CN114010517A - Coenzyme Q10 skin-care gel for moisturizing, wrinkle removing and whitening and preparation method thereof - Google Patents
Coenzyme Q10 skin-care gel for moisturizing, wrinkle removing and whitening and preparation method thereof Download PDFInfo
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- CN114010517A CN114010517A CN202111230935.5A CN202111230935A CN114010517A CN 114010517 A CN114010517 A CN 114010517A CN 202111230935 A CN202111230935 A CN 202111230935A CN 114010517 A CN114010517 A CN 114010517A
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Abstract
The invention relates to the technical field of skin care products, in particular to coenzyme Q10 skin care gel for moisturizing, wrinkle removing and whitening and a preparation method thereof. The skin-care gel disclosed by the invention contains two main components of coenzyme Q10 and ganoderma lucidum spore oil, and active components related to skin moisturizing, wrinkle resisting and whitening, such as melatonin, vitamin E, hexapeptide, sodium hyaluronate, allantoin, betaine, taurine and the like are added, and the skin-care gel is prepared according to a preparation process of the gel.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to coenzyme Q10 skin care gel for moisturizing, wrinkle removing and whitening and a preparation method thereof.
Background
The dry skin is mainly characterized by tight skin, dry and desquamation of individual parts, and itching of the whole body after bathing, and the phenomena are related to age increase, climate change, insufficient sleep, overfatigue, overheating bath water, strong alkalinity of washing products and the like. The skin is the natural coat of human body and is divided into three major parts of epidermis, dermis and hypodermis from outside to inside, and the epidermis is divided into stratum corneum, stratum lucidum, stratum granulosum, acanthosphere and stratum basale. The stratum corneum, the outermost layer of the skin, plays an important role in the integrity of the skin barrier function. A sebum membrane is formed on the horny layer, and is a semitransparent milky membrane formed by emulsifying sebum, sweat and epidermal cell secretion, and free fatty acid, lactate, urea and uric acid in the sebum membrane are natural moisturizing factors and play a role in moisturizing the skin. The horny layer and the sebum membrane can prevent the loss of skin moisture, and under normal conditions, the water content of the horny layer is about 10 percent, and the water-deficient skin is formed when the water content is lower than the level; skin dryness occurs due to lack of water, and is mainly caused by impaired proliferation and differentiation of keratinocytes, reduced lipid content and reduced hydration, mainly occurs in the epidermis layer, while the dermis layer and subcutaneous tissues are not affected. Skin dryness is mainly caused by alterations in the structure of the stratum corneum of the epidermis and by disturbances in the skin barrier function.
The epidermal barrier of the skin is composed of two functional components: a cellular protein matrix consisting of interconnected keratinocytes arranged in layers and keratinocytes in the outermost layer; second is intercellular lipids. Damage to either component of the epidermis leads to increased transepidermal water loss, leading to xeroderma, manifesting as dry skin, desquamation, roughness, fine fissures, and itching, with normal stratum corneum water content of 20% to 35% and below 10% with marked xeroderma. The keratinocyte and natural moisturizing factor are used, the keratinocyte is constantly and regularly renewed, and can penetrate through all layers from the lowest layer to be finally shed, when the moisture is sufficient, the undegraded desmosomes are stripped, and the keratinocyte on the surface is separated and shed. Unlike normal skin, dry skin exhibits retention of keratinocyte desmosomes in the normally exfoliated stratum corneum, resulting in a rapid exfoliation of thin flakes or scale-like keratinocytes that can be visibly seen, which is not detectable in single cell exfoliation. The function of the epidermal barrier is damaged, the organism has an automatic repair function, the repair function is called as the physiological repair of the epidermal barrier, if a self-balance signal associated with the function of repairing the epidermal barrier is started, the self-repair function of the epidermal barrier can be started through the synthesis of grease, coenzyme Q10 in the human body plays an important role in the skin repair, the normal functions of two components of the epidermal barrier can be maintained and ensured, and the integrity, the water balance, the hydration and the shedding of aged cutin of the skin are ensured.
