмонального введения | |
WO2016019353A1 (en) | Electronic cigarettes, cartridges, and inhalable formulations of medicinal cannabis compounds, and apparatuses and methods for making and using the same | |
NZ582152A (en) | An inhalable composition comprising nicotine and oxygen | |
US20210059301A1 (en) | Dual-chamber aerosol dispenser | |
US20230413913A1 (en) | Atomization nozzle for aerosol delivery device | |
RU2785535C1 (ru) | Микроволновый нагревательный блок и способ микроволнового нагрева | |
JP2024075572A (ja) | マイクロ波加熱ユニットおよび方法 | |
RU2803182C2 (ru) | Способ составления предшественника аэрозоля для устройства доставки аэрозоля | |
AU2013101201A4 (en) | Formulation for enhanced, rapid dosing of herbal medicines. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20240222 Address after: Nashatel, Switzerland Applicant after: PHILIP MORRIS PRODUCTS S.A. Country or region after: Switzerland Address before: Zug City Applicant before: Nvx Laboratories Ltd. Country or region before: Switzerland |
|
TA01 | Transfer of patent application right |