CN114010690B - Traditional Chinese medicine composition for treating leucoderma and application thereof - Google Patents

Traditional Chinese medicine composition for treating leucoderma and application thereof Download PDF

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CN114010690B
CN114010690B CN202111487971.XA CN202111487971A CN114010690B CN 114010690 B CN114010690 B CN 114010690B CN 202111487971 A CN202111487971 A CN 202111487971A CN 114010690 B CN114010690 B CN 114010690B
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traditional chinese
chinese medicine
medicine composition
treating leucoderma
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CN114010690A (en
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秘明堂
解彩霞
韩茂娟
曹金凤
岳坤
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Laiwu Central Hospital Of Xinwen Mining Group
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

The invention discloses a traditional Chinese medicine composition for treating leucoderma and application thereof, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following components in parts by weight: 50 to 65 parts of Chinese angelica, 20 to 40 parts of liquorice, 25 to 35 parts of pseudo-ginseng, 25 to 35 parts of tribulus terrestris, 15 to 25 parts of magnet, 15 to 25 parts of pyrite and 20 to 40 parts of cortex dictamni. The traditional Chinese medicine composition can be applied to preparing medicines for treating leucoderma, and the medicines are water decoction, capsules or paste. The traditional Chinese medicine composition takes the effects of dispelling wind, nourishing blood, activating blood circulation, soothing liver, regulating qi, tonifying qi, strengthening exterior, tonifying kidney, benefiting lung, supplementing copper ions and trace elements as treatment rules, and has good curative effects on treating leucoderma when being taken by water decoction, ground into powder, filled into capsules or prepared into paste for application.