Therefore, the coenzyme Q10 is very promising in application in developing skin care products with moisturizing and wrinkle removing functions.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention aims to provide coenzyme Q10 skin-care gel for moisturizing, wrinkle-removing and whitening and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
a coenzyme Q10 skin-care gel for moisturizing, wrinkle removing and whitening skin comprises the following raw materials in parts by weight: 100.03-0.20 part of coenzyme Q, 1.0-3.0 parts of ganoderma lucidum spore oil, 0.1-3 parts of melatonin, 0.05-0.10 part of vitamin E, 1.0-3.0 parts of hexapeptide, 0.1-0.3 part of sodium hyaluronate, 0.2-0.6 part of allantoin, 0.1-0.3 part of betaine, 0.1-0.3 part of taurine, 60.1-0.3 part of vitamin B, 0.3-1.0 part of 3-O-ethyl ascorbic acid ether, 0.4-1.0 part of xanthan gum, 3-8 parts of butanediol, 1.0-3.0 parts of polyoxyethylene 100 stearate, 1-2 parts of cetearyl glucoside, 0.1-0.5 part of polyoxyethylene stearate ether, 1.0-3.0 part of hexadecanol, 1.0-3.0 part of glycerol stearate, 3.0 parts of cyclopentasidiomethylsiloxane, 3.0-5.0 parts of squalane and 0-0 part of water.
In the skin, coenzyme Q10 is present not only in living cells, but also in skin surface lipids, which are part of the stratum corneum, forming the outermost barrier of the skin. Skin surface lipids consist of a mixture of sebum secreted by sebaceous glands and lipids mainly derived from keratinocytes. Because of their location on the skin surface, skin surface lipids are often exposed to ultraviolet radiation, air pollution, chemical oxidants and microbial contamination. Studies have shown that skin surface lipid coenzyme Q10 levels decrease with age and also after in vitro uv irradiation. The structural changes of the stratum corneum are the main cause of skin dryness, and the main components of the stratum corneum are structural proteins, intercellular lipids, natural moisturizing factors and enzyme systems. The barrier function of the skin and the hydration of the stratum corneum are largely dependent on the levels of lipids and natural moisturizing factors in the stratum corneum. Research shows that after the skin is treated by the external liniment containing the coenzyme Q10, the content of the coenzyme Q10 in skin surface lipid is obviously improved, and the content of the coenzyme Q10 in the skin surface lipid cannot be improved by taking a large amount of the coenzyme Q10 orally. This demonstrates that coenzyme Q10 supplementation by external preparations can directly counteract the short-term environmental stress-induced and age-related coenzyme Q10 deficiency on the skin surface. In particular, young people with normal coenzyme Q10 values may benefit because spontaneously occurring external oxidative stress may be neutralized rapidly by coenzyme Q10. Coenzyme Q10 supplementation is also a significant benefit in the elderly population where skin is already aging. Therefore, it is advantageous to use a coenzyme Q10 containing formulation to protect the outermost skin layer for any age of skin. Studies with coenzyme Q10 have also shown that topical application of Q10 to the skin can penetrate the skin, be metabolically converted, exert an antioxidant effect and can maintain cellular energy levels. These effects are not only beneficial to the elderly suffering from Q10 deficiency, but also may supplement the Q10 levels that are lost over time. People of all ages can be treated with the formula containing Q10 on a regular basis to more effectively combat short-term damage due to uv radiation and stress, and to promote long-term anti-aging effects on the skin.
Ganoderma spore is the extremely fine granule ejected from pileus of Ganoderma in mature period, and is the germ cell of Ganoderma. A process for extracting ganoderma spore oil from ganoderma spore wall includes such steps as supercritical carbon dioxide fluid extraction to obtain ganoderma spore oil, which contains fatty acids, unsaturated fatty acids including oleic acid, linoleic acid, palmitoleic acid, linolenic acid, saturated fatty acids including stearic acid, palmitic acid, etc, supercritical carbon dioxide extraction to obtain 5 compounds including dibutyl terephthalate, ergosta-4, 6, 8(14) -22-tetraen-3-one, ergosta-7, 22-dien-3 beta-ol, monoglyceryl tetracosanoate and palmitic acid. The research on the antioxidation and the anti-aging of the ganoderma lucidum spore oil proves that the ganoderma lucidum spore oil has stronger scavenging capacity on NaNO2, DPPH free radicals and superoxide anion free radicals and has an obvious dose effect relationship; research on anti-aging effect of model mice with aging caused by D-galactose shows that the ganoderma lucidum spore oil can improve spleen index, thymus index, SOD and CAT activity of the mice and has an anti-oxidation function; can promote the expression of C3mRNA and inhibit the expression of P21mRNA, supposedly enhance the biological defense reaction of the C3 complement pathway of a model mouse, possibly be one of the mechanisms of improving the immunity of an aged mouse by ganoderma lucidum spore oil, and change the expression of an inhibitory factor P21 by down-regulating the expression of P21mRNA, possibly be one of the anti-aging mechanisms of the ganoderma lucidum spore oil. Researchers observe the effects of the ganoderan on the oxidation resistance and the skin aging delaying of the skin tissues of mice aged by D-galactose. 2-month-old Kunming mice are randomly divided into a normal group, an aging model group, a vitamin E group and a ganoderma lucidum polysaccharide group, and the last 3 groups are injected with D-galactose subcutaneously. Establishing a mouse aging model, simultaneously, intragastrically administering physiological saline, vitamin E (250 mg.kg < -1 >) and ganoderan (250 mg.kg < -1 >) every day, taking the back skin of the mouse after 42 days as a pathological section, observing the change of skin tissue morphology, detecting the thickness of epidermis and dermis, and determining the content of superoxide dismutase (SOD) and the expression level of CuZn-SOD mRNA in the skin.
