AU2013101201A4

AU2013101201A4 - Formulation for enhanced, rapid dosing of herbal medicines.

Info

Publication number: AU2013101201A4
Application number: AU2013101201A
Authority: AU
Inventors: Leigh Barrett
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-09-09
Filing date: 2013-09-09
Publication date: 2013-10-10
Anticipated expiration: 2021-09-09

Abstract

A liquid herbal formulation intended for inhalation and/or buccal dosage comprising one or more prepared herbs in combination excipient ingredients containing water and either one or both glycerol and propylene glycol. A liquid herbal formulation containing one or more herbal substances or extracts intended for vaporisation, and buccal and/or inhalation delivery that is essentially free of oily substances. A TGA listed liquid herbal formulation intended for dosage delivery via a constructed, powered personal inhalation device intended for self medication. A liquid herbal formulation that is supplied within or to be used in conjunction with a constructed, powered personal inhalation device, intended or advertised for therapeutic or personal benefit. A compounded herbal formulation intended for inhalation via a powered personal medication device.

Description

EDITORIAL NOTE 2013101201 There is two pages of the description only Formulation for enhanced, rapid dosing of herbal medicines Medicaments and delivery technology continue to develop. Over the last several hundred years personal medication in the Western world has transitioned from a circumstance where many families had their own knowledge and tradition of treatments, through to a virtual loss of this knowledge and tradition with most remedies being purchased. Today, while most remedies are purchased, the emergence of modern communication methods has contributed to an increased availability of data but also a loss of traditional dosage regimes. Inhalation of vapours is a recognised dosage regime in both modern and traditional ethno-botanical paradigms; traditionally volatile oils and substances such as menthol, pine oil and eucalyptus are used; and in modern medicaments, metered dose aerosols are employed. Similarly the absorption of modern medicaments via the buccal tissues is known (for example nicotine) in metered doses and volatiles and other substances, via chewing gum. Personal inhalers are known in the form of electronic cigarettes however these contain restricted substances that are associated with adverse health effects. The advantage of inhalation and buccal delivery methods is they provide rapid satisfaction or resolution of symptoms. This innovation combines traditional regimes of using vaporised herbs and the modern capability to create these vapours for personal use; as desired in a constructed, powered device. The benefits of this system are convenient use and rapid delivery of mild, herbal medicines. The use of inhalation and buccal absorption facilitates rapid transition to the circulatory system, and triggers olfactory mediated responses such as hypothalamic and endocrine response not typically effected by encapsulated and tableted forms of herbal substances. Herbs are selected for their ability to both redress a personal or medicinal concern and to effectively deliver benefits via vapours. The herbs will be prepared to enable their use in pharmaceutical dosage forms and then compounded in a fluid base that enables the delivery of the herb via vapour. Typically one or several herbs will be dried, then fluid extracted and concentrated and dried, and then quantitatively formulated in a fluid base that comprises water and either or both glycerine and propylene glycol. Most typically the non-aqueous phase will be 20 to 75% of the formulation. Herbals will be contained at concentrations that are conducive to therapeutic dosing of that substance. Oily carriers and substances are avoided because of their ability to deposit lipids in the lungs, potentially contributing to adverse effects. The formulation may be flavoured, preserved and otherwise supplemented as is typical for oral dosage forms. Herbs will be firstly selected from those that are 'listable' within the Australian Register of Therapeutic Goods. Thereafter only herbs and compounding substances that are compatible with vaporisation will be selected. These will be substances that have been traditionally used in regimes of oral, buccal or inhalation therapies. Examples will include but not be limited to green or black tea, coffee, mint, lavender, echinacea, ginger, fennel, lime flowers (Linden), and particularly herbs used in medicinal teas. It is noted that vaporisation practice is particularly suited to herbal substances that are rich in polyphenols. For example a product intended for use in weight management would adopt the findings of the National Health and Medical Research Council of Australia and supply an extract of green tea with standardised constituents of catechins (> 100 mg polyphenols) and caffeine in 50% glycerol and the reminder water and flavour; the product could then be utilised for vaporisation and rapid buccal uptake of active constituents promoting thermogenesis and energy expenditure. An alternative formulation could be prepared using a similar concentration green coffee extract, propylene glycol and water promoting mood enhancement, physical vitality and energy. The formulation is supplied either within; or ready to be added to a constructed, powered vapour inhalation device. The device is activated by drawing breath across or through the apparatus; this contributes to vaporisation of the formulation, and the vapours are inhaled into the oral and potentially nasal cavity. The user may use as little or as much of the inhalation as is required to satisfy. Conditions that may be remedied by this method may include for example, low energy, hunger pangs, stress, pain, cough and colds, digestive imbalance, menopausal symptoms, libido imbalance, mood imbalance, and other symptomatic conditions. Outcomes of the dosing regime will be accordingly be correlated with the herbal substance used and the dose consumed; in all cases rapid results can be anticipated, and as a result, the required medication quantity can be minimised.

Claims

1. A liquid herbal formulation intended for inhalation and/or buccal dosage comprising one or more prepared herbs in combination excipient ingredients containing water and either one or both glycerol and propylene glycol.

2. A liquid herbal formulation containing one or more herbal substances or extracts intended for vaporisation, and buccal and/or inhalation delivery that is essentially free of oily substances.

3. A TGA listed liquid herbal formulation intended for dosage delivery via a constructed, powered personal inhalation device intended for self medication.

4. A liquid herbal formulation that is supplied within or to be used in conjunction with a constructed, powered personal inhalation device, intended or advertised for therapeutic or personal benefit.

5. A compounded herbal formulation intended for inhalation via a powered personal medication device.