Description

Traditional Chinese medicine composition for treating leucoderma and application thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating leucoderma and application thereof.
Background
Vitiligo is a relatively common acquired pigmentary skin disease and is characterized by complete loss of pigment from local or generalized skin mucous membranes. Due to the loss of melanocyte function of the skin, but the mechanism is not clear. All parts of the body can occur, usually around the back of the fingers, wrists, forearms, face, neck and genitals.
The pathogenesis of the leucoderma is not clear, and the pathogenesis of the leucoderma is considered to be genetic, autoimmune, insufficient or lack of copper elements in a body, mental factors, self-destruction of melanocytes, trauma, sunlight solarization and other reasons. The current common treatment methods comprise hormone treatment, local treatment, transplantation treatment, immunosuppressant and vitamin D3 derivative, mainly aims at relieving symptoms, is difficult to completely cure the white class, and does not have a specific medicine and an ideal treatment method.
The traditional Chinese medicine has profound profuse traditional Chinese medicine treatment, stronger pertinence of treatment based on syndrome differentiation, can comprehensively improve the overall health degree of patients, can improve the clinical curative effect and effectively reduce the recurrence risk, and has high medicine safety. The traditional Chinese medicine takes overall view and treatment based on syndrome differentiation as the center, and gradually shows obvious advantages in the treatment of the disease. Therefore, the research and development of the traditional Chinese medicine composition for treating leucoderma or inhibiting leucoderma has important significance.
Disclosure of Invention
Aiming at the problems of poor effect and difficult cure of treating leucoderma in the prior art, the invention provides the traditional Chinese medicine composition for treating leucoderma and the application thereof.
The invention is realized by the following technical scheme:
a traditional Chinese medicine composition for treating leucoderma comprises the following components in parts by weight: 50 to 65 parts of Chinese angelica, 20 to 40 parts of liquorice, 25 to 35 parts of pseudo-ginseng, 25 to 35 parts of tribulus terrestris, 15 to 25 parts of magnet, 15 to 25 parts of pyrite and 20 to 40 parts of cortex dictamni.
Further, the traditional Chinese medicine composition for treating leucoderma comprises the following components in parts by weight: 60 parts of angelica, 30 parts of liquorice, 30 parts of pseudo-ginseng, 30 parts of caltrop, 20 parts of magnetite, 20 parts of native copper and 30 parts of cortex dictamni.
In the invention, the traditional Chinese medicine composition is applied to the preparation of the medicine for treating leucoderma.
Further, the medicine is water decoction, capsule or ointment.
The traditional Chinese medicine composition for treating the vitiligo takes the effects of dispelling wind, nourishing blood, promoting blood circulation, soothing liver, regulating qi, tonifying qi, strengthening exterior, tonifying kidney, benefiting lung, supplementing copper ions and trace elements as treatment rules, and has good curative effects on treating the vitiligo by being decocted in water, ground into powder, filled into capsules or prepared into paste for oral administration.
The angelica sinensis is sweet, pungent and warm in taste, enters liver, heart and spleen channels, has the effects of enriching blood and activating blood, regulating menstruation and relieving pain, and relaxing bowel, and is used for treating blood deficiency and chlorosis, dizziness and palpitation, irregular menstruation, amenorrhea and dysmenorrheal, deficiency cold and abdominal pain, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, carbuncle, cellulitis and pyocutaneous disease. The wine-soaked Chinese angelica can activate blood and dredge channels, and is used for treating amenorrhea and dysmenorrhea, rheumatic arthralgia and traumatic injury.
Notoginseng radix, warm in nature, sweet in taste, slightly bitter in taste, entering liver meridian and stomach meridian, has effects of removing blood stasis, stopping bleeding, detumescence and relieving pain, and can be used for hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, traumatic swelling and pain.
The caltrop is slightly warm in nature, pungent and bitter in taste, enters liver meridian, and has the effects of calming liver, resolving depression, promoting blood circulation, dispelling wind, improving eyesight and relieving itching.
Cortex Dictamni Radicis, bitter in flavor, enters spleen, stomach and bladder channels, and has effects of clearing heat and eliminating dampness, dispelling pathogenic wind and removing toxic substance. Can be used for treating damp-heat sore, yellow water dripping, eczema, rubella, scabies, sore, rheumatism, heat arthralgia, jaundice, and dark urine.
Magnetitum, cold in nature, salty in taste, containing trace elements, enters liver, heart and kidney meridians, and has effects of suppressing hyperactive liver, subsiding yang, improving hearing and eyesight, relieving convulsion, tranquilizing mind, and improving inspiration and asthma. Can be used for treating dizziness, blurred vision, tinnitus, deafness, palpitation, insomnia, deficiency of the kidney, and asthma.
Native copper, neutral in nature, pungent in taste, containing copper ions, enters liver meridian, and has effects of removing blood stasis, setting bone and relieving pain. Can be used for treating traumatic injury, swelling and pain, and fracture of tendons and bones.
Licorice, nature and taste: sweet and neutral. Meridian tropism: it has effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
Advantageous effects
The traditional Chinese medicine composition takes the treatment principles of dispelling wind, nourishing blood, promoting blood circulation, soothing liver, regulating qi, tonifying qi, strengthening exterior, tonifying kidney, benefiting lung, supplementing copper ions and trace elements, and has good curative effect on treating leucoderma when being taken by water decoction, ground into powder, filled into capsules or prepared into paste for application.
Detailed Description
The following examples are given for the detailed implementation and specific operation of the present invention, but the scope of the present invention is not limited to the following examples.
Example 1
A Chinese medicinal composition for treating vitiligo comprises: 60 g of angelica, 30 g of liquorice, 30 g of pseudo-ginseng, 30 g of caltrop, 20 g of magnetite, 20 g of native copper and 30 g of cortex dictamni.
Vitiligo is a common acquired depigmentation skin mucosa disease, the pathogenesis of the vitiligo is not completely clear at present, and the traditional Chinese medicine composition for treating the vitiligo is adopted from 1 month in 2012 to 12 months in 2020. Respectively making into paste (decocting the Chinese medicinal materials in water for 3 hr, filtering, concentrating the filtrate to thick paste, adding Mel, decocting with slow fire, stirring, and making into pill by pulling flag or dripping water, and children take No. 1 capsule (each capsule contains 0.3 g of fine powder) twice a day or grinding into superfine powder for patients of different ages.
Data and method
(1) Clinical data
166 patients with stationary phase vitiligo vulgaris all come from the outpatient clinic of our hospital and are divided into two groups: the group of children comprises 68 children, 30 men and 38 women, the average age is 6.5 years (3 to 14 years), and the average course of disease is 1.3 years (1 month to 3.2 years). 98 adults, 40 men and 58 women have the average age of 38.2 years (18 to 59 years) and the average course of disease of 3.2 years (2 months to 6 years). Two groups of patients have no cardiovascular and cerebrovascular diseases, digestive system diseases and urinary system diseases, no endocrine diseases and sunlight sensitivity diseases, patients with skin tumor diseases, cataract and glaucoma, and patients in pregnancy and lactation period, and no systemic medicine or external medicine treatment is available 8 weeks before clinical observation. (2) Method of treatment
The ointment formula is orally administered to 68 cases of children, 2 times per day, and 3-5 ml each time. In adult group, 98 capsules are orally taken 2 times a day, 4 capsules each time.
(3) Observation method and therapeutic effect judgment standard
Before and after the treatment of the patients, at the 4 th, 8 th, 12 th, 16 th and 20 th weeks, follow-up visits are carried out, and the curative effect and the adverse reaction are observed and recorded. The judgment standard of the curative effect is as follows: basically, the white spot of the patient is completely removed, and the normal skin color is recovered; the obvious effect means that the white spot part of the affected part is removed or reduced, and the area for recovering normal skin color accounts for more than or equal to 50 percent of the area of skin damage; improvement: the white spot of the affected part is removed or reduced, and the area of recovered normal skin color accounts for 10 to 49 percent of the area of skin damage; and (4) invalidation: the white spots are not regenerated by pigment or the skin damage area is not increased; the total effective rate is measured by the basic cure rate, the obvious effective rate and the improvement rate.
(4) Results
Group of children 68 cases: 38 cases are cured, the obvious effect is 12 cases, 10 cases are improved, the ineffective effect is 8 cases, and the effective rate is 88.2 percent;
adult group 98 cases: the traditional Chinese medicine composition has 46 cured cases, obvious effect of 18 cases, improvement of 10 cases and no effect of 24 cases, and the effective rate is 75.5 percent.
The curative effect grades of two groups of patients are compared, wherein the total effective rate of the children group is 88.2 percent, the total effective rate of the adults group is 75.5 percent, and the total effective rate of the children group is superior to that of the adults group.
(5) Adverse reaction
The patients in both children and adults have no adverse reaction.