As a result, the thicknesses (mum) of the epidermis and the dermis of the mice in the aging model group are obviously thinner than those in the normal group, and the thicknesses of the epidermis and the dermis of the mice in the vitamin E group and the ganoderma lucidum polysaccharide group are obviously thicker than those in the aging model group. Histopathology shows that, compared with the aging model group, the ganoderma lucidum polysaccharide group has good epidermal structure, thickened dermis, clear boundary of epidermis and dermis, clear basement membrane, evenly distributed dermal collagen fiber, even and compact nuclear chromosome, abundant subcutaneous fat and normal hair follicle and gland. Compared with normal mice, the skin SOD activity of the mice of the aging model group is obviously reduced, the enzyme activity can be obviously recovered by both the ganoderma lucidum polysaccharide and the vitamin E, and the ganoderma lucidum polysaccharide is stronger than the vitamin E. In addition, the cycle threshold (Ct) of CuZn-SOD mRNA expression in the skin of the ganoderan mice is obviously reduced. The results show that the ganoderan can increase the thickness of epidermis and dermis of aged mice, improve the structure of skin tissues and increase the level of antioxidase in the skin tissues. The research finds that the coenzyme Q10 is dissolved into the ganoderma lucidum spore oil, the coenzyme Q10 can fully play the roles of supplementing and repairing skin lipid components and has an important moisturizing effect on the skin, the composition has good film-forming property, a compact film can be formed on the surface of the skin, the water loss on the surface of the skin is reduced, the hydration effect of the stratum corneum is enhanced, the water locking effect is achieved, and the skin moisturizing cosmetic prepared for external use has a good curative effect.
The peptide belongs to degraded micromolecular collagen and contains amino acid groups; peptide is also a component originally existing in human body, two amino acids are called as two-peptide, three amino acids are called as three-peptide, and so on. The hexapeptide is an oligopeptide chain consisting of six amino acid groups. The hexapeptide is also called hexapeptide (Areginine Essence) and is extracted from a strain called unicellular green dense bacterium which is found in the south Pole gulf ice river mud at the earliest time, and the hexapeptide fine structure can effectively relieve and inhibit the forehead raising line, the contraction and the activity of the eye fishtail line and the peripheral muscles help the muscles relax, so that the peptide tissue recovers a smooth line. The plant hexapeptide is extracted from natural herbaceous plant and cut by selective enzyme, and possesses all the characteristics of hexapeptide. Meanwhile, the plant hexapeptide also has good water solubility and safety, so the plant hexapeptide is also called green peptide. The hexapeptide can promote the growth of collagen cells and fibroblasts, and has the functions of resisting wrinkles and aging; can inhibit nerve conduction, avoid muscle over contraction, and prevent fine lines; can relax muscle, effectively recombine collagen elasticity, and restore skin smoothness. The skin care effects of the peptides are firstly to prevent aging and wrinkle, wherein the five peptides and the six peptides are most known, the former can inhibit metal protein decomposition enzyme and stimulate collagen regeneration, and the latter is also called botulinum toxin and can block the conduction between nerves and muscles and relax over-active muscles so as to achieve the effects of smoothing surface fine lines and wrinkles such as dynamic lines and expression lines, and the other combined peptides respectively have the functions of activating hormone estrogen, improving sagging breasts, resisting eye bags and the like.
The invention provides a skin-care gel with the functions of moisturizing, removing wrinkles and whitening, which consists of coenzyme Q10 and ganoderma lucidum spore oil, the gel contains two main components of coenzyme Q10 and ganoderma lucidum spore oil, and active components related to skin moisturizing, preventing wrinkles and whitening, such as melatonin, vitamin E, hexapeptide, sodium hyaluronate, allantoin, betaine, taurine, vitamin B6, 3-O-ethyl ascorbic acid ether and the like, are added, the skin-care gel is prepared according to the preparation process of the gel, the product is a better and longer-acting skin-care preparation with the functions of moisturizing, removing wrinkles and whitening, softening cutin, softening and tendering skin, and having the effects of locking water, helping the skin to accelerate the removal of aged cells, enabling the skin to be more fresh and cool, accelerating the absorption of nutrients and generating whitening effects, reducing the skin sensitivity, and having the long-acting effects of moisturizing, removing wrinkles and whitening on dry skin, can relieve the dryness of the skin, gradually eliminate the dryness symptom and present youthful beautiful appearance.
The material also comprises the following raw materials in parts by weight: 2.0-4.0 parts of beta-glucan, 0.2-0.4 part of phenoxyethanol and 0.1-0.3 part of methylparaben.
Preferably, the feed consists of the following raw materials in parts by weight: 100.05 parts of coenzyme Q, 1.0 part of ganoderma lucidum spore oil, 0.2 part of melatonin, 0.05 part of vitamin E, 1.0 part of hexapeptide, 0.15 part of sodium hyaluronate, 0.4 part of allantoin, 0.15 part of betaine, 0.2 part of taurine, 60.2 parts of vitamin B, 0.5 part of 3-O-ethyl ascorbic acid ether, 0.4 part of xanthan gum, 5 parts of butanediol, 2.0 parts of polyoxyethylene 100 stearate, 1.5 parts of cetearyl glucoside, 0.1 part of polyoxyethylene stearyl ether, 1.0 part of cetostearyl alcohol, 2.0 parts of glycerol stearate, 4.0 parts of cyclopenta dimethyl siloxane, 4.0 parts of squalane, 3.0 parts of beta-glucan, 0.3 part of ethanol phenoxy, 0.2 part of methyl hydroxybenzoate and 160 parts of water.
The preparation method of the coenzyme Q10 skin-care gel for moisturizing, wrinkle-removing and whitening comprises the following steps:
s1, dissolving coenzyme Q10 in ganoderma lucidum spore oil, and mixing with vitamin E to obtain solution A;
s2, adding betaine, allantoin, sodium hyaluronate, xanthan gum, taurine and butanediol into a proper amount of water, heating and dissolving until no particles are dissolved to obtain solution B;
s3, heating cetearyl glucoside, polyoxyethylene 100 stearate, polyoxyethylene stearyl alcohol ether and glycerol stearate until the materials are completely melted, then stopping heating, adding cyclopentadimethylsiloxane and squalane, and continuously stirring until the materials are completely dissolved to obtain solution C;
s4, adding the hexapeptide, the vitamin B6, the 3-O-ethyl ascorbic acid ether, the beta-glucan and the melatonin into a proper amount of water, and dissolving to obtain a solution D;
and S5, pouring the solution B into the solution C for rapid and uniform emulsification, and then sequentially adding the solution A and the solution D for uniform emulsification.
In the step S1, heating Ganoderma spore oil in water bath of 40-60 deg.C, adding coenzyme Q10, dissolving, and mixing with vitamin E to obtain solution A.
In the step S2, betaine, allantoin, sodium hyaluronate, xanthan gum, taurine and butanediol are added into 60-80 parts by weight of water, the mixture is heated to 75-85 ℃, and the mixture is stirred for 15-30min at constant temperature until no particles are dissolved, so that liquid B is obtained.
In the step S3, cetearyl glucoside, polyoxyethylene 100 stearate, polyoxyethylene stearyl alcohol ether and glyceryl stearate are mixed, heated in a water bath at 75-85 ℃, stirred until the mixture is completely melted, then the heating is stopped, cyclopentadimethylsiloxane and squalane are added, and the mixture is continuously stirred until the mixture is completely dissolved, so that liquid C is obtained.
In step S4, the hexapeptide, the vitamin B6, the 3-O-ethyl ascorbic acid ether, the beta-glucan and the melatonin are added into 60-80 parts by weight of water and dissolved to obtain solution D.
And step S5, pouring the solution B into the solution C, quickly and uniformly emulsifying, cooling to 40-50 ℃, and then sequentially adding the solution A and the solution D, and uniformly emulsifying.