Claims (4)

1. The traditional Chinese medicine composition for treating leucoderma is characterized by being prepared from the following components in parts by weight: 50 to 65 parts of Chinese angelica, 20 to 40 parts of liquorice, 25 to 35 parts of pseudo-ginseng, 25 to 35 parts of tribulus terrestris, 15 to 25 parts of magnet, 15 to 25 parts of native copper and 20 to 40 parts of cortex dictamni.
2. The traditional Chinese medicine composition for treating leucoderma according to claim 1, which is prepared from the following components in parts by weight: 60 parts of angelica, 30 parts of liquorice, 30 parts of pseudo-ginseng, 30 parts of caltrop, 20 parts of magnetite, 20 parts of native copper and 30 parts of cortex dictamni.
3. Use of a Chinese medicinal composition according to claim 1 or 2 in the preparation of a medicament for the treatment of vitiligo.
4. The use of claim 3, wherein the medicament is a water decoction, capsule or ointment.
CN202111487971.XA 2021-12-08 2021-12-08 Traditional Chinese medicine composition for treating leucoderma and application thereof Active CN114010690B (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105535076A (en) * 2016-02-09 2016-05-04 安丽凤 Medicine prepared from angelica and tribulus terrestris and used for treating leucoderma as well as preparation method and application thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105535076A (en) * 2016-02-09 2016-05-04 安丽凤 Medicine prepared from angelica and tribulus terrestris and used for treating leucoderma as well as preparation method and application thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
徐天予.几组相似药名的用药鉴别.《云南中医中药杂志》.2010,(第01期), *
杨永辉.乌蛇荣皮汤治疗白癜风一则.《山东中医杂志》.2011,第30卷(第03期), *

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