The invention has the beneficial effects that: the invention provides a skin-care gel with the functions of moisturizing, removing wrinkles and whitening, which consists of coenzyme Q10 and ganoderma lucidum spore oil, the gel contains two main components of coenzyme Q10 and ganoderma lucidum spore oil, and active components related to skin moisturizing, preventing wrinkles and whitening, such as melatonin, vitamin E, hexapeptide, sodium hyaluronate, allantoin, betaine, taurine, vitamin B6, 3-O-ethyl ascorbic acid ether and the like, are added, the skin-care gel is prepared according to the preparation process of the gel, the product is a better and longer-acting skin-care preparation with the functions of moisturizing, removing wrinkles and whitening, softening cutin, softening and tendering skin, and having the effects of locking water, helping the skin to accelerate the removal of aged cells, enabling the skin to be more fresh and cool, accelerating the absorption of nutrients and generating whitening effects, reducing the skin sensitivity, and having the long-acting effects of moisturizing, removing wrinkles and whitening on dry skin, can relieve the dryness of the skin, gradually eliminate the dryness symptom and present youthful beautiful appearance.
Detailed Description
The present invention will be further described with reference to the following examples for facilitating understanding of those skilled in the art, and the description of the embodiments is not intended to limit the present invention.
Example 1
A coenzyme Q10 skin-care gel for moisturizing, wrinkle removing and whitening skin is composed of the following raw materials in parts by weight: 100.05 parts of coenzyme Q, 1.0 part of ganoderma lucidum spore oil, 0.2 part of melatonin, 0.05 part of vitamin E, 1.0 part of hexapeptide, 0.15 part of sodium hyaluronate, 0.4 part of allantoin, 0.15 part of betaine, 0.2 part of taurine, 60.2 parts of vitamin B, 0.5 part of 3-O-ethyl ascorbic acid ether, 0.4 part of xanthan gum, 5 parts of butanediol, 2.0 parts of polyoxyethylene 100 stearate, 1.5 parts of cetearyl glucoside, 0.1 part of polyoxyethylene stearyl ether, 1.0 part of cetostearyl alcohol, 2.0 parts of glycerol stearate, 4.0 parts of cyclopenta dimethyl siloxane, 4.0 parts of squalane, 3.0 parts of beta-glucan, 0.3 part of ethanol phenoxy, 0.2 part of methyl hydroxybenzoate and 160 parts of water.
The preparation method of the coenzyme Q10 skin-care gel for moisturizing, wrinkle-removing and whitening comprises the following steps:
s1, heating Ganoderma spore oil in water bath at 50 deg.C, adding coenzyme Q10, dissolving, and mixing with vitamin E to obtain solution A;
s2, in the step S2, adding betaine, allantoin, sodium hyaluronate, xanthan gum, taurine and butanediol into 80 parts by weight of water, heating to 80 ℃, stirring at constant temperature for 25min until no particles are dissolved, and obtaining solution B;
s3, mixing cetearyl glucoside, polyoxyethylene 100 stearate, polyoxyethylene stearyl alcohol ether and glycerol stearate, heating in a water bath at 80 ℃, stirring until the materials are completely molten, stopping heating, adding cyclopentadimethylsiloxane and squalane, and continuously stirring until the materials are completely dissolved to obtain a solution C;
s4, in the step S4, adding the hexapeptide, the vitamin B6, the 3-O-ethyl ascorbic acid ether, the beta-glucan and the melatonin into 80 parts by weight of water, and dissolving to obtain a solution D;
and S5, pouring the solution B into the solution C, quickly and uniformly emulsifying, cooling to 45 ℃, sequentially adding the solution A and the solution D, and uniformly emulsifying.
Example 2
A coenzyme Q10 skin-care gel for moisturizing, wrinkle removing and whitening skin is composed of the following raw materials in parts by weight: 100.03 parts of coenzyme Q, 1.0 part of ganoderma lucidum spore oil, 0.1 part of melatonin, 0.05 part of vitamin E, 1.0 part of hexapeptide, 0.1 part of sodium hyaluronate, 0.2 part of allantoin, 0.1 part of betaine, 0.1 part of taurine, 60.1 parts of vitamin B, 0.3 part of 3-O-ethyl ascorbic acid ether, 0.4 part of xanthan gum, 3 parts of butanediol, 1.0 part of polyoxyethylene 100 stearate, 1 part of cetearyl glucoside, 0.1 part of polyoxyethylene stearyl ether, 1.0 part of cetearyl alcohol, 1.0 part of glycerol stearate, 3.0 parts of cyclopenta dimethyl siloxane, 3.0 parts of squalane, 2.0 parts of beta-glucan, 0.2 part of phenoxyethanol, 0.1 part of methyl hydroxybenzoate and 120 parts of water.
The preparation method of the coenzyme Q10 skin-care gel for moisturizing, wrinkle-removing and whitening comprises the following steps:
s1, heating Ganoderma spore oil in 40 deg.C water bath, adding coenzyme Q10, dissolving, and mixing with vitamin E to obtain solution A;
s2, in the step S2, adding betaine, allantoin, sodium hyaluronate, xanthan gum, taurine and butanediol into 60 parts by weight of water, heating to 75 ℃, stirring at constant temperature for 15min until no particles are dissolved, and obtaining liquid B;
s3, mixing cetearyl glucoside, polyoxyethylene 100 stearate, polyoxyethylene stearyl alcohol ether and glycerol stearate, heating in a water bath at 75 ℃, stirring until the mixture is completely melted, stopping heating, adding cyclopentadimethylsiloxane and squalane, and continuously stirring until the mixture is completely dissolved to obtain a solution C;
s4, in the step S4, the hexapeptide, the vitamin B6, the 3-O-ethyl ascorbic acid ether, the beta-glucan and the melatonin are added into 60 parts by weight of water and dissolved to obtain a solution D;
and S5, pouring the solution B into the solution C, quickly and uniformly emulsifying, cooling to 40 ℃, sequentially adding the solution A and the solution D, and uniformly emulsifying.
Example 3
A coenzyme Q10 skin-care gel for moisturizing, wrinkle removing and whitening skin is composed of the following raw materials in parts by weight: 100.20 parts of coenzyme Q, 3.0 parts of ganoderma lucidum spore oil, 3 parts of melatonin, 0.10 part of vitamin E, 3.0 parts of hexapeptide, 0.3 part of sodium hyaluronate, 0.6 part of allantoin, 0.3 part of betaine, 0.3 part of taurine, 60.3 parts of vitamin B, 1.0 part of 3-O-ethyl ascorbic acid ether, 1.0 part of xanthan gum, 8 parts of butanediol, 3.0 parts of polyoxyethylene 100 stearate, 2 parts of cetearyl glucoside, 0.5 part of polyoxyethylene stearyl ether, 3.0 parts of cetearyl alcohol, 3.0 parts of glycerol stearate, 5.0 parts of cyclopenta dimethyl silicone polymer, 5.0 parts of squalane, 4.0 parts of beta-glucan, 0.4 part of phenoxyethanol, 0.3 part of methyl hydroxybenzoate and 160 parts of water.
The preparation method of the coenzyme Q10 skin-care gel for moisturizing, wrinkle-removing and whitening comprises the following steps:
s1, heating Ganoderma spore oil in water bath at 60 deg.C, adding coenzyme Q10, dissolving, and mixing with vitamin E to obtain solution A;
s2, in the step S2, adding betaine, allantoin, sodium hyaluronate, xanthan gum, taurine and butanediol into 80 parts by weight of water, heating to 85 ℃, stirring at constant temperature for 30min until no particles are dissolved, and obtaining solution B;
s3, mixing cetearyl glucoside, polyoxyethylene 100 stearate, polyoxyethylene stearyl alcohol ether and glycerol stearate, heating in a water bath at 85 ℃, stirring until the materials are completely molten, stopping heating, adding cyclopentadimethylsiloxane and squalane, and continuously stirring until the materials are completely dissolved to obtain a solution C;
s4, in the step S4, the hexapeptide, the vitamin B6, the 3-O-ethyl ascorbic acid ether, the beta-glucan and the melatonin are added into 60-80 parts by weight of water and dissolved to obtain a solution D;
and S5, pouring the solution B into the solution C, quickly and uniformly emulsifying, cooling to 50 ℃, sequentially adding the solution A and the solution D, and uniformly emulsifying.
Comparative example 1
This comparative example differs from example 1 in that:
the comparative example adopts sesame oil with equal weight parts to replace ganoderma lucidum spore oil.
Comparative example 2
This comparative example differs from example 1 in that:
the comparative example contains 0 part of coenzyme Q10, 1.0 part of ganoderma lucidum spore oil and 1.0 part of hexapeptide.
Comparative example 3
This comparative example differs from example 1 in that:
the comparative example contains 0.05 part of coenzyme Q10, 1.0 part of ganoderma lucidum spore oil and 0 part of hexapeptide.
The skin care gels of example 1 and comparative examples 1-3 were subjected to a moisturizing test, in which 32 subjects, women between the ages of 25-35, were found, and divided into 1 test group and 3 control groups of 8 persons each. Prior to the test, the subjects required a uniform mild cleanser to wash the flexor side of the arm and draw 5X 5cm on the left and right arm2And numbering the square experimental areas with symmetrical positions, taking the right arm as a testing area for smearing the moisturizing product, taking the symmetrical area corresponding to the left arm as a blank control, sitting the tester in a constant environment for 30min, detecting each test part by using an Antsci-skin-sp skin tester, and repeating the steps for 5 times to obtain an average value. And then, lightly coating the solution of each humectant on each area in sequence, and uniformly coating. The test sample amount in each area is 0.05g, the test sample is applied for 1, 2, 4, 6, 8 and 10 hours and then detected at the parts respectively, m values are detected for each test area for 5 times in each time period, and the average value of the m values of 5 times in the time period is obtained. The whole study was carried out at a temperature of 26-28 ℃ and humidityThe air conditioning is carried out in an air conditioning room with the air conditioning degree of 38-40%. To better evaluate the data obtained, the concept of hydration was introduced, where the hydration of the site was determined by dividing the m-average value of each test by the m-average value of a blank without humectant applied, and when the hydration was greater than 1, it indicated that the skin moisture content increased after application of the test sample. When the hydration rate is less than 1, it means that the moisture content of the skin is reduced after the test sample is applied. The results of the experiment are as follows:
from the above experimental results, it can be seen that the skin care gel containing coenzyme Q10, ganoderma lucidum spore oil and hexapeptide has better effect than the skin care gel containing only two of the skin care gel, which is mainly the result of the combined action of coenzyme Q10, ganoderma lucidum spore oil and hexapeptide.
The coenzyme Q10, the ganoderma lucidum spore oil and the hexapeptide are used in a combined manner, so that the effect of any one of the coenzyme Q10, the ganoderma lucidum spore oil and the hexapeptide is greatly improved, a better and longer-acting skin moisturizing, wrinkle preventing and whitening skin care preparation is obtained, the cutin is softened, the skin is soft and smooth, the skin care preparation has the water locking effect, the skin can be helped to quickly remove aged cells, the skin is enabled to be more fresh and cool, the nutrition absorption and the whitening effect are accelerated, the skin sensitivity phenomenon can be reduced, the skin care preparation has the long-acting moisturizing, wrinkle removing and whitening effects on dry skin, the skin can be relieved, the dry symptom gradually disappears, and the youthful and beautiful appearance is presented.
The above-described embodiments are preferred implementations of the present invention, and the present invention may be implemented in other ways without departing from the spirit of the present invention.
Claims (9)
1. A coenzyme Q10 skin-care gel for moisturizing, wrinkle removing and whitening skin is characterized in that: the feed comprises the following raw materials in parts by weight: 100.03-0.20 part of coenzyme Q, 1.0-3.0 parts of ganoderma lucidum spore oil, 0.1-3 parts of melatonin, 0.05-0.10 part of vitamin E, 1.0-3.0 parts of hexapeptide, 0.1-0.3 part of sodium hyaluronate, 0.2-0.6 part of allantoin, 0.1-0.3 part of betaine, 0.1-0.3 part of taurine, 60.1-0.3 part of vitamin B, 0.3-1.0 part of 3-O-ethyl ascorbic acid ether, 0.4-1.0 part of xanthan gum, 3-8 parts of butanediol, 1.0-3.0 parts of polyoxyethylene 100 stearate, 1-2 parts of cetearyl glucoside, 0.1-0.5 part of polyoxyethylene stearate ether, 1.0-3.0 part of hexadecanol, 1.0-3.0 part of glycerol stearate, 3.0 parts of cyclopentasidiomethylsiloxane, 3.0-5.0 parts of squalane and 0-0 part of water.
2. The coenzyme Q10 skin care gel for moisturizing, wrinkle-removing and whitening according to claim 1, which is characterized in that: the feed also comprises the following raw materials in parts by weight: 2.0-4.0 parts of beta-glucan, 0.2-0.4 part of phenoxyethanol and 0.1-0.3 part of methylparaben.
3. The coenzyme Q10 skin care gel for moisturizing, wrinkle-removing and whitening according to claim 1, which is characterized in that: the composition is characterized by comprising the following raw materials in parts by weight: 100.05 parts of coenzyme Q, 1.0 part of ganoderma lucidum spore oil, 0.2 part of melatonin, 0.05 part of vitamin E, 1.0 part of hexapeptide, 0.15 part of sodium hyaluronate, 0.4 part of allantoin, 0.15 part of betaine, 0.2 part of taurine, 60.2 parts of vitamin B, 0.5 part of 3-O-ethyl ascorbic acid ether, 0.4 part of xanthan gum, 5 parts of butanediol, 2.0 parts of polyoxyethylene 100 stearate, 1.5 parts of cetearyl glucoside, 0.1 part of polyoxyethylene stearyl ether, 1.0 part of cetostearyl alcohol, 2.0 parts of glycerol stearate, 4.0 parts of cyclopenta dimethyl siloxane, 4.0 parts of squalane, 3.0 parts of beta-glucan, 0.3 part of ethanol phenoxy, 0.2 part of methyl hydroxybenzoate and 160 parts of water.
4. The method for preparing the coenzyme Q10 skin-care gel for moisturizing, wrinkle-removing and whitening as claimed in any one of claims 1-3, is characterized in that: the method comprises the following steps:
s1, dissolving coenzyme Q10 in ganoderma lucidum spore oil, and mixing with vitamin E to obtain solution A;
s2, adding betaine, allantoin, sodium hyaluronate, xanthan gum, taurine and butanediol into a proper amount of water, heating and dissolving until no particles are dissolved to obtain solution B;
s3, heating cetearyl glucoside, polyoxyethylene 100 stearate, polyoxyethylene stearyl alcohol ether and glycerol stearate until the materials are completely melted, then stopping heating, adding cyclopentadimethylsiloxane and squalane, and continuously stirring until the materials are completely dissolved to obtain solution C;
s4, adding the hexapeptide, the vitamin B6, the 3-O-ethyl ascorbic acid ether, the beta-glucan and the melatonin into a proper amount of water, and dissolving to obtain a solution D;
and S5, pouring the solution B into the solution C for rapid and uniform emulsification, and then sequentially adding the solution A and the solution D for uniform emulsification.
5. The preparation method of the coenzyme Q10 skin-care gel for moisturizing, wrinkle-removing and whitening according to claim 4, wherein the preparation method comprises the following steps: in the step S1, heating Ganoderma spore oil in 40-60 deg.C water bath, adding coenzyme Q10 for dissolving, and mixing with vitamin E to obtain solution A.
6. The preparation method of the coenzyme Q10 skin-care gel for moisturizing, wrinkle-removing and whitening according to claim 4, wherein the preparation method comprises the following steps: and in the step S2, adding betaine, allantoin, sodium hyaluronate, xanthan gum, taurine and butanediol into 60-80 parts by weight of water, heating to 75-85 ℃, stirring at constant temperature for 15-30min until no particles are dissolved, and obtaining solution B.
7. The preparation method of the coenzyme Q10 skin-care gel for moisturizing, wrinkle-removing and whitening according to claim 4, wherein the preparation method comprises the following steps: in the step S3, cetearyl glucoside, polyoxyethylene 100 stearate, polyoxyethylene stearyl alcohol ether and glyceryl stearate are mixed, heated in a water bath at 75-85 ℃, stirred until the mixture is completely melted, then the heating is stopped, cyclopentadimethylsiloxane and squalane are added, and the mixture is continuously stirred until the mixture is completely dissolved, so that liquid C is obtained.
8. The preparation method of the coenzyme Q10 skin-care gel for moisturizing, wrinkle-removing and whitening according to claim 4, wherein the preparation method comprises the following steps: in the step S4, the hexapeptide, the vitamin B6, the 3-O-ethyl ascorbic acid ether, the beta-glucan and the melatonin are added into 60-80 parts by weight of water and dissolved to obtain a solution D.
9. The preparation method of the coenzyme Q10 skin-care gel for moisturizing, wrinkle-removing and whitening according to claim 4, wherein the preparation method comprises the following steps: and in the step S5, pouring the solution B into the solution C, quickly and uniformly emulsifying, cooling to 40-50 ℃, and then sequentially adding the solution A and the solution D, and uniformly emulsifying.
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| CN104840375A (en) * | 2015-04-11 | 2015-08-19 | 广东医学院 | A group of coenzyme Q10 masks with effects of spot removing, wrinkle preventing and whitening |
| CN110215407A (en) * | 2018-09-26 | 2019-09-10 | 嫦娥创新（武汉）生物科技有限公司 | A kind of anti-ageing compact composition and its cosmetics and application |
| CN111658567A (en) * | 2020-07-20 | 2020-09-15 | 广州葆雀化妆品有限公司 | Face-beautifying hexapeptide stock solution |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840375A (en) * | 2015-04-11 | 2015-08-19 | 广东医学院 | A group of coenzyme Q10 masks with effects of spot removing, wrinkle preventing and whitening |
| CN110215407A (en) * | 2018-09-26 | 2019-09-10 | 嫦娥创新（武汉）生物科技有限公司 | A kind of anti-ageing compact composition and its cosmetics and application |
| CN111658567A (en) * | 2020-07-20 | 2020-09-15 | 广州葆雀化妆品有限公司 | Face-beautifying hexapeptide stock solution |